KEGG   NETWORK: N01934
Entry
N01934                      Network                                
Name
L1CAM interactions
Definition
(L1CAM,CNTN1/2) == L1CAM -> (ANK2/3+SPTAN1+SPTBN),(EZR+ACTB,ACTG1),(FGFR2,KDR),(MAP2+(TUBA+TUBB))
  Expanded
(3897,1272,6900) == 3897 -> (287,288+6709+6711,6712,57731,51332),(7430+60,71),(2263,3791),(4133+(7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06546 IgSF CAM signaling
Type
Reference
Pathway
hsa04517 IGSF CAM signaling   
Gene
3897  L1CAM; L1 cell adhesion molecule
1272  CNTN1; contactin 1
6900  CNTN2; contactin 2
287  ANK2; ankyrin 2
288  ANK3; ankyrin 3
6709  SPTAN1; spectrin alpha, non-erythrocytic 1
6711  SPTBN1; spectrin beta, non-erythrocytic 1
6712  SPTBN2; spectrin beta, non-erythrocytic 2
57731  SPTBN4; spectrin beta, non-erythrocytic 4
51332  SPTBN5; spectrin beta, non-erythrocytic 5
7430  EZR; ezrin
60  ACTB; actin beta
71  ACTG1; actin gamma 1
2263  FGFR2; fibroblast growth factor receptor 2
3791  KDR; kinase insert domain receptor
4133  MAP2; microtubule associated protein 2
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Reference
PMID:29444459
  Authors
Hillen AEJ, Burbach JPH, Hol EM
  Title
Cell adhesion and matricellular support by astrocytes of the tripartite synapse.
  Journal
Prog Neurobiol 165-167:66-86 (2018)
DOI:10.1016/j.pneurobio.2018.02.002
Reference
PMID:31455004
  Authors
Maten MV, Reijnen C, Pijnenborg JMA, Zegers MM
  Title
L1 Cell Adhesion Molecule in Cancer, a Systematic Review on Domain-Specific Functions.
  Journal
Int J Mol Sci 20:ijms20174180 (2019)
DOI:10.3390/ijms20174180
Reference
PMID:33451101
  Authors
Kalafatakis I, Savvaki M, Velona T, Karagogeos D
  Title
Implication of Contactins in Demyelinating Pathologies.
  Journal
Life (Basel) 11:life11010051 (2021)
DOI:10.3390/life11010051
Reference
PMID:33585481
  Authors
Duncan BW, Murphy KE, Maness PF
  Title
Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization.
  Journal
Front Cell Dev Biol 9:625340 (2021)
DOI:10.3389/fcell.2021.625340
Reference
PMID:26909348
  Authors
Leshchyns'ka I, Sytnyk V
  Title
Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.
  Journal
Front Cell Dev Biol 4:9 (2016)
DOI:10.3389/fcell.2016.00009
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