Best Enterprise Medical Practice Management Software
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Compare the Top Enterprise Medical Practice Management Software as of December 2025
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What is Enterprise Medical Practice Management Software?
Medical practice management software helps healthcare practices streamline day-to-day operations such as appointment scheduling, patient registration, insurance and billing, and financial reporting. It centralizes patient records, provider schedules, claim submissions, and payments into a unified platform to reduce administrative burden and improve accuracy. Many solutions integrate with electronic health records (EHR) or electronic medical records (EMR) systems, automate revenue cycle management, and support compliance with regulations like HIPAA. With features like patient portals, telehealth integration, and analytics dashboards, the software enhances both practice efficiency and patient experience. Overall, medical practice management software frees up staff time, boosts operational productivity, and allows providers to focus more on delivering quality patient care. Compare and read user reviews of the best Enterprise Medical Practice Management software currently available using the table below. This list is updated regularly.
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1
RXNT
RXNT
RXNT is an ambulatory healthcare technology pioneer that empowers medical practices and healthcare organizations to succeed and scale through innovative, data-backed, AI-powered software. Our fully-integrated, ONC-certified suite of medical software—like Clinical EHRs, Practice Management, Medical Billing and RCM, E-Prescribing, Practice Scheduling, Patient Portal, and more—optimizes clinical outcomes and RCM for your practice. Used by tens of thousands of medical professionals—from large physician practices to medical billing companies—to drive growth, streamline business operations, and improve patient care across all 50 U.S. states. Our unified “Full Suite” system employs a secure, central database so your data passes through every product in real-time from anywhere, and more than 125 million prescriptions have been transmitted and over $7 billion in claims have been processed using RXNT.Starting Price: $118/month -
2
ScriptSure
DAW Systems, Inc.
Discover the pinnacle of E-Prescribing solutions with ScriptSure Cloud ERX – the unparalleled winner of the esteemed White Coat Award for Most Accurate Prescriptions in 2021, 2022, and 2023, securing its position as an 11-time recipient of this prestigious accolade. ScriptSure Cloud ERX seamlessly integrates full e-prescribing capabilities, EPCS (controlled substance prescribing) and weekly updates to medications and daily updates to pharmacy lists. With ScriptSure you get price transparency as well; detailed costs, alternatives and ePA requirement indicators for most medications. Enjoy a user-friendly interface and streamlined workflow methods for electronic refills, order sets, compound medication ordering, prescription printing, patient reports and comprehensive audit logs. Security and compliance are paramount, with ScriptSure being fully HIPAA compliant, ensuring the confidentiality and privacy of patient data. ScriptSure is fast, accurate and built for patient safety. -
3
Ensora Mental Health
TheraNest
For solo and small-group mental health practice owners, TheraNest is the EHR and practice-management platform that simplifies clinical documentation, streamlines billing, and empowers sustainable practice growth without administrative headaches. Unlike SimplePractice and TherapyNotes, TherapyNotes uniquely allows therapists to run secure group telehealth sessions (up to 20 participants), automatically insert evidence-based Wiley® treatment plans, and access built-in flat-rate RCM services — all in one place. TheraNest gives therapists back time, control, and confidence by combining workflow automation, AI-enhanced documentation, and reliable U.S.-based support.Starting Price: $29 per month -
4
Opus
Opus
Opus is a comprehensive EHR, CRM, and RCM platform designed to streamline operations for behavioral health treatment centers, including addiction, mental health, and SUD (substance use disorder) clinics. The platform provides integrated tools for patient management, billing, scheduling, and telehealth services. Opus enhances efficiency with features like intelligent lead routing, insurance verification, automated tasks, and customizable forms. It also includes advanced reporting, AI-driven progress note generation, and seamless lab integrations. With a focus on flexibility and scalability, Opus is ideal for small to large multi-center organizations in the behavioral health space. -
5
Service Center
Office Ally
Service Center by Office Ally is a trusted Revenue Cycle Management and patient payments platform used by more than 80,000 healthcare providers and health services organizations, which process more than 950 million transactions annually. Service Center is a cost-effective solution enabling providers to control their revenue cycle. With a user-friendly interface, Service Center helps providers check and verify patients’ eligibility and benefits, submit, correct, and check the status of their claims online, and receive remittance advice. Accepting standard ANSI formats, data entry and pipe-delimited formats, Service Center helps streamline administrative tasks and create more efficient workflows for providers.Starting Price: $0 -
