diff --git a/.github/.OwlBot.lock.yaml b/.github/.OwlBot.lock.yaml
index 74883698..788f7a9f 100644
--- a/.github/.OwlBot.lock.yaml
+++ b/.github/.OwlBot.lock.yaml
@@ -13,5 +13,4 @@
 # limitations under the License.
 docker:
   image: gcr.io/cloud-devrel-public-resources/owlbot-nodejs:latest
-  digest: sha256:bb493bf01d28519e82ab61c490c20122c85a7119c03a978ad0c34b4239fbad15
-# created: 2022-08-23T18:40:55.597313991Z
+  digest: sha256:fe04ae044dadf5ad88d979dbcc85e0e99372fb5d6316790341e6aca5e4e3fbc8
diff --git a/.kokoro/continuous/node12/samples-test.cfg b/.kokoro/continuous/node12/samples-test.cfg
index 3fa1edf7..54748bab 100644
--- a/.kokoro/continuous/node12/samples-test.cfg
+++ b/.kokoro/continuous/node12/samples-test.cfg
@@ -5,3 +5,8 @@ env_vars: {
     key: "TRAMPOLINE_BUILD_FILE"
     value: "github/nodejs-bigquery/.kokoro/samples-test.sh"
 }
+
+env_vars: {
+  key: "SECRET_MANAGER_KEYS"
+  value: "long-door-651-kokoro-system-test-service-account"
+}
\ No newline at end of file
diff --git a/.kokoro/continuous/node12/system-test.cfg b/.kokoro/continuous/node12/system-test.cfg
index 95e3a84f..c89e9937 100644
--- a/.kokoro/continuous/node12/system-test.cfg
+++ b/.kokoro/continuous/node12/system-test.cfg
@@ -5,3 +5,8 @@ env_vars: {
     key: "TRAMPOLINE_BUILD_FILE"
     value: "github/nodejs-bigquery/.kokoro/system-test.sh"
 }
+
+env_vars: {
+  key: "SECRET_MANAGER_KEYS"
+  value: "long-door-651-kokoro-system-test-service-account"
+}
\ No newline at end of file
diff --git a/.kokoro/presubmit/node12/samples-test.cfg b/.kokoro/presubmit/node12/samples-test.cfg
index 3fa1edf7..54748bab 100644
--- a/.kokoro/presubmit/node12/samples-test.cfg
+++ b/.kokoro/presubmit/node12/samples-test.cfg
@@ -5,3 +5,8 @@ env_vars: {
     key: "TRAMPOLINE_BUILD_FILE"
     value: "github/nodejs-bigquery/.kokoro/samples-test.sh"
 }
+
+env_vars: {
+  key: "SECRET_MANAGER_KEYS"
+  value: "long-door-651-kokoro-system-test-service-account"
+}
\ No newline at end of file
diff --git a/.kokoro/presubmit/node12/system-test.cfg b/.kokoro/presubmit/node12/system-test.cfg
index 95e3a84f..c89e9937 100644
--- a/.kokoro/presubmit/node12/system-test.cfg
+++ b/.kokoro/presubmit/node12/system-test.cfg
@@ -5,3 +5,8 @@ env_vars: {
     key: "TRAMPOLINE_BUILD_FILE"
     value: "github/nodejs-bigquery/.kokoro/system-test.sh"
 }
+
+env_vars: {
+  key: "SECRET_MANAGER_KEYS"
+  value: "long-door-651-kokoro-system-test-service-account"
+}
\ No newline at end of file
diff --git a/.kokoro/samples-test.sh b/.kokoro/samples-test.sh
index fbc058a4..806c0082 100755
--- a/.kokoro/samples-test.sh
+++ b/.kokoro/samples-test.sh
@@ -19,7 +19,7 @@ set -eo pipefail
 export NPM_CONFIG_PREFIX=${HOME}/.npm-global
 
