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\name{calculatePosteriorAvg}
\alias{calculatePosteriorAvg}
\title{Calculate the posterior average for indicators of concordant and
discordant differential expression}
\description{
This function calculates the posterior average for indicators of concordant and
discordant differential expression from the saved log files. See details.
}
\usage{
calculatePosteriorAvg(object, NCONC=2, NDIFF=1, burnin=0)
}
\arguments{
\item{object}{ Object of class \code{XdeMcmc}}
\item{NCONC}{Integer: number of studies for which the gene must be
differentially expressed (in the same direction) to be classified as
concordant differential expression}
\item{NDIFF}{Integer: number of studies for which a gene must be
up- or down-regulated to be classified as differentially expressed.
It is the union of concordant and discordant differential
expression.}
\item{burnin}{Integer: number of MCMC iterations for the burnin. Posterior means
are computed from the MCMC samples following burnin.}
}
\details{
For each iteration,
1. calculate the sign of delta * Delta
2. For each gene, compute the number of positive signs (P) and the
number of negative signs (N) (a G x 2 matrix, where G is the number of
genes in common across all studies). P + N is <= S, where S is the
number of studies.
3. for a given gene, the discordant indicator is simply when P * N
is nonzero.
4. The concordant indicator requires P * N = 0 AND P + N >=
NCONC, where NCONC is specified by the user.
5. differential expression is simply | P | + | N | >= NDIFF. By
default, NDIFF is 1 but can be user-specified.
The posterior average is then computed from the mean over all MCMC iterations.
}
\value{
A G x 3 matrix.
}
\author{RS}
\seealso{\code{\link{posteriorAvg}}}
\keyword{manip}
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