the virtues which are desirable for scientific theories to possess. In this paper I discuss the several species of theoretical virtues called 'fertility', and argue in each case that the desirability of 'fertility' can be explicated in terms of other, more fundamental theoretical virtues.

Several philosophers have recently argued that policies aimed at reducing human fertility are a practical and morally justifiable way to mitigate the risk of dangerous climate change. There is a powerful objection to such “population engineering” proposals: even if drastic fertility reductions are needed to prevent dangerous climate change, implementing those reductions would wreak havoc on the global economy, which would seriously undermine international antipoverty efforts. In this article, we articulate this economic objection to population engineering and show (...) how it fails. We argue, first, that the economic objection paints an inaccurate picture of the complicated relationship between demographic change and economic growth, and second, that any untoward economic effects of fertility reduction can be mitigated with additional policies. Specifically, we argue that supplementing fertility reduction with policies that facilitate the emigration of younger people from developing nations to developed nations could allow for both global reductions in GHG emissions and continued economic stability. Further, we show that moral arguments against such unprecedented increases in immigration are unsuccessful. We conclude that population engineering is a practical and morally justifiable tool for addressing the twin evils of climate change and global poverty. (shrink)

Australian women who are university graduates have fewer children than non-graduates. In most cases this appears to be the result of circumstantial pressures not preference. Long years of study fill the most fertile years of women students and new graduates need further time to establish their careers. The chance of medical infertility increases with age so, for some, this means that childbearing is not postponed but ruled out. Graduates who do make the transition from university to professional work find that (...) working hours are long and that professional occupations are now both highly demanding and insecure. Women who take time off to care for young children must depend on one insecure income (their partner’s) rather than two, and their return to work is uncertain. These difficulties of time, money and insecurity are compounded by problems in finding a suitable partner. They are magnified by the enduring tendency of women to marry up. Thus it can be more difficult for women graduates to find husbands than it is for women who are non-graduates. (shrink)

Transhumanism is a movement that seeks to transcend certain limitations inherent in the human condition as we know it. But does it justify overriding the dignity of current human beings in order to satisfy the desire to increase human potential and improve human beings as such, in order to obtain other human beings? Does it justify disregarding the dignity of women in order to obtain new human beings through fertilization? To answer these questions, we have made a sweep over the (...) ideas of transhumanism that drive this type of techniques, to later understand the vision that women have in the use of in vitro fertilization, the hidden discrimination under these procedures and the clarification of the true emancipation and restoration of women's rights in relation to the use of in vitro fertilization. -/- El transhumanismo es un movimiento que busca trascender ciertos límites inherentes a la condición humana como la conocemos. Sin embargo, ¿justifica dejar de lado la dignidad de los seres humanos actuales por cumplir el deseo de aumentar el potencial humano y mejorar al ser humano como tal para obtener otros seres humanos?, ¿justifica pasar por encima de la dignidad de una mujer para obtener nuevos seres humanos a través de la fertilización in vitro? Para responder a estas preguntas hemos hecho un barrido sobre las ideas del transhumanismo que impulsa este tipo de técnicas, para luego comprender la visión que se tiene de la mujer en el uso de la fertilización in vitro, la discriminación oculta bajo estos procedimientos y la aclaración de la verdadera emancipación y restablecimiento de los derechos de la mujer en relación con el uso de la fertilización in vitro. (shrink)

Population is a key factor of national power. Declining fertility rates, especially in major economies, are reshaping global power dynamics by shrinking workforces amidst aging populations. In response, more nations are adopting techno-natalist policies, promoting reproductive technologies (“reprotech”) like IVF to increase birth rates. Advances in genetic embryo selection, gene editing, in vitro gametogenesis, and artificial wombs could further enhance these policies by improving birth rates, health, and human capital. This article examines current and emerging reprotechnologies, the policy landscape, (...) socioeconomic and geopolitical implications, and future research directions. By shaping national and global gene pools, reprotech policies and practices offer a paradigmatic case of gene–culture coevolution. If these technologies prove safe and effective, nations that embrace them are likely to gain geopolitical and evolutionary advantages over those that do not. (shrink)

Soil fertility is a critical factor in ensuring healthy crop growth and agricultural productivity. Traditional methods of assessing soil fertility, which rely on laboratory testing to measure essential nutrients like Nitrogen (N), Phosphorus (P), and Potassium (K), are often time-consuming, labor-intensive, and impractical for small-scale farmers. To address these challenges, this paper proposes an advanced framework that combines Internet of Things (IoT) technology with an optical transducer for efficient soil fertility analysis. The optical transducer measures the absorption (...) of light by soil, accurately detecting the presence and levels of N, P, and K. IoT-enabled sensors monitor additional parameters, such as pH, temperature, and moisture, providing comprehensive real-time data. This data is transmitted to farmers, enabling them to make timely and informed decisions regarding fertilizer application. The proposed system eliminates the need for laboratory testing, offering a faster, more cost-effective solution. By accurately identifying nutrient deficiencies and minimizing fertilizer overuse, this technology helps preserve soil health, improve crop yields, and promote sustainable farming practices. The integration of IoT and optical sensing technology represents a promising innovation in agriculture, enhancing productivity while reducing environmental impact. (shrink)

Abstract The global decline in fertility rates — the average number of children born per woman — is entering a pivotal phase with major implications for societies, economies, and global power structures. This paper examines the causes, trajectories, consequences, and possible adaptive strategies of this demographic transition. Drawing on recent data and country-level examples, the paper explores how ageing populations, shrinking workforces, slower economic growth, migration flows, and environmental factors may shape the world in coming decades. Regions differ significantly (...) in their trajectories and adaptive capacity, and policy responses will vary accordingly. -/- . (shrink)

Achieving Sustainable Population Management Through Economic Growth and Replacement Fertility -/- Introduction -/- Population management is a crucial challenge in today’s world. Some countries face overpopulation, which strains resources, infrastructure, and economic growth. Others experience depopulation, leading to labor shortages, economic decline, and social instability. The correct approach depends on a country’s current demographic and economic status. -/- Overpopulated countries must first decrease their population to a sustainable level while achieving high GDP per capita before considering replacement fertility. (...) -/- Depopulating countries must stabilize their population at a sustainable level before transitioning to replacement fertility to prevent economic collapse. -/- This essay examines the causes and consequences of overpopulation and depopulation, providing case studies and solutions to achieve sustainable population levels. -/- The Challenges of Overpopulation -/- Overpopulation occurs when a country’s population exceeds the available resources, infrastructure, and economic capacity, leading to several issues: -/- 1. Resource Depletion – High demand for food, water, land, and energy causes shortages and environmental destruction. -/- 2. Economic Struggles – When job creation and infrastructure growth fail to match population increase, unemployment and poverty rise. -/- 3. Environmental Degradation – Overpopulation accelerates climate change, deforestation, and pollution. -/- 4. Overburdened Public Services – Governments struggle to provide adequate healthcare, education, and housing. -/- 5. Social Instability – Overcrowded cities and high competition for resources lead to crime, protests, and political unrest. -/- Case Studies: Overpopulated Countries -/- India (1.4 billion, fertility rate ~2.0) – Struggles with water shortages, traffic congestion, and high unemployment. -/- Bangladesh (170 million, fertility rate ~2.1) – One of the most densely populated countries, facing flooding, land shortages, and slums. -/- Nigeria (223 million, fertility rate ~5.3) – Rapid growth threatens food security, job opportunities, and deforestation. -/- Philippines (114 million, fertility rate ~1.9) – Faces urban congestion, limited land space, and housing crises. -/- Pakistan (240 million, fertility rate ~3.5) – Struggles with energy shortages, poor healthcare, and rising poverty. -/- The Correct Approach for Overpopulated Countries -/- Overpopulated nations must not immediately adopt replacement fertility (2.1 children per woman) because their population is already too large. Instead, they should: -/- 1. Reduce Population to a Manageable Level -/- Implement family planning programs and education initiatives to encourage lower birth rates. -/- Set fertility targets below 2.1 (e.g., 1.5 to 1.8) to gradually reduce population size. -/- Offer economic incentives for smaller families, such as tax benefits and free contraceptives. -/- 2. Strengthen Economic Growth and Increase GDP Per Capita -/- Invest in technology, high-value industries, and education to improve productivity. -/- Develop smart urban planning to reduce congestion and improve living conditions. -/- Ensure fair wages and social safety nets to prevent extreme poverty. -/- 3. Stabilize at Replacement Fertility After Achieving Balance -/- Once population levels become sustainable, shift to replacement fertility (2.1 children per woman) to prevent economic decline. -/- Encourage sustainable urbanization and green technologies to manage resources efficiently. -/- Without these measures, overpopulated countries will continue to struggle with worsening poverty, environmental destruction, and declining quality of life. -/- The Risks of Depopulation -/- While overpopulation creates challenges, depopulation also presents significant risks: -/- 1. Economic Decline – Fewer workers result in lower productivity, labor shortages, and reduced economic growth. -/- 2. Aging Populations – Fewer young people mean fewer taxpayers to support healthcare and pensions. -/- 3. Urban and Rural Decay – Population decline leads to abandoned homes, closed schools, and stagnation. -/- 4. Loss of Global Influence – Countries with shrinking populations lose economic and political power. -/- Case Studies: Depopulating Countries -/- Japan (125 million, fertility rate ~1.3) – The world’s most rapidly aging nation, relying on robotics and automation. -/- South Korea (51 million, fertility rate ~0.78) – Facing a severe birth rate crisis, threatening long-term economic stability. -/- Italy (59 million, fertility rate ~1.2) – Experiencing rural depopulation, with entire villages abandoned. -/- Germany (84 million, fertility rate ~1.4) – Uses immigration to sustain its economy but still faces a shrinking workforce. -/- China (1.4 billion, fertility rate ~1.2) – After the one-child policy, it now struggles with a declining labor force. -/- Are Depopulating Countries on the Right Path? -/- Some depopulating countries have adapted well, while others face long-term crises. -/- Countries Handling Depopulation Effectively -/- Germany – Uses skilled immigration and robotics to compensate for labor shortages. -/- Japan – Invests in automation and AI to maintain productivity despite an aging population. -/- Canada – Encourages high-skilled immigration to offset declining birth rates. -/- Countries Struggling with Depopulation -/- South Korea – Despite incentives like cash rewards and tax breaks for families, birth rates remain low. -/- Italy – Rural areas are becoming ghost towns, with little government intervention. -/- China – Ending the one-child policy has not significantly increased birth rates. -/- These countries must stabilize their population before adopting replacement fertility (2.1 children per woman) to avoid economic collapse. -/- The Correct Approach for Depopulating Countries -/- Depopulating nations should not immediately aim for replacement fertility. Instead, they must: -/- 1. First Reach a Sustainable Population Level -/- If a country’s population is declining too quickly, stabilizing at 2.1 fertility too soon will not fix the economy. -/- Governments should aim for fertility rates between 1.6 and 1.9 before transitioning to 2.1. -/- 2. Encourage Higher Fertility Gradually -/- Offer childcare subsidies, free education, and paid parental leave to make parenting more affordable. -/- Promote work-life balance so families can afford more children. -/- 3. Use Immigration to Stabilize Workforce Levels -/- Countries like Germany and Canada use skilled immigration to maintain their economies. -/- Immigration policies should attract workers in high-demand industries. -/- 4. Invest in Automation and AI -/- Japan and South Korea are leading in robotics to replace human labor shortages. -/- Automation ensures productivity remains stable, even with fewer workers. -/- By following these steps, depopulating nations can create a balanced, self-sustaining economy before adopting replacement fertility. -/- Conclusion: Achieving Population Balance for Long-Term Sustainability -/- The correct population strategy depends on a country’s demographic situation: -/- Overpopulated countries must first reduce their population and achieve high GDP per capita before stabilizing at replacement fertility. -/- Depopulating countries must first stabilize their population before transitioning to replacement fertility. -/- This approach aligns with the universal law of balance, ensuring that societies do not suffer from excessive resource depletion or economic collapse. Overpopulation and depopulation are both extreme imbalances—countries must find the middle ground for long-term prosperity. -/- By implementing these strategies, nations can build a future where economic growth, resource management, and population levels are harmonized for sustainable development. -/- . (shrink)

