Homo sapiens (human): 2342
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Entry
2342 CDS
T01001
Symbol
FNTB, FPTB
Name
(RefSeq) farnesyltransferase, CAAX box, subunit beta
KO
K05954
protein farnesyltransferase subunit beta [EC:
2.5.1.58
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00900
Terpenoid backbone biosynthesis
Drug target
Lonafarnib:
D04768
<JP/US>
Tipifarnib:
D03720
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
2342 (FNTB)
09180 Brite Hierarchies
09181 Protein families: metabolism
01006 Prenyltransferases [BR:
hsa01006
]
2342 (FNTB)
Enzymes [BR:
hsa01000
]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.58 protein farnesyltransferase
2342 (FNTB)
Prenyltransferases [BR:
hsa01006
]
Protein prenylation
Farnesyltransferase/geranylgeranyltransferase 1
2342 (FNTB)
BRITE hierarchy
SSDB
Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Prenyltrans
SQHop_cyclase_C
Motif
Other DBs
NCBI-GeneID:
2342
NCBI-ProteinID:
NP_002019
OMIM:
134636
HGNC:
3785
Ensembl:
ENSG00000257365
UniProt:
P49356
A0A384MEJ5
Structure
PDB
PDBj
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All DBs
Position
14:64986895..65062650
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AA seq
437 aa
AA seq
DB search
MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
NT seq
1314 nt
NT seq
+upstream
nt +downstream
nt
atggcttctccgagttctttcacctactattgccctccatcttcctcccccgtctggtca
gagccgctgtacagtctgaggcccgagcacgcgcgagagcggttgcaggacgactcggtg
gaaacagtcacgtccatagaacaggcaaaagtagaagaaaagatccaagaggtcttcagt
tcttacaagttcaaccaccttgtaccaaggcttgttttgcagagggagaagcacttccat
tatctgaaaagaggccttcgacaactgacagatgcctatgagtgtctggatgccagccgc
ccatggctctgctattggatcctgcacagcttggaactgctagatgaacccatcccccag
atagtggctacagatgtgtgtcagttcctggagctgtgtcagagcccagaaggtggcttt
ggaggaggacccggtcagtatccacaccttgcacccacatatgcagcagtcaatgcattg
tgcatcattggcaccgaggaggcctatgacatcattaacagagagaagcttcttcagtat
ttgtactccctgaagcaacctgacggctcctttctcatgcatgtcggaggtgaggtggat
gtgagaagcgcatactgtgctgcctccgtagcctcgctgaccaacatcatcactccagac
ctctttgagggcactgctgaatggatagcaaggtgtcagaactgggaaggtggcattggc
ggggtaccagggatggaagcccatggtggctataccttctgtggcctggccgcgctggta
atcctcaagagggaacgttccttgaacttgaagagcttattacaatgggtgacaagccgg
cagatgcgatttgaaggaggatttcagggccgctgcaacaagctggtggatggctgctac
tccttctggcaggcggggctcctgcccctgctccaccgcgcactgcacgcccaaggtgac
cctgcccttagcatgagccactggatgttccatcagcaggccctgcaggagtacatcctg
atgtgctgccagtgccctgcgggggggcttctggataaacctggcaagtcgcgtgatttc
taccacacctgctactgcctgagcggcctgtccatagcccagcacttcggcagcggagcc
atgttgcatgatgtggtcctgggtgtgcccgaaaacgctctgcagcccactcacccagtg
tacaacattggaccagacaaggtgatccaggccactacatactttctacagaagccagtc
ccaggttttgaggagcttaaggatgagacatcggcagagcctgcaaccgactag
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