#=GF ID RepB_primase_C
#=GF AC PF22448.2
#=GF DE RepB DNA-primase C-terminal helical domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE ECOD:EF14973
#=GF GA 26.10 26.10;
#=GF TC 26.40 26.50;
#=GF NC 26.00 25.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RC Paper describing PDB structure 3h20
#=GF RN [1]
#=GF RM 19416864
#=GF RT Structure and function of primase RepB' encoded by
#=GF RT broad-host-range plasmid RSF1010 that replicates exclusively in
#=GF RT leading-strand mode.
#=GF RA Geibel S, Banchenko S, Engel M, Lanka E, Saenger W;
#=GF RL Proc Natl Acad Sci U S A. 2009;106:7810-7815.
#=GF DR INTERPRO; IPR054366;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC RepB_primase is a DNA-primase produced by P4-like phages. It is
#=GF CC a zinc-independent primase unlike Pri-type primases. It takes up
#=GF CC a dumbbell shaped consisting of an N-terminal catalytic domain
#=GF CC separated by a long alpha-helix plus tether and a C-terminal
#=GF CC helical-bundle domain. Primases are necessary for phage
#=GF CC replication. RepBprime primases such as in this family
#=GF CC recognise both ssiA and ssiB, ie only 1 single-stranded primase
#=GF CC initiation site on each strand, independently of each other and
#=GF CC then synthesise primers that are elongated by DNA polymerase
#=GF CC III. The phage is thus replicated exclusively in leading strand
#=GF CC mode [1].
#=GF SQ 57
#=GS A0A9W6D0V1_9BACT/115-160 AC A0A9W6D0V1.1
#=GS A0A2Z6E0W6_HYDTE/245-298 AC A0A2Z6E0W6.1
#=GS A1VWM7_POLNA/461-515 AC A1VWM7.1
#=GS U9VYL2_9CYAN/146-200 AC U9VYL2.1
#=GS A0A4U0PGE3_9NEIS/808-862 AC A0A4U0PGE3.1
#=GS A0AA37MGH5_9HYPH/417-470 AC A0AA37MGH5.1
#=GS A0A5K8A658_9BACT/199-253 AC A0A5K8A658.1
#=GS A0A1S2VKB4_9BACT/200-253 AC A0A1S2VKB4.1
#=GS C7NP03_HALUD/220-270 AC C7NP03.1
#=GS A0A0M9E1X1_9BACT/194-248 AC A0A0M9E1X1.1
#=GS A0A1Y4CZV7_9BACT/241-295 AC A0A1Y4CZV7.1
#=GS A0A0N0UZM9_9BACT/99-153 AC A0A0N0UZM9.1
#=GS B4WV80_SYNS7/486-537 AC B4WV80.1
#=GS A0A840MPH5_9PROT/787-841 AC A0A840MPH5.1
#=GS K9SN24_9CYAN/341-394 AC K9SN24.1
#=GS A0A257CCQ7_9BURK/676-728 AC A0A257CCQ7.1
#=GS A0A3B7A6C6_9RHOO/736-789 AC A0A3B7A6C6.1
#=GS K9SP96_9CYAN/440-493 AC K9SP96.1
#=GS K9SPR7_9CYAN/133-186 AC K9SPR7.1
#=GS L8LYG1_9CYAN/1005-1057 AC L8LYG1.1
#=GS A0A848FLC5_9BURK/257-311 AC A0A848FLC5.1
#=GS A0A6P2FSL5_9BURK/243-296 AC A0A6P2FSL5.1
#=GS A0A848FIQ4_9BURK/2-56 AC A0A848FIQ4.1
#=GS A0A1W2EYV2_9BACT/205-259 AC A0A1W2EYV2.1
#=GS A0AA91GEJ1_9CYAN/180-233 AC A0AA91GEJ1.1