This paper seeks to bring cosmopsychism, a contemporary metaphysical position on the nature of mind and consciousness, into contact with the philosophical tradition of Hinduism. Behind this exercise lies the motivation to examine how ideas developed within this rich tradition could aid in the effort to think constructively and creatively about issues which occupy the contemporary literature on panpsychism, and in particular cosmopsychism. I argue that, within the Hindu philosophical corpus, contemporary cosmopsychism finds its most natural allies in two world-affirming (...) views: Kashmir Śaivism, and the integral Advaita of Sri Aurobindo. After discussing these views, and their affinities to cosmopsychism, I argue that one important potential contributions of such perspectives lies in the fact that they present us with a form of priority monism little developed within contemporary philosophy. I call this neglected perspective generative monism, and I offer a preliminary exposition of the view and of its explanatory potential. (shrink)

Invited review of the anthology of new papers _Philosophy of Chemistry: Growth of a New Discipline_.

East Asian countries such as South Korea have recently made headlines for experimenting with different methods to incentivise people to have (more) children, in a bid to reverse declining birth rates. Many such incentives—child benefits, cash bonuses, dating events, and so on—appear morally innocuous at first glance. I will demonstrate in this analysis, however, that they amount to stopgap measures which reveal fundamental shortcomings with the way various nation states are approaching the so-called ‘problem’ of fertility decline.

What role should legislation or policy play in avoiding the complications of in-vitro fertilization? In this article, we focus on single versus double embryo transfer, and assess three arguments in favour of mandatory single embryo transfer: risks to the mother, risks to resultant children, and costs to society. We highlight significant ethical concerns about each of these. Reproductive autonomy and non-paternalism are strong enough to outweigh the health concerns for the woman. Complications due to non-identity cast doubt on the extent (...) to which children are harmed. Twinning may offer an overall benefit rather than burden to society. Finally, including the future health costs for children in reproductive policy is inconsistent with other decisions. We conclude that mandatory single embryo transfer is not justified and that a number of countries should reconsider their current embryo transfer policy. (shrink)

Water hyacinth (Eichhornia crassipes), an invasive aquatic weed, poses significant environmental and economic challenges due to its rapid proliferation in water bodies. However, its high biomass production and rich organic content make it a promising raw material for composting. This study explores the potential of water hyacinth compost (WHC) as an alternative organic fertilizer and its effects on soil properties and plant growth. The composting process enhances nutrient availability, improving soil fertility by increasing organic matter, nitrogen, phosphorus, and microbial (...) activity. WHC has been found to enhance soil aeration, water-holding capacity, and cation exchange capacity (CEC), leading to improved crop productivity. Additionally, it contributes to sustainable weed management by converting an invasive species into a valuable agricultural input. However, challenges such as high moisture content, heavy metal accumulation, and proper composting techniques must be addressed for effective utilization. The study highlights the need for further research on optimizing water hyacinth composting methods and integrating it into sustainable farming practices. By converting this noxious weed into a beneficial soil amendment, water hyacinth composting presents a dual solution—environmental management and agricultural enhancement. The findings suggest that water Hyacinth Compost can be a viable organic alternative to synthetic fertilizers, promoting eco-friendly and cost-effective farming practices. (shrink)

This paper comes out of a panel honoring the work of Anne Donchin (1940-2014), which took place at the 2016 Congress of the International Network on Feminist Approaches to Bioethics (FAB) in Edinburgh. My general aim is to highlight the contributions Anne made to feminist bioethics, and to feminist reproductive ethics in particular. My more specific aim, however, is to have a kind of conversation with Anne, through her work, about whether reproductive justice could demand insurance coverage for in vitro (...) fertilization. I quote liberally from Anne’s work for this purpose, but also to shower the reader with her words, reminding those of us who knew her well what a wonderful colleague she was. (shrink)

Recent advances in stem cell research suggest that in the future it may be possible to create eggs and sperm from human stem cells through a process that we term in vitro gametogenesis (IVG). IVG would allow treatment of some currently untreatable forms of infertility. It may also allow same-sex couples to have genetically-related children. For example, cells taken from one man could potentially be used to create an egg, which could then be fertilised using naturally produced sperm from another (...) man to create a genetically-related child with half of its DNA from each of the men. In this chapter, we consider whether this technology could justifiably be denied to same-sex couples if it were made available as a fertility treatment to different-sex couples. We argue that it could not. (shrink)

Gender inequality generates negative consequences for the economy, social sphere, and often the environment at the level of individual countries and the world. In this way, inequality creates a gender gap. The issue of reducing the gender gap was highlighted in the Sustainable Development Goals and drew scientists' attention from various fields and international organizations to a multifaceted study of the gender gap phenomenon at different levels. The article analyzes available indicators that measure the gender gap and the conducted earlier (...) research on the factors that influence gender equality. We chose the Global Gender Gap Index. We found a statistically significant impact on the gender gap: the share of women in the total population, the level of achievement of the Sustainable Development Goals, the level of democracy, and GNI per capita. Thus, by accelerating the achievement of sustainable development goals and implementing democratic reforms, countries are reducing the gender gap in society. Our study did not confirm the statistically significant inverse relationship between fertility rates and the gender gap, which was previously established based on incomplete statistical information. Also, the gender gap is not affected by the country's population growth or by the country's belonging to one of the four groups by per capita income. The impact of migration processes on gender equality requires an in-depth and additional analysis based on data showing the impact of migration movements influenced by the war between Russia and Ukraine. (shrink)

Because many involuntarily childless people have equal interests in benefitting from assisted reproductive technologies like in vitro fertilization as a mode of treatment, we have normative reasons to ensure inclusive access to such interventions for as many of these people as is reasonable and possible. However, the prevailing eligibility criterion for access to assisted reproductive technologies—'infertility'—is inadequate to serve the goal of inclusive access. This is because the prevailing frameworks of infertility, which include medical and social infertility, fail to precisely (...) capture and unify the relevance of certain involuntarily childless experiences as warranting assisted reproductive technology (ART) treatment. I argue that the least we can do for those who have an interest in accessing ARTs is to conceptualize involuntarily childless experiences in dialogue with interactionist and ecological models of disability, to outline a unified and more inclusive eligibility criterion. (shrink)

Spermatogenesis is the process of producing sperm in the testicles. It occurs in several stages, starting with the primordial germ cells, which differentiate into spermatogonia. Spermatogonia undergo successive mitoses to form primary spermatocytes, which, in turn, undergo meiosis, resulting in secondary spermatocytes. Secondary spermatocytes later transform into spermatids, which are immature sperm. Spermatids undergo maturation and differentiation to become mature sperm, ready for fertilization. This process is highly regulated by hormones and is essential for male fertility and reproduction. Spermatogenesis (...) is a complex process divided into three phases: spermatogonial or proliferative phase, meiotic phase, and spermiogenic phase, which are strictly related to animal physiology. These phases are influenced by several factors, including temperature, nutrition, diseases, and stress. Understanding these factors that influence spermatogenesis determines the animals’ productivity, in cases of changes, it can be suspected whether they are of genetic origin or environmental causes. (shrink)

