... | ... |
@@ -5,9 +5,14 @@ |
5 | 5 |
\title{Compute a binary gene mutation data matrix from SNP and other mutation |
6 | 6 |
event-level data.} |
7 | 7 |
\usage{ |
8 |
-getBinaryMutationData(mutInfo, mutData, maxVariantFreq = 0.2, |
|
9 |
- maxNormalPopulationFreq = 0.005, maxSiftScore = 0.05, |
|
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- minPolyPhenScore = 0.85) |
|
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+getBinaryMutationData( |
|
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+ mutInfo, |
|
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+ mutData, |
|
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+ maxVariantFreq = 0.2, |
|
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+ maxNormalPopulationFreq = 0.005, |
|
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+ maxSiftScore = 0.05, |
|
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+ minPolyPhenScore = 0.85 |
|
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+) |
|
11 | 16 |
} |
12 | 17 |
\arguments{ |
13 | 18 |
\item{mutInfo}{A data frame with the following named columns: |
... | ... |
@@ -48,6 +53,4 @@ along columns, and 1s indicating deleterious mutations. |
48 | 53 |
Compute a binary gene mutation data matrix from SNP and other mutation |
49 | 54 |
event-level data. |
50 | 55 |
} |
51 |
-\concept{ |
|
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-rcellminer |
|
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-} |
|
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+\concept{rcellminer} |
... | ... |
@@ -1,4 +1,4 @@ |
1 |
-% Generated by roxygen2 (4.1.1): do not edit by hand |
|
1 |
+% Generated by roxygen2: do not edit by hand |
|
2 | 2 |
% Please edit documentation in R/getBinaryMutationData.R |
3 | 3 |
\name{getBinaryMutationData} |
4 | 4 |
\alias{getBinaryMutationData} |
... | ... |
@@ -15,7 +15,7 @@ Gene, the name of the gene associated with the mutation event; |
15 | 15 |
probe.ids, a unique identifier specifying the mutation event; |
16 | 16 |
SNP_1000_genome, the frequency of the mutation event in SNP 1000; |
17 | 17 |
ESP5400, the frequency of the mutation event in ESP5400; |
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-SNP_type, the type of mutation event, chosen from "MISSENSE", "FRAMESHIFT", |
|
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+SNP_type, the type of mutation event, chosen from "MISSENSE", "FRAMESHIFT", |
|
19 | 19 |
"NONFRAMESHIFT", "NONSENSE", "SPLICING"; |
20 | 20 |
SIFT_score, the SIFT score; |
21 | 21 |
Polyphen_score, the POLYPHEN score. |
... | ... |
@@ -34,7 +34,7 @@ exclude frequently occuring events); default value = 0.2.} |
34 | 34 |
\item{maxNormalPopulationFreq}{The maximum freqency of a mutation in the normal |
35 | 35 |
population (used to exclude likely germline variants); default value = 0.005.} |
36 | 36 |
|
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-\item{maxSiftScore}{The maximum accepted SIFT score (used to exclude |
|
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+\item{maxSiftScore}{The maximum accepted SIFT score (used to exclude |
|
38 | 38 |
presumed non-deleterious mutations); default value = 0.05.} |
39 | 39 |
|
40 | 40 |
\item{minPolyPhenScore}{The minimum accepted POLYPHEN score (used to |
1 | 1 |
new file mode 100644 |
... | ... |
@@ -0,0 +1,54 @@ |
1 |
+% Generated by roxygen2 (4.1.1): do not edit by hand |
|
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+% Please edit documentation in R/getBinaryMutationData.R |
|
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+\name{getBinaryMutationData} |
|
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+\alias{getBinaryMutationData} |
|
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+\title{Compute a binary gene mutation data matrix from SNP and other mutation |
|
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+event-level data.} |
|
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+\usage{ |
|
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+getBinaryMutationData(mutInfo, mutData, maxVariantFreq = 0.2, |
|
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+ maxNormalPopulationFreq = 0.005, maxSiftScore = 0.05, |
|
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+ minPolyPhenScore = 0.85) |
|
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+} |
|
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+\arguments{ |
|
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+\item{mutInfo}{A data frame with the following named columns: |
|
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+Gene, the name of the gene associated with the mutation event; |
|
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+probe.ids, a unique identifier specifying the mutation event; |
|
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+SNP_1000_genome, the frequency of the mutation event in SNP 1000; |
|
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+ESP5400, the frequency of the mutation event in ESP5400; |
|
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+SNP_type, the type of mutation event, chosen from "MISSENSE", "FRAMESHIFT", |
|
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+"NONFRAMESHIFT", "NONSENSE", "SPLICING"; |
|
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+SIFT_score, the SIFT score; |
|
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+Polyphen_score, the POLYPHEN score. |
|
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+Rownames of mutInfo should be set to probe.ids, i.e., the unique mutation |
|
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+event specifier.} |
|
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+ |
|
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+\item{mutData}{A matrix with event level mutation information, with SNPs, etc. |
|
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+along rows and samples along columns. Rownames of mutData should exactly |
|
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+match those of mutInfo. The i-th row of mutInfo should thus give detailed |
|
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+information for the mutation event with data specified in the i-th row of |
|
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+mutData.} |
|
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+ |
|
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+\item{maxVariantFreq}{The maximum proportion of mutant samples (used to |
|
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+exclude frequently occuring events); default value = 0.2.} |
|
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+ |
|
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+\item{maxNormalPopulationFreq}{The maximum freqency of a mutation in the normal |
|
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+population (used to exclude likely germline variants); default value = 0.005.} |
|
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+ |
|
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+\item{maxSiftScore}{The maximum accepted SIFT score (used to exclude |
|
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+presumed non-deleterious mutations); default value = 0.05.} |
|
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+ |
|
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+\item{minPolyPhenScore}{The minimum accepted POLYPHEN score (used to |
|
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+exclude presumed non-deleterious mutations); default value = 0.85.} |
|
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+} |
|
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+\value{ |
|
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+A binary gene mutation matrix, with genes along rows, samples |
|
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+along columns, and 1s indicating deleterious mutations. |
|
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+} |
|
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+\description{ |
|
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+Compute a binary gene mutation data matrix from SNP and other mutation |
|
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+event-level data. |
|
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+} |
|
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+\concept{ |
|
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+rcellminer |
|
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+} |
|
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+ |