The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

Biomedical ontologies are emerging as critical tools in genomic and proteomic research where complex data in disparate resources need to be integrated. A number of ontologies exist that describe the properties that can be attributed to proteins; for example, protein functions are described by Gene Ontology, while human diseases are described by Disease Ontology. There is, however, a gap in the current set of ontologies—one that describes the protein entities themselves and their relationships. We have designed a PRotein Ontology (PRO) (...) to facilitate protein annotation and to guide new experiments. The components of PRO extend from the classification of proteins on the basis of evolutionary relationships to the representation of the multiple protein forms of a gene (products generated by genetic variation, alternative splicing, proteolytic cleavage, and other post-translational modification). PRO will allow the specification of relationships between PRO, GO and other OBO Foundry ontologies. Here we describe the initial development of PRO, illustrated using human proteins from the TGF-beta signaling pathway. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

The philosophical, legal, and HCI literature concerning artificial intelligence (AI) has explored the ethical implications and values that these systems will impact on. One aspect that has been only partially explored, however, is the role of deception. Due to the negative connotation of this term, research in AI and Human–Computer Interaction (HCI) has mainly considered deception to describe exceptional situations in which the technology either does not work or is used for malicious purposes. Recent theoretical and historical work, however, has (...) shown that deception is a more structural component of AI than it is usually acknowledged. AI systems that enter in communication with users, in fact, forcefully invite reactions such as attributions of gender, personality and empathy, even in the absence of malicious intent and often also with potentially positive or functional impacts on the interaction. This paper aims to operationalise the Human-Centred AI (HCAI) framework to develop the implications of this body of work for practical approaches to AI ethics in HCI and design. In order to achieve this goal, we take up the analytical distinction between “banal” and “strong” deception, originally proposed in theoretical and historical scholarship on AI (Natale in Deceitful media: artificial intelligence and social life after the turing test, Oxford University Press, New York, 2021), as a starting point to develop ethical reflections that will empower designers and developers with practical ways to solve the problems raised by the complex relationship between deception and communicative AI. The paper considers how HCAI can be applied to conversational AI (CAI) systems in order to design them to develop banal deception for social good and, at the same time, to avoid its potential risks. (shrink)

This study thoroughly investigates the financial behaviors of financially independent, young, single professionals aged 24 to 35 in Balayan, Batangas, amidst a period of global inflation. Focusing on five industries—education, finance, government, healthcare, and retail—the research employs a mixed-methods approach. Quantitative analysis, involving 75 respondents through a 4-point Likert scale survey, is complemented by qualitative insights from in-depth interviews with 5 participants from each industry. The findings from numerical values revealed that demographics did not impact working professionals' saving habits and (...) buying behaviors during the global inflation surge. This suggests that despite differences in age, gender, industry, employment status, and monthly income or salary, all professionals prioritized robust, strong savings and reduced spending to ensure financial stability. The research underscores the significance for professionals in various industries to prioritize specific aspects of personal financial management during the prevailing global inflation surge. The study suggests that, irrespective of industry, working professionals should prioritize specific aspects of personal financial management during the global inflation surge. (shrink)

The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...) reference. We illustrate its use in facilitating an alignment between PRO and Reactome protein entities. We also address issues of scalability, describing our first steps into the use of text mining to identify protein-related entities, the large-scale import of proteoform information from expert curated resources, and our ability to dynamically generate PRO terms. Web views for individual terms are now more informative about closely-related terms, including for example an interactive multiple sequence alignment. Finally, we describe recent improvement in semantic utility, with PRO now represented in OWL and as a SPARQL endpoint. These developments will further support the anticipated growth of PRO and facilitate discoverability of and allow aggregation of data relating to protein entities. (shrink)

The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

The Protein Ontology provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation of experimentally known forms and annotations thereof is expected to expose discrepancies, differences, and gaps in our knowledge. We have annotated the early events of innate immune signaling mediated by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting ontology and annotation data set has (...) allowed us to identify species-specific gaps in experimental data and possible functional differences between species, and to employ inferred structural and functional relationships to suggest plausible resolutions of these discrepancies and gaps. (shrink)

Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our (...) previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. This paper describes (1) our continuing efforts in the OMIT ontology development and (2) the application of the OMIT to enable a semantic approach for knowledge capture of miRNA-target interactions. (shrink)

The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a framework (...) for the formal representation of protein classes and protein forms in the OBO Foundry. It is designed to enable data retrieval and integration and machine reasoning at the molecular level of proteins, thereby facilitating cross-species comparisons, pathway analysis, disease modeling and the generation of new hypotheses. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of (...) large amounts of ncRNA biological and clinical data. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users. (shrink)

This work, in English "Struggle for power, organic crisis and judicial independence", has its origin in research academics of the IAEN carried out to provide expert advise to the Inter American Court of Human Rights in the case Quintana and others (Supreme Court of Justice) vs the State of Ecuador. The research is about the nature of the evolution of the ecuadorian state, the dynamics of its institutions, its players, parties, laws, its factors of instability, the way rights have been (...) deployed since the return to democracy in 1979, those who have benefited from neoliberal democracy and those who have paid the costs, and where in all this was the Supreme Court of Justice. The Introduction takes a look at this origin of the work and its intellectual import, provides a brief characterization of the Inter American Sistem of Human Rights Protection, how the Quintana Case fits within it, and an overview of the chapters and their logic. The first chapter analyzes the institutional and sociological factors that have contributed to Ecuador's historically unstable state, based primarily in an antagonistic struggle for power between the Executive and Legislative branches. The second chapter analyzes the economic and political factors that provoked an organic crisis, or crisis of hegemony, between 1997 and 2007 in Ecuador. The third chapter analyzes the evolution of the way in which judges are selected in Europe, the outcomes they have generated, and how they compare with the ecuadorian systems of judge selection in terms of securing judicial independence. The fourth chapter develops a theory of judicial independence in democracy and analyzes how Ecuador measures up to that standard, from when it became a neoliberal minimal democracy in 1981, to when it became a neoliberal false democracy as a consequence of instalation of a system evidently lacking in the people's support under the guise of the 1998 Constitution and its system of judge selection, and the new democratic horizons set by the 2008 Constitution, and the judicial system that springs from it. (shrink)

This paper explores anti-natalism and attitudes towards environmental preservation. Anti-natalisms of a certain kind, what I call “compassion-based anti-natalisms”, adhere to the principle of minimising suffering, and this goes hand-in-hand with the common belief that protecting the environment from destruction is the right thing to do. However, I argue that environmental preservation is, in fact, antithetical to the anti-natalist’s aims. This is because environmental preservation is, as I argue, primarily for future generations and has, therefore, pro-natalist attachments: environmental preservation promotes (...) and enables future generations. As a result, environmental preservation conflicts with three of the anti-natalist’s fundamental values: the goal of extinction, an overall reduction in suffering, and adherence to a duty of non-procreation. Because of this, I discuss two possible attitudes the anti-natalist might take towards environmental preservation: Destruction and Apathy. Destruction involves the active degradation and destruction of the environment to bring about extinction as soon as possible. Apathy is to be “hands-off” towards preservation and degrade the environment more slowly. I state that Apathy is the most suitable attitude for the anti-natalist to take towards the environment because it ascertains a sensible balance within the anti-natalist’s values and does not introduce new, morally objectionable outcomes. Finally, I discuss some practical limitations to Apathy and how the anti-natalist might best act in the context of the real world. I conclude that anti-natalists might have to compromise on their values and, paradoxically, support environmental preservation. (shrink)