TRANSPORTE DE GAMETAS, FERTILIZAÇÃO E SEGMENTAÇÃO • _____OBJETIVO O entendimento do desenvolvimento embrionário nos estágios iniciais, desde a deposição dos espermatozoides na fêmea, passando pela fertilização deste no ovócito e na formação do zigoto, é de suma importância para diferenciar especialistas em reprodução e manejo reprodutivo no mercado de trabalho e, também, durante a vida acadêmica. Compreender os processos que levam à formação do zigoto na fêmea é essencial para avaliar a capacidade reprodutiva dos animais e, mediante técnicas, avaliar o (...) trato reprodutivo da fêmea e o desenvolvimento do embrião até a formação do feto e, por fim, em um novo animal sadio na propriedade. Com esse trabalho, o estudante de veterinária ou zootecnia, que deseja se aprofundar na fisiologia da reprodução animal, identificará os mecanismos que são envolvidos no transporte dos gametas, bem como os processos que estes últimos devem completar para alcançar a fertilização e para desencadear as divisões iniciais do embrião. • _____INTRODUÇÃO A fertilização ou fecundação é o processo pelo qual os gametas masculino (espermatozoide) e feminino (ovócito) se fundem para gerar um novo indivíduo. Seu êxito depende da culminação adequada dos diferentes processos que devem sofrer os gametas durante sua maduração e percurso; do transporte oportuno destes no trato reprodutivo da fêmea, assim como de uma série de adaptações dos órgãos genitais internos da mãe. A segmentação refere-se às primeiras divisões celulares do embrião. • _____TRANSPORTE DO OVÓCITO O ovócito que é liberado na ovulação, e que se encontra coberto pelas células do cumulus (figura 1), é capturado pela fímbria do infundíbulo ao aderir aos cílios. Esse processo é altamente eficaz, inclusive em espécies onde os ovários possuem várias formações globosas, por exemplo nas porcas, onde os ovidutos capturam entre 95 e 100% dos ovócitos que são ovulados. As contrações das camadas musculares do oviduto e o movimento intenso dos cílios da mucosa faz com que as secreções fluam em direção ao útero, transportando assim o complexo cumulus-ovócito. Esse transporte é relativamente rápido até alcançar a junção da ampola com o istmo (que é considerado o local de fertilização do espermatozoide e ovócito) a partir do qual se torna lento. Devido a fêmea estar em estro, o processo está sob controle endócrino, isto é, controle hormonal através do estradiol. Nas fêmeas domésticas, ao contrário das mulheres, o transporte ao longo do oviduto é extremamente eficiente, pois os embriões passam para o útero sem dificuldade, de modo que gestações ectópicas (tubárias ou em cavidade) são quase inexistentes. A égua, frequentemente, retém por muito tempo os ovócitos não fertilizados no oviduto, provavelmente devido a não secreção de substâncias (como a prostaglandina E) que poderiam favorecer sua passagem, como se propõe que aconteça com os embriões. A figura 2 apresenta um ovócito com suas respectivas estruturas. Figura 1: ovócitos de uma vaca madurados in vitro. Nota-se as células do cumulus que os recobre. Figura 2: estruturas do ovócito de uma ovelha que se encontra na etapa de ovócito secundário, depois da ovulação. Elaborado pelo autor. • _____TRANSPORTE ESPERMÁTICO Para que os espermatozoides sejam capazes de fertilizar o ovócito, deverão sofrer uma série de mudanças bioquímicas e morfológicas ao longo de sua passagem pelo aparelho reprodutor tanto masculino como feminino. Uma vez produzidos na parede do túbulo seminífero, os espermatozoides são liberados em direção ao lúmen tubular e transportados passivamente para uma estrutura ramificada conhecida como rede testicular (rete testis). Dessa rede são conduzidos em direção ao epidídimo passando através de 10 a 20 ductos eferentes localizados no polo superior do testículo. O epidídimo é dividido em três seções denominadas cabeça, corpo e cauda; é constituído por um só ducto longo e tortuoso que continua com o canal deferente. Ao final desemboca nas ampolas seminais, no ducto ejaculatório e na uretra. As funções do epidídimo são as de maduração, transporte e armazenamento dos espermatozoides. O transporte através do epidídimo é lento, aproximadamente de 10 dias em touros, e segue sendo passivo. Os espermatozoides tomados da cabeça do epidídimo são ainda imaturos e incapazes de fertilizar, enquanto os armazenados na cauda são completamente maduros. Durante o trânsito pelo epidídimo os espermatozoides adquirem motilidade e o potencial para fertilizar, o acrossomo é remodelado e a gota citoplasmática migra para o flagelo e é liberada. Quando um macho ejacula com muita frequência, é possível observar espermatozoides com gota citoplasmática no sêmen, já que não há tempo suficiente para que completem sua maduração. Os espermatozoides são expulsados fora do organismo durante a cópula, na masturbação ou em emissões espontâneas. Na ejaculação, os espermatozoides que se encontram suspensos nos fluidos do testículo e do epidídimo, misturam-se ao chegar na uretra com as secreções das glândulas acessórias para formar o sêmen. Essas secreções denominadas plasma seminal, proporcionam substâncias para manter o metabolismo energético das células espermáticas, e integram suas membranas elementos que impedem uma capacitação prematura. Durante a cópula, o sêmen é depositado na vagina ou no útero, variando entre as espécies (tabela 1). Na monta natural, geralmente, o serviço ocorre no momento propício, já que está definido pela fase do ciclo estral em que a fêmea é receptiva ao macho. No entanto, na inseminação artificial, é o macho que deverá determinar o momento ideal, e para isso é importante considerar a vida média dos gametas, ao qual é muito curta no caso dos ovócitos (tabela 1). Tabela 1: local de depósito do sêmen, volume da ejaculação e vida média dos gametas. Espécie Local de deposição Volume (ml) Velocidade de ejaculação Vida média do ovócito Vida média do espermatozoide Bovinos Intravaginal 2 1 – 3 seg 8 h 30 – 48 h Caninos Intravaginal 2 – 30 (10 média) 6 – 45 min 48 – 72 h 9 – 11 d Equinos Intrauterina 50 – 200 20 – 60 seg 6 – 8 h 72 – 120 h Humanos Intravaginal 3 - - 5 – 6 d Ovinos Intravaginal 1 1 – 2 seg 16 – 24 h 30 – 48 h Suínos Intrauterina 200 – 400 5 – 20 min 8 – 10 h 24 – 48 h Onde d = dias; h = horas. A vida fértil do ovócito é muito curta, portanto, o momento do serviço é de grande importância para obter altos índices de fertilização. Independentemente do local em que os espermatozoides sejam depositados no aparelho reprodutor feminino, serão expostos às secreções genitais e sofrem uma série de mudanças em seu trajeto até o local de fertilização antes de penetrar no ovócito. Nas espécies em que o sêmen é depositado na parte cranial da vagina, uma parte do mesmo penetra através da cérvix, enquanto outra parte é eliminada do aparelho genital da fêmea, em pouco tempo, através do fluxo retrógrado. O meio vaginal não é adequado e imobiliza os espermatozoides em pouco tempo, pelo qual deverão entrar no útero onde o ambiente é mais propício. O transporte espermático na fêmea é o resultado da alta contratilidade, do movimento ciliar e o fluido do aparelho genital durante o estro, ao qual está sob controle endócrino e do sistema nervoso. Esse transporte é favorecido pelas características especiais do muco estral, cujas moléculas formam uma espécie de canais que facilitam a passagem dos espermatozoides. Pelo contrário, durante a fase lútea seu transporte é dificultado. Além do meio vaginal, a cérvix também atua como barreira natural para limitar a passagem dos espermatozoides, diminuindo assim a possibilidade de polispermia. Funciona, também, como um filtro que seleciona os espermatozoides aptos dos que não o são, uma vez que somente os primeiros possuem uma motilidade vigorosa que lhes permite passar pelo muco altamente hidratado. Na vaca a cérvix é considerada como um reservatório espermático. Quando atravessam a cérvix, os espermatozoides seguem sua deslocação tanto por movimento próprio como pelas contrações uterinas e tubárias. Nas espécies em que o local de depósito do sêmen do macho na fêmea é intrauterino, como equinos, a principal barreira que os espermatozoides enfrentam é a união ou junção útero-tubárica. A união entre o útero e o oviduto (istmo do oviduto) serve como reservatório funcional dos espermatozoides nas espécies domésticas. Poucos minutos depois da cópula, é possível encontrar alguns espermatozoides no oviduto, que é conhecido como fase de transporte rápido. No entanto, esses espermato-zoides não são os que participam do processo de fertilização e podem apresentar certas anormalidades. Existe um segundo tipo de transporte denominado fase sustentada, a qual consiste na migração prolongada dos espermatozoides em direção as partes mais craniais do aparelho genital feminino, que conduzem à colonização do reservatório funcional e na liberação gradual dos espermatozoides dos reservatórios espermáticos, incluindo este último. O reservatório do istmo fornece aos espermatozoides um ambiente propício, protegendo-os contra a fagocitose, prolongando assim a sua viabilidade. Aqui os esper-matozoides permanecem aderidos a superfície das células ciliadas do epitélio até a finalização de sua capacitação, depois da qual são liberados quando alteram seu padrão de motilidade flagelada, fenômeno conhecido como hipermotilidade, e migram em ondas em direção ao local da fertilização. Dos milhões de espermatozoides ejaculados, somente alguns milhares alcançarão o istmo do oviduto e um número sumamente pequeno será encontrado nas imediações do ovócito no momento da fertilização. • _____CAPACITAÇÃO ESPERMÁTICA E REAÇÃO ACROSSÔMICA A capacitação é um processo gradual e essencial para a fertilização. Os espermato-zoides devem passar por um dado tempo de “incubação” no aparelho genital da fêmea e sofrer uma série de mudanças antes de serem capazes de fecundar o ovócito. A capacita-ção dos espermatozoides começa quando eles entram em contato com as secreções do aparelho genital da fêmea e termina no istmo do oviduto. Durante esse percurso a superfície da cabeça do espermatozoide se modifica já que algumas moléculas como o colesterol são removidas da membrana plasmática, aumentando sua fluidez e alterando suas propriedades bioquímicas. Entre outras coisas, essa reorganização dos lipídios facilita a entrada de cálcio extracelular pelos canais iônicos e ocasiona a desestabilização da membrana, tornando-a mais fusogênica. Também são eliminados outros fatores (conhecidos genericamente como fatores descapacitantes) que expõem receptores membranais indispensáveis para a realização da união entre o espermatozoide e o ovócito durante a fertilização. Os espermatozoides capacitados apresentam um padrão de hipermotilidade e uma maior atividade metabólica, características que devem obter para que sejam capazes de penetrar as camadas do ovócito. A capacitação é necessária para que ocorra a reação acrossômica. A reação acrossomal ou acrossômica (RA) é um fenômeno de exocitose que é desencadeada pela ligação entre as proteínas e receptores localizados na membrana do espermatozoide e a zona pelúcida do ovócito (figura 3). Envolve a fusão da membrana plasmática do espermatozoide com a membrana externa de seu acrossomo; formando, assim, pequenas vesículas, cujo conteúdo de enzimas hidrolíticas, como a hialuronidase e a acrosina, é liberado em direção ao seu exterior, facilitando a penetração da zona pelúcida. A adesão do espermatozoide à zona pelúcida é específica da espécie e depende de glicoproteínas presentes na membrana dos ovócitos maduros; a cabeça do espermatozoide se une com essas glicoproteínas mediante receptores específicos e atravessam em direção oblíqua a zona pelúcida até chegar ao espaço perivitelino. Nos mamíferos, particularmente em roedores e nos humanos, algumas dessas glicoproteínas são conhecidas como ZP1, ZP2 e ZP3. Pensa-se que a união da membrana espermática a esta última é o que desencadeia a reação acrossomal. Posteriormente, as vilosidades do ovócito entram em contato com o espermatozoide e a membrana presente na secreção equatorial da cabeça do espermatozoide, que tem proteínas fusogênicas específicas, une-se