Fig. 2

Time course curves are indicated for GLP-1 and GIP in healthy controls (a, b) and patients with type 2 diabetes (c, d) during three different meal sequences: RF, black circles; FR, white circles; or MR, white triangles (a–d). The p values for differences due to sequence (X), time (Y), and the interaction of sequence and time (Z), were calculated by mixed effects models as follows: (a) X0.000, Y0.000 and Z0.000; (b) X0.000, Y0.000 and Z0.000; (c) X0.000, Y0.000 and Z0.000; and (d) X0.000, Y0.000 and Z0.000. AUC_{−15–240 min} are indicated (RF, black bars; FR, white bars; MR, hatched bars) (e, f). AUCs were analysed by Wilcoxon’s rank sum test; *, ^† and ^‡ indicate p < 0.05 for RF vs FR; RF vs MR; and FR vs MR, respectively