Archive for July, 2024

2 Xenarthran Specimens Separated by 21,000 Years

July 25, 2024

I have a collection of animal skulls including those from dog, cat, raccoon, and squirrel. They are road-killed specimens. I was taking a stroll during my vacation last month at Callaway Gardens and found a skull that at first I couldn’t identify. I began to consider it as armadillo, then turned my head and saw the bleached carapace of an armadillo, thus confirming my diagnosis. It was near a road and likely was killed by a collision with a car. Armadillos use roadways to colonize new territory and are especially vulnerable to the danger posed by vehicles. The nine-banded armadillo (Dasypus novemcinctus) has recolonized southeastern North America over the past 100 years after being absent from the region for 10,000 years. Genetic studies suggest many Pleistocene-aged specimens of armadillos found at fossil sites were wrongly identified as being the beautiful armadillo (Dasypus bellus), an extinct species twice the size of the nine-banded armadillo, but they were actually the latter. (See: https://markgelbart.wordpress.com/2017/01/19/a-recent-study-of-pleistocene-armadillo-dna-yields-2-surprising-results/ )

Armadillo skull I found at Callaway Gardens.

Armadillo carapace, bleached from a lengthy exposure to the sun, found near the skull.

Another specimen of a xenarthran (a group including sloths, anteaters, armadillos, and glyptodonts) was recently excavated along the Reconquista River in Merlo, Argentina, and it is of much greater importance because the authors of the below referenced study propose it is evidence humans butchered it 21,000 years ago. The specimen was identified as a Neosclerocalyptus sp., a type of now extinct glyptodont. It couldn’t be identified to the species level because it was missing its skull. Scientists believe humans butchered the animal on a sandbar, and it was partially covered in river sediment before eolian winds covered it completely with sand. Scientists are confident in the calibrated radio-carbon dates taken from the beast’s hip bone, indicating the animal lived 21,000 years ago. It’s consistent with the stratigraphic evidence. They dated a clam shell in sediment beneath where the glyptodont remains were found and that dated to 30,000 years BP.

Image of glyptodont from the below referenced study with the bones that show evidence suggesting human butchery.

Image showing cut marks that the authors of the below study believe were from a stone knife.

Scientists found 32 cut marks on the glyptodont bones, and they were strategically placed as if the butcher was cutting off the largest most palatable pieces of meat. They were v-shaped, evidence the marks were made by human-made knives and not by carnivore or rodent gnawing. The former are u-shaped and the latter are w-shaped. Some archaeologists believe v-shaped incisions can also be made by bones rolling against rocks in river currents, but the authors of this study seem certain humans made these marks. However, there is no lithic evidence (no tools), and of course, no human remains found nearby. If humans did butcher this glyptodont, it would show humans were roaming the Americas thousands of years earlier than previously thought. There is some tantalizing but uncertain evidence of humans at other sites in South America and southwestern North America that suggests humans were in the Americas about 20,000 years ago.

A glyptodont provided plenty of protein–they weighed a ton. Glyptodonts differed from armadillos in the structure of their carapace. It was inflexible like a turtle shell. Armadillo carapaces are flexible, allowing them to roll up in a defensive ball.

Reference:

Del Papa, M. et. al.

“Anthropic Cut Marks in Extinct Megafauna Bones from the Pampean Region (Argentina) at the Last Glacial Maximum”

PLOS One July 2024

My Experience with Sildenafil

July 18, 2024

I’m writing this article for fellow old men over the age of 55 years old who are experiencing erectile disfunction and are considering the option of getting a prescription for a boner pill.

I always had a reliable erection since well before puberty, and I rarely had a problem performing in the bedroom. Throughout my late 50’s, I noticed a decline in the frequency of my erections, but I still could have successful performances when needed. I used to joke that old people sex wasn’t as good as young people sex, but it was better than no sex at all. My partner (my wife) and I have enjoyed lovemaking twice a week for decades. I long realized I wasn’t the stud I used to be, but I was satisfied with my sex drive for my age. About 6 weeks before my 62nd birthday, I began having a hard time sustaining an erection. I could get an erection, but it wouldn’t stay hard enough for long enough. Sometimes, I would lose my erection in the middle of intercourse. That was not satisfactory. We would then try mutual masturbation, and sometimes I would ejaculate without even getting hard. That was definitely not satisfactory. I began researching boner pills, now constantly promoted on television advertisements.

Being able to have a reliable erection is important for a man’s psychological well-being. I wouldn’t go to the doctor if I had cancer, but I went to the doctor to get a prescription for a boner pill. I like this song, “Shut up, I have an erection,” because it illustrates the importance of an erection for a man.

I take the generic sildenafil. It’s white and round. The original was blue and diamond-shaped and much more expensive.

