Fig. 7
From: A novel method for subgroup discovery in precision medicine based on topological data analysis
Representation of the ER+ TCGA cohort through the Mapper graph. A The Mapper graph built on the TCGA data using the lens function of 222 genes identified from the hotspot detection algorithm results for the METABRIC data. Each labelled node represents a group of patients with similar gene expression. The node size represent the number of patients covered, indicated in the top right legend. The bottom right legend describes the attribute function colouring the graph, which is the occurrence of relapse before 10-years. Hotspot detection identified highlighted in red as a hotspot. B Mapper graph coloured by the distance of TCGA patients to the METABRIC hotspot centroid according to the 222 lens function genes. C Kaplan-Meier curve differentiating OS survival outcome in months between the hotspot group and the remaining ER+ cohort