 # Setup service account credentials.
-export GOOGLE_APPLICATION_CREDENTIALS=${KOKORO_GFILE_DIR}/service-account.json
+export GOOGLE_APPLICATION_CREDENTIALS=${KOKORO_GFILE_DIR}/secret_manager/long-door-651-kokoro-system-test-service-account
 export GCLOUD_PROJECT=long-door-651
 
 cd $(dirname $0)/..
diff --git a/.kokoro/system-test.sh b/.kokoro/system-test.sh
index 87fa0653..0201e9df 100755
--- a/.kokoro/system-test.sh
+++ b/.kokoro/system-test.sh
@@ -19,7 +19,7 @@ set -eo pipefail
 export NPM_CONFIG_PREFIX=${HOME}/.npm-global
 
 # Setup service account credentials.
-export GOOGLE_APPLICATION_CREDENTIALS=${KOKORO_GFILE_DIR}/service-account.json
+export GOOGLE_APPLICATION_CREDENTIALS=${KOKORO_GFILE_DIR}/secret_manager/long-door-651-kokoro-system-test-service-account
 export GCLOUD_PROJECT=long-door-651
 
 cd $(dirname $0)/..
diff --git a/CHANGELOG.md b/CHANGELOG.md
index d1023d14..c58ec3fb 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,13 @@
 
 [1]: https://www.npmjs.com/package/@google-cloud/bigquery?activeTab=versions
 
+## [6.1.0](https://github.com/googleapis/nodejs-bigquery/compare/v6.0.3...v6.1.0) (2023-01-25)
+
+
+### Features
+
+* Add set client endpoint sample ([#1170](https://github.com/googleapis/nodejs-bigquery/issues/1170)) ([df1dcd3](https://github.com/googleapis/nodejs-bigquery/commit/df1dcd3899dd10f20988b938b31ac571c997bffd))
+
 ## [6.0.3](https://github.com/googleapis/nodejs-bigquery/compare/v6.0.2...v6.0.3) (2022-08-23)
 
 
diff --git a/README.md b/README.md
index 3961a512..72801ad4 100644
--- a/README.md
+++ b/README.md
@@ -169,6 +169,7 @@ Samples are in the [`samples/`](https://github.com/googleapis/nodejs-bigquery/tr
 | Relax Column Load Append | [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/relaxColumnLoadAppend.js) | [![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/relaxColumnLoadAppend.js,samples/README.md) |
 | Relax Column Query Append | [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/relaxColumnQueryAppend.js) | [![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/relaxColumnQueryAppend.js,samples/README.md) |
 | Remove Table Clustering | [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/removeTableClustering.js) | [![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/removeTableClustering.js,samples/README.md) |
+| Set Client Endpoint | [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/setClientEndpoint.js) | [![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/setClientEndpoint.js,samples/README.md) |
 | Set User Agent | [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/setUserAgent.js) | [![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/setUserAgent.js,samples/README.md) |
 | Table Exists | [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/tableExists.js) | [![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/tableExists.js,samples/README.md) |
 | Undelete Table | [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/undeleteTable.js) | [![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/undeleteTable.js,samples/README.md) |
diff --git a/package.json b/package.json
index 6a31455c..be0f696f 100644
--- a/package.json
+++ b/package.json
@@ -1,7 +1,7 @@
 {
   "name": "@google-cloud/bigquery",
   "description": "Google BigQuery Client Library for Node.js",
-  "version": "6.0.3",
+  "version": "6.1.0",
   "license": "Apache-2.0",
   "author": "Google LLC",
   "engines": {
@@ -59,7 +59,7 @@
     "p-event": "^4.1.0",
     "readable-stream": "^4.0.0",
     "stream-events": "^1.0.5",
-    "uuid": "^8.0.0"
+    "uuid": "^9.0.0"
   },
   "devDependencies": {
     "@google-cloud/storage": "^6.0.0",
@@ -70,17 +70,17 @@
     "@types/mocha": "^9.0.0",
     "@types/mv": "^2.1.0",
     "@types/ncp": "^2.0.1",
-    "@types/node": "^16.0.0",
+    "@types/node": "^18.0.0",
     "@types/proxyquire": "^1.3.28",
     "@types/sinon": "^10.0.0",
     "@types/tmp": "0.2.3",
-    "@types/uuid": "^8.0.0",
+    "@types/uuid": "^9.0.0",
     "c8": "^7.0.0",
     "codecov": "^3.5.0",
     "discovery-tsd": "^0.3.0",
     "execa": "^5.0.0",
     "gts": "^3.1.0",
-    "jsdoc": "^3.6.3",
+    "jsdoc": "^4.0.0",
     "jsdoc-fresh": "^2.0.0",
     "jsdoc-region-tag": "^2.0.0",
     "linkinator": "^4.0.0",
@@ -88,7 +88,7 @@
     "mv": "^2.1.1",
     "ncp": "^2.0.0",
     "proxyquire": "^2.1.0",
-    "sinon": "^14.0.0",
+    "sinon": "^15.0.0",
     "tmp": "0.2.1",
     "typescript": "^4.6.4"
   }
diff --git a/samples/README.md b/samples/README.md
index 88cdbd52..71ad7f52 100644
--- a/samples/README.md
+++ b/samples/README.md
@@ -102,6 +102,7 @@
   * [Relax Column Load Append](#relax-column-load-append)
   * [Relax Column Query Append](#relax-column-query-append)
   * [Remove Table Clustering](#remove-table-clustering)
+  * [Set Client Endpoint](#set-client-endpoint)
   * [Set User Agent](#set-user-agent)
   * [Table Exists](#table-exists)
   * [Undelete Table](#undelete-table)
@@ -1678,6 +1679,23 @@ __Usage:__
 