6
Sevocity EHR
Sevocity
If you're looking for a long-term, stable EHR company that gets to know and serve you and your practice, you've come to the right place. #1 rated implementation and the only EHR that offers free ongoing customization and personalized training by practice and provider, live US-based support 24/7/365 and affordable all-inclusive pricing.Starting Price: $379.00/month -
7
DoctorConnect
Adtel International
DoctorConnect delivers industry-leading patient engagement and automation tools that help healthcare providers improve efficiency, reduce no-shows, and enhance patient satisfaction. With over 32 years of experience, we support thousands of doctors, clinics, and hospitals nationwide. Our platform integrates with hundreds of EMR and PM systems to simplify communication and daily operations. Key Features: • ARIA Phase 1 – AI receptionist for 24/7 call answering, triage, and transfers • ARIA Phase 2 – AI scheduling automation for real-time booking and rescheduling • Automated Reminders and Recalls • Digital Patient Forms and Surveys • Automated Waitlist and No-Show Recovery • Secure Messaging, Telehealth, and Online Payments • And more Discover how DoctorConnect can boost revenue, streamline workflow, and transform your patient experience.Starting Price: $210 -
8
OpenPM
OpenPractice
Open Practice is pleased to present OpenPM, our cloud-based RCM platform that has propelled the company through 17 consecutive years of double-digit growth. OpenPM connects all the disparate elements of the revenue cycle including; Scheduling & Registration, Billing, Clearinghouse, and Patient Payments/Collections. The result is highly automated accounts receivables management for optimized cash flow, and extensive reporting to help you proactively manage your organization. All of this control is securely hosted and delivered through the browser you already have, providing the perfect combination of security and availability. Medical billing software, revenue cycle management solutions, practice management software, practice management system, medical practice management, EMR integration, EHR integration, practice management scheduling, patient scheduling, online patient billing, patient billing, automatic patient billing and payments, patient payments, electronic patient payments. -
9
Mercury One Plus
CrisSoft
Mercury One Plus is a Medical Practice Management solution that puts the fundamentals of Revenue Cycle Management at your fingertips; it acts as a stepping stone from standard billing to intermediate billing. Mercury One Plus is offered exclusively on the cloud, with the highest level of security- you can access your data anywhere 24/7. A complete product with big functionality, Mercury One Plus includes: patient demographics input, 100 plus reports to choose from, charge entry, full history of patient activity, ERA posting, credit card acceptance, and much more. Mercury Products are HIPAA compliant with a guaranteed connection to any clearinghouse or insurance company. Mercury One Plus's automated job system will facilitate a daily system tune-up: housecleaning; folder maintenance; daily backups; 837 exports; 835 imports;HL7. All subscriptions come with the expert help of CrisSoft Support. Willing to partner/intergrate with all EMR's through REST.Starting Price: $249.00 -
10
AZZLY
AZZLY
AZZLY Rize is the premier clinical and business platform for addiction treatment and mental health organizations. As an all-in-one substance use disorder and mental health specific EHR, Patient Engagement and RCM platform, we serve small, medium, and large clinics. Key features for OUTPATIENT Programs include: scheduling, appointment reminder, Zoom telehealth, treatment plans, progress notes, assessments and surveys. For RESIDENTIAL programs: census, medication management, bed board, withdrawal management, DrFirst e-prescribing, EPCS, PDMP, labs. For all levels of care: alerts, patient engagement portal, electronic billing and claims submission built in. AZZLY Rize empowers your staff through its 5 star training and support services, its simplicity and automation. As a true all-in-one EHR/PM/RCM platform, improved compliance, workflow and accurate billing are achieved real-time. We proudly serve programs in over 33 states and are hosted in Microsoft Azure's private cloud network.Starting Price: $50/user/month -
11
MedEvolve
MedEvolve
MedEvolve Practice Management (PM) software provides unmatched transparency, automation and accountability for the healthcare revenue cycle. Built in automation and advanced analytics solutions reduce administrative burden and ensure staff are not only productive, but effective in the work effort they put in and that they are achieving the expected results. Additionally, MedEvolve’s effective intelligence solutions enable a remote workforce with task management, tracking and virtual communication tools that integrate directly with the practice management software. Increase margin, improve net collection rate and reduce overhead costs with effective intelligence. MedEvolve PM integrates with over 40 different EHR systems. We believe physician practices should be able to choose the best EHR for their clinicians, and the best practice management software for their administrative and billing staff. -
