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 # circRNAprofiler: an R-based computational framework for the downstream analysis of circular RNAs

 circRNAprofiler is an R-based framework that only requires an R
 installation and offers 15 modules for a comprehensive in silico
 analysis of circRNAs. This computational framework allows to combine and
 analyze circRNAs previously detected by multiple publicly available
 annotation-based circRNA detection tools. It covers different aspects of
 circRNAs analysis from differential expression analysis, evolutionary
 conservation, biogenesis to functional analysis. The pipeline used by
 circRNAprofiler is highly automated and customizable. Furthermore,
 circRNAprofiler includes additional functions for data visualization
 which facilitate the interpretation of the results.

 ## Installation

 You can install the latest release of circRNAprofiler from Bioconductor
 using:

 
 ``` r

 if (!requireNamespace("BiocManager", quietly = TRUE))
     install.packages("BiocManager")
 

 BiocManager::install("circRNAprofiler")
 ```
 

 To install the latest development version use:

 
 ``` r

 if (!requireNamespace("BiocManager", quietly = TRUE))
     install.packages("BiocManager")
 
 # The following initializes usage of Bioc devel
 BiocManager::install(version='devel')
 
 BiocManager::install("circRNAprofiler")

 ```
 

 ## Documentation

 Detailed information on using this package can be found in the package
 vignettes:

 
 ``` r
 browseVignettes("circRNAprofiler")
 ```
 

 ## Bugs and Issues
 
 We work hard to ensure that circRNAprofiler is a powerful tool
 empowering your research. However, no software is free of bugs and
 issues, therefore we would love to get feedback from our users.
 
 ## Citation
 
 If you find this code useful in your research, please cite:

 Aufiero, S., Reckman, Y.J., Tijsen, A.J. et al. circRNAprofiler: an
 R-based computational framework for the downstream analysis of circular
 RNAs. BMC Bioinformatics 21, 164 (2020).
 <https://doi.org/10.1186/s12859-020-3500-3>