In this article I rethink death and mortality on the basis of birth and natality, drawing on the work of the Italian feminist philosopher Adriana Cavarero. She understands birth to be the corporeal event whereby a unique person emerges from the mother’s body into the common world. On this basis Cavarero reconceives death as consisting in bodily dissolution and re-integration into cosmic life. This impersonal conception of death coheres badly with her view that birth is never exclusively material but (...) always has ontological significance as the appearance of someone new and singular in the world of relations with others. This view of birth calls for a relational conception of death, which I develop in this article. On this conception, death is always collective, affecting all those with whom the one who dies has maintained relations: As such, our different deaths shade into one another. Moreover, because each person is unique in virtue of consisting of a unique web of relations with others, death always happens to persons as webs of relations. Death is relational in this way as a corporeal, and specifically biological, phenomenon, to which we are subject as bodily beings and as interdependent living organisms. I explore this with reference to Simone de Beauvoir’s memoir of her mother’s death from cancer. Finally I argue that, on this relational conception, death is something to be feared. (shrink)

Arendt claims that our natality (i.e., our condition of being born) is the “source” or “root” of our capacity to begin (i.e., of our capacity to initiate something new). But she does not fully explain this claim. How does the capacity to begin derive from the condition of birth? That Arendt does not immediately and unambiguously provide an answer to this question can be seen in the fact that her notion of natality has received very different interpretations. In (...) the present paper, I seek to clarify the notion. I bring together and examine Arendt’s scattered remarks about natality and propose a new interpretation that responds to the stated question. Along the way, I show how the various existing interpretations have arisen and argue that, in view of that question, they are inadequate. (shrink)

Jurgen Habermas has argued that carrying out pre-natal germline enhancements would be inimical to the future child's autonomy. In this article, I suggest that many of the objections that have been made against Habermas' arguments by liberals in the enhancement debate misconstrue his claims. To explain why, I begin by explaining how Habermas' view of personal autonomy confers particular importance to the agent's embodiment and social environment. In view of this, I explain that it is possible to draw two arguments (...) against germline enhancements from Habermas' thought. I call these arguments ‘the argument from negative freedom’ and ‘the argument from natality’. Although I argue that many of the common liberal objections to Habermas are not applicable when his arguments are properly understood, I go on to suggest ways in which supporters of enhancement might appropriately respond to Habermas' arguments. (shrink)

This essay develops Hannah Arendt's concept of natality as an ontological structure of forgetfulness rather than mere biological or political metaphor. Through sustained engagement with The Human Condition (1958), Between Past and Future (1961), and On Revolution (1963), alongside critical readings by Peg Birmingham, Dana Villa, and Adriana Cavarero, I demonstrate that natality names the capacity for metabolic rupture, the positive power to release the determining hold of the past. This analysis reveals natality as structurally identical to (...) the forgetfulness enabling individual cognition (through figure-ground withdrawal) and epistemological transformation (through paradigmatic rupture): in all three registers, withdrawal constitutes the enabling medium for unprecedented appearance. The essay concludes by examining how contemporary algorithmic governance threatens to eliminate natality through total memory systems that foreclose the temporal gap where political freedom appears. (shrink)

In the first part of the paper, I discuss Benatar’s asymmetry argument for the claim that it would have been better for each of us to have never lived at all. In contrast to other commentators, I will argue that there is a way of interpreting the premises of his argument which makes all of them come out true. (This will require one departure from Benatar’s own presentation.) Once we see why the premises are true, we will, however, also realise (...) that the argument trades on an ambiguity that renders it invalid. In the second part of the paper, I consider whether discussions of how best to implement the anti-natalist conclusion crosses a moral barrier. I ask whether we can, independently of any philosophical argument, raise a legitimate moral objection to discussions of how best to end all life on earth. I discuss three views concerning the role of our pre-philosophical views and attitudes in philosophical debates: the external view according to which these attitudes set moral barriers to the content of philosophical debate whilst themselves standing outside this debate; the internal view according to which our intuitions are part of the material for philosophical reflection and play no further role; and the intermediate view according to which our pre-reflective views and attitudes, without themselves requiring philosophical validation, can play an important role when it comes to issues regarding the implementation of philosophical claims. (shrink)