About 30 years ago, scientists were working on developing a new medication to treat high blood pressure and chest pain. They invented sildenafil, a drug in the class of phosphodiesterase-5 inhibitors. Ph-5 is an enzyme that prevents men from having constant erections. Researchers discovered 1 of the side effects of taking this medication was improved blood flow to the penis. A slightly altered form of sildenafil is used for treating high blood pressure, but the drug company realized the market for treating erectile disfunction was potentially much more lucrative because there already were many blood pressure medicines but nothing for treating erectile disfunction. The FDA approved sildenafil (known as Viagra) in 1998. Several other PH-5 drugs have been approved since including tadafil (Cialis), avanfil (Stendra), and vardafil (Lenitra). Studies show these drugs work better than placebos by a statistically significant margin, though men taking placebos often respond positively as well, showing erectile disfunction can be a psychological issue. Another study found no evidence men develop a tolerance for these drugs and need ever higher dosages, so they are not physically addicting like heroin.

I was concerned some evidence suggests these types of drugs can cause vision problems. A study of 213,000 health insurance claims found men who regularly took boner pills were almost twice as likely to develop vision problems. A case study was published of 17 men who took boner pills for the first time and experienced vision problems that lasted for as long as 3 weeks. Men who take these medications were twice as likely to suffer retinal detachment and 44% more likely to experience ocular vascular occlusions. High risk groups include people with high blood pressure, men who have low blood pressure when they sleep, and men who inherit the risk of getting retinal pigmentosa. Men who suffered heart attacks were 10 times more likely to develop vision problems. I decided to take the risk because it was small, and going blind wouldn’t be the end of the world. I planned to learn how to play the xylophone and figure out how to do housework while blind, if I did become sightless. I made an appointment with my doctor’s physician’s assistant because she could see me sooner than my doctor. When I made the appointment the secretary told me the physician’s assistant was a woman, and I had to assure her this wouldn’t bother me. I wanted to try the drug, but I wasn’t going to order a medicine this important from some dodgy online source. The physician’s assistant gave me a perfunctory exam and classified it as a wellness visit, so the insurance company would pay for it. I described my condition in detail, and she told me it was not unusual for a 61-year-old man to experience erectile disfunction. She prescribed 100 milligrams a day of sildenafil, but suggested I take half a pill (50 milligrams). The generic pills are cheap–$1.25 each–and are definitely worth the price.

I’m very careful when taking drugs, and I take 50 milligrams before lunch on Wednesdays and 25 milligrams on Sunday mornings when I awake. (My partner and I have had a regular twice a week schedule for decades–Wednesday afternoons and Sunday mornings.) I respond well to sildenafil. I start to feel it working after about 15 minutes. All I have to do is think about something sexy, and I have an erection that lasts as long as needed. For some time before I started taking sildenafil, I wondered whether I was simply tired of my partner. We’d made love ~3,148 times, and I thought maybe I just couldn’t keep it up for the 3,149th time. I can now banish that thought. When I have a strong sildenafil-induced erection my partner seems more desirable. The drug exceeded my expectations. I only wanted to turn the clock back by a couple of months, but now I can screw like a 30-year-old porn star. The refractory period is shorter. I can get a 2nd erection after resting for 15 minutes or so, though it is harder to ejaculate–I’m still a 62-year-old man. I’ve experienced no failures so far and have taken the pill over 20 times. However, my partner knows I can perform better, and she expects more from me. She’s a very demanding woman.

Side effects are minimal. My vision does get a little shady with a bluish tint, but nothing close to an impairment. I get a little congested–a side effect I also experience when starting to drink wine. I feel like I need to burp a little–pretty mild, if a person considers this indigestion. None of these symptoms last more than an hour or two.

The last time I made love before I began the medication, I had a successful performance, and I wanted to try unmedicated sex before writing this article. This didn’t happen because I saw no reason not to bring my A-game with boner pills still in my medicine cabinet. I’m going to keep this prescription filled for the rest of my life. I noticed many years ago that I also had better performances when I was hungover after a night of binge drinking, and I wonder if alcohol withdrawal creates a similar biochemical response as a PH-5 inhibitor.

I’m too lazy this week to add a reference section to this article, but there are dozens of studies about PH-5 inhibitors that are easily found and accessible online with a simple google search.

Cat Parasites Influence Human Behavior

July 11, 2024

A cat parasite (Toxoplasma gondii) infects about 30% of the worldwide human population. There is no cure. The human body has no way of ridding itself of these parasites, and there is no medicine that can be used to treat them. Billions of people on earth have cysts on their brains caused by the cat parasites in their bodies. Fortunately, most people suffer no symptoms from hosting cat parasites. A small number of people may experience flu-like symptoms, but most people are unaware they host cat parasites. Cat parasites can cause an increased risk of miscarriages for pregnant women, and they can cause problems for people with weakened immune systems, but they are harmless for the vast majority of human hosts.