a membrana plasmática do ovócito, fusionando-se e permitindo a entrada do núcleo espermático ao citoplasma (figura 4). A capacitação dos espermatozoides é fundamental para o êxito da fertilização, uma vez que apenas os aptos estarão perfeitos e íntegros para que a união e percepção das glicoproteínas presentes nos mesmos possam ocorrer de forma ideal para a penetração deste no ovócito, fertilizá-lo e formar um zigoto. Figura 3: estrutura do espermatozoide. Nota: a membrana é acrossomal e não acrossonal. Elaborado pelo autor. Figura 4: eventos que ocorrem durante a fertilização. A – depois de passar através das células do cumulus, o espermatozoide entra em contato com a zona pelúcida, onde receptores da membrana plasmática reconhecem as proteínas da zona pelúcida; B – é desencadeada, então, a reação acrossomal; C – para que o espermatozoide penetre na zona pelúcida; D – ao atravessar a zona pelúcida e entrar no espaço perivitelino, a cabeça do espermatozoide entra em contato com a membrana vitelina; ambas membranas se fusionam graças ao reconhecimento de proteínas fusogênicas que estão no segmento equatorial. E – ocorre, então, que o núcleo do espermatozoide penetra no citoplasma do ovócito; uma das consequências da fusão da membrana com a cabeça do espermatozoide é a reação cortical, em que os grânulos corticais do ovócito liberam seu conteúdo em direção ao espaço perivitelino, o que resulta na alteração da estrutura da zona pelúcida e da membrana vitelina para bloquear a polispermia. Elaborado pelo autor. • _____CONSEQUÊNCIAS DA PENETRAÇÃO Bloqueio da polispermia A fusão das membranas dos gametas durante a penetração permite a entrada da fosfolipase C zeta (PLCζ) – fator solúvel que provém do espermatozoide – que desencadeia liberação e oscilações de Ca2+ no retículo endoplasmático. Isso, por sua vez, provoca a migração e fusão dos grânulos corticais, com a consequente liberação de enzimas, que mudam tanto a estrutura da zona pelúcida (por exemplo a inativação de ZP3), como a da membrana vitelina. Desse modo, impede-se que outros espermatozoides as penetrem, evitando assim a polispermia (figura 5). Figura 5: os grânulos corticais que encontram-se na periferia do citoplasma, debaixo da superfície da membrana do ovócito, migram e fusionam-se sobre a mesma, liberando seu conteúdo no espaço perivitelino imediatamente depois da penetração do espermatozoide. A – como conse-quência, tanto a membrana vitelina como a zona pelúcida são modificadas, impedindo a entrada de mais espermatozoides, o que evita a polispermia. B – o ovócito retoma, então, sua segunda divisão meiótica, que ocasiona a expulsão do segundo corpúsculo polar, e na formação dos pronúcleos feminino e masculino. C – continuando, os pronúcleos migram, suas membranas se dissolvem e os cromossomos de ambos se condensam e se unem. Completa-se, assim, a singamia e forma-se, então, o zigoto. Elaborado pelo autor baseado nos livros de embriologia e fisiologia da reprodução conforme vida bibliografia. Ativação do ovócito e formação de pronúcleos Na maioria das fêmeas domésticas, com exceção da cadela, o ovócito encontra-se suspenso na metáfase II da segunda meiose no momento da ovulação. A entrada da PLCζ do espermatozoide no citoplasma do ovócito, e a consequente liberação de Ca2+, faz com que o ovócito se ative, terminando a segunda divisão meiótica e expulse o segundo corpo polar. Posteriormente, o material nuclear do ovócito se reorganiza para formar o pronú-cleo feminino. Entretanto, a membrana nuclear do espermatozoide se dissolve, a cromatina descondensa-se, as protaminas são substituídas por histonas, e se forma uma nova membrana nuclear, dando lugar ao pronúcleo masculino. Singamia Uma vez que os pronúcleos feminino e masculino são formados, migram para o centro do ovócito, aproximam-se, suas membranas se dispersam e os cromossomos paternos e maternos se associam, com o qual recupera a condição diploide e dá origem ao zigoto (figura 5). • _____DESENVOLVIMENTO EMBRIONÁRIO Poucas horas após a fertilização ocorre a primeira divisão do zigoto em duas, depois em 4, 8, 16 e 32 células, denominadas blastômeros. Essas divisões mitóticas são conhecidas como divisões de segmentação ou clivagem (figura 6), uma vez que são realizadas sem aumento do citoplasma, de modo que com cada divisão os blastômeros se tornam menores. A partir das 16 células o embrião se chama mórula, e é visto como uma massa celular compacta. A compactação deve-se a informação de proteínas de ligação entre os blastômeros. O embrião acumula líquido em seu interior, formando uma cavidade denominada blastocele. Esse processo é conhecido como blastulação; o embrião, assim, passa a ser chamado de blastocisto. Nessa etapa é possível diferenciar duas populações de células embrionárias: a massa celular interna, embrioblasto ou botão embrionário (que dará origem ao embrião), e a massa celular externa, células superficiais ou trofoblasto, do qual se originam a maioria das membranas fetais. Ao continuar a multiplicação das células e a acumulação de líquido, o blastocisto aumenta de tamanho, convertendo-se em blastocisto expandido. A zona pelúcida torna-se mais fina e, finalmente, o embrião eclode; isto é, o embrião é liberado da zona pelúcida. • _____FERTILIZAÇÕES ATÍPICAS Polispermia É a penetração de dois ou mais espermatozoides no óvulo. Esta condição é letal nos mamíferos, já que o número cromossômico desse zigoto é maior que 2n, o envelheci-mento do ovócito da porca, como consequência do serviço tardio, favorece a apresentação da polispermia, por isso, é comum ver números de nascimentos de média de 10 a 12 leitões por parição nessa espécie. Nas aves, no entanto, a penetração de mais de um espermatozoide é normal, embora apenas um pronúcleo masculino se formará, fundindo-se com o feminino. Figura 6: etapas do processo de segmentação/clivagem. Fonte: aula de reprodução da professora Domenica Palomaris, UFT. Ginogênese É o desenvolvimento de um embrião a partir de um óvulo normal fecundado por um espermatozoide, mas sem a fusão dos cromossomos masculinos com os da fêmea. A função do espermatozoide, nesse caso, é a de ativação do ovócito para que este inicie seu desenvolvimento, mas não há fusão com o núcleo do espermatozoide. Ocorre em plantas, em nematódeos e em algumas espécies de peixes, por exemplo a Poecilia formosa, espécie em que os ovócitos das fêmeas são ativados por machos de outra espécie relacio-nada. Partenogênese Consiste no desenvolvimento do embrião sem a participação do espermatozoide. Ocorre em alguns insetos, o zangão, por exemplo, é partenogenético. Também pode apresentar-se em perus, cujos embriões são machos e, geralmente, morrem antes da eclosão. • _____GÊMEOS Existem dois tipos de gêmeos: idênticos ou monozigóticos e os não idênticos ou dizigóticos. Idênticos ou monozigóticos Originam-se do mesmo zigoto, sendo assim, possuem o mesmo genótipo e um fenótipo similar e, portanto, são do mesmo sexo. Em laboratório é possível gerá-los ao seccionar uma mórula em duas ou mais partes, por meio de um micromanipulador. Uma vez que possuem o mesmo genótipo, os produtos resultantes são clones. Não idênticos ou dizigóticos Provêm da fertilização de dois óvulos distintos por espermatozoides diferentes. Possuem, portanto, genótipos e fenótipos diferentes, e podem ser de sexo diferente. REFERÊNCIAS BIBLIOGRÁFICAS ALBERTS, Bruce et al. Biologia molecular da célula. Artmed Editora, 2010. AUSTIN, Colin Russell; SHORT, Roger Valentine. Reproduction in Mammals, Book I: Germ Cells and Fertilization. 1982. BEARDEN, Henry Joe et al. Reproducción animal aplicada. México: Manual Moderno, 1982. BOSCH, P.; WRIGHT JR, R. W. The oviductal sperm reservoir in domestic mammals. Archivos de medicina veterinaria, v. 37, n. 2, p. 95-105, 2005. CAPALLEJAS, Roberto Brito; RODRÍGUEZ, Lourdes Tagle. Fisiología de la reproducción animal: con elementos de biotecnología. Editorial Félix Varela, 2010. CROXATTO, Horacio B. Physiology of gamete and embryo transport through the fallopian tube. Reproductive biomedicine online, v. 4, n. 2, p. 160-169, 2002. CUPPS, Perry T. (Ed.). Reproduction in domestic animals. Elsevier, 1991. DIEDRICH, Smidt et al. Endocrinología y Fisiología de la Reproducción de los Animales Zootécnicos. 1972. DUKES, Henry Hugh; SWENSON, Melvin J.; REECE, William O. Dukes fisiologia dos animais domésticos. Editora Guanabara Koogan, 1996. FERREIRA, A. de M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns (causas e tratamentos). Juiz de Fora: Minas Gerais–Brasil, p. 422, 2010. HAFEZ, Elsayed Saad Eldin; HAFEZ, Bahaa. Reprodução animal. São Paulo: Manole, 2004. HUNTER, Ronald Henry Fraser. The Fallopian tubes in domestic mammals: how vital is their physiological activity?. Reproduction Nutrition Development, v. 45, n. 3, p. 281-290, 2005. HUNTER, R. H. F.; RODRIGUEZ‐MARTINEZ, H. Capacitation of mammalian spermatozoa in vivo, with a specific focus on events in the Fallopian tubes. Molecular Reproduction and Development: Incorporating Gamete Research, v. 67, n. 2, p. 243-250, 2004. GALINA, Carlos; VALENCIA, Javier. Reproducción de los animales domésticos. 2006. HOPPER, Richard M. (Ed.). Bovine reproduction. John Wiley & Sons, 2014. HYTTEL, Poul; SINOWATZ, Fred; VEJLSTED, Morten. Embriologia veterinária. Elsevier Brasil, 2012. KÖLLE, Sabine; REESE, Sven; KUMMER, Wolfgang. New aspects of gamete transport, fertilization, and embryonic development in the oviduct gained by means of live cell imaging. Theriogenology, v. 73, n. 6, p. 786-795, 2010. MCKINNON, Angus O. et al. (Ed.). Equine reproduction. John Wiley & Sons, 2011. OLIVERA, Martha et al. El espermatozoide, desde la eyaculación hasta la fertilización. Revista Colombiana de Ciencias Pecuarias, v. 19, n. 4, p. 426-436, 2006. PLANT, Tony M.; ZELEZNIK, Anthony J. (Ed.). Knobil and Neill's physiology of reproduction. New York: Academic Press, 2014. RODRIGUEZ-MARTINEZ, Heriberto. Role of the oviduct in sperm capacitation. Theriogenology, v. 68, p. S138-S146, 2007. SAAVEDRA LEOS, María Dolores. Estudio de la composición de los gránulos corticales y del oolema de ovocitos porcinos y bovinos madurados y fecundados in vitro. Proyecto de investigación:, 2010. SENGER, Phillip L. et al. Pathways to pregnancy and parturition. Current Conceptions, Inc, 2004. SUAREZ, Susan S. The oviductal sperm reservoir in mammals: mechanisms of formation. Biology of Reproduction, v. 58, n. 5, p. 1105-1107, 1998. VALENCIA MÉNDEZ, Javier de J. Fisiología de la reproducción porcina. 1986. FIXAÇÃO DO ASSUNTO 1. Defina e diferencie fertilização e segmentação. 2. Disserte sobre o transporte do ovócito. Por que no istmo o transporte do ovócito se torna lento? 3. Fale sobre a eficiência do transporte do gameta no trato genital da fêmea e sobre a retenção de ovócitos pela égua. 4. Defina as células do cumulus e explique seu papel sobre o ovócito. 5. Quais as estruturas que compõem o ovócito? Qual a função de cada uma? 6. Todos os ovócitos das fêmeas domésticas são iguais? Justifique. 7. Disserte sobre o papel dos hormônios e das secreções sobre o transporte do ovócito no trato genital da fêmea. 8. Disserte sobre o transporte do espermatozoide. Por que há transporte rápido e lento dos espermatozoides? 9. Fale sobre o local de deposição do sêmen nas espécies domésticas e como esse influen-cia na eficiência da reprodução. 10. Por que a vida média do espermatozoide canino é maior que as outras espécies? 11. Quais as mudanças que os espermatozoides precisam sofrer para conseguir êxito na fertilização e por quê? 12. Defina fase de transporte rápido, fase sustentada e hipermotilidade. Qual a importân-cia de cada um? 13. Como ocorre a reação acrossômica? 14. O que é polispermia e como ocorre seu bloqueio? 15. Como ocorre a ativação do ovócito e como se formam os pronúcleos? 16. O que é e qual a importância da singamia? 17. Disserte sobre as divisões de segmentação e qual a importância destas para o êxito da reprodução. 18. Defina e diferencia mórula e blastocisto. 19. Defina e diferencie ginogênese e partenogênese. 20. Qual o papel endócrino e quais hormônios e enzimas atuam sobre o transporte de gametas, sobre a fertilização e sobre a segmentação? (shrink)

