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  • DNDi_Logo_No-Tagline_Full Colour
  • Our work
    • Diseases
      • Sleeping sickness
      • Visceral leishmaniasis
      • Cutaneous leishmaniasis
      • Chagas disease
      • Parasitic worms
      • Mycetoma
      • Dengue
      • Paediatric HIV
      • Cryptococcal meningitis
      • Hepatitis C
      • Pandemic preparedness
      • Antimicrobial resistance
    • Research & development
      • R&D portfolio & list of projects
      • Drug discovery
      • Translational research
      • Clinical trials
      • Registration & access
      • Evidence for impact
      • Treatments delivered
    • Advocacy
      • Open and collaborative R&D
      • Transparency of R&D costs
      • Pro-access policies and IP
      • Children’s health
      • Gender equity
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      • AI and new technologies
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      • Our partners
      • Partnering with us
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      • Dengue Alliance
      • HAT Platform
      • LEAP Platform
      • redeLEISH Network
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      • DNDi Eastern Africa
      • DNDi Japan
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Home

Research and development

We put neglected communities at the heart of drug R&D

Home

Research and development

We put neglected communities at the heart of drug R&D

Advancing medical innovation from laboratory bench to patient bedside

Our teams have been working since 2003 to address gaps in the traditional biomedical R&D system that lead to serious unmet medical needs for neglected patients. Acting as a ‘conductor of a virtual orchestra’, DNDi collaborates with research partners around the world at all stages of the R&D process. Together, we’ve discovered, developed, and delivered new treatments that reduce illness, suffering, and death from some of the world’s most neglected diseases.

Drug discovery

Translational research

Clinical trials

Registration and access

Evidence for impact

Project portfolio

We are working on more than 40 research and treatment access projects, including 21 focused on identifying or developing new chemical entities.

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Treatments delivered

We have delivered seventeen new treatments for six deadly diseases, saving millions of lives.

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Scientific articles

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Scientific articles
15 Aug 2026

Identification of new Trypanosoma cruzi-specific protein synthesis inhibitors by using a developed high-throughput in vitro translation assay

International Journal for Parasitology: Drugs and Drug Resistance
Scientific articles
5 Aug 2026

ICH E21: from landmark guidance to specific action for maternal and child health 

Scientific articles
3 Aug 2026

A Phase IIa, Proof-of-Concept, Placebo-Controlled, Randomised Trial to Investigate the Efficacy and Safety of Oxfendazole as a Macrofilaricidal Drug in Adults Harbouring Lymphatic Filarial Worms

Infectious Diseases and Therapy
Scientific articles
19 Aug 2026

A serological method’s ability to distinguish treatment regimens by assessing early antibody decline in Chagas patients: insights from E1224 data

The Journal of Infectious Diseases
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Target product profiles (TPPs)

TPPs serve to ensure that all products are designed from the start for the people and places that need them by describing the ideal specifications needed for a treatment.

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Events

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11-13 October 2026

Berlin, Germany & Online

World Health Summit 2026

14-17 September

Copenhagen, Denmark

Hepatitis C virus, flaviviruses and related viruses (HCV-Flavi) 2026

25-28 August 2026

Addis Ababa, Ethiopia

Seventy-sixth session of the WHO Regional Committee for Africa

16-19 August 2026

Brasilia, Brazil

61st Congress of the Brazilian Society of Tropical Medicine (Medtrop 2026)

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International non-profit developing safe, effective, and affordable treatments for the most neglected patients.

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