View source for Medicine:Premature ejaculation

{{Short description|Ejaculation and climax soon after initiating sexual activity}}
{{About|the medical condition|the music group|Premature Ejaculation (band)}}

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'''Premature ejaculation''' ('''PE''') is a male [[Medicine:Sexual dysfunction|sexual dysfunction]] that occurs when a male [[Medicine:Ejaculation|expels semen]] (and most likely experiences [[Biology:Orgasm|orgasm]]) soon after beginning sexual activity, and with minimal penile stimulation.<ref>{{cite book |last1=Jern |first1=Patrick |title=The International Encyclopedia of Human Sexuality |chapter=Ejaculation, premature |date=2015 |pages=328–330 |doi=10.1002/9781118896877.wbiehs126|isbn=978-1-4051-9006-0 }}</ref> It has also been called ''early ejaculation'', ''rapid ejaculation'', ''rapid climax'', ''premature climax'' and (historically) ''ejaculatio praecox.'' There is no uniform cut-off defining "premature", but a consensus of experts at the International Society for Sexual Medicine endorsed a definition of around one minute after penetration.<ref name=ISSM2014/> The [[International Classification of Diseases]] (ICD-10) applies a cut-off of 15 seconds from the beginning of [[Biology:Sexual intercourse|sexual intercourse]].<ref name=ISSM2014/>

Although men with premature ejaculation describe feeling that they have less control over ejaculating, it is not clear if that is true, and many or most average men also report that they wish they could last longer. In males, typical intravaginal ejaculation latency time is approximately 4–8 minutes.<ref name = Oxford2009/> The opposite condition is [[Medicine:Delayed ejaculation|delayed ejaculation]].<ref>{{cite journal | year = 2007 | title = Premature and delayed ejaculation: Genetic and environmental effects in a population-based sample of Finnish twins|journal=The Journal of Sexual Medicine| volume = 4 | issue = 6| pages = 1739–1749 | doi=10.1111/j.1743-6109.2007.00599.x| pmid = 17888070 | last1 = Jern| first1 = Patrick| last2 = Santtila| first2 = Pekka| last3 = Witting| first3 = Katarina| last4 = Alanko| first4 = Katarina| last5 = Harlaar| first5 = Nicole| last6 = Johansson| first6 = Ada| last7 = von Der Pahlen| first7 = Bettina| last8 = Varjonen| first8 = Markus| last9 = Vikström| first9 = Nina| last10 = Ålgars| first10 = Monica| last11 = Sandnabba| first11 = Kenneth}}</ref>

Men with PE often report emotional and relationship distress, and some avoid pursuing sexual relationships because of PE-related embarrassment.<ref name=Barnes>{{cite journal |author1=Barnes T. |author2=I. Eardley |title= Premature Ejaculation: The Scope of the Problem |journal= Journal of Sex and Marital Therapy| volume=33|pages=151–170|year=2007 |pmid=17365515 |issue=3 |doi=10.1080/00926230601098472|s2cid=41366014 }}</ref> Compared with males, females consider PE less of a problem,<ref>{{cite journal |author1=Byers, E.S. |author2=G. Grenier |title= Premature or Rapid Ejaculation: Heterosexual Couples' Perceptions of Men's Ejaculatory Behavior |journal= Archives of Sexual Behavior |volume=32 |pages=261–70 |year=2003 |pmid= 12807298 |issue=3|doi=10.1023/A:1023417718557|s2cid=37472401 }}</ref> but several studies show that the condition also causes female partners distress.<ref name=Barnes /><ref>{{cite journal |author= Limoncin, E.|title= Premature Ejaculation Results in Female Sexual Distress: Standardization and Validation of a New Diagnostic Tool for Sexual Distress |journal= Journal of Urology |year=2013 |pmid=23142691 |doi=10.1016/j.juro.2012.11.007 |volume=189 |issue=5 |pages=1830–5|hdl= 11573/540121 |display-authors=0}}</ref><ref>{{cite journal |author1=Graziottin, A. |author2=S. Althof |title= What Does Premature Ejaculation Mean to the Man, the Woman, and the Couple? |journal= Journal of Sexual Medicine |volume=8 |pages=304–9 |year=2011 |pmid=21967392 |doi=10.1111/j.1743-6109.2011.02426.x}}</ref>

==Cause==
The causes of premature ejaculation are unclear. Many theories have been suggested, including that PE was the result of masturbating quickly during adolescence to avoid being caught, performance anxiety, [[Philosophy:Passive-aggressive behavior|passive-aggressive behavior]] or having too little sex; but there is little evidence to support any of these theories.<ref name = Oxford2009>Strassberg, D. S., & Perelman, M. A. (2009). Sexual dysfunctions. In P. H. Blaney & T. Millon (Eds.), ''Oxford textbook of psychopathology'' (2nd ed.), (pp. 399–430). NY: Oxford University Press.</ref>

Several physiological mechanisms have been hypothesized to contribute to causing premature ejaculation, including [[Chemistry:Serotonin|serotonin]] receptors, a genetic predisposition, elevated penile sensitivity and nerve conduction atypicalities.<ref name = Althof2007>Althof, S. E. (2007). "Treatment of rapid ejaculation: Psychotherapy, pharmacotherapy, and combined therapy", pp. 212–240 in S. R. Leiblum (Ed.), ''Principles and practice of sex therapy'' (4th ed.). NY: Guilford. {{ISBN|978-1593853495}}</ref> [[Scientist]]s have long suspected a [[Biology:Genetics|genetic]] link to certain forms of premature ejaculation. However, studies have been inconclusive in isolating the gene responsible for lifelong PE.

The nucleus paragigantocellularis of the brain has been identified as having involvement in ejaculatory control.<ref>{{cite journal |vauthors=Coolen LM, Olivier B, Peters HJ, Veening JG |title=Demonstration of ejaculation-induced neural activity in the male rat brain using 5-HT1A agonist 8-OH-DPAT |journal=Physiol. Behav. |volume=62 |issue=4 |pages=881–91 |year=1997|pmid=9284512 |doi=10.1016/S0031-9384(97)00258-8|s2cid=35436289 |hdl=2066/25592 |hdl-access=free }}</ref> PE may be caused by [[Medicine:Prostatitis|prostatitis]]<ref name=Althof2010/> or as a medication side effect.