#=GS A0A0M9E5N9_9BACT/161-215 AC A0A0M9E5N9.1
#=GS A0A0M9E9K4_9BACT/24-78 AC A0A0M9E9K4.1
#=GS D3NQL2_AZOS1/816-869 AC D3NQL2.1
#=GS A0A0K6H9L6_9NEIS/786-840 AC A0A0K6H9L6.1
#=GS A0A8H3WV75_GIGMA/678-731 AC A0A8H3WV75.1
#=GS G1UWJ3_9BACT/4-57 AC G1UWJ3.1
#=GS A0A103E3Y1_9BURK/133-171 AC A0A103E3Y1.1
#=GS A0A939GDZ6_9BACT/225-278 AC A0A939GDZ6.1
#=GS A0A6M8SW76_9NEIS/394-437 AC A0A6M8SW76.1
#=GS K9SN36_9CYAN/571-624 AC K9SN36.1
#=GS A0A9W6D4Q3_9BACT/89-143 AC A0A9W6D4Q3.1
#=GS A0A6S7DFV9_9BURK/774-830 AC A0A6S7DFV9.1
#=GS A0A848FIR5_9BURK/630-670 AC A0A848FIR5.1
#=GS A0A5K7ZCM7_9BACT/199-253 AC A0A5K7ZCM7.1
#=GS A0AA34SBE1_9RHOB/241-296 AC A0AA34SBE1.1
#=GS A0A1W2CX18_9BACT/205-259 AC A0A1W2CX18.1
#=GS A0A2I0CLM7_9PSED/787-841 AC A0A2I0CLM7.1
#=GS A0A3P1XYI1_9BACT/908-972 AC A0A3P1XYI1.1
#=GS L8LYG1_9CYAN/440-493 AC L8LYG1.1
#=GS A0A7V8NN48_9BACT/245-297 AC A0A7V8NN48.1
#=GS A1WLS8_VEREI/1-54 AC A1WLS8.1
#=GS A0A1K1LHV0_9BACT/657-711 AC A0A1K1LHV0.1
#=GS A0A4V3D4S1_9BURK/786-840 AC A0A4V3D4S1.1
#=GS K9SN24_9CYAN/194-245 AC K9SN24.1
#=GS A0A2Z5GB31_9BACT/193-242 AC A0A2Z5GB31.1
#=GS A0A1Y6DCT9_9GAMM/236-289 AC A0A1Y6DCT9.1
#=GS A0A3N6N0L1_9BURK/775-825 AC A0A3N6N0L1.1
#=GS A0A2Z5GBD3_9BACT/427-483 AC A0A2Z5GBD3.1
#=GS A0A221KJW0_VITFI/808-862 AC A0A221KJW0.1
#=GS A0A2Z5GAG0_9BACT/1454-1510 AC A0A2Z5GAG0.1
#=GS A0A6P1J4S3_9BURK/243-296 AC A0A6P1J4S3.1
#=GS S0G2I9_9BACT/203-257 AC S0G2I9.1
A0A9W6D0V1_9BACT/115-160 .dn--ESTTDFAYALSLARRG.FSDDQIRQRILSERTDWSNHKGE...........K------------eskt.
A0A2Z6E0W6_HYDTE/245-298 ..t-DYSRLDWMIVTEMLEQG.FSVAAVEVAMREASPLLEERKKG...........HIDDYITRTVTKA.....
A1VWM7_POLNA/461-515 ..v-NLSRVDSMIAVRLRVTG.HAQEAIADALRLCAPGIRETLET..........rDWLAYARRAARFA.....
U9VYL2_9CYAN/146-200 enr---KNADHEIASRMLIAG.FSEKQTAQTIAQASPNAANIKSQ..........dGRKAYGQEAVKKA.....
A0A4U0PGE3_9NEIS/808-862 ..i-DLSRVDSMIAVRLRATG.HGQDEIATVLEACAPSIRTADEG..........rNWHDYAQRTARYA.....
A0AA37MGH5_9HYPH/417-470 ..p-DPSRVDALIARRLRATG.HDEAAVAALITACAPGVPRIGRH...........AWQGYGWRAAAHA.....
A0A5K8A658_9BACT/199-253 ..g-DESATDFAYALALLRRG.TDPEVIADRLLQERKDWTHHKGQ..........rRQAAYLQRTIRRA.....
A0A1S2VKB4_9BACT/200-253 ..n-STSEYDFARVCSLIRLG.WSDQQIITELTETSPDIRSRKGK...........HTDTYIRRTIQAA.....
C7NP03_HALUD/220-270 ..p-STSEADMATVSMLLVWG.FSEVDIADIMRACRPRVKLRD--...........-RDDYLTNTITN-t....
A0A0M9E1X1_9BACT/194-248 ...KDQSATDFSYALALIRRG.YTDAQIENLIKMERLDFKNHSGE..........kRMAYYLKITIKRA.....
A0A1Y4CZV7_9BACT/241-295 ...EDYSRVDAMIALRMRANG.HSREAVEETIRACAPTIREKQTG..........rNWQRYAERTSDYA.....
