Predoc research fellowship - Neuroscience Translational Research

Prof. Alessandra Bolino is seeking a highly motivated research fellow to join the research team at the San Raffaele Scientific Institute in Milan, Italy (https://www.unisr.it/en/docenti/b/bolino-alessandra). This role is central to an innovative research program dedicated to developing therapeutic strategies for the most severe forms of inherited peripheral neuropathies with childhood onset, the demyelinating Charcot-Marie Tooth type 4.

The successful candidate will contribute to unravel the interplay between the mTOR complexes and Rho-mediated signalling pathway in the context of myelination taking advantage of established and extensively characterized in vivo and ex vivo models of inherited neuropathies. This project develops from data recently published in Nature Communications (Sawade et al. 2020) and in PNAS (Guerrero-Valero et al., 2021).

Candidate profile

• Applicants must hold a degree in Medicine (MD) or Pharmaceutical Chemistry and Technology (CTF), or a Master’s degree in Biotechnology or Biology;
• Applicants possess demonstrated interest in neuroscience, supported by a strong academic record and hands-on laboratory training;
• Independent research capability;
• Organizational skills;
• A primary requirement is a demonstrated commitment to pursuing advanced academic research through a PhD program.
  
  
  

Duties and Responsibilities

• Establishment and manipulation of Schwann cells/Dorsal Root Ganglia neurons co-cultures;
• Molecular biology and biochemical analyses from primary cells and tissues;
• Preclinical trials using in vivo models of severe demyelinating inherited neuropathies;
• Immunohistochemistry and confocal microscopy on primary cultures and tissues;
• Analyses of proteomics datasets;
• Ensure rigorous data integrity via Electronic Lab Notebooks (ELN).
  
  
  

Work details

• Type of contract: full time;
• Immediately available;
• Place of work: Human Inherited Neuropathies Unit at Ospedale San Raffaele (MI).
  
  
  

How To Apply

Please submit a letter of intent, your curriculum vitae, and the contact information for academic references to Alessandra Bolino, bolino.alessandra@hsr.it.

At San Raffaele Scientific Institute, a world-renowned center of excellence for clinical and scientific activities, we believe that embracing diversity and promoting an open and inclusive environment are crucial to our success.

We are committed to ensuring that equal employment opportunities are provided based on merit, without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural or social background, gender identity or expression, national or ethnic origin, or any other legally recognized status protected under applicable laws.

We offer attractive conditions and rewards appropriate for an internationally competitive research.