This review critically appropriates Stephanie Gray Connors’ On IVF through a Lonerganian method of inquiry: beginning from attentive experience, moving through intelligent understanding, reasonable judgment, and culminating in responsible evaluation. Connors’ work is praised for its empathetic attention to the existential pain of infertility, its clear articulation of the moral structure distinguishing ends from means, and its systematic unfolding of the layers of harm intrinsic to in vitro fertilization. Ascending from the immediate drama of suffering to the broader metaphysical horizon, (...) Connors situates human procreation within a theology of giftedness rather than technological production. Her advocacy for Restorative Reproductive Medicine exemplifies an ethics that collaborates with natural finality rather than subverting it. Furthermore, her pastoral call to repentance and healing reveals an understanding of moral failure not as condemnation, but as an opportunity for conversion and renewed fidelity to the dignity of life. Connors' inquiry thus fulfills, in the domain of bioethics, the transcendental precepts of authentic moral reflection: be attentive, be intelligent, be reasonable, and be responsible. In doing so, On IVF emerges not merely as a critique of a contemporary practice, but as a summons to a more reverent participation in the mystery of human life. (shrink)

Human eggs for basic, fertility and stem-cell research are in short supply. Many experiments that require their use cannot be carried out at present, and, therefore, the benefits that could emerge from these are either delayed or never materialise. This state of affairs is problematic for scientists and patients worldwide, and it is a matter that needs our attention. Recent advances in chimera research have opened the possibility of creating human/non-human animal chimeras intended for human gamete production (chimeras-IHGP). In (...) this paper, I examine four arguments against the creation of such chimeras and prove that all of them are found wanting. I conclude by showing that there is a strong moral reason for scientists to pursue this research avenue. (shrink)

This book is a survey of the most important developments in Austrian philosophy in its classical period from the 1870s to the Anschluss in 1938. Thus it is intended as a contribution to the history of philosophy. But I hope that it will be seen also as a contribution to philosophy in its own right as an attempt to philosophize in the spirit of those, above all Roderick Chisholm, Rudolf Haller, Kevin Mulligan and Peter Simons, who have done so much (...) to demonstrate the continued fertility of the ideas and methods of the Austrian philosophers in our own day. For some time now, historians of philosophy have been gradually coming to terms with the idea that post-Kantian philosophy in the German-speaking world ought properly to be divided into two distinct traditions which we might refer to as the German and Austrian traditions, respectively. The main line of the first consists in a list of personages beginning with Kant, Fichte, Hegel and Schelling and ending with Heidegger, Adorno and Bloch. The main line of the second may be picked out similarly by means of a list beginning with Bolzano, Mach and Meinong, and ending with Wittgenstein, Neurath and Popper. As should be clear, it is the Austrian tradition that has contributed most to the contemporary mainstream of philosophical thinking in the Anglo-Saxon world. For while there are of course German thinkers who have made crucial contributions to the development of exact or analytic philosophy, such thinkers were outsiders when seen from the perspective of native German philosophical culture, and in fact a number of them found their philosophical home precisely in Vienna. When, in contrast, we examine the influence of the Austrian line, we encounter a whole series of familiar and unfamiliar links to the characteristic concerns of more recent philosophy of the analytic sort. As Michael Dummett points out in his Origins of Analytic Philosophy, the newly fashionable habit of referring to analytic philosophy as "Anglo-American" is in this light a "grave historical distortion". If, he says, we take into account the historical context in which analytic philosophy developed, then such philosophy "could at least as well be called "Anglo-Austrian" (1988, p. 7). Much valuable scholarly work has been done on the thinking of Husserl and Wittgenstein, Mach and the Vienna Circle. The central axis of Austrian philosophy, however, which as I hope to show in what follows is constituted by the work of Brentano and his school, is still rather poorly understood. Work on Meinong or Twardowski by contemporary philosophers still standardly rests upon simplified and often confused renderings of a few favoured theses taken out of context. Little attention is paid to original sources, and little effort is devoted to establishing what the problems were by which the Austrian philosophers in general were exercised -- in spite of the fact that many of these same problems have once more become important as a result of the contemporary burgeoning of interest on the part of philosophers in problems in the field of cognitive science. (shrink)

Fyodor Dostoevsky’s literary corpus presents a fertile ground for interdisciplinary analysis, particularly at the intersection of existential philosophy and psychoanalysis. His novels grapple with profound questions of human nature, morality, freedom, guilt, and redemption, while simultaneously portraying intense psychological landscapes. This academic issue centers on examining the internal conflicts of Dostoevsky’s characters through the lenses of philosophical existentialism—particularly the thought of Søren Kierkegaard and Friedrich Nietzsche—and psychoanalytic theory, drawing from Sigmund Freud, Jacques Lacan, and Carl Jung. At the core of (...) Dostoevsky’s narratives lies a tension between rationalism and irrationalism, faith and nihilism, individuality and collective identity. Characters such as Raskolnikov (Crime and Punishment), Ivan Karamazov (The Brothers Karamazov), and the Underground Man (Notes from Underground) serve as case studies for this examination. These figures embody psychological fragmentation and the struggle for meaning in a world perceived as morally ambiguous or even absurd. -/- The issue investigates how Dostoevsky anticipates psychoanalytic concepts such as the unconscious, repression, the death drive, and the divided self. It also explores how his theological and moral concerns engage with existential themes of despair, freedom, and authenticity. The analysis asks: How does Dostoevsky dramatize the philosophical problem of evil through psychological interiority? In what ways do his characters' inner conflicts reflect broader metaphysical anxieties about the human condition? By engaging with both philosophical discourse and psychoanalytic frameworks, this issue aims to contribute to a deeper understanding of Dostoevsky’s unique synthesis of narrative, psychology, and spiritual inquiry. -/- EXISTENTIAL DILEMMAS — FREEDOM, CHOICE, AND THE BURDEN OF SELFHOOD -/- Dostoevsky’s characters are essentially case studies in existential dilemmas, and he uses their inner turmoil to dramatize themes like freedom, moral responsibility, and the fragmented self. Here’s a breakdown of how these themes manifest in some of his key characters: -/- 1. Freedom as Both Gift and Curse -/- Dostoevsky’s characters often confront absolute freedom—but rather than liberating them, it frequently becomes a source of anxiety, confusion, and moral crisis. -/- The Underground Man (Notes from Underground) is perhaps the clearest example. He rebels against determinism and rational egoism, insisting that man will act irrationally just to prove he is free. He says, “What man wants is simply independent choice, whatever that independence may cost and wherever it may lead.” This paradox—freedom as self-sabotage—illustrates Dostoevsky’s challenge to Enlightenment rationalism and shows how unmoored freedom can become destructive. Raskolnikov (Crime and Punishment) uses freedom to test the Nietzschean idea of the “extraordinary man, ” believing he can transgress moral boundaries for a higher purpose. However, his intellectual freedom brings him unbearable psychological guilt. The burden of having to justify his freedom morally and spiritually becomes his torment. 2. The Anxiety of Choice and Moral Responsibility -/- Freedom, for Dostoevsky, is inseparable from choice, and every choice carries moral and existential weight. His characters are often paralyzed by the responsibility of choosing, especially in a world where moral foundations are unclear or contested. -/- In The Brothers Karamazov, Ivan Karamazov intellectualizes the problem of evil and chooses to reject God’s world on moral grounds. But this “choice” becomes a torment, as his decision not to believe leaves him morally adrift. His nihilism is mirrored in the actions of Smerdyakov, showing that ideas and choices have real, often catastrophic consequences. Dmitri Karamazov also illustrates the anxiety of choice. His impulsive decisions reflect a man torn between sensual indulgence and spiritual longing. His choices are expressions of an uncentered self, deeply aware of his moral failures. 3. The Burden of Selfhood -/- Dostoevsky’s characters often struggle under the burden of self-consciousness, a theme he explores long before it became central to existentialist thought. His characters are not simply individuals—they are divided individuals, plagued by internal contradictions. -/- The Underground Man again exemplifies this. He cannot act decisively because he is consumed by the need to understand and second-guess himself. His hyper-consciousness paralyzes him. “To be too aware is a sickness, ” he says—a core existential insight. -/- In The Double, Golyadkin is literally confronted with another version of himself, dramatizing the inner fragmentation of identity. This prefigures what Sartre would later call “bad faith”—the inability to unify one’s self-concept under freedom. Stavrogin in Demons embodies the self completely detached from moral law. His philosophical detachment and emotional apathy turn freedom into a horrifying vacuum—a portrait of existential despair when freedom is stripped of all ethical or spiritual grounding. (shrink)