12
PatientNOW
PatientNow
patientNOW is a comprehensive software system designed to manage your entire aesthetic medical office. For over 14 years we have been upgrading our software to meet the needs of aesthetic medicine by listening to the suggestions and requests of our physicians and their staff that has resulted in an EMR software product that also includes Practice Management and a Patient Engagement system designed to capture prospects, retain current patients and grow your practice revenue. -
13
Pomelo Health
Pomelo Health
Pomelo Health is a leader in the patient engagement and management space in North America since 2012. Pomelo’s suite of products includes an all-in-one patient engagement platform, a waiting room solution, and a vaccination solution for COVID-19 and other immunization campaigns. Key features to Pomelo’s patient engagement platform include e-booking, email and text appointment reminders, e-forms, telemedicine, broadcasts, and secure messaging. With thousands of healthcare practices in North America using its software, Pomelo is proven to improve patient satisfaction and reduce no-shows. The Pomelo Health vaccination solution is used by governments in both the US and Canada as well as some of the largest pharmacy chains including Walmart Canada. -
14
Pabau
Pabau
Pabau is an all-in-one clinic software that has been designed for Clinics, Spa's, and Salons, and helps these businesses to save time and enable growth. Our powerful and extensive list of features allow you to craft the perfect experience for your clients, to ensure they leave happy and ready to re-book. Thousands of clinics currently use our system to supercharge their business. Electronic Medical Records, Calendars, Payment systems, Online bookings, Automated pre-care / after-care, Before-and-after systems, email / SMS reminders, and much more. -
15
Juvonno
Juvonno
Experience the future of clinic management with Juvonno – the all-in-one EMR and practice management software designed to grow your business. Trusted by healthcare professionals since 2005, Juvonno doesn't just optimize your workflows; it transforms the way you run your clinic. Gain unparalleled efficiency with powerful automation tools for booking, billing, charting, scheduling, marketing & communications. Juvonno is your key to saving time, streamlining workflows, and delivering superior patient care. Access your clinic anytime, anywhere with Juvonno's cloud-based platform. Reach patients, manage staff, and access files from any device, no matter where you are. But that's not all – Juvonno's revolutionary tool, JComm, delivers EMR-integrated messaging to scale your patient outreach efforts. Text patients 1-on-1 directly from Juvonno, and effortlessly deliver timely text and email campaigns for birthdays, appointments, insurance reminders, AR balances and more.Starting Price: $55 per month -
16
Vitrify IVF Software
Vitrify IVF Software
Vitrify is a UK-based provider of advanced IVF clinic management software trusted by fertility centers worldwide. Their platform simplifies complex IVF workflows, from patient cycle tracking to lab management and cryopreservation. Featuring cloud-based infrastructure, real-time analytics, and enterprise-grade security, Vitrify ensures patient data is encrypted, access-controlled, and fully compliant. The software offers extensive customization to fit each clinic’s unique needs, with modules for appointment scheduling, pharmacy inventory, marketing, and reporting. AI-driven predictive analytics help clinics optimize treatments and improve success rates. Supported by over a decade of experience, Vitrify delivers seamless operations and outstanding customer support.Starting Price: $20 -
17
Compliance Manager by Healthicity
Healthicity
Healthcare compliance simplified, including risk management and HIPAA compliance. Compliance Manager includes all of the crucial elements necessary to create and maintain an effective compliance program. Features customized workflows, corrective actions, open lines of communication, and real-time reporting. Compliance Manager simplifies compliance by hosting everything in one secure, easy-to-use, online application: Audit Management Compliance Checklist Incident Management Reporting Functionality So whether you're training employees, conducting risk assessments, or investigating incidents, you can manage your entire program in one easy-to-use application.Starting Price: $500 -
18
eHospital Systems
Adroit Infosystems
eHospital Systems is a customizable, comprehensive, and integrated Hospital Management System designed to manage all hospital operations. The ideal client base for eHospital is Healthcare facilities, multi-specialty clinics, and medical practitioners. Multi-Location functionality allows your hospitals, satellite clinics, and medical stores to be interconnected. Traditional approaches encompass paper-based information processing as well as resident work position and mobile data acquisition and presentation. The customizable alert software sends the text, IM, and email reminders and improves the quality of patient care. This hospital management software helps you to be aware of revenue streams, patient records, and other critical metrics in real-time at your fingertips. -
19
Pappyjoe
Dr. Toms International
