We detect inappropriate manipulation and duplication in many figure types, including blots (western blots), microscopy images, and light photography. Imagetwin is a powerful addition to the peer-review process. All kinds of integrity issues are automatically detected and can be quickly verified by a reviewer. A significant proportion of academic manuscripts contain image-related problems like manipulation and plagiarism. Unfortunately, even though automated solutions for text plagiarism now exist, there has been no such solution for images in the past. ...