Computational and information‐theoretic research in philosophy has become increasingly fertile and pervasive, giving rise to a wealth of interesting results. In consequence, a new and vitally important field has emerged, the philosophy of information (PI). This essay is the first attempt to analyse the nature of PI systematically. PI is defined as the philosophical field concerned with the critical investigation of the conceptual nature and basic principles of information, including its dynamics, utilisation, and sciences, and the elaboration and application of (...) information‐theoretic and computational methodologies to philosophical problems. I argue that PI is a mature discipline for three reasons: it represents an autonomous field of research; it provides an innovative approach to both traditional and new philosophical topics; and it can stand beside other branches of philosophy, offering a systematic treatment of the conceptual foundations of the world of information and the information society. (shrink)

The liberal international legal order faces a legitimacy crisis today that becomes visible with the recent anti-internationalist turn, the rise of populism and the recent Russian invasion of Ukraine. Either its authority or legitimacy has been tested many times over the last three decades. The article argues that this anti-internationalist trend may be read as a reaction against the neoliberal form taken by international law, not least over the last three decades. In uncovering the intricacies of international law’s legitimacy crisis, (...) the article uncovers the paradox of global constitutionalism: that its need to adopt a sectoral form of integration may cause a legitimacy gap/deficit because international authorities, resting their legitimacy primarily on instrumental grounds, may face problems in compensating for the legitimacy deficit caused by the erosion of domestic sovereignty and extending their legitimacy to non-instrumental grounds. This paradox has one necessary structural and two contingent content-related implications for domestic democracies: (1) it necessarily narrows down the regulatory space of nation-states; and this may in turn (2) impair democratic stability and solidarity, and (3) provide a fertile ground for populism. Drawing on Raz’s service conception, the article focuses on the interaction between international and domestic authorities and highlights the problematic aspects of the neoliberal constitutionalization of international law. (shrink)

Within the framework of 'Temporalities and the Urban Fabric: Co-Producing Liminal Spaces in Transitional Epochs,' this rigorous examination unravels the multilayered nuances of temporality and its intimate relationship with urban spaces in times of transition. The research delineates the intricate interplay between public exhibitions, urban realms, and socio-political paradigms, particularly within the dynamic settings of the metropolitan entities of Houston and Amsterdam. These cities, as epitomes of temporal urban flux, become fertile grounds for exploring the ephemeral essence of liminal spaces (...) and their transformative manifestations. By weaving together diverse academic domains – from Design Computation and Fabrication to Urban Communities and Spatial Justice – this study underscores the symbiotic fusion of Augmented Reality (AR) and Gamification within the broader canvas of urban temporalities. Crucially, the research accentuates the transformative potential of Extended Reality (XR) in augmenting the theoretical and methodological contours of urban studies within these transitional epochs. (shrink)

Cities have consistently served as fertile grounds for the emergence and growth of radical ideas, political transformations, and social movements, with urban landscapes nurturing visionary concepts, idealism, and revolutionary ideologies. This research delves into the captivating world of radical cities, exploring the power of image and visual narratives to communicate and comprehend urban activism within diverse contexts. By analyzing various case studies and student works, we aim to create, study, and reimagine vivid portrayals of urban activism, radical urbanism, and future (...) socio-spatial developments. The focus lies on developing innovative visual modalities and collaborative critical pedagogical approaches that engage with the complexities of radical cities across North America, Latin America, Asia, Europe, and beyond. In this study, we explore the potential of image and visual narratives to decode and understand pivotal societal transitions in radical cities. By employing imaginative and critical pedagogy, we aspire to foster a more profound comprehension of urban activism and its impact on shaping the cities of the future. (shrink)

Speech acts are governed by a variety of illocutionary norms. Building on Sbisà’s (2019) work, this chapter attempts to develop a common framework to study them. Four families of illocutionary rules are identified: (i) Validity rules set conditions for (actual) performance; (ii) Cooperative rules set conditions for cooperative performance; (iii) Illocutionary goals set conditions for successful performance; (iv) Illocutionary obligations set conditions for compliance. Illocutionary rules are often taken to play a constitutive role: speech acts are said to be constituted (...) by the unique set of rules that regulates them. Against this view, it is argued that many illocutionary rules are instead best construed as rationally derivable expectations of cooperation. This alternative paradigm provides fertile ground to reconcile scholarly disagreement between speech act theorists, and yields a promising explanation of how illocutionary norms are learned and evolve through time. (shrink)

This dissertation investigates ancient ecological and indigenous cultural forms in response to contemporary crises of ecology and psychology—"an alienation that haunts the modern soul while increasingly choking the biosphere." Lady Raglan's (1939) documentation of foliate masks carved into churches throughout much of Europe is taken as a starting place: faces where "oak leaves grow from the mouth and ears, and completely encircle the head" (p. 45). Another data point: excavation beneath Notre Dame Cathedral uncovers a Roman-era stone block dedicated to (...) Cernunnos ("The Horned One"), demonstrating literal encasement of pre-Christian fertility traditions in stone (Evans, 1988). The inquiry examines such documented traditional forms alongside Classical, Roman, Greek, Sumerian, and Near-East archeological and textual sources, exploring how historical patterns of human-earth relationality might inform contemporary crises through the rediscovery of autochthonous creativity: the natural human capacity to reconnect with body, symbol, ancestry, memory, and ecological life-worlds. The study introduces the method of epistrophic hermeneutics: a novel synthesis of hermeneutics with Hillmanian therapeia and epistrophē—defined by Hillman (2007/2016o) as "the reversion or return of soul phenomena to the archetype, according to the principle of likeness or analogy" (p. 153). The term hermeneutic of hospitality is introduced as an alternative to hermeneutics of faith or suspicion, respectively – a practice of epistemic humility at depth, rooted in what Hillman (1981/2013a) termed a "poetic basis of mind"(p. 31). The method embraces Hillman's dictum that "we can never be purely phenomenal or truly objective" because "one is never beyond the subjectivism given with the soul's native dominants of fantasy structures" (Hillman, 1981/2013a, p. 32). Archetypes, in this sense, are understood as "the primary forms that govern the psyche" (p. 13): participatory lenses of the epistemic eye. A hermeneutic of hospitality thus protects epistemological pluralism that includes cultural diversity yet continues deeper, beyond tokenism and into a celebration of pluralism at epistemic depth: that is, a protection of the living ecosystem of mind and image. Concretely, this reading stance follows Hillman's (1986/2016f) therapeutic attitude: "Instead of inquiry: interest, respect, welcome, praise—even attachment. To greet… even mythic presences that may be unpopular or demonized."(p. 96) This epistrophic work aims to "release the mind into its originality beyond the old entrapped condition" (Hillman, 1986/2016d, p. 295), aligning with the work’s principle of autochthonous creativity. The argument proceeds via case-rich exegesis. In Classical Greece, Dionysian masks give the Green Man civic expression; Dionysus appears as “a horned god… crowned with serpents” (Euripides, Bacchae, trans. 1996, p. 34), binding horns, snakes, and vegetation to ecstatic ritual. This vegetal–animal fusion has deep Mesopotamian precedent: Enki of the Sumerian wetlands was “the Wild Bull of Eridu” whose iconography shows “two streams, the Euphrates and the Tigris, flowing out of his shoulders” (Kramer, 1961, p. 76), while Damu embodied “the power in the rising sap” (Jacobsen, 1976, p. 39)—both figures conjoining fertility, water, and vegetal renewal. The parallel is explicit in Greek cult: Dionysus Limnaios, “Dionysus of the Swamps,” inhabited Athens’ oldest sanctuary where “water pours abundantly from under the rocks” (Pausanias, Description of Greece, 1.20.3), mirroring the Sumerian Dumuzi-abzi, “the power to renew life in the watery deep” (Katz, 2003, p. 35). Wild Bull Dumuzi is at once bull and cowherd—divine animal and shepherd—whose “bitter laments when he dies as the dry heat of summer yellows the pastures” (Wolkstein & Kramer, 1983, p. 64) mark the seasonal transition toward death and dormancy. The archetypal union of Goddess and God appears again in Baal and Baalath, “the male power identified especially with water” meeting “earth,” whose union makes “plants and trees, animals and men… the offspring” (Patai, 1990, p. 45)—a cosmogony of ecological reciprocity. These figures also share the power of metamorphosis. Humbaba’s “seven splendours” enable constant transformation—“Humbaba’s face keeps changing!” (George, 2003, p. 37)—a capacity echoed in Dionysus, who is “a lion, a bull, a boar, a bear, a panther, a snake, and now a tree, fire, water” (Euripides, Bacchae, trans. 1996, p. 101). In Near Eastern vegetal–arboreal myth, Adonis is born from the trunk of his mother-tree Myrrha, which “split open to allow the birth” (Graves, 1960, p. 74); Osiris is enclosed within a tree’s girth, Isis crafting his wooden phallus for resurrection (Graves, 1960, p. 60). Likewise, Ningishzida’s “winding roots, embodiments of living supernatural power, free themselves from the trunk and become live serpents entwined around it” (Black & Green, 1992, p. 136), a precise analogue to Dionysus Perikonis who “twines himself around the column” (Pausanias, Description of Greece, 10.19.3). Taken together, these scenes form a coherent archetypal grammar: a horned-vegetal deity mediating between water and earth, embodying seasonal death and renewal, uniting the powers of plant, animal, and human through metamorphosis, and returning life to the land through sacred union. This grammar repeats across Sumerian, Levantine, and Greek worlds, providing the imaginal architecture that will later be carved into the foliate heads of Medieval Europe. By tracing – text by text, altar by altar, mask by mask – how these symbolic forms have historically mediated human–earth relationship, the study demonstrates that epistemic pluralism at depth is precisely the restoration of a type of human culture capable of ecological harmonization. This is not a dynamic that can be simulated through instrumental control; it depends on the cultivation of consciousness that lives in participatory reciprocity with the more-than-human world: an epistemic eye that glints green. A hermeneutic of hospitality, in this sense, is not merely a method of interpretation but a protection of epistemological pluralism capable of return to the imagination of the Earth. The image of the Green Man describes just this: a dynamic bridge mediating between the many worlds of participatory and epistemic possibility. His mythic dance, rooted in water and leaf, horn and mask, death and return, is the precise form through which the restoration of the living Earth and the living soul become an indivisible act. Published January 2023. DOI: 10.13140/RG.2.2.18447.50089. (shrink)

Contrary to political and philosophical consensus, we argue that the threats posed by climate change justify population engineering, the intentional manipulation of the size and structure of human populations. Specifically, we defend three types of policies aimed at reducing fertility rates: choice enhancement, preference adjustment, and incentivization. While few object to the first type of policy, the latter two are generally rejected because of their potential for coercion or morally objectionable manipulation. We argue that forms of each policy type (...) are pragmatically and morally justified tools for preventing the harms of global climate change. (shrink)

