KEGG   NETWORK: N01688
Entry
N01688                      Network                                
Name
ADRB3-UCP1 signaling pathway
Definition
ADRB3 -> GNAS -> ADCY -> cAMP -> PKA -> JMD1A+SWI/SNF+PPARG => UCP1
  Expanded
155 -> 2778 -> 107,108,109,196883,111,112,113,114,115 -> C00575 -> 5566,5567,5568 -> (55818,51780)+(51412,57492,60,6595,6597,6598,6599,6601,6602,6603,6604,6605,71,8110,8193,8289,86)+5468 => 7350
Class
nt06529 Thermogenesis
Type
Reference
Pathway
hsa04714  Thermogenesis
Gene
155  ADRB3; adrenoceptor beta 3
2778  GNAS; GNAS complex locus
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
55818  KDM3A; lysine demethylase 3A
51780  KDM3B; lysine demethylase 3B
51412  ACTL6B; actin like 6B
57492  ARID1B; AT-rich interaction domain 1B
60  ACTB; actin beta
6595  SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
6597  SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
6598  SMARCB1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
6599  SMARCC1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
6601  SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
6602  SMARCD1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
6603  SMARCD2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
6604  SMARCD3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
6605  SMARCE1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
71  ACTG1; actin gamma 1
8110  DPF3; double PHD fingers 3
8193  DPF1; double PHD fingers 1
8289  ARID1A; AT-rich interaction domain 1A
86  ACTL6A; actin like 6A
5468  PPARG; peroxisome proliferator activated receptor gamma
7350  UCP1; uncoupling protein 1
Metabolite
C00575  3',5'-Cyclic AMP
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:30603371
  Authors
Inagaki T
  Title
Histone demethylases regulate adipocyte thermogenesis.
  Journal
Diabetol Int 9:215-223 (2018)
DOI:10.1007/s13340-018-0366-y
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