Population is a key factor of national power. Declining fertility rates, especially in major economies, are reshaping global power dynamics by shrinking workforces amidst aging populations. In response, more nations are adopting techno-natalist policies, promoting reproductive technologies (“reprotech”) like IVF to increase birth rates. Advances in genetic embryo selection, gene editing, in vitro gametogenesis, and artificial wombs could further enhance these policies by improving birth rates, health, and human capital. This article examines current and emerging reprotechnologies, the policy landscape, socioeconomic (...) and geopolitical implications, and future research directions. By shaping national and global gene pools, reprotech policies and practices offer a paradigmatic case of gene–culture coevolution. If these technologies prove safe and effective, nations that embrace them are likely to gain geopolitical and evolutionary advantages over those that do not. (shrink)

In this paper, I explore the prospects for risk-based arguments in favour of anti-natalism, which explain the wrongness of procreation in terms of wrongful risk-imposition on the resultant child. After considering and rejecting two risk-based arguments from the existing literature - David Benatar's and Matti Häyry's - I propose a more promising version that focuses on the lack of appropriate justification for imposing the risks of existence, namely, one that refers to the essential interests of the child on whom those (...) risks are imposed. The paper proceeds in four parts. In Part 2, I set the stage for my discussion by clarifying the basic structure of risk-based arguments and identifying some of their important features. In Parts 3-5, I consider three distinct risk-based arguments for anti-natalism and argue that only the third, justificatory argument has the potential to be successful. (shrink)

A critical overview of the latest discussion of anti-natalism, with particular reference to David Benatar's work and three additional rationales for anti-natalism that differ from Benatar's.

Transhumanism proposes human enhancement while regarding the human body as unfit for the future. This fulfills age-old aspirations for a perfect and durable body. We use “alienation” as a concept to analyze this mismatch between human aspirations and our current condition. For Hannah Arendt alienation may be accounted for in terms of earth- and world-alienation, as well as alienation from human nature, and especially from the given (“resentment of the given”). In transhumanism, the biological body is an impediment to human (...) accomplishment. At most, this movement accepts “clean” bodies, not bodies with excretions. We argue that real human bodies are valued in the event of giving birth, so a modified concept that Arendt proposed, natality, seems a suitable way to explore the dialectic alienation-reconciliation involving the body (Arendt’s “A child has been born unto us”), when re-read by some feminist scholars. (shrink)

This paper investigates the existential and ethical implications of birth within socially structured systems of expectation. It centers on the destabilizing question a child may ask—“Why was I born?”—and interprets it as a moment of cognitive awakening rather than rebellion or emotional accusation. The study argues that reproduction is frequently embedded within unconscious parental projections and social continuities, thereby generating tension between imposed identity and emerging individuality. It further proposes that intelligence does not arise from repetition of inherited answers, but (...) from questioning as a distinct cognitive expression. Questioning is clarified as neither equivalent to love nor reducible to defiance; instead, it is understood as the mind’s structural movement toward coherence when confronted with existential ambiguity. Drawing upon existential philosophy, political theory, developmental psychology, and phenomenology, the paper argues that authentic human flourishing requires two foundational conditions: birth without psychological ownership and inquiry without suppression. Together, these conditions establish a framework for ethical natality and intellectual freedom. (shrink)

The ethics of biological procreation has received a great deal of attention in recent years. Yet, as I show in this paper, much of what has come to be called procreative ethics is conducted in a strangely abstract, impersonal mode, one which stands little chance of speaking to the practical perspectives of any prospective parent. In short, the field appears to be flirting with a strange sort of practical irrelevance, wherein its verdicts are answers to questions that no-one is asking. (...) I go on to articulate a theory of what I call existential grounding, a notion which explains the role that prospective children play in the lives of many would-be parents. Procreative ethicists who want their work to have real practical relevance must, I claim, start to engage with this markedly first-personal kind of practical consideration. (shrink)

Livro-texto de introdução à lógica, com (mais do que) pitadas de filosofia da lógica, produzido como uma versão revista e ampliada do livro Forallx: Calgary. Trata-se da versão de 13 de outubro de 2022. Comentários, críticas, correções e sugestões são muito bem-vindos.