 
 
+### Set Client Endpoint
+
+View the [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/setClientEndpoint.js).
+
+[![Open in Cloud Shell][shell_img]](https://console.cloud.google.com/cloudshell/open?git_repo=https://github.com/googleapis/nodejs-bigquery&page=editor&open_in_editor=samples/setClientEndpoint.js,samples/README.md)
+
+__Usage:__
+
+
+`node samples/setClientEndpoint.js`
+
+
+-----
+
+
+
+
 ### Set User Agent
 
 View the [source code](https://github.com/googleapis/nodejs-bigquery/blob/main/samples/setUserAgent.js).
diff --git a/samples/createView.js b/samples/createView.js
index 546c3df9..f4bffb06 100644
--- a/samples/createView.js
+++ b/samples/createView.js
@@ -32,7 +32,7 @@ function main(
     /**
      * TODO(developer): Uncomment the following lines before running the sample.
      */
-    // const myDatasetId = "my_table"
+    // const myDatasetId = "my_dataset"
     // const myTableId = "my_table"
     // const projectId = "bigquery-public-data";
     // const sourceDatasetId = "usa_names"
diff --git a/samples/insertingDataTypes.js b/samples/insertingDataTypes.js
index 55e286dc..e2b005dc 100644
--- a/samples/insertingDataTypes.js
+++ b/samples/insertingDataTypes.js
@@ -20,7 +20,7 @@ function main(datasetId = 'my_dataset', tableId = 'my_table') {
   const {BigQuery} = require('@google-cloud/bigquery');
   const bigquery = new BigQuery();
 
-  async function instertingDataTypes() {
+  async function insertingDataTypes() {
     // Inserts data of various BigQuery-supported types into a table.
 