At some point in the future – perhaps within the next few decades – it will be possible for foetuses to develop completely outside the womb. Ectogenesis, as this technology is called, raises substantial issues for the abortion debate. One such issue is that it will become possible for a woman to have an abortion, in the sense of having the foetus removed from her body, but for the foetus to be kept alive. We argue that while there is a (...) right to an abortion, there are reasons to doubt that there is a right to the death of the foetus. Our strategy in this essay is to consider and reject three arguments in favour of this latter right. The first claims that women have a right not to be biological mothers, the second that women have a right to genetic privacy, and the third that a foetus is one's property. Furthermore, we argue that it follows from rejecting the third claim that genetic parents also lack a right to the destruction of cryopreserved embryos used for in vitro fertilization. The conclusion that a woman possesses no right to the death of the foetus builds upon the claims that other pro-choice advocates, such as Judith Jarvis Thomson, have made. (shrink)

Ecological Psychology and Enactivism both challenge representationist cognitive science, but the two approaches have only begun to engage in dialogue. Further conceptual clarification is required in which differences are as important as common ground. This paper enters the dialogue by focusing on important differences. After a brief account of the parallel histories of Ecological Psychology and Enactivism, we cover incompatibility between them regarding their theories of sensation and perception. First, we show how and why in ecological theory perception is, crucially, (...) not based on sensation. We elucidate this idea by examining the biological roots of work in the two fields, concentrating on Gibson and Varela and Maturana. We expound an ecological critique of any sensation-based approach to perception by detailing two topics: classic retinal image theories and perception in single-celled organisms. The second main point emphasizes the importance of the idea of organism-environment mutuality and its difference from structural coupling of sensations and motor behavior. We point out how ecological - phenomenological methods of inquiry grow out of mutualism and compare Gibson’s idea of visual kinesthesis to Merleau-Ponty’s idea of the lived body. Third, we conclude that Ecological Psychology and varieties of Enactivism are laying down different paths to pursue related goals. Thus, convergence of Ecological Psychology and Enactivism is not possible given their conflicting assumptions, but cross-fertilization is possible and desirable. (shrink)

Some have suggested that images can be arguments. Images can certainly bolster the acceptability of individual premises. We worry, though, that the static nature of images prevents them from ever playing a genuinely argumentative role. To show this, we call attention to a dilemma. The conclusion of a visual argument will either be explicit or implicit. If a visual argument includes its conclusion, then that conclusion must be demarcated from the premise or otherwise the argument will beg the question. If (...) a visual argument does not include its conclusion, then the premises on display must license that specific conclusion and not its opposite, in accordance with some demonstrable rationale. We show how major examples from the literature fail to escape this dilemma. Drawing inspiration from the graphical logic of C. S. Peirce, we suggest instead that images can be manipulated in a way that overcomes the dilemma. Diagrammatic reasoning can take one stepwise from an initial visual layout to a conclusion—thereby providing a principled rationale that bars opposite conclusions—and the visual inscription of this correct conclusion can come afterward in time—thereby distinguishing the conclusion from the premises. Even though this practical application of Peirce’s logical ideas to informal contexts requires that one make adjustments, we believe it points to a dynamic conception of visual argumentation that will prove more fertile in the long run. (shrink)

The Javanese philosophical concept of “Gemah Ripah Loh Jinawi” paints a vivid picture of a dreamed utopia, often translated as a land of abundant natural wealth, fertility, and profound peace and prosperity. While this vision frequently appears to remain an elusive ideal in contemporary reality, this article argues for a re-evaluation of its essence, moving beyond a purely materialist interpretation. We draw parallels between “Gemah Ripah Loh Jinawi” and concepts such as the Judaic notion of “Shalom” and the “pursuit (...) of happiness” embedded in Thomas Jefferson’s Declaration of Independence, demonstrating a shared yearning for a holistic well-being that transcends mere economic prosperity. Furthermore, by employing Neutrosophic Logic, we aim to analyze “Gemah Ripah Loh Jinawi” as a complex, multi-dimensional aspiration, acknowledging its degrees of truth, falsity, and inherent indeterminacy. This framework allows for a nuanced understanding of how this Javanese ideal seeks a complete abundance, blending material wealth with profound spiritual growth, offering a potent vision for human flourishing beyond the confines of modern materialism. (shrink)

Researchers are working to derive sperm from banked testicular tissue taken from pre-pubertal boys who face therapies or injuries that destroy sperm production. Success in deriving sperm from this tissue will help to preserve the option for these boys to have genetically related children later in life. For the twin moral reasons of preserving access and equity in regard to having such children, clinicians and researchers are justified in offering the option to the parents of all affected boys. However, some (...) parents may wish to decline the option to bank tissue from their boys because the technique may seem too unfamiliar or unusual, but over time people may become more comfortable with the technique as they have done with other novel assisted reproductive treatments. Other parents may wish to decline the option because of moral or religious reasons. A prominent natural law theory holds, for example, that the ARTs that would be involved in using sperm derived from banked tissue to produce a child are morally objectionable. Some parents might not want to bank tissue in order to shield their son from using ARTs they see as objectionable. Clinicians and researchers should respect parents who wish to decline banking tissue, but parents should ordinarily embrace choices that protect the possible interests their sons may have as adult men, including the wish to have genetically related children. (shrink)

The Oxford Handbook of Metaphysics offers the most authoritative and compelling guide to this diverse and fertile field of philosophy. Twenty-four of the world's most distinguished specialists provide brand-new essays about 'what there is': what kinds of things there are, and what relations hold among entities falling under various categories. They give the latest word on such topics as identity, modality, time, causation, persons and minds, freedom, and vagueness. The Handbook's unrivaled breadth and depth make it the definitive reference work (...) for students and academics across the philosophical spectrum. (shrink)

Assisted reproductive technologies have greatly increased our control over reproductive choices, leading some bioethicists to argue that we face unprecedented moral obligations towards progeny. Several models attempting to balance the principle of procreative autonomy with these obligations have been proposed. The least demanding is the minimal threshold model (MTM), according to which every reproductive choice is permissible, except creating children whose lives will not be worth living. Hence, as long as the future child is likely to have a life worth (...) living, prospective parents may be allowed to use preimplantation genetic diagnosis (PGD) to select embryos with genetic diseases or disabilities. Assuming a consequentialist person‐affecting view of morality, this paper investigates whether the MTM is an appropriate tool to guide procreative decisions given the continuous development of reproductive genetic technologies. In particular, I consider germline genome editing (GGE) and I argue that its application in human reproduction, unlike PGD, should be conceived as person‐affecting towards future progeny. I claim that even if we assume the plausibility of the MTM within PGD, we are committed to accepting that a greater moral obligation towards progeny should guide procreative decisions if GGE were available. In this case, the MTM should no longer be considered an appropriate instrument to guide procreative choices. Finally, I investigate when we face this greater moral obligation, concluding that it applies only when prospective parents have already engaged in the in vitro fertilization process. (shrink)

In this paper, I argue that, if ‘the overrepresentation of Christian theists in analytic philosophy of religion is unhealthy for the field, since they would be too much influenced by prior beliefs when evaluating religious arguments’ (De Cruz and De Smedt (2016), 119), then a first step toward a potential remedy is this: analytic philosophers of religion need to restructure their analytical tasks. For one way to mitigate the effects of confirmation bias, which may be influencing how analytic philosophers of (...) religion evaluate arguments in Analytical Philosophy of Religion (APR), is to consider other points of view. Applied to APR, this means considering religious beliefs, questions, and arguments couched in non-Christian terms. In this paper, I focus on Islam in particular. My aim is to show that Islam is a fertile ground of philosophical questions and arguments for analytic philosophers of religion to engage with. Engaging with questions and arguments couched in non-Christian terms would help make work in APR more diverse and inclusive of religions other than Christianity, which in turn would also be a first step toward attracting non-Christians to APR. (shrink)

ABSTRACT This paper contributes to the debate about the strawman fallacy. It is the received view that strawmen are employed to fool not the arguer whose argument they distort, but instead a third party, an audience. I argue that strawmen that fool their victims exist and are an important variation of the strawman fallacy because of their special perniciousness. I show that those who are subject to hermeneutical lacunae or who have since forgotten parts of justifications they have provided earlier (...) are especially vulnerable to falling for strawmen aimed at their own positions or arguments. Adversarial argumentation provides especially fertile ground for strawmen that fool their own victims, but cooperative argumentation is no fail-safe protection from them either. (shrink)