Recent crises in Europe and beyond have renewed a longstanding debate on the status and treatment of refugees. Hannah Arendt famously questioned the limits of universalistic human rights discourse based on the widespread phenomena of statelessness and displacement that emerged during and after World War II. In this paper, we analyze recent patterns of inclusion and exclusion of refugees in Italy through the lens of Arendtian narrative and theorizing. We consider three cases of interaction between families, schools, and other public (...) institutions in light of the shifting normative framework before and during the war in Ukraine. Two major insights emerge from this analysis. From a pedagogical point of view, the most promising educational practices with refugees are those centered on enabling their agency and corresponding experiences of "natality". From an ethical-political perspective, these practices highlight a latent tension between the universalistic scope of human rights enshrined in the human rights declarations and their structural dependence on the particular norms and procedures enacted by nation states. The understanding and teaching of human rights within our political communities is inseparable from the practices that engage with refugees. In this sense, our practices of inclusion and exclusion affect the understanding of national borders as a barrier or threshold with other political communities, but also the interpretation of our own ethical-political principles. (shrink)

This article advances the Algorithmic Authoritarianism Hypothesis: that contemporary artificial intelligence does not generate authoritarianism ex nihilo, but functions as a powerful accelerator of its political, psychological, and institutional preconditions. Drawing primarily on Hannah Arendt’s concepts of natality, judgment, and the erosion of the common world, alongside Michel Foucault’s account of governmentality and Shoshana Zuboff’s analysis of instrumentarian power, the article argues that algorithmic governance reshapes the conditions under which democratic action remains possible. By rendering social behaviour predictable, optimisable, (...) and anticipatable, AI systems displace political authorship from collective judgment toward technical modulation, producing a form of “soft authoritarianism” that preserves electoral forms while hollowing out substantive freedom. Using the United States as an illustrative case rather than an exceptional one, the article diagnoses a contemporary “digital Weimar” condition in which loneliness, epistemic fragmentation, and predictive control converge. Against this tendency, it reclaims political natality as the capacity to interrupt algorithmic recurrence through spontaneous action and judgment. The article concludes by outlining the contours of an “algorithmic humanism” oriented toward preserving unpredictability, plurality, and democratic agency under conditions of technological acceleration. (shrink)

An in-depth critique of the assumptions and claims of contemporary natal astrology.

A form of pessimism can support the claim that we have a collective duty to prevent the creation of additional human beings. More specifically, I argue that axiological pessimism, which suggests that human existence is overall bad (for humans) because of a form of evil it causes, implies that we should end human procreation, provided that we do not thereby generate further such evil. In turn, this conclusion can support anti‐natalism, the normative view that we should refrain from procreating.

In this article I reconsider David Benatar's primary argument for anti‐natalism—the asymmetry argument—and outline a three‐step process for rejecting it. I begin in Part 2 by reconstructing the asymmetry argument into three main premises. I then turn in Parts 3–5 to explain how each of these premises is in fact false. Finally, I conclude in Part 6 by considering the relationship between the asymmetry argument and the quality of life argument in Benatar's overall case for anti‐natalism and argue that it (...) is the latter argument that is actually doing the work. In this sense, the asymmetry argument is not only unsuccessful in generating Benatar's anti‐natalist conclusion, it is also unnecessary as well. (shrink)

Does Benatar’s anti-natalism—the view that it is better never to have been—imply that death is better than continued living? This is known as the pro-mortalist question, a compelling, unresolved question surrounding anti-natalist discourse. In order to answer this question, I analyse two theories about the badness of death that Benatar uses to argue against the idea that anti-natalism implies pro-mortalism. The first is that death deprives one of the good things in life. The second is that death annihilates the person. (...) However, I argue that these theories fail to block pro-mortalism. As such, I conclude that Benatar’s anti-natalism implies pro-mortalism, suggesting that if it is better never to have been, then it is better to cease to be. (shrink)

Recently, Kenneth Himma (2010) argued that salvific exclusivism, some common beliefs about Hell, and a plausible moral principle entailed anti-natalism. Himma is on to something. But given the dialectic between Himma and a staunch critic, Shawn Bawulski (2013), I’ll provide a stronger version of Himma’s argument that allows us to discard a commitment to salvific exclusivism and satisfactorily respond to some of Bawulski’s strongest objections. In this paper, I’ll argue that some common beliefs about Hell, a risk-averse decision principle, and (...) Himma’s moral principle—reworked in light of the risk-averse decision principle—entail anti-natalism. (shrink)