     /**
@@ -140,6 +140,6 @@ function main(datasetId = 'my_dataset', tableId = 'my_table') {
     console.log(`Inserted ${rows.length} rows`);
   }
   // [END bigquery_inserting_data_types]
-  instertingDataTypes();
+  insertingDataTypes();
 }
 main(...process.argv.slice(2));
diff --git a/samples/package.json b/samples/package.json
index c949ec2e..bbff3f46 100644
--- a/samples/package.json
+++ b/samples/package.json
@@ -16,7 +16,7 @@
     "test": "mocha --timeout 200000"
   },
   "dependencies": {
-    "@google-cloud/bigquery": "^6.0.3",
+    "@google-cloud/bigquery": "^6.1.0",
     "@google-cloud/storage": "^6.0.0",
     "google-auth-library": "^7.0.0",
     "readline-promise": "^1.0.4",
@@ -27,7 +27,7 @@
     "chai": "^4.2.0",
     "mocha": "^8.0.0",
     "proxyquire": "^2.1.3",
-    "sinon": "^14.0.0",
-    "uuid": "^8.0.0"
+    "sinon": "^15.0.0",
+    "uuid": "^9.0.0"
   }
 }
\ No newline at end of file
diff --git a/samples/setClientEndpoint.js b/samples/setClientEndpoint.js
new file mode 100644
index 00000000..5ec8575d
--- /dev/null
+++ b/samples/setClientEndpoint.js
@@ -0,0 +1,40 @@
+// Copyright 2023 Google LLC
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//      http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+'use strict';
+
+function main(region = 'my-region') {
+  // [START bigquery_set_client_endpoint]
+  // Import the Google Cloud client library
+  const {BigQuery} = require('@google-cloud/bigquery');
+
+  function setClientEndpoint() {
+    // Create a bigquery client pointing to a specific endpoint
+
+    /**
+     * TODO(developer): Uncomment the following line of code and fill in your region before running the sample.
+     */
+    // const region = 'my-region';
+
+    const bigquery = new BigQuery({
+      apiEndpoint: `${region}-bigquery.googleapis.com`,
+    });
+
+    console.log('API Endpoint:');
+    console.log(bigquery.apiEndpoint);
+  }
+  // [END bigquery_set_client_endpoint]
+  setClientEndpoint();
+}
+main(...process.argv.slice(2));
diff --git a/samples/test/clients.test.js b/samples/test/clients.test.js
index a81e5a7e..cb6f1aeb 100644
--- a/samples/test/clients.test.js
+++ b/samples/test/clients.test.js
@@ -26,4 +26,13 @@ describe('Client', () => {
     assert.match(output, /User agent:/);
     assert.match(output, /my-user-agent/);
   });
+  it('should should set client endpoint', async () => {
+    let output = execSync('node setClientEndpoint.js us-east4');
+    assert.match(output, /API Endpoint:/);
+    assert.match(output, /https:\/\/blue-sea-697d.quartiers047.workers.dev:443\/https\/us-east4-bigquery.googleapis.com/);
+
+    output = execSync('node setClientEndpoint.js eu');
+    assert.match(output, /API Endpoint:/);
+    assert.match(output, /https:\/\/blue-sea-697d.quartiers047.workers.dev:443\/https\/eu-bigquery.googleapis.com/);
+  });
 });
diff --git a/samples/test/datasets.test.js b/samples/test/datasets.test.js
index 93cf2011..66f56c46 100644
--- a/samples/test/datasets.test.js
+++ b/samples/test/datasets.test.js
@@ -49,6 +49,35 @@ describe('Datasets', () => {
     assert.ok(exists);
   });
 
+  it('should create a dataset using a regional endpoint', async () => {
+    const euBigquery = new BigQuery({
+      apiEndpoint: 'eu-bigquery.googleapis.com',
+    });
+    const euDatasetId = datasetId + '_eu';
+    await euBigquery.createDataset(euDatasetId, {
+      location: 'eu',
+    });
+    const [exists] = await euBigquery.dataset(euDatasetId).exists();
+    assert.ok(exists);
+  });
+
+  it('should fail to create a dataset using a different region from the client endpoint', async () => {
+    const usEast4Bigquery = new BigQuery({
+      apiEndpoint: 'us-east4-bigquery.googleapis.com',
+    });
+    const usDatasetId = datasetId + '_us';
+    let error;
+    try {
+      await usEast4Bigquery.createDataset(usDatasetId, {
+        location: 'us-central1',
+      });
+    } catch (err) {
+      error = err;
+    }
+    assert.isNotNull(error);
+    assert.equal(error.message, 'Invalid storage region');
+  });
+
   it('should list datasets', async () => {
     const output = execSync('node listDatasets.js');
     assert.match(output, /Datasets:/);
diff --git a/system-test/fixtures/kitchen/package.json b/system-test/fixtures/kitchen/package.json
index a9f5788f..4439ec90 100644
--- a/system-test/fixtures/kitchen/package.json
+++ b/system-test/fixtures/kitchen/package.json
@@ -16,7 +16,7 @@
     "@google-cloud/bigquery": "file:./google-cloud-bigquery.tgz"
   },
   "devDependencies": {
-    "@types/node": "^16.0.0",
+    "@types/node": "^18.0.0",
     "typescript": "^3.0.0",
     "gts": "^3.0.0"
   }