A0A0N0UZM9_9BACT/99-153 ...DDPSATDFSFVLALLRTG.HTEQQIEQRIIMERPDFRNHQGE..........kRKQQYIERTIKRA.....
B4WV80_SYNS7/486-537 ...KDVRTNDMAIASRALEAG.YSPVEVKAVIAQNSPHAKSLRG-...........-PDTYGARTVEKA.....
A0A840MPH5_9PROT/787-841 ...VDLSRVDSMIAVRMRVTG.HDQAAIEGAIRQCAPATRQKDEG..........rDWNDYAQRTARYA.....
K9SN24_9CYAN/341-394 ..k-IPSIIDQKISANMYVTG.FDREEINEALDSHSPRIHGRTES...........YKQNYFDQHITP-t....
A0A257CCQ7_9BURK/676-728 ...VDESRVDFQASMVMFADG.WTESETMEGLMSSSPALSGRHL-...........DTGAYALRTVQRA.....
A0A3B7A6C6_9RHOO/736-789 ..p-DWSEVDFLACRELAKKG.WNTERLENALYATSPELHDRKRG...........HESDYIRRTVTAA.....
K9SP96_9CYAN/440-493 ..g-IYHSADRLIAQKLAQRG.YSKESIRNAIARASPELMNQAPE...........GRKSYIRRLVQR-v....
K9SPR7_9CYAN/133-186 .kg--GIKADRDIARKLVAAG.FTKKQVANAIAKHSPVCAKCTRG...........QRVDYIRKYIAPA.....
L8LYG1_9CYAN/1005-1057 ..d-KAINNDRGIASTMRAAG.YQRAEIREAIEQASPQTANLSKE...........EAKGYFYD-----klfs.
A0A848FLC5_9BURK/257-311 ...VDFERVDWAIATHLAKSGrYSRQEIERALHEGSPHIEHGQPG...........GIEGYARRTAAQA.....
A0A6P2FSL5_9BURK/243-296 ..f-DASRADWMAAVAMFRKG.YAFQDVADAIAQHSPGIDGRKGA...........AVADYVTRTAGKA.....
A0A848FIQ4_9BURK/2-56 ...VDFERMDWAIALHLAKSGhYARADIERALREGSPHIEHGRPG...........GIEDYARQVSERA.....
A0A1W2EYV2_9BACT/205-259 ..g-DESATDFAYAVALFRRG.MHENDVKCRILEQRDEWKNHSGQ..........rQKEAYLNRTLCK-a....
A0AA91GEJ1_9CYAN/180-233 ..f-DDSKADFIITCDLLRIG.ITENIIKNTLKKTSPNLETRKIG...........HIEDYLDRTIAAA.....
A0A0M9E5N9_9BACT/161-215 .gn--ESSTDFAYTLALIRCG.YTDSQIKNRLLSERNNWDNHVGD..........kKIMQYLKRTIQKA.....
A0A0M9E9K4_9BACT/24-78 ..g-DNSSADLSYAIALFRRG.NSENEIINAIIRERSNWNNHKGK..........kRLEEYLIRTVRRA.....
D3NQL2_AZOS1/816-869 ..g-DQSARDYGAALALLRRG.YTDEQVAAAMRQASPHAEQHRSS...........RDFDYAEHTVAKA.....
A0A0K6H9L6_9NEIS/786-840 ...VDLSRVDSMIAVRMRVTG.HDQAAIEGAIRQCAPATRQKDEG..........rDWNDYAQRTARYA.....
A0A8H3WV75_GIGMA/678-731 ...MDMSRADFMICKDMAKQG.YSSEQLEQALTAASPELPTRKLG...........HEMDYCQRTVRA-v....
G1UWJ3_9BACT/4-57 ..a--RSRLDYMTALYLRCAG.YSKADVANGIYRHAPAPVDERGR..........nEKIDYGRQIVGHA.....
A0A103E3Y1_9BURK/133-171 ..a-----VDTQIARVMRRNG.FTREQVEAIIARQASRSARL---...........-------------aaadd
A0A939GDZ6_9BACT/225-278 .hs--FSEHDFGIVIGLVRKG.WDDDRIAAHLVAHSPNLSSRKKR...........YTGKYIARTIEKA.....
A0A6M8SW76_9NEIS/394-437 ...VDWKRVDFDAASSALQQR.RPQAEVIAAITACSPRCVNADSA...........-------------ekv..
K9SN36_9CYAN/571-624 .ee--GINADRDIAIKLFAAR.YSPSQIRTAIMKASPRCTGIDEQ...........QKLDYVRKFII--nr...
