We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ScanProsite tool

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This form allows you to scan proteins for matches against the PROSITE collection of motifs as well as against your own patterns.

Option 1 - Submit PROTEIN sequences to scan them against the PROSITE collection of motifs.
Option 2 - Submit MOTIFS to scan them against a PROTEIN sequence database.
Option 3 - Submit PROTEIN sequences and MOTIFS to scan them against each other.

STEP 1 - Submit PROTEIN sequences [ help ]

Submit PROTEIN sequences (max. 10) Examples
Submit a PROTEIN database (max. 16MB) for repeated scans (The data will be stored on our server for 1 month).

Supported input:

UniProtKB accessions e.g. P98073 or identifiers e.g. ENTK_HUMAN ^*
PDB identifiers e.g. 4DGJ
Sequences in FASTA format

* All UniProtKB/Swiss-Prot accessions/identifiers and all UniProtKB/TrEMBL accessions/identifiers of entries belonging to a reference proteome are accepted.

If you already have a code for your database, enter the code:
Otherwise, upload your database as a FASTA file to obtain a code

STEP 2 - Select options [ help ]

Exclude motifs with a high probability of occurrence from the scan
Exclude profiles from the scan
Run the scan at high sensitivity (show weak matches for profiles)

STEP 1 - Submit PROTEIN sequences [ help ]

Submit PROTEIN sequences (max. 1'000) Examples
Submit a PROTEIN database (max. 16MB) for repeated scans (The data will be stored on our server for 1 month).

Supported input:

UniProtKB accessions e.g. P98073 or identifiers e.g. ENTK_HUMAN ^*
PDB identifiers e.g. 4DGJ
Sequences in FASTA format

* All UniProtKB/Swiss-Prot accessions/identifiers and all UniProtKB/TrEMBL accessions/identifiers of entries belonging to a reference proteome are accepted.

If you already have a code for your database, enter the code:
Otherwise, upload your database as a FASTA file to obtain a code

STEP 2 - Enter a MOTIF or a combination of MOTIFS Examples [ help ]

Supported input:

A PROSITE accession e.g. PS50240 or identifier e.g. TRYPSIN_DOM
Your own pattern e.g. P-x(2)-G-E-S-G(2)-[AS]

A combination of PROSITE accessions/identifiers e.g. PS50240 and PS50068 , e.g. PS50240 and not ( PS00134 or PS00135 )

A combination of PROSITE accessions/identifiers and your own pattern e.g. PS50240 and P-x(2)-G-E-S-G(2)-[AS]

» More

» Options [ help ]

Profile option

Run the scan at a high sensitivity (show weak matches for profiles)

Pattern options

Number of X characters in a scanned sequence that can be matched by a conserved position in a pattern:
Match mode :

STEP 3 - Select output options and submit your job

Output format:
Maximum number of displayed matches:	If you select 100'000, results are returned by email and not all output formats are available.
Retrieve complete sequences:	If you choose this option, not all output formats are available.

Receive your results by email

Email :	Note that not all output formats are available for results returned by email.
Job title :	If available, the job title will be included in the subject of the results email.