Recent years have seen a surge of interest in the question of whether humans should reproduce. Some say human life is too punishing and cruel to impose upon an innocent. Others hold that such harms do not undermine the great and possibly unique value of human life. Tracing these outlooks historically in the debate has barely begun. What might philosophers have said, or what did they say, about human life itself and its value to merit reproduction? This article looks to (...) Kant, who wrote much on whether, by reproducing, humans do wrong or right morally. It assesses two main arguments: one examining whether perfect or imperfect duties condone reproduction, the other whether Kant’s teleological or, in the opposite sense, his eschatological outlooks can salvage reproduction. These two arguments are essential for building the entire argument. This article finds that, although Kant’s arguments against reproducing are strong, some of his writing seems to support reproduction as a good. Yet, must we must assume an author, even one who strove for systematicity, must be consistent over his entire oeuvre on every issue, especially if not handled directly in a single work? The article concludes that Kant does not sufficiently, systematically support anti-natalism as more moral than pro-natalism. It is best for the current debate to grapple with the very dilemma that daunted Kant. (shrink)

This article examines one of the sources of David Benatar’s anti-natalism. This is the view that ‘all procreation is [morally] wrong.’ (Benatar and Wasserman, 2015:12) One of its sources is the claim that each of our lives is objectively bad, hence bad whether we think so or not. The question I will pose is whether the constraints of metaphysical naturalism allow for an objective devaluation of human life sufficiently negative to justify anti-natalism. My thesis is that metaphysical naturalism does not (...) have the resources to support such a negative evaluation. Metaphysical naturalism is the view that causal reality is exhausted by nature, the space-time system and its contents. The gist of my argument is that the ideal standards relative to which our lives are supposed to be axiologically substandard cannot be merely subjective expressions of our desires and aversions; they must be (i) objectively binding standards that are (ii) objectively possible in the sense of concretely realizable. The realizability condition, however, cannot be satisfied on metaphysical naturalism; ergo, failure to meet these ideal standards cannot show that our lives are objectively bad. (shrink)

This essay argues that the birth of a newborn child demands greater moral reflection and collective responsibility than the death of an individual. While death signifies the completion of a life already shaped, birth represents an open future whose direction depends upon social, political, and ethical structures. The paper develops a conceptual distinction between death as closure and birth as possibility, extending the discussion into themes of intergenerational justice, civic responsibility, and existential freedom. Drawing implicitly on traditions associated with (...) class='Hi'>natality (Hannah Arendt), responsibility ethics (Hans Jonas), relational ethics (Emmanuel Levinas), existential freedom (Jean-Paul Sartre), and justice between generations (John Rawls), the essay situates birth as a profound ethical event. It concludes that each newborn silently interrogates the moral condition of society, making birth not merely a private celebration but a public ethical moment that renews humanity’s accountability toward the future. (shrink)

The human experience moves continuously between personal success and philosophical hopelessness which philosophers including Arthur Schopenhauer along with Albert Camus, David Benatar, John Gray and Thomas Ligotti have emphasized upon in their writings. The analysis in this paper will be about their evaluations of optimistic beliefs as well as the concepts of human advancement and search for values in life. According to Schopenhauer suffering dominates life but Camus explains that defiance or revolt allows people to discover meaning beyond absurdism. Benatar (...) and Ligotti present contrary arguments because they choose anti-natalism alongside their belief that consciousness is a horror. For Ligotti and Benatar, Consciousness is something which should not have been as it causes more harm than good. Research has not yet explored how pessimists build their psychological strength and why seemingly pleasant art, and intellectual activities might reduce existential fear. The systematic study of psychology enables this paper to demonstrate that understanding life’s absurd nature enables a thoughtful approach to existence, instead into making an individual to into a cycle of misery. (shrink)