PE has been classified into four subtypes - lifelong, acquired, variable and subjective PE. The pathophysiology of lifelong PE is mediated by a complex interplay of central and peripheral serotonergic, dopaminergic, oxytocinergic, endocrinological, genetic and epigenetic factors. Acquired PE may occur due to psychological problems - such as sexual performance anxiety, and psychological or relationship problems - and/or co-morbidity, including [[Medicine:Erectile dysfunction|erectile dysfunction]], prostatitis and hyperthyroidism.<ref>{{Cite web |url=https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Sexual-and-Reproductive-Health-2021.pdf |title=Archived copy |access-date=2021-12-21 |archive-date=2021-11-06 |archive-url=https://web.archive.org/web/20211106164930/https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Sexual-and-Reproductive-Health-2021.pdf |url-status=dead }}</ref>

==Mechanism==
The physical process of ejaculation requires two actions: emission and expulsion. The emission is the first phase. It involves deposition of fluid from the ampullary vas deferens, seminal vesicles and prostate gland into the posterior urethra.<ref>{{cite journal |vauthors=Böhlen D, Hugonnet CL, Mills RD, Weise ES, Schmid HP |title=Five meters of H(2)O: the pressure at the urinary bladder neck during human ejaculation |journal=Prostate |volume=44 |issue=4 |pages=339–41 |year=2000 |pmid=10951500|doi=10.1002/1097-0045(20000901)44:4<339::AID-PROS12>3.0.CO;2-Z|s2cid=26120815 }}</ref> The second phase is the expulsion phase. It involves closure of bladder neck, followed by the rhythmic contractions of the urethra by pelvic-perineal and bulbospongiosus muscle and intermittent relaxation of the external male urethral sphincter.<ref>{{cite journal |vauthors=Master VA, Turek PJ |title=Ejaculatory physiology and dysfunction |journal=Urol. Clin. North Am. |volume=28 |issue=2 |pages=363–75, x |year=2001 |pmid=11402588|doi=10.1016/S0094-0143(05)70145-2}}</ref>

Sympathetic motor neurons control the emission phase of ejaculation reflex, and expulsion phase is executed by somatic and autonomic motor neurons. These motor neurons are located in the thoracolumbar and lumbosacral [[Biology:Spinal cord|spinal cord]] and are activated in a coordinated manner when sufficient sensory input to reach the ejaculatory threshold has entered the [[Biology:Central nervous system|central nervous system]].<ref>{{cite journal |vauthors=deGroat WC, Booth AM |title=Physiology of male sexual function |journal=Ann. Intern. Med. |volume=92 |issue=2 Pt 2 |pages=329–31 |year=1980 |pmid=7356224 |doi=10.7326/0003-4819-92-2-329}}</ref><ref>{{cite journal |vauthors=Truitt WA, Coolen LM |title=Identification of a potential ejaculation generator in the spinal cord |journal=Science |volume=297 |issue=5586 |pages=1566–9 |year=2002 |pmid=12202834 |doi=10.1126/science.1073885|bibcode=2002Sci...297.1566T |s2cid=29708727 }}</ref>

===Intromission time===
The 1948 Kinsey Report suggested that three-quarters of men ejaculate within two minutes of penetration in over half of their sexual encounters.<ref>{{citation|author=Kinsey, Alfred |title=Sexual Behavior in the Human Male |year=1948 |publisher=W. B. Saunders Co |location=Philadelphia}}</ref>

Evidence {{asof|2005|lc=y}} supports an average intravaginal ejaculation latency time (IELT) of six and a half minutes in 18- to 30-year-olds.<ref>{{cite web |url=http://www.bandolier.org.uk/band137/b137-4.html |title=Ejaculation delay: what's normal? [July 2005; 137-4] |access-date=2007-10-21 |url-status=bot: unknown |archive-url=https://web.archive.org/web/20170708163713/http://www.bandolier.org.uk/band137/b137-4.html |archive-date=2017-07-08 }}</ref><ref>{{cite journal |vauthors=Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M |title=A multinational population survey of intravaginal ejaculation latency time |journal=The Journal of Sexual Medicine |volume=2 |issue=4 |pages=492–7 |year=2005 |pmid=16422843 |doi=10.1111/j.1743-6109.2005.00070.x}}</ref> If the disorder is defined as an IELT percentile below 2.5, then premature ejaculation could be suggested by an IELT of less than about two minutes.<ref>{{cite journal |vauthors=Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH |title=Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data |journal=The Journal of Sexual Medicine |volume=2 |issue=4 |pages=498–507 |year=2005 |pmid=16422844 |doi=10.1111/j.1743-6109.2005.00069.x}}</ref> Still, it is possible for some men with abnormally low IELTs to be satisfied with their performance and not report a lack of control.<ref>{{Cite journal |last1=Brock |first1=Gerald B. |last2=Bénard |first2=Francois |last3=Casey |first3=Richard |last4=Elliott |first4=Stacy L. |last5=Gajewski |first5=Jerzy B. |last6=Lee |first6=Jay C. |date=2009 |title=Canadian Male Sexual Health Council Survey to Assess Prevalence and Treatment of Premature Ejaculation in Canada |url=https://linkinghub.elsevier.com/retrieve/pii/S1743609515326023 |journal=The Journal of Sexual Medicine |language=en |volume=6 |issue=8 |pages=2115–2123 |doi=10.1111/j.1743-6109.2009.01362.x |pmid=19572961 |quote=Nevertheless, it is well accepted that men with IELTs below 1.5 minutes may be “happy” with their performance and do not report a lack of control, and therefore, do not suffer from PE.|url-access=subscription }}</ref> Likewise, those with higher IELTs may consider themselves premature ejaculators, and suffer from quality of life issues normally associated with premature ejaculation, and even benefit from non-pharmaceutical treatment.<ref>{{Cite journal |last1=Shindel |first1=Alan W. |last2=Althof |first2=Stanley E. |last3=Carrier |first3=Serge |last4=Chou |first4=Roger |last5=McMahon |first5=Chris G. |last6=Mulhall |first6=John P. |last7=Paduch |first7=Darius A. |last8=Pastuszak |first8=Alexander W. |last9=Rowland |first9=David |last10=Tapscott |first10=Ashley H. |last11=Sharlip |first11=Ira D. |date=2022 |title=Disorders of Ejaculation: An AUA/SMSNA Guideline |url=http://www.auajournals.org/doi/10.1097/JU.0000000000002392 |journal=Journal of Urology |language=en |volume=207 |issue=3 |pages=504–512 |doi=10.1097/JU.0000000000002392 |pmid=34961344 |s2cid=245511620 |issn=0022-5347 |quote=Waldinger et al. conceptualized two provisional diagnoses that may be applicable in the context of men who have concerns about PE but do not meet specific criteria for either lifelong or acquired PE. Natural variable PE is defined as occasional short ELT that occurs irregularly and inconsistently and over which the man feels diminished sense of control. This condition is typically minimally or non-disruptive of overall sexual satisfaction and does not occur with a frequency that poses serious impediment for the patient. Subjective PE (SPE, also known as PE-like dysfunction) is defined as subjective concern or preoccupation about short ELT that is within population norms.24 Data on management of these provisional conditions is limited; for the time being education and/or psychosexual therapy, rather than pharmacotherapy, are favored as the treatments of choice for Natural variable PE and SPE.|url-access=subscription }}</ref>