PappyJoe: The Easiest & Efficient Clinic Management System. Now Doctors and the Clinics can manage Patient flow and keep accurate EMR and EHR records. Our color coded Calendar system makes the Patient management process much simpler. Choose either our cloud based online version or our premise based offline version. Fast track feature allows Doctors and staff to access information from a single window. Our advanced EMR systems retrieve treatment and billing related information in an instant. Never miss an appointment or face unannounced cancellations. Send automatic SMS/Email alerts to patients days before the session. Voted as the Best,Easy & Cost Effective Dental Software in the world by 'Dentistry International'. Access your data through our integrated mobile app for iOs and Android. All our products are secured using the state of the art 256 bit encryption technology.Starting Price: $16.00 per month -
20
Upvio
Upvio Healthtech
Upvio is the most seamless and efficient practice experience platform, created to streamline workflows, eliminate repetitive admin time, and drive success in a digital-first healthcare ecosystem. Upvio’s solution in the healthcare industry targets healthcare providers across various specialties and organizations of all sizes. Upvio is perfect to streamline and automate various operations and processes, such as appointment scheduling, telehealth, messaging, patient monitoring, and payments. It is designed to meet regulatory requirements and compliance standards, such as HIPAA and GDPR, and offers features specifically tailored to the healthcare industry, such as automated reminders, customizable forms, full telehealth features, a virtual waiting room, and remote vital signs assessment. It is an affordable solution with easy integration and support for varying levels of technical expertise, including dedicated account managers for setup and ongoing support.Starting Price: $39/user/month -
21
Clinicea
Clinicea
We're the best all-in-one, cloud-based, clinic management platform for growing, ambitious clinics. Clinicea is loved for its unique technology that can replicate paper to generate a super-specialised EMR for you. Deploy virtual assistants to get questionnaires filled, and consents signed. Already in use by 40 specialities across 5 continents. Engage 24x7. Deploy white labelled tools for Online Bookings, Patient Portals, Auto-Invoicing. There’s lots more. No apps, no downloads, just a click. Comprehensive, easy and does it all. Take a demo and see live what the next-generation technology can do for you.Starting Price: $59 per user per month -
22
Theralytics
Theralytics
Theralytics was created to provide ABA practices with a comprehensive, user-friendly practice management solution. Developed by Board Certified Behavior Analysts and healthcare technology experts, Theralytics simplifies the complexities of managing an ABA practice while ensuring top-level security and efficiency. Designed specifically for ABA providers, Theralytics offers an all-in-one platform to optimize operations with features like data collection, scheduling, billing, and real-time analytics. By streamlining workflows and enabling data-driven decision-making, ABA practices can focus more on delivering quality care. Plus, with its affordable pricing, Theralytics caters to practices of all sizes, offering a cost-effective solution that meets the unique needs of ABA management.Starting Price: $150 per month -
23
LifeLinkr
LifeLinkr
LifeLinkr (with over 15 years of customer experience) offers comprehensive IVF software for fertility clinics and patients. This platform streamlines and optimizes IVF treatment, improving patient outcomes and clinic efficiency. LifeLinkr aims to make IVF treatment more accessible and successful worldwide with innovative technology solutions and expert support always available. Unique Features Access clinic operations globally with LifeLinkr’s cloud-based platform. Advanced encryption ensures complete data security. Smooth data migration with no downtime for continuity. Gain comprehensive insights into patient journeys and histories Products and Services Offered IVF Software: Manages patient data, tracks treatments & streamlines clinic workflows Data Analytics: Provides insights for personalized treatment & improved success rates. Clinic Management Tools: Handles scheduling, billing and inventory efficiently.Starting Price: $25/month -
24
DeepScribe
DeepScribe
DeepScribe’s AI-powered scribe captures the natural conversation between a clinician and patient and automatically writes medical documentation, allowing clinicians to focus on patient care instead of note-taking. Through an easy-to-use mobile app, DeepScribe records the natural clinical encounter and transcribes it in real time. Our proprietary AI then extracts the medical information from the transcript, classifies it into a standard note, and then integrates that note directly into a clinician’s electronic health record system. Unlike traditional scribes, dictation tools, or other solutions, the ambient nature of DeepScribe means it doesn’t intrude on the patient visit or disrupt the clinical workflow. Providers can simply talk to their patient like normal, then review their notes after the visit and sign-off in their EHR. DeepScribe handles documentation, charting, and even populates suggested diagnostic coding based on the information extracted from the visit. -
25
NextGen Healthcare EHR
