Year: 2011
Type: article
Abstract: Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.
DOI: 10.3322/caac.20114
Institutions: UCLouvain, KU Leuven, Oslo University Hospital, University of Pennsylvania, University of Rochester Medicine, University of Rochester, Medical College of Wisconsin, Roswell Park Comprehensive Cancer Center, Harvard University, Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Wayne State University, BC Cancer Agency, University of Oslo, Medical University of Warsaw, University of Liège, University of Toronto, Institute of Physical Chemistry, Polish Academy of Sciences
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,330
Funders: American Cancer Society, Kreftforeningen, Australian Government, European Commission, Fundacja na rzecz Nauki Polskiej, Fonds Wetenschappelijk Onderzoek, Vlaamse regering, National Institutes of Health, European Regional Development Fund, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases
Awards: G1024165418, G1232653614, Signal transduction in ER stress: the role of the 'Unfolded protein response' in anticancer therapy., G1538205366, ROLE OF OXIDIZED CARDIOLIPIN TRANSLOCATION IN OXIDATIVE STRESS-INDUCED APOPTOSIS, G2475180354, G2737586502, Photophysics of Photodynamic Therapy, Biological mechanisms involved with PDT in the treatment of MPM, G3705288623, G3807442600, Iron, NO, and Lipid Peroxide in Photodynamic Therapy, Danger-associated molecular patters: revealing the molecular signals dictating the communication between dying cells with the immune system, Photodynamic Therapy of Localized Infections, Macrophage Targeted Photodynamic Therapy, G6810937322, G825913206, G8715288521, G9000080926, G9000128668, G9000176827, G9000177717, PHOTODYNAMIC THERAPY (PDT) AND TUMOR IMMUNITY, G9000227749
OpenAlex ID: W2151734986