==Diagnosis==
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) defines premature ejaculation as "A persistent or recurrent pattern of ejaculation occurring during partnered sexual activity within approximately 1 minute following vaginal penetration and before the person wishes it," with the additional requirements that the condition occurs for a duration longer than 6 months, causes clinically significant distress, and cannot be better explained by relationship distress, another mental disorder, or the use of medications.<ref name="ISSM2014">{{cite journal |last1=Serefoglu |first1=Ege Can |last2=McMahon |first2=Chris G. |last3=Waldinger |first3=Marcel D. |last4=Althof |first4=Stanley E. |last5=Shindel |first5=Alan |last6=Adaikan |first6=Ganesh |last7=Becher |first7=Edgardo F. |last8=Dean |first8=John |last9=Giuliano |first9=Francois |last10=Hellstrom |first10=Wayne J.G. |last11=Giraldi |first11=Annamaria |last12=Glina |first12=Sidney |last13=Incrocci |first13=Luca |last14=Jannini |first14=Emmanuele |author14-link=Emmanuele A. Jannini |last15=McCabe |first15=Marita |date=June 2014 |title=An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation. |journal=Sexual Medicine |volume=2 |issue=2 |pages=41–59 |doi=10.1002/sm2.27 |pmc=4184676 |pmid=25356301 |last16=Parish |first16=Sharon |last17=Rowland |first17=David |last18=Segraves |first18=Robert Taylor |last19=Sharlip |first19=Ira |last20=Torres |first20=Luiz Otavio}}</ref> These factors are identified by talking with the person, not through any diagnostic test.<ref name=ISSM2014/> The DSM-5 allows for specifiers whether the condition is lifelong or acquired, applying in general or only to certain situations, and severity based on the time under one minute, however these subtypes have been criticised as lacking validity due to insufficient evidence.<ref name="Serefoglu" />

The 2007 [[Medicine:ICD-10|ICD-10]] defined PE as ejaculating without control, and within around 15 seconds.<ref name=ISSM2014/>

==Treatments==
Several treatments have been tested for treating premature ejaculation. A combination of medication and non-medication treatments is often the most effective method.<ref name="EAU2017">{{cite book |last1=Hatzimouratidis |first1=K. |url=http://uroweb.org/wp-content/uploads/16-Male-Sexual-Dysfunction_2017_web.pdf |title=EAU Guidelines on Erectile Dysfunction, Premature Ejaculation, Penile Curvature and Priapism |last2=Giuliano |first2=F. |last3=Moncada |first3=I. |last4=Muneer |first4=A. |last5=Salonia |first5=A. |last6=Verze |first6=P. |last7=Parnham |first7=A. |last8=Serefoglu |first8=E.C. |date=2017 |publisher=European Association of Urology |archive-url=https://web.archive.org/web/20180316214009/http://uroweb.org/wp-content/uploads/16-Male-Sexual-Dysfunction_2017_web.pdf |archive-date=16 March 2018}}</ref>

===Self-treatment===
Many men attempt to treat themselves for premature ejaculation by trying to distract themselves, such as by trying to focus their attention away from the sexual stimulation. There is little evidence to indicate that it is effective and it tends to detract from the sexual fulfillment of both partners. Other self-treatments include thrusting more slowly, withdrawing the penis altogether, purposefully ejaculating before sexual intercourse, and using more than one condom. Some men report these to have been helpful.<ref name = Oxford2009/>

===Sex therapy===
Several techniques have been developed and applied by sex therapists, including Kegel exercises (to strengthen the muscles of the pelvic floor) and Masters and Johnson's "stop-start technique" (to desensitize the male's responses) and "squeeze technique" (to reduce excessive arousal).<ref name="EAU2017" />{{rp|27}}

To treat premature ejaculation, Masters and Johnson developed the "squeeze technique", based on the Semans technique developed by James Semans in 1956.<ref>Kaplan (1974), pp. 298–299</ref> Men were instructed to pay close attention to their arousal pattern and learn to recognize how they felt shortly before their "point of no return", the moment ejaculation felt imminent and inevitable. Sensing it, they were to signal their partner, who squeezed the head of the penis between thumb and index finger, suppressing the ejaculatory reflex and allowing the male to last longer.<ref name="Castleman">{{cite book|author=Castleman, M.|isbn=978-1594869914|url=https://archive.org/details/GreatSex/mode/2up |title=Great Sex|year=2004|pages=136–138 |publisher=Rodale, Inc. }}</ref><ref>{{citation|author1=Masters, W. |author2=V. Johnson |title= Human Sexual Inadequacy |year=1970|publisher=Little Brown & Company }}</ref><ref>{{cite book|author1=Belliveau, F.|author2=L. Richter |title= Understanding Human Sexual Inadequacy |year=1970|publisher=Hodder and Stoughton }}</ref>