A0A9W6D4Q3_9BACT/89-143 .dn--ESTTDFAYALSLARRG.FSDDQIRQRILSERTDWSNHKGE..........kRIQDYLDRTIGR-v....
A0A6S7DFV9_9BURK/774-830 ..a-DPSRIDSLIAVRLRVTG.HSMADIEAAILFCGLGSRAPEAAa........erDWQAYARRTARYA.....
A0A848FIR5_9BURK/630-670 ...VDFERMDWAIALHLAKSGhYARADIERALREGSPHIEHGR--...........-------------p....
A0A5K7ZCM7_9BACT/199-253 ..g-DDSATDFAYVLALLRQG.VDPEIITERLLNEREDWTHHKGE..........rRQTAYLKRTIRKA.....
A0AA34SBE1_9RHOB/241-296 tsq---SEIDWHFCFHAFRHG.YDVMQVTQGIMQFSPDISERKGSt.........eGAEQYAFYTAQKA.....
A0A1W2CX18_9BACT/205-259 ..g-DESATDFAFSMALFRRG.LNQNEVRRQILEQRTIWKNHSNP..........kQKDAYLNRTISKA.....
A0A2I0CLM7_9PSED/787-841 ...VDLSRLDSMIAVRMRVTG.HDQAAIEGAIRQCAPATRQKDEG..........rDWNDYAQRTARYA.....
A0A3P1XYI1_9BACT/908-972 ...MDCSQVDGMIGIRMRVTG.HTAGQVRSALERNGPEMRRRNMTagefaakyryrNWERYARETAE--nf...
L8LYG1_9CYAN/440-493 ..s-FYHSGDKYLAEKLAQRG.YSKEAIRRTLLRASPNLLNQVAS...........RRQSYLRSLVER-f....
A0A7V8NN48_9BACT/245-297 ..p-DWSIVDLWVARRLLSQR.WTPAQVHEILRLASPQFPRRHG-...........NPDDYLRRTVAHA.....
A1WLS8_VEREI/1-54 ...MDVSKADYMIGVDMARKG.FSPDQIGRAIEQASPELPTRKAG...........HEADYVARTVKA-v....
A0A1K1LHV0_9BACT/657-711 ...EDYSRVDAMIALRLRATG.HSRDAVMEAVRQCAPAIRETPAR..........rDWQRYAERTADYA.....
A0A4V3D4S1_9BURK/786-840 ...VDLSRVDSMIAVRMRVTG.HDQAAIEGAIRQCAPATRQKDEG..........rDWNDYAQRTARYA.....
K9SN24_9CYAN/194-245 .aa---ITADRQIARDMYVAG.LERGQISQAILQKSPQAQGLSKR...........IEARYIQET----tks..
A0A2Z5GB31_9BACT/193-242 ...-------SMIALRMRATH.HDRSAILAAILDGAPRSRPVDANh........nhQWEYYGQRTADSA.....
A0A1Y6DCT9_9GAMM/236-289 ..r-SPSEADWKLSVIALMNG.YGIDIVRQLIMEHSTGLQDRKKG...........HVEDYLARTVGKA.....
A0A3N6N0L1_9BURK/775-825 ..l-DISSIDAAIAVRLRVTG.YTRAEVEHALMSERAGEEARD--...........-WDGYARWA----adfa.
A0A2Z5GBD3_9BACT/427-483 ..i-DYSRLDSMIALRMRATH.HDRSDIQAAILDGAPRSRPADANp........nhQWEYYAQRTADSA.....
A0A221KJW0_VITFI/808-862 ..i-DLSRVDSMIAVRLRATG.HGQDEIATVLEACAPSIRTTDEG..........rNWHDYAQRTARYA.....
A0A2Z5GAG0_9BACT/1454-1510 ..i-DYSRLDSMIALRMRATH.HDRSAIEAAILDGAPRSRPADANh........nhQWEYYAQRTADSA.....
A0A6P1J4S3_9BURK/243-296 ..f-DASRADWMAAVAMFRKG.YAFQDVADAIAQHSPGIDGRKGA...........AVADYVTRTAGKA.....
S0G2I9_9BACT/203-257 .gn--ESATDFAYALALYRRG.FIRTEIYNRIIQERQDWRNHAGE..........qKKIHYLTRTLLK-a....
#=GC seq_cons ....D.SpsDhhlAlphhtpG.aspsplpsslhpsuPphpscctt...........phpsYhpRThptA.....
//
