ID NTDP_STRMU Reviewed; 177 AA.
AC Q8DSK1;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 18-JUN-2025, entry version 95.
DE RecName: Full=Nucleoside triphosphate/diphosphate phosphatase {ECO:0000255|HAMAP-Rule:MF_01568};
DE EC=3.6.1.15 {ECO:0000255|HAMAP-Rule:MF_01568};
DE EC=3.6.1.6 {ECO:0000255|HAMAP-Rule:MF_01568};
GN OrderedLocusNames=SMU_1781;
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159;
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC -!- FUNCTION: Has nucleoside phosphatase activity towards nucleoside
CC triphosphates and nucleoside diphosphates. {ECO:0000255|HAMAP-
CC Rule:MF_01568}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC diphosphate + phosphate + H(+); Xref=Rhea:RHEA:23680,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01568};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-
CC phosphate + phosphate + H(+); Xref=Rhea:RHEA:36799,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01568};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01568};
CC -!- SIMILARITY: Belongs to the Ntdp family. {ECO:0000255|HAMAP-
CC Rule:MF_01568}.
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DR EMBL; AE014133; AAN59408.1; -; Genomic_DNA.
DR RefSeq; NP_722102.1; NC_004350.2.
DR RefSeq; WP_002263684.1; NC_004350.2.
DR AlphaFoldDB; Q8DSK1; -.
DR SMR; Q8DSK1; -.
DR STRING; 210007.SMU_1781; -.
DR KEGG; smu:SMU_1781; -.
DR PATRIC; fig|210007.7.peg.1589; -.
DR eggNOG; COG3557; Bacteria.
DR HOGENOM; CLU_109787_1_0_9; -.
DR OrthoDB; 1645325at2; -.
DR PhylomeDB; Q8DSK1; -.
DR Proteomes; UP000002512; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.380.10; FomD-like; 1.
DR HAMAP; MF_01568; Ntdp; 1.
DR InterPro; IPR007295; DUF402.
DR InterPro; IPR035930; FomD-like_sf.
DR InterPro; IPR050212; Ntdp-like.
DR InterPro; IPR016882; SA1684.
DR NCBIfam; NF010183; PRK13662.1; 1.
DR PANTHER; PTHR39159; -; 1.
DR PANTHER; PTHR39159:SF1; UPF0374 PROTEIN YGAC; 1.
DR Pfam; PF04167; DUF402; 1.
DR PIRSF; PIRSF028345; UCP028345; 1.
DR SUPFAM; SSF159234; FomD-like; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT CHAIN 1..177
FT /note="Nucleoside triphosphate/diphosphate phosphatase"
FT /id="PRO_0000248120"
FT ACT_SITE 23
FT /note="Proton donor"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
FT BINDING 87
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
FT BINDING 103
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
FT BINDING 105
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
FT BINDING 107
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
FT BINDING 107
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
FT BINDING 120
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
FT BINDING 123
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01568"
SQ SEQUENCE 177 AA; 21005 MW; 8F8D3E04B5EF19FA CRC64;
MKLPKEGDFI TIQSYKHDGS LHRTWRDTMV LKTTENAVIG VNDHTLVTES DGRRWVTREP
AIVYFHKKFW FNIIAMIRDN GVSYYCNLAS PYIMDQEALK YIDYDLDVKV FADGEKKLLD
VDEYELHKQK MGYSSDIDYI LKENVKILVD WINNGKGPFS QSYINIWYKR YLELKNR
//