The squeeze technique worked, but many couples found it cumbersome. From the 1970s to the 1990s, sex therapists refined the Masters and Johnson approach, largely abandoning the squeeze technique and focused on a simpler and more effective technique called the "stop-start" technique. During intercourse, as the male gets the sensation of approaching climax, both partners stop moving and remain still until the male's feelings of ejaculatory inevitability subside, at which point, they are free to resume active intercourse.<ref name="Castleman" /><ref>Kaplan (1989), pp. 48–58</ref><ref>{{cite book|author1=Metz, M. |author2=B. McCarthy |title= Coping With Premature Ejaculation |isbn=9781572243408|pages=123–128|year=2003 |publisher= New Harbinger Publications }}</ref><ref>{{cite book|author= Silverberg, S. |title= Lasting Longer: The Treatment Program for Premature Ejaculation |pages=44–57|orig-year=1978|year=2010 |publisher= Physicians Medical Press }}</ref><ref>{{cite book|author= Birch. R.W.|title= A Short Book About Lasting Longer|pages=27–38|year=2007 |publisher= PEC Publishing|isbn=978-1449523237 }}</ref>

The functional-sexological approach to treating premature ejaculation, as developed by François de Carufel & Gilles Trudel, offers a novel method focusing on sexual function improvement without interrupting sexual activity. This treatment, distinct from traditional behavioral techniques like the squeeze and stop-start methods, has demonstrated significant improvements in the duration of intercourse, sexual satisfaction, and overall sexual function. A pivotal study by De Carufel & Trudel (2006) showcases the effectiveness of this approach.<ref>De Carufel, F., & Trudel, G. (2006). Effects of a new functional-sexological treatment for premature ejaculation. Journal of Sex & Marital Therapy, 32(2), 97-114.</ref> Moreover, the Cochrane review on psychosocial interventions for premature ejaculation recognizes the De Carufel study as having a low risk of bias, highlighting its methodological robustness among psychosocial intervention studies.<ref>Cochrane Database of Systematic Reviews. (2011). Psychosocial interventions for premature ejaculation. Cochrane Database of Systematic Reviews.</ref> This acknowledgment points to the functional-sexological treatment as a promising avenue for individuals and couples grappling with premature ejaculation, suggesting a shift towards more contemporary and empirically supported treatments in the field.<ref>{{Cite journal |last=Hartmann |first=Uwe |date=2007 |title=Re: Effects of a New Functional-Sexological Treatment for Premature Ejaculation |url=https://www.europeanurology.com/article/S0302-2838(07)00932-3/fulltext |journal=European Urology |volume=52 |issue=4 |pages=1259–1261|doi=10.1016/j.eururo.2007.07.021 |pmid=17933037 }}</ref> Access to functional-sexological therapy can be limited due to a shortage of qualified professionals. A study published in the ''Journal of Sex & Marital Therapy'' found that many individuals experience difficulties in seeking treatment for sexual concerns, largely due to a lack of awareness about available services and the scarcity of trained sex therapists, making these services appear inaccessible to those in need.<ref>{{Cite journal |last1=Herbenick |first1=Debby |last2=Fu |first2=Tsung-chieh |last3=Bowling |first3=Jill |last4=Fahs |first4=Breanne |last5=Schick |first5=Vanessa |title=The US Public's Use of and Interest in Sex Therapy |journal=Journal of Sex & Marital Therapy |volume=49 |issue=3 |year=2023 |pages=256–273 |doi=10.1080/0092623X.2023.2264470 |doi-broken-date=1 July 2025 |url=https://www.tandfonline.com/doi/full/10.1080/0092623X.2023.2264470 }}</ref>

===Medications===
{{See also|Chemistry:List of investigational sexual dysfunction drugs}}

[[Chemistry:Dapoxetine|Dapoxetine]], a [[Chemistry:Selective serotonin reuptake inhibitor|selective serotonin reuptake inhibitor]] (SSRI), has been approved for the treatment of premature ejaculation in several countries.<ref name=":0" /><ref>{{cite journal|last=Hutchinson|first=K|author2=Cruickshank, K |author3=Wylie, K |title=A benefit-risk assessment of dapoxetine in the treatment of premature ejaculation.|journal=Drug Safety|date=May 1, 2012|volume=35|issue=5|pages=359–72|pmid=22452563|doi=10.2165/11598150-000000000-00000|s2cid=35249748}}</ref><ref>{{cite journal|last=McMahon|first=CG|author2=Althof, SE, Kaufman, JM, Buvat, J, Levine, SB, Aquilina, JW, Tesfaye, F, Rothman, M, Rivas, DA, Porst, H|title=Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials.|journal=The Journal of Sexual Medicine|date=February 2011|volume=8|issue=2|pages=524–39|doi=10.1111/j.1743-6109.2010.02097.x|pmid=21059176}}</ref> Other SSRIs are used off-label to treat PE, including [[Chemistry:Fluoxetine|fluoxetine]], [[Chemistry:Paroxetine|paroxetine]],<ref>{{Cite journal |last1=Zhang |first1=Dong |last2=Cheng |first2=Yue |last3=Wu |first3=Kerong |last4=Ma |first4=Qi |last5=Jiang |first5=Junhui |last6=Yan |first6=Zejun |date=2019-01-03 |title=Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis |journal=BMC Urology |volume=19 |issue=1 |pages=2 |doi=10.1186/s12894-018-0431-7 |doi-access=free |issn=1471-2490 |pmc=6318994 |pmid=30606186}}</ref> [[Chemistry:Sertraline|sertraline]], [[Chemistry:Citalopram|citalopram]], [[Chemistry:Escitalopram|escitalopram]] and [[Chemistry:Clomipramine|clomipramine]].<ref name=":0">{{Citation |last1=Crowdis |first1=Marissa |title=Premature Ejaculation |date=2022 |url=https://www.ncbi.nlm.nih.gov/books/NBK546701/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31536307 |access-date=2022-07-19 |last2=Nazir |first2=Saad}}</ref> The opioid [[Chemistry:Tramadol|tramadol]], an atypical oral [[Biology:Analgesic|analgesic]] is also used.<ref name=":0" /><ref>{{cite journal |last=Wong |first=BL |author2=Malde, S |date=Jan 2013 |title=The use of tramadol "on-demand" for premature ejaculation: a systematic review. |journal=Urology |volume=81 |issue=1 |pages=98–103 |doi=10.1016/j.urology.2012.08.037 |pmid=23102445}}</ref> Results have found PDE5 inhibitors to be effective in combination treatment with SSRIs.<ref name=":0" /> The full effects of these medications typically emerge after 2-3 weeks, with results indicating about ejaculatory delay of up to 4 times greater than before medication if the medication is combined with psychotherapy.<ref name=":0" /> Premature ejaculation can return upon discontinuation,<ref name=":0" /> and the side effects of these SSRIs can also include [[Medicine:Anorgasmia|anorgasmia]], [[Medicine:Erectile dysfunction|erectile dysfunction]], and diminished [[Philosophy:Libido|libido]].<ref name=":0" />

