Fig. 1

Time course curves are indicated for glucose, insulin, C-peptide and glucagon in healthy controls (a–d) and patients with type 2 diabetes (e–h) during three different meal sequences: RF, black circles; FR, white circles; or MR, white triangles (a–h). The p values for differences due to sequence (X), time (Y), and the interaction of sequence and time (Z), were calculated by mixed effects models as follows: (a) X0.000, Y0.001 and Z0.007; (b) X0.000, Y0.000 and Z0.012; (c) X0.000, Y0.000 and Z0.001; (d) X0.000, Y0.000 and Z0.000; (e) X0.000, Y0.000 and Z0.000; (f) X0.000, Y0.004 and Z0.614; (g) X0.000, Y0.163 and Z0.000; (h) X0.000, Y0.000 and Z0.000. AUC_{−15–240 min} are indicated (RF, black bars; FR, white bars; MR, hatched bars) (i–l). AUCs were analysed by Wilcoxon’s rank sum test; * and ^† indicate p < 0.05 for RF vs FR, and RF vs MR, respectively