NextGen Healthcare
NextGen Healthcare provides ambulatory practices of all sizes award-winning solutions along with dedicated support and professional services. We align with your goals to achieve the success that results in healthier patients and happier providers. NextGen® Enterprise EHR offers your practice configurable clinical content, intuitive workflows, and an integrated patient experience platform that incorporates telehealth. With NextGen® Mobile, your providers’ smartphones become an extension of your EHR, which saves valuable time. Managed cloud hosting keeps your practice secure and makes upgrades easy, though on-premise options are also available. NextGen® Office is a cloud-based EHR designed to support your practice growth, save staff time, and increase patient volume. This fully integrated clinical and billing platform features specialty-specific EHR content, mobile accessibility, a revenue cycle management system, and a convenient patient portal. -
26
eMedicalPractice
eMedicalPractice
eMedPractice is a cloud-based software system designed to streamline healthcare management functions. Our comprehensive solution begins with the seamless integration of our robust Electronic Health Records (EHR), Practice Management (PM) and Revenue Cycle Management (RCM) modules into one unified platform. This powerful combination of features is just the beginning. We offer a full suite of solutions and services to help you practice with efficiency and optimize workflows. Whether you're a small practice or a large healthcare organization, eMedPractice can help you save time, reduce costs, and enhance patient care. With our clinician-first software, you can manage patient data, automate administrative tasks, and improve revenue generation.Starting Price: $199.00/month -
27
HelloNote
HelloNote
The only practice management solution with integrated EMR to enhance workflow, efficiency, and patient care. Built by therapists for occupational, physical, and speech therapists! Easy accessibility, secure, and works on most browsers. Access patient records from anywhere. Our calendar integrates with appointment booking and documentation to easily track your office flow. Users can enter their own information before visiting your office to ease their experience and streamline your intake process. HelloNote allows you to spend more time with your patients. From the start of your workday, to the end. We don’t break the bank. Priced to work with your practice. No hidden fees or set-up fees. Ever. No need for rulers, we have graphs and charts to plot your data and track productivity. From generating patient Reports to billing, and beyond. From password protection, to lightning fast servers with daily backups. We’ll keep you and your data safe.Starting Price: $49 per month -
28
GreenSense Billing
GreenSense Billing
GreenSense Billing Medical Scheduling tool that simplifies your day conveniently for all your medical scheduling needs. You would never have to worry about your medical billing hassles ever again. Insurance Eligibility Verification Find out about any insurance coverage before the patient makes an appointment. With our eEligibility verification tool you can run queries for individual cases as well as run a batch. Appointment Alerts and Reminders Reduce delays and late arrivals with automated alert reminders. Notify your patients before each appointment to avoid late arrivals and no-shows. Snapshot Your Medical Schedule In the Instant view, you can see the number of your daily medical appointments for each provider and for any particular practice location.Starting Price: 3% -
29
Ambra Health
Ambra Health
Ambra Health is a sophisticated cloud-based medical data and image management platform for hospitals, radiology practices, medical groups, and contract research organizations. Scalable, intuitive, and highly interoperable, the Ambra Health software empowers healthcare providers to improve collaboration by allowing efficient image exchange with their patients and departments. Ambra’s secure storage solution enables users to save all imaging within a single repository and allows them to store various types of medical imaging file formats including TFF, JPEG, DOC, and more. Core features include EMR HL7 Bridge, PACS integration, Cloud VNA, EMR / EHR integration, telestroke, informatics-first migration, and more. -
30
Mediclinic
Mediclinic
Medical or Any Business. A revolution where you do not need to switch software. You can use your own unique QR code to have new and existing clients /patients connect with you. Just add our API. Online Bookings, Mobile App where Patients can SHARE docs, upload to you directly & get invoices. Mobile App for Provider and Patient keep Patients connected & loyal to you. Get instant notifications to admin, and Provider. The patient can add info, verify vaccination, consent, store & communicate personal info, and comply with Privacy Laws. Add small video files and pictures to your Online Shop and stock management. Easy way to sell any products, services or anything at all. (Mediclinic is so flexible we even have restaurants using our software for this purpose). The MOST Secure, Totally Free, communication platform with call & video with fully end-to-end encryption for all users- Chat & Video call is already integrated within the Software. No need for third party software.Starting Price: $25 per month