[[Medicine:Topical anesthetic|Topical anesthetic]]s such as [[Chemistry:Lidocaine|lidocaine]] and [[Chemistry:Benzocaine|benzocaine]], commonly known as delay sprays, that are applied to the tip and shaft of the penis have also been developed to essentially numb the intended area. These topical anesthetics are applied 10–15 minutes before sexual activity and have fewer potential side effects as compared to SSRIs.<ref>{{Cite journal |last1=Shabsigh |first1=Ridwan |last2=Kaminetsky |first2=Jed |last3=Yang |first3=Michael |last4=Perelman |first4=Michael |date=April 2017 |title=Pd69-02 Double-Blind, Randomized Controlled Trial of Topical 4% Benzocaine Wipes for Management of Premature Ejaculation: Interim Analysis |url=http://www.jurology.com/doi/10.1016/j.juro.2017.02.3143 |journal=Journal of Urology |language=en |volume=197 |issue=4S |doi=10.1016/j.juro.2017.02.3143 |s2cid=78743713 |issn=0022-5347|url-access=subscription }}</ref> However, this is sometimes disliked due to the reduction of sensation in the penis as well as for the partner (due to the medication rubbing onto the partner if condoms are not used).<ref>{{cite journal |author1=MacCarty E.J. |author2=Dinsmore W.W. | year = 2010 | title = Premature Ejaculation: Treatment Update | journal = International Journal of STD & AIDS | volume = 21 | issue = 2| pages = 77–81 |pmid=20089991 |doi=10.1258/ijsa.2009.009434 |s2cid=5431867 }}</ref> In North America, the most popular delay spray, [https://stud100.ca/ Stud 100], is approved by the [[Organization:Food and Drug Administration|FDA]] and [[Organization:Health Canada|Health Canada]].<ref>{{Cite web |title=Health Canada |url=https://dhpp.hpfb-dgpsa.ca/dhpp/resource/46020 |website=Details for: Stud 100 - Drug & Health Product Portal}}</ref> Another research was conducted in 21 men who were randomized (15 treatment, 6 placebo) and had complete follow-up data. Baseline mean ± standard deviation IELT was 74.3 ± 31.8 vs 84.9 ± 29.8 seconds among the treatment and placebo groups, respectively (p=0.39). After 2 months, men in the treatment group had significant improvement in IELT with a mean increase of 231.5 ± 166.9 seconds (95% confidence interval of 139-323 seconds) which was significantly greater than men on placebo (94.2 ± 67.1 seconds, p= 0.043).<ref>{{Cite journal |last1=Shabsigh |first1=Ridwan |last2=Kaminetsky |first2=Jed |last3=Yang |first3=Michael |last4=Perelman |first4=Michael |date=April 2017 |title=Pd69-02 Double-Blind, Randomized Controlled Trial of Topical 4% Benzocaine Wipes for Management of Premature Ejaculation: Interim Analysis |url=http://www.jurology.com/doi/10.1016/j.juro.2017.02.3143 |journal=Journal of Urology |language=en |volume=197 |issue=4S |doi=10.1016/j.juro.2017.02.3143 |s2cid=78743713 |issn=0022-5347|url-access=subscription }}</ref>