Toxoplasm gondii has an interesting life cycle. This parasite can only reproduce inside a cat’s digestive system because they depend upon the high level of linoleic acid in a cat’s gut. For some unexplained reason mice with toxoplasm in their brains become sexually interested in cat feces. This causes them to behave recklessly, and they are more likely to be eaten by a cat, thus propagating more parasites. Cats are clean animals, and people do not get toxoplasm by petting cats. Instead, people get infected when they eat raw meats, fruits, or vegetables that have toxoplasm on them. Cat feces with toxoplasm in it is common throughout the environment, and the parasite just gets on everything and is consumed by animals that people eat.

Cats are clean, but they defecate in the environment and their parasites can contaminate meat and plants.

Toxoplasm gondii lifecycle.

Toxoplasm gondii.

Toxoplasm also causes infected humans to act recklessly. A study of hundreds of people in Turkey found humans who were infected with toxoplasm were more likely to be involved in car accidents. Other studies suggest infected people are more prone to rage. However, another study indicates reckless behavior can have positive benefits. A study of hundreds of businessmen found those infected made on average $6000 more per year than uninfected businessmen.

Toxoplasm influences wolf behavior as well. Infected wolves are more likely to be pack leaders. Infected chimpanzees lose their aversion to leopard urine. And infected hyena cubs wander closer to lions. How weird that a micro-organism actually influences the behavior of much more advanced animals. In the words of the fictional Cosmo Kramer, “nature is a mad scientist.”

References:

Genova, B. ; S. Wilson, J. Dubey, L. Knoll

“Intestinal Delta-6 desaturase activist Determines Host Range for Toxoplasm Reproduction”

PLOS Biology 2019

Lerner , D.; L. Akaersu. S. Johnson

“Nothing Ventured, Nothing Gained: Parasite Infection is Associated with Entrepreneurial Initiation, Engagement, and Performance”

Entrepreneurship Theory and Practice 45 (1) 2020

Meyer, C.; et. al.

“Parasite Infection Increases Risk-taking in a Social Intermediate Host Carnivore”

Communication Biology 2022

Yerelis, K; I. Balciogles, A. Ozlilgia

“Is Toxoplasm gondii a Potential Risk for Traffic Accidents in Turkey?”

Forensic Science International 2006

Pleistocene Jumping Mice (Zapus and Napaeozapus sp.)

July 4, 2024

Imagine a human who could jump about the length of a football field. The incredible jumping mice can leap over 40 times the length of their bodies (not counting their long tails), the equivalent of a human who could jump from their own 20-yard line on a football field to their opponent’s goal line. This ability to leap 10 feet away helps them escape predators when the mice leap to safety in dense grass or leaf litter.

There are 4 known species and 2 genera of jumping mice in North America including the meadow jumping mouse (Zapus hudsonius), the western jumping mouse (Z. princeps), the Pacific jumping mouse (Z. trintotatus), and the woodland jumping mouse (Napaeozapus insignis). The woodland jumping mouse is considered to be in a different genus because they have fewer teeth and quite different penis and ear bones. Though morphologically, there are 4 recognized species in North America, a genetic study suggests there are 28 different lineages, and statistically there should be 15 species. Fossil remains of jumping mice date to the early Pliocene, and they originally evolved at least 5 million years ago. Climate fluctuations during the Pleistocene caused speciation. Still, they are closely related. Pacific and western jumping mice can interbreed.

Range map for the 4 species of North American jumping mice.

Woodland jumping mouse. The extra-long tail distinguishes jumping mice from field mice in the Peromyscus genus.

Jumping mice are adapted to live in cool moist climates. Woodland jumping mice prefer grassy habitat near streams that flow through spruce forests. They occur in just the northernmost area of Georgia. The subspecies that lives in the southern Appalachians is known as N. insignis roanensis. They ranged farther south during Ice Ages. Fossil remains of meadow jumping mice were found at Ladds in Bartow County, Georgia, and it still ranges through areas of northern Georgia.

Jumping mice feed upon grass seeds, fungi, fruit, and insects. They hibernate during winter in shallow underground burrows, under tree roots, or in hollow logs. If they didn’t put enough fat on during summer and early fall, they will die during hibernation. Jumping mice that colonize human dwellings don’t hibernate. Not much is known about jumping mice because they kill their young in captivity and can’t be kept for observation for more than 1 generation like other mice can.

Reference:

Malone, J.; J. Domboski, J. Cook

“Integrative Species Delimitation of the Widespread North America Jumping Mice (Zapodinae)”

Molecular Phylogenetics and Evolution 44 2017


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