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Bioinformatics, Volume 41
Volume 41, Number 1, 2025
- Daniel Mechtersheimer

, Wenze Ding
, Xiangnan Xu
, Sanghyun Kim, Carolyn Sue, Yue Cao
, Jean Y. H. Yang
:
IMPACT: interpretable microbial phenotype analysis via microbial characteristic traits.
Volume 41, Number 3, 2025
- Rawan Shraim

, Brian Mooney, Karina L. Conkrite, Amber K. Hamilton, Gregg B. Morin
, Poul H. Sorensen, John M. Maris, Sharon J. Diskin
, Ahmet Sacan:
ImmunoTar - integrative prioritization of cell surface targets for cancer immunotherapy.
Volume 41, Number 4, 2025
- Zhuoyu Wei, Yongqi Shen, Xiang Tang, Jian Wen, Youyi Song, Mingqiang Wei, Jing Cheng, Xiaolei Zhu

:
AVPpred-BWR: antiviral peptides prediction via biological words representation.
Volume 41, Number 7, 2025
- Sicen Liu

, Shutao Chen, Tao Bai, Bin Liu
:
FusionEncoder: identification of intrinsically disordered regions based on multi-feature fusion. - Meiling Liu, Shuangshuang Wang, Zeyu Luo

, Guohua Wang, Yuming Zhao:
Multistage attention-based extraction and fusion of protein sequence and structural features for protein function prediction.
Volume 41, Number 9, 2025
- Asato Yoshinaga, Osamu Maruyama

:
CDACHIE: chromatin domain annotation by integrating chromatin interaction and epigenomic data with contrastive learning. - Tianci Wang, Xin Lai, Shenjie Wang, Yuqian Liu, Xiaoyan Zhu, Jiayin Wang

:
MRDagent: iterative and adaptive parameter optimization for stable ctDNA-based MRD detection in heterogeneous samples. - Tong Wang

, Zhi-Ping Liu
:
getDNB: identifying dynamic network biomarkers of hepatocellular carcinoma from time-varying gene regulations utilizing graph embedding techniques for anomaly detection. - Helena García-Cebollada

, Alfonso López, Vladimir Espinosa Angarica, Juan José Galano-Frutos
, Javier Sancho:
ProteinLIPs: a web server for identifying highly polar and poorly packed interfaces in proteins. - Carl M. Kobel, Velma T. E. Aho, Ove Øyås, Niels Nørskov-Lauritsen, Ben J. Woodcroft

, Phillip B. Pope
:
CompareM2 is a genomes-to-report pipeline for comparing microbial genomes. - Shuang Wang, Tianle Ma, Kaiyu Dong, Peifu Han, Xue Li

, Junteng Ma, Mao Li, Tao Song:
MVSO-PPIS: a structured objective learning model for protein-protein interaction sites prediction via multi-view graph information integration. - Joseph L. Hellerstein

, Lucian P. Smith, Lillian T. Tatka, Steven S. Andrews
, Michael A Kochen, Herbert M. Sauro
:
Discovering subnetworks in SBML models. - Ryan R. Wick, Benjamin P. Howden, Timothy P. Stinear

:
Autocycler: long-read consensus assembly for bacterial genomes. - Johannes Hingerl

, Alexander Karollus
, Julien Gagneur
:
Flashzoi: an enhanced Borzoi for accelerated genomic analysis. - Ke Yan

, Shutao Chen, Bin Liu, Hao Wu:
Accurate prediction of toxicity peptide and its function using multi-view tensor learning and latent semantic learning framework. - Xiang Liu, Yi-Han