===Surgical treatments===
Two different surgeries, both developed in [[Earth:South Korea|South Korea]], are available to permanently treat premature ejaculation: selective dorsal [[Medicine:Neurectomy|neurectomy]] (SDN)<ref>{{Cite journal |doi = 10.1111/j.1365-2605.2012.01296.x|pmid = 22882515|title = Selective resection of dorsal nerves of penis for premature ejaculation|journal = International Journal of Andrology|volume = 35|issue = 6|pages = 873–879|year = 2012|last1 = Zhang|first1 = G.-X.|last2 = Yu|first2 = L.-P.|last3 = Bai|first3 = W.-J.|last4 = Wang|first4 = X.-F.|doi-access = free}}</ref> and glans penis augmentation using a [[Chemistry:Hyaluronan|hyaluronan]] gel.<ref>{{Cite journal |pmid = 15057258|year = 2004|last1 = Kim|first1 = J. J.|title = Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation|journal = International Journal of Impotence Research|volume = 16|issue = 6|pages = 547–51|last2 = Kwak|first2 = T. I.|last3 = Jeon|first3 = B. G.|last4 = Cheon|first4 = J.|last5 = Moon|first5 = D. G.|doi = 10.1038/sj.ijir.3901226| s2cid=205677292 |doi-access = }}</ref><ref>{{Cite journal |doi = 10.1038/ijir.2008.26|pmid = 18548080|title = Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation|journal = International Journal of Impotence Research|volume = 20|issue = 4|pages = 425–428|year = 2008|last1 = Kwak|first1 = T. I.|last2 = Jin|first2 = M. H.|last3 = Kim|first3 = J. J.|last4 = Moon|first4 = D. G.| s2cid=32849162 |doi-access = }}</ref> Circumcision has shown no effect on PE.<ref name=":1">{{Cite journal |last1=Anaissie |first1=James |last2=Yafi |first2=Faysal A. |last3=Hellstrom |first3=Wayne J. G. |year=2016 |title=Surgery is not indicated for the treatment of premature ejaculation |journal=Translational Andrology and Urology |volume=5 |issue=4 |pages=607–612 |doi=10.21037/tau.2016.03.10 |pmc=5001994 |pmid=27652232 |doi-access=free }}</ref> The International Society for Sexual Medicine guidelines do not recommend either surgical treatment due to the risk of permanent loss of sexual function and insufficient reliable data<ref name=":1" /><ref name="moon2016">{{Cite journal |last1=Moon |first1=Du Geon |year=2016 |title=Is there a place for surgical treatment of premature ejaculation? |journal=Translational Andrology and Urology |volume=5 |issue=4 |pages=502–507 |doi=10.21037/tau.2016.05.06 |pmc=5002006 |pmid=27652223 |doi-access=free }}</ref><ref name="Serefoglu" /> and on the basis of violating the medical principle of non-maleficence as the surgery can lead to complications, of which some might not yet be known.<ref name=":1" /> The most common complication of surgery is the recurrence of PE, reported to occur in about 10% of surgeries.<ref name=":1" /> Other sources consider SDN as a safe and efficient treatment<ref>{{Cite journal |last1=Yang |first1=D. Y. |last2=Ko |first2=K. |last3=Lee |first3=W. K. |last4=Park |first4=H. J. |last5=Lee |first5=S. W. |last6=Moon |first6=K. H. |last7=Kim |first7=S. W. |last8=Kim |first8=S. W. |last9=Cho |first9=K. S. |last10=Moon Du |first10=G. |last11=Min |first11=K. |year=2013 |title=Urologist's Practice Patterns Including Surgical Treatment in the Management of Premature Ejaculation: A Korean Nationwide Survey |journal=The World Journal of Men's Health |volume=31 |issue=3 |pages=226–31 |doi=10.5534/wjmh.2013.31.3.226 |pmc=3888892 |pmid=24459656 |last12=Yang |first12=S. K. |last13=Son |first13=H. |last14=Park |first14=K.}}</ref> and these surgeries are popular in Asian countries.<ref name="Serefoglu" /><ref name="moon2016" /> 

==Epidemiology==
Premature ejaculation is a prevalent [[Medicine:Sexual dysfunction|sexual dysfunction]] in males;<ref name="premature ejaculation">{{cite web|url=http://www.mayoclinic.com/health/premature-ejaculation/DS00578|title=Premature ejaculation|publisher=Mayo Clinic.com|access-date=2007-03-02}}</ref> however, because of the variability in time required to ejaculate and in partners' desired duration of sex, exact prevalence rates of PE are difficult to determine. In the "Sex in America" surveys (1999 and 2008), [[Organization:University of Chicago|University of Chicago]] researchers found that between [[Social:Adolescence|adolescence]] and age 59, approximately 30% of men reported having experienced PE at least once during the previous 12 months, whereas about 10 percent reported [[Medicine:Erectile dysfunction|erectile dysfunction]] (ED).<ref name="Laumann">{{cite journal |author= Laumann, E.O.|title= Sexual Dysfunction in the United States: Prevalence and Predictors |journal= Journal of the American Medical Association |volume=281 |pages=537–44 |year=1999 |pmid= 10022110|doi=10.1001/jama.281.6.537 |issue=6|display-authors=0|doi-access=free }}</ref> In males, although ED is the most prevalent sex problem after age 60, and may be more prevalent than PE overall according to some estimates,<ref name="erectile dysfunction">{{cite journal | pmid = 20497307 | doi=10.1111/j.1743-6109.2010.01849.x |volume=7 | issue=7 | title=Next Men's Clinic Erectile dysfunction in the community: trends over time in incidence, prevalence, GP consultation and medication use—the Krimpen study: trends in ED|date=July 2010 |vauthors=Schouten BW, Bohnen AM, Groeneveld FP, Dohle GR, Thomas S, Bosch JL |journal=J Sex Med | pages=2547–53}}</ref> premature ejaculation remains a significant issue that, according to the survey, affects 28 percent of men age 65–74, and 22 percent of men age 75–85.<ref name="Laumann" /> Other studies report PE prevalence ranging from 3 percent to 41 percent of men over 18, but the great majority estimate a prevalence of 20 to 30 percent—making PE a very common sex problem.<ref name="Barnes" /><ref name="Althof2010">{{cite journal |author= Althof, S.E.|title= International Society for Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation |journal= Journal of Sexual Medicine|volume=7|pages=2947–69|year=2010|pmid=21050394 |doi=10.1111/j.1743-6109.2010.01975.x |issue=9|display-authors=0}}</ref><ref name="premature ejaculation" /><ref>{{cite journal |author= Mathers, M.J.|title= Premature Ejaculation in Urological Routine Practice |journal= Aktuelle Urologie |volume=44 |pages=33–9 |year=2013|pmid= 23381878 |doi=10.1055/s-0032-1331727 |issue=1|s2cid= 198315452 |display-authors=0}}</ref><ref name="Serefoglu">{{cite journal |author1=Serefoglu E.C. |author2=T.R. Saitz |title= New Insights on Premature Ejaculation: A Review of Definition, Classification Prevalence, and Treatment |journal= Asian Journal of Andrology |volume=14|pages=822–9 |year=2012|pmid=23064688 |doi=10.1038/aja.2012.108 |issue=6 |pmc=3720102}}</ref><ref>{{cite journal |author1=Tang, W.S. |author2=E.M. Khoo |title= Prevalence and Correlates of Premature Ejaculation in a Primary Care Setting: A Preliminary Cross-Sectional Study |journal= Journal of Sexual Medicine |volume=8 |pages=2071–8 |year=2011|pmid= 21492404 |doi=10.1111/j.1743-6109.2011.02280.x |issue=7}}</ref><ref>{{cite journal |author= Porst, H.|title= The Premature Ejaculation Prevalence and Attitudes (PEPA) Survey: Prevalence, Co-morbidities, and Professional Help-Seeking |journal= European Urology |volume=51|pages=816–824|year=2007|pmid=16934919|doi=10.1016/j.eururo.2006.07.004 |issue=3|display-authors=0}}</ref><ref>{{cite journal |author= Rowland, D.|title= Self-Reported Premature Ejaculation and Aspects of Sexual Functioning and Satisfaction |journal= Journal of Sexual Medicine |volume=1|pages=225–32|year=204|pmid= 16429622|issue=2 |doi=10.1111/j.1743-6109.2004.04033.x|display-authors=0}}</ref>