We introduce the notion of complexity, first at an intuitive level and then in relatively more concrete terms, explaining the various characteristic features of complex systems with examples. There exists a vast literature on complexity, and our exposition is intended to be an elementary introduction, meant for a broad audience. -/- Briefly, a complex system is one whose description involves a hierarchy of levels, where each level is made of a large number of components interacting among themselves. The time evolution (...) of such a system is of a complex nature, depending on the interactions among subsystems in the next level below the one under consideration and, at the same time, conditioned by the level above, where the latter sets the context for the evolution. Generally speaking, the interactions among the constituents of the various levels lead to a dynamics characterized by numerous characteristic scales, each level having its own set of scales. What is more, a level commonly exhibits ‘emergent properties’ that cannot be derived from considerations relating to its component systems taken in isolation or to those in a different contextual setting. In the dynamic evolution of some particular level, there occurs a self-organized emergence of a higher level and the process is repeated at still higher levels. -/- The interaction and self-organization of the components of a complex system follow the principle commonly expressed by saying that the ‘whole is different from the sum of the parts’. In the case of systems whose behavior can be expressed mathematically in terms of differential equations this means that the interactions are nonlinear in nature. -/- While all of the above features are not universally exhibited by complex systems, these are nevertheless indicative of a broad commonness relative to which individual systems can be described and analyzed. There exist measures of complexity which, once again, are not of universal applicability, being more heuristic than exact. The present state of knowledge and understanding of complex systems is itself an emerging one. Still, a large number of results on various systems can be related to their complex character, making complexity an immensely fertile concept in the study of natural, biological, and social phenomena. -/- All this puts a very definite limitation on the complete description of a complex system as a whole since such a system can be precisely described only contextually, relative to some particular level, where emergent properties rule out an exact description of more than one levels within a common framework. -/- We discuss the implications of these observations in the context of our conception of the so-called noumenal reality that has a mind-independent existence and is perceived by us in the form of the phenomenal reality. The latter is derived from the former by means of our perceptions and interpretations, and our efforts at sorting out and making sense of the bewildering complexity of reality takes the form of incessant processes of inference that lead to theories. Strictly speaking, theories apply to models that are constructed as idealized versions of parts of reality, within which inferences and abstractions can be carried out meaningfully, enabling us to construct the theories. -/- There exists a correspondence between the phenomenal and the noumenal realities in terms of events and their correlations, where these are experienced as the complex behavior of systems or entities of various descriptions. The infinite diversity of behavior of systems in the phenomenal world are explained within specified contexts by theories. The latter are constructs generated in our ceaseless attempts at interpreting the world, and the question arises as to whether these are reflections of `laws of nature' residing in the noumenal world. This is a fundamental concern of scientific realism, within the fold of which there exists a trend towards the assumption that theories express truths about the noumenal reality. We examine this assumption (referred to as a ‘point of view’ in the present essay) closely and indicate that an alternative point of view is also consistent within the broad framework of scientific realism. This is the view that theories are domain-specific and contextual, and that these are arrived at by independent processes of inference and abstractions in the various domains of experience. Theories in contiguous domains of experience dovetail and interpenetrate with one another, and bear the responsibility of correctly explaining our observations within these domains. -/- With accumulating experience, theories get revised and the network of our theories of the world acquires a complex structure, exhibiting a complex evolution. There exists a tendency within the fold of scientific realism of interpreting this complex evolution in rather simple terms, where one assumes (this, again, is a point of view) that theories tend more and more closely to truths about Nature and, what is more, progress towards an all-embracing ‘ultimate theory’ -- a foundational one in respect of all our inquiries into nature. We examine this point of view closely and outline the alternative view -- one broadly consistent with scientific realism -- that there is no ‘ultimate’ law of nature, that theories do not correspond to truths inherent in reality, and that successive revisions in theory do not lead monotonically to some ultimate truth. Instead, the theories generated in succession are incommensurate with each other, testifying to the fact that a theory gives us a perspective view of some part of reality, arrived at contextually. Instead of resembling a monotonically converging series successive theories are analogous to asymptotic series. -/- Before we summarize all the above considerations, we briefly address the issue of the complexity of the {\it human mind} -- one as pervasive as the complexity of Nature at large. The complexity of the mind is related to the complexity of the underlying neuronal organization in the brain, which operates within a larger biological context, its activities being modulated by other physiological systems, notably the one involving a host of chemical messengers. The mind, with no materiality of its own, is nevertheless emergent from the activity of interacting neuronal assemblies in the brain. As in the case of reality at large, there can be no ultimate theory of the mind, from which one can explain and predict the entire spectrum of human behavior, which is an infinitely rich and diverse one. (shrink)

News about the first baby born after a mitochondrial replacement technique (MRT; specifically maternal spindle transfer) broke on September 27, 2016 and, in a matter of hours, went global. Of special interest was the fact that the mitochondrial replacement procedure happened in Mexico. One of the scientists behind this world first was quoted as having said that he and his team went to Mexico to carry out the procedure because, in Mexico, there are no rules. In this paper, we explore (...) Mexico's rule of law in relation to mitochondrial replacement techniques and show that, in fact, certain instances of MRTs are prohibited at the federal level and others are prohibited at the state level. According to our interpretation of the law, the scientists behind this first successful MRT procedure broke federal regulations regarding assisted fertilization research. (shrink)

"The task of defining Shakti requires a departure from the reductionist tendencies of early Indology, which often categorized the Goddess merely as a ‘consort’ or a ‘fertility archetype’. Within Shakta Upasana (worship of Shaktism), Shakti is not an attribute of the Divine; She is the ontological definition of Divinity itself. She is the kinetic absolute, the dynamic aspect of the ultimate reality (Brahman) that renders the transcendent accessible, cognizable, and realizable. Shakti is the mechanism of Vimarśa (divine self-reflection); the (...) mirror in which the infinite Consciousness (Shiva/Prakāśa) recognizes its own existence. Without Shakti, the Absolute is Shava (a corpse): inert, powerless, and effectively non-existent.". (shrink)

The ontological nature of works of music has been a particularly lively area of philosophical debate during the past few years. This paper serves to introduce the reader to some of the most fertile and interesting issues. Starting by distinguishing three questions – the categorial question, the individuation question, and the persistence question – the article goes on to focus on the first: the question of which ontological category musical works fall under. The paper ends by introducing, and briefly considering, (...) meta-ontological questions in the ontology of music. (shrink)

The epistemology of religion is the branch of epistemology concerned with the rationality, the justificatory status and the knowledge status of religious beliefs – most often the belief in the existence of an omnipotent, omniscient and loving God as conceived by the major monotheistic religions. While other sorts of religious beliefs – such as belief in an afterlife or in disembodied spirits or in the occurrence of miracles – have also been the focus of considerable attention from epistemologists, I shall (...) concentrate here on belief in God. There were a number of significant works in the epistemology of religion written during the early and mid Twentieth Century. The late Twentieth Century, however, saw a surge of interest in this area, fuelled by the work of philosophers such as William Alston, Alvin Plantinga and Linda Zagzebski amongst others. Alston, Plantinga and Zagzebski succeeded in importing, into the epistemology of religion, various new ideas from mainstream epistemology – in particular, externalist approaches to justification, such as reliabilism, and virtue theoretic approaches to knowledge (see, for instance, Alston, 1986, 1991, Plantinga, 1988, 2000, Zagzebski, 1993a, 1993b). This laid fertile ground for new research – questions about the justificatory and knowledge status of belief in God begin to look very different when viewed through the lens of theories such as these. I will begin by surveying some of this groundbreaking work in the present article, before moving on to work from the last five years – a period in which the epistemology of religion has again received impetus from a number of ideas from mainstream epistemology; ideas such as pragmatic encroachment, phenomenal conservatism and externalist theories of evidence. (shrink)

Relevance logic has become ontologically fertile. No longer is the idea of relevance restricted in its application to purely logical relations among propositions, for as Dunn has shown in his (1987), it is possible to extend the idea in such a way that we can distinguish also between relevant and irrelevant predications, as for example between “Reagan is tall” and “Reagan is such that Socrates is wise”. Dunn shows that we can exploit certain special properties of identity within the context (...) of standard relevance logic in a way which allows us to discriminate further between relevant and irrelevant properties, as also between relevant and irrelevant relations. The idea yields a family of ontologically interesting results concerning the different ways in which attributes and objects may hang together. Because of certain notorious peculiarities of relevance logic, however,1 Dunn’s idea breaks down where the attempt is made to have it bear fruit in application to relations among entities which are of homogeneous type. (shrink)

Is it wrong to create a blind child, for example by in vitro fertilization, if you could create a sighted child instead? Intuitively many people believe it is wrong, but this belief is difficult to justify. When there is a possibility to create and select either ‘blind’ or ‘sighted’ embryos choosing a set of ‘blind’ embryos seems to harm no-one since choosing ‘sighted’ embryos would create a different child altogether. So when the parents choose ‘blind’ embryos, they give some specific (...) individual a life that is the only option for her. Because her life is worth living (as blind peoples’ lives are), the parents have not wronged the child by creating her. This is the reasoning behind the famous non-identity problem. I suggest that the non-identity problem is based on a misunderstanding. I claim that when choosing a ‘blind’ embryo, prospective parents harm ‘their child’, whoever she or he will be. Put another way: parents harm their child in the de dicto sense and that is morally wrong. (shrink)

While researchers in business ethics, moral philosophy, and jurisprudence have advanced the study of corporate agency, there have been very few attempts to bring together insights from these and other disciplines in the pages of the Journal of Business Ethics. By introducing to an audience of business ethics scholars the work of outstanding authors working outside the field, this interdisciplinary special issue addresses this lacuna. Its aim is to encourage the formulation of innovative arguments that reinvigorate the study of corporate (...) agency and stimulate further cross-fertilization of ideas between business ethics, law, philosophy, and other disciplines. (shrink)

Philosophers of science discuss whether theory selection depends on aesthetic judgments or criteria, and whether these putatively aesthetic features are genuinely extra-epistemic. As examples, judgments involving criteria such as simplicity and symmetry are often cited. However, other theory selection criteria, such as fecundity, coherence, internal consistency, and fertility, more closely match those criteria used in art contexts and by scholars working in aesthetics. Paying closer attention to the way these criteria are used in art contexts allows us to understand (...) some evaluative and developmental practices in scientific theory selection as genuinely aesthetic, enlarging the scope of the goals of science. (shrink)

First, the thorny problem of locating the Midwest is treated. Second, the ancient Stoics’ understanding of nature is proposed as a fertile field of ecological wisdom. The significance of nature in Stoicism is explained. Stoic philosophers (big-S Stoics) are distinguished from stoical non-philosophers (small-s stoics). Nature’s lessons for living a good Stoic life are drawn. Are such lessons too theoretical to provide practical guidance? This worry is addressed by examining the examples of Cincinnatus and Cato the Elder—ancient Romans lauded for (...) their virtues who worked the land. They exhibited the virtues of civic responsibility, justice, self-sufficiency, parsimony, perseverance, equanimity, modesty, and respect for limits—an agrarian virtue dear to Wendell Berry. Agrarianism views rural society as superior to urban society and the independent farmer as superior to the paid worker. Reflection on the virtues of stoical Roman agrarians suggests that features of Roman Stoic agrarianism resonate with a contemporary instantiation of Stoicism in the Midwest. The main thesis is that Midwest Stoic agrarianism (MSA), guided by an array of earthy virtues, promotes agricultural practices that harmonize with nature and support living in agreement with nature, while rejecting agricultural practices contrary to nature and propelled by vice. MSA endorses, e.g., locally sourced, sustainably grown crops instead of CAFOs. MSA tackles the ecological and sociopolitical pressures confronting Midwest farmers in the Anthropocene and can fortify environmental virtue ethics beyond this region. (shrink)

Artificial gametes, derived from stem cells, have the potential to enable in vitro fertilization of embryos. Currently, artificial gametes are only being generated in laboratory animals; however, considerable efforts are underway to develop artificial gametes using human cell sources. These artificial gametes are being proposed as a means to address infertility through assisted reproductive technologies. Nonetheless, the availability of artificial gametes obtained from adult organisms can potentially expand the possibilities of reproduction. Various groups, such as same-sex couples, post-menopausal women, and (...) deceased donors, could potentially utilize artificial gametes to conceive genetically related offspring. The advent of artificial gametes raises significant bioethical questions. Should all these reproductive scenarios be accepted? How can we delineate the range of future reproductive choices? A normative bioethical framework may be necessary to establish a consensus regarding the use of human artificial gametes. This review aims to present the current state of research on the biological roadmap for generating artificial gametes, while also summarizing proposed approaches to establish a normative framework that delineates ethically acceptable paths for reproduction. (shrink)