This paper critically examines Hannah Arendt’s institutions of forgiveness and promise, as outlined in The Human Condition (1998), and their limitations when applied to acts of “Radical evil.” Arendt defines radical evil such as the Holocaust or Hiroshima as unforgivable because such acts alter the course of humanity and destroy the conditions for human plurality and autonomy. However, this paper argues that excluding radical evil from forgiveness contradicts Arendt’s own principles of natality, action, and freedom, which depend on the (...) ability to begin anew. Arendt’s linkage of promise to memory and stability further creates a paradox, as it simultaneously preserves and restricts freedom. Drawing on Jacques Derrida’s Forgiveness (1999), the paper proposes that unconditional forgiveness even for radical evil is essential to restoring human plurality and moving beyond historical trauma. Derrida’s notion of forgiveness as an exceptional, unconditional “gift” provides a more viable framework for reconciliation and renewal in the modern world. Thus, where Arendt’s theory leaves humanity suspended in the aftermath of atrocity, Derrida’s deconstructive approach offers a pathway toward ethical regeneration and collective healing. (shrink)

David Benatar argues that coming into existence is always a harm, and that – for all of us unfortunate enough to have come into existence – it would be better had we never come to be. We contend that if one accepts Benatar’s arguments for the asymmetry between the presence and absence of pleasure and pain, and the poor quality of life, one must also accept that suicide is preferable to continued existence, and that his view therefore implies both anti-natalism (...) and pro-mortalism . This conclusion has been argued for before by Elizabeth Harman – she takes it that because Benatar claims that our lives are ‘awful’, it follows that ‘we would be better off to kill ourselves’ (Harman 2009: 784). Though we agree with Harman’s conclusion, we think that her argument is too quick, and that Benatar’s arguments for non-pro-mortalism deserve more serious consideration than she gives them. We make our case using a tripartite structure. We start by examining the prima facie case for the claim that pro-mortalism follows from Benatar’s position, presenting his response to the contrary, and furthering the dialectic by showing that Benatar’s position is not just that coming into existence is a harm, but that existence itself is a harm. We then look to Benatar’s treatment of the Epicurean line, which is important for him as it undermines his anti-death argument for non-pro-mortalism. We demonstrate that he fails to address the concern that the Epicurean line raises, and that he cannot therefore use the harm of death as an argument for non-pro-mortalism. Finally, we turn to Benatar’s pro-life argument for non-pro-mortalism, built upon his notion of interests, and argue that while the interest in continued existence may indeed have moral relevance, it is almost always irrational. Given that neither Benatar’s anti-death nor pro-life arguments for non-pro-mortalism work, we conclude that pro-mortalism follows from his anti-natalism, As such, if it is better never to have been, then it is better no longer to be. -/- . (shrink)

Philosopher Fiona Wollard recently advocated interpreting the achievements of women while giving birth. People readily recognize men-related achievements, like running a marathon, but not achievements related to giving birth. We expand on Woollard's notion of reproductive achievements, comparing them with ideas of human enhancement, which aims at humans becoming "stronger and faster". Criticisms to evolutionary psychology challenge its defense of a notion of a fixed human nature, and its disregard for the experience of birth. Some female scholars link human evolution (...) to the presence of premature infants requiring attention from mothers and alloparents. They explain why this gave an advantage to the human species, enhancing cooperation and other desirable traits. Other scholars develop philosophies of birth, mostly based on Arendt's conception of natality, questioning a human nature not sensitive to gender, excluding birth and childhood. Then we move to transhumanism, proponent of human enhancement. Transhumanism questions our biological inheritance for being flawed and outdated, including giving birth, restricting this to a source of great suffering. This assessment of the given does not consider its ambiguous, dialectical character. Because of that, tinkering with nature both accomplishes and frustrates the goals of human enhancement. (shrink)

I provide an overview of the differences between psychological pessimism and philosophical pessimism. Based on a historic reading of the original 19th century German pessimist philosophers I provide a definition of what I call "transcendental pessimism" and sketch some of the reasons why it is different from other pessimist perspectives such as anti-natalism.