There is a common misconception that younger men are more likely to develop premature ejaculation and that its frequency decreases with age.<ref>{{Cite news |last=Pearson |first=Catherine |date=2023-10-15 |title=8 Sex Myths That Experts Wish Would Go Away |url=https://www.nytimes.com/2023/10/15/well/family/sex-myths.html |access-date=2024-03-11 |work=The New York Times |language=en-US |issn=0362-4331}}</ref><ref>{{Cite journal |title=Premature ejaculation: challenging new and the old concepts |last1=Kalejaiye |first1=Odunayo |last2=Almekaty |first2=Khaled |date=2017-12-04 |journal=F1000Research |issue=6:2084 |doi=10.12688/f1000research.12150.1 |language=en |pmc=5717471 |pmid=29259775 |last3=Blecher |first3=Gideon |last4=Minhas |first4=Suks|volume=6 |page=2084 |doi-access=free }}</ref> Prevalence studies have indicated, however, that rates of PE are relatively constant across age groups.<ref name="Althof2007" />

==History==

=== Naturalism ===
Male mammals ejaculate quickly during intercourse, prompting some biologists to speculate that rapid ejaculation had evolved into genetic makeup of human males to increase their chances of passing their genes.<ref>{{cite journal|last1=Wright|first1=Karen|title=Evolution of the Orgasm|journal=Discover Magazine|date=June 1, 1992|url=http://discovermagazine.com/1992/jun/evolutionofthebi59}}</ref><ref>{{cite book|last1=Carufel|first1=Francois de|title=Premature Ejaculation: Theory, Evaluation and Therapeutic Treatment|date=2016|publisher=Taylor & Francis|isbn=9781317280750|page=6|url=https://books.google.com/books?id=diMlDwAAQBAJ&pg=PA6}}</ref>

Ejaculatory control issues have been documented for more than 1,500 years. The ''Kamasutra'', the 4th century BCE Indian marriage handbook, declares that "if a male be long-timed, the female loves him the more, but if he be short timed, she is dissatisfied with him."<ref>{{Cite journal |last=Astbury-Ward |first=Edna |date=2002 |title=From Kama Sutra to dot.com: The history, myths and management of premature ejaculation |url=http://www.tandfonline.com/doi/abs/10.1080/1468199021000017218 |journal=Sexual and Relationship Therapy |language=en |volume=17 |issue=4 |pages=368 |doi=10.1080/1468199021000017218 |s2cid=146305025 |issn=1468-1994}}</ref><ref>{{Cite journal |last1=Gajjala |first1=Sukumar Reddy |last2=Khalidi |first2=Azheel |date=2014 |title=Premature ejaculation: A review |journal=Indian Journal of Sexually Transmitted Diseases and AIDS |volume=35 |issue=2 |pages=92–95 |doi=10.4103/0253-7184.142391 |doi-access=free |issn=2589-0557 |pmc=4553859 |pmid=26396440}}</ref> 

Waldinger summarizes professional perspectives from early in the twentieth century.<ref name="Waldinger2013">{{Cite book|last1=Waldinger|first1=Marcel D.|title=Premature Ejaculation|year=2013|pages=5–24|doi=10.1007/978-88-470-2646-9_2|isbn=978-88-470-2645-2|chapter=History of Premature Ejaculation}}</ref>

Sex researcher Alfred Kinsey did not consider rapid ejaculation a problem, but viewed it as a sign of "masculine vigor" that could not always be cured.<ref>Kaplan (1974), p. 292</ref> The belief that it should be considered a disease rather than a normal variation, has also been disputed by some modern researchers.<ref>{{Cite journal|last1=Puppo|first1=Vincenzo|last2=Puppo|first2=Giulia|date=2016|title=Comprehensive review of the anatomy and physiology of male ejaculation: Premature ejaculation is not a disease|journal=Clinical Anatomy|volume=29|issue=1|pages=111–119|doi=10.1002/ca.22655|pmid=26457680|s2cid=9213013}}</ref>

=== Medicalization ===
 In the 19th century, a symptom called ''spermatorrhoea'' invented by William Acton in 1857, meaning excessive or involuntary semen discharge, was developed and at the time used as a medical justification of [[Philosophy:Celibacy|celibacy]].<ref name=":15">{{Cite journal |last1=Hart |first1=Graham |last2=Wellings |first2=Kaye |date=2002-04-13 |title=Sexual behaviour and its medicalisation: in sickness and in health |url=https://www.bmj.com/content/324/7342/896 |journal=BMJ |language=en |volume=324 |issue=7342 |pages=896–900 |doi=10.1136/bmj.324.7342.896 |issn=0959-8138 |pmc=1122837 |pmid=11950742}}</ref><ref name=":13">{{Cite journal |last=Grunt-Mejer |first=Katarzyna |date=2022-07-03 |title=The history of the medicalisation of rapid ejaculation—A reflection of the rising importance of female pleasure in a phallocentric world |url=https://www.tandfonline.com/doi/full/10.1080/19419899.2021.1888312 |journal=Psychology & Sexuality |language=en |volume=13 |issue=3 |pages=565–582 |doi=10.1080/19419899.2021.1888312 |issn=1941-9899 |s2cid=233924065|url-access=subscription }}</ref> Spermatorrhoea was later sub-classified into other symptom clusters based partially on how it affected semen.<ref name=":13" /> Treatment for spermatorrhoea at the time included catheterisation, [[Medicine:Cauterization|cauterisation]], circumcision, and sticking needles through the perineum into the [[Biology:Prostate|prostate]].<ref name=":13" /> In the 19th and early 20th centuries, cultural stigma towards researching sexuality drove its unpopularity as a subject of study among doctors and in publications.<ref name=":15" /> The first recognition the symptoms described in spermatorrhoea as a disorder in itself is believed to be in 1883, termed ''ejaculatio praecox''.<ref name=":13" /> The origin of the modern version of ejaculatio praecox, called premature ejaculation, is thought to have begun with Alfred Adler before major developments of [[Social:Psychoanalysis|psycohanalytic theory]].<ref name=":16">{{Cite journal |last=Grunt-Mejer |first=Katarzyna |date=2022-07-03 |title=The history of the medicalisation of rapid ejaculation—A reflection of the rising importance of female pleasure in a phallocentric world |url=https://www.tandfonline.com/doi/full/10.1080/19419899.2021.1888312 |journal=Psychology & Sexuality |language=en |volume=13 |issue=3 |pages=565–582 |doi=10.1080/19419899.2021.1888312 |issn=1941-9899 |s2cid=233924065|url-access=subscription }}</ref>

Through the mid 20th century, [[Biography:Sigmund Freud|Sigmund Freud]] published widely accepted and virtually unchallenged theories that rapid ejaculation was due to neurosis, that penetrative sex was the only right way to achieve female orgasm, and that a man's erection was essential to female orgasm.<ref name="Kaplan1974">{{Cite book |last=Kaplan |first=Helen Singer |url=https://books.google.com/books?id=EQI-TEM2fSoC |title=How to overcome premature ejaculation |date=1989 |publisher=Brunner/Mazel |isbn=9780876305423 |location=New York |page=295 |edition=2nd |oclc=1008628084}}</ref><ref name=":14">{{Cite journal |last=Grunt-Mejer |first=Katarzyna |date=2022-07-03 |title=The history of the medicalisation of rapid ejaculation—A reflection of the rising importance of female pleasure in a phallocentric world |url=https://www.tandfonline.com/doi/full/10.1080/19419899.2021.1888312 |journal=Psychology & Sexuality |language=en |volume=13 |issue=3 |pages=565–582 |doi=10.1080/19419899.2021.1888312 |issn=1941-9899 |s2cid=233924065|url-access=subscription }}</ref> It stated that males who ejaculate prematurely have unconscious hostility toward females, so they ejaculate rapidly, which satisfies them but frustrates their partners, who are unlikely to experience [[Biology:Orgasm|orgasm]] that quickly.<ref name="Kaplan1989">{{Cite book |last=Kaplan |first=Helen Singer |url=https://books.google.com/books?id=AovC97CUny0C |title=The new sex therapy: active treatment of sexual dysfunctions |date=1974 |publisher=Brunner/Mazel |isbn=9780876300831 |location=New York |page=28 |oclc=1015728698}}</ref> Freudians claimed that premature ejaculation could be cured using psychoanalysis. But even years of psychoanalysis accomplished little, if anything, in curing premature ejaculation.<ref name="Kaplan1989" /> In 1974, there was no evidence found to suggest that men with premature ejaculation harbor unusual hostility toward females. This so-called ''coital imperative'' has later been argued as a medically recognised disorder that did not actually serve the satisfaction of women but rather contributed to the pressure on and pathologisation of men in obtaining a so-called optimal time to ejaculation.<ref name=":14" /><ref name=":24">{{Cite journal |last=Stegenga |first=Jacob |date=2021-12-02 |title=Medicalization of Sexual Desire |journal=European Journal of Analytic Philosophy |volume=17 |issue=2 |pages=5–34 |doi=10.31820/ejap.17.3.4 |issn=1849-0514|doi-access=free }}</ref>

==See also==
*[[Medicine:Anorgasmia|Anorgasmia]]
*[[Medicine:Delayed ejaculation|Delayed ejaculation]]
*Edging (sexual practice)
*Pre-ejaculate
*Retrograde ejaculation
*[[Medicine:Erectile dysfunction|Erectile dysfunction]]
*Blue balls
*Pull-out method
*Foreplay
*[[Chemistry:Dapoxetine|Dapoxetine]]

==References==
{{Reflist}}

==Cited sources==
* {{cite book|ref=Kaplan74|author= Kaplan, Helen S. |title= The New Sex Therapy |year=1974 |publisher=Psychology Press|isbn=9780876300831}}
* {{cite book|ref=Kaplan89|author= Kaplan, Helen S. |title= How to Overcome Premature Ejaculation |year=1989 |publisher=Routledge|isbn=9780876305423}}

==Further reading==
* {{cite magazine|last=Hamblin|first=James|date=2012|title=When Is Ejaculation 'Premature,' and When Should a Penis Be Made Numb?|url=https://www.theatlantic.com/health/archive/2012/11/when-is-ejaculation-premature-and-when-should-a-penis-be-made-numb/265071/|magazine=The Atlantic|access-date=6 March 2017|quote=According to [Dr. John Mulhall], when we talk casually about premature ejaculation ... we're usually talking about what the medical community would consider 'premature-ejaculatory-like syndrome,' or simply 'rapid ejaculation.' ... Mulhall says it comes down to whether the guy lasts long ''enough''. If his partner is made wholly replete in 90 seconds, then a man who lasts 95 seconds can be fine. But if another guy lasts 15 minutes, and that's not cutting it, then it's a problem and can be considered rapid. }} {{free access}}

== External links ==
{{Medical resources
|  DiseasesDB =
|  ICD10 = {{ICD10|F|52|4|f|50}}
|  ICD9 = {{ICD9|302.75}}
|  ICDO =
|  OMIM =
|  MedlinePlus = 001524
|  eMedicineSubj = med
|  eMedicineTopic = 643
|  MeshID =
}}
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{{sex|state=expand}}
{{Mental and behavioural disorders|selected = physical}}
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[[Category:Andrology]]

{{Sourceattribution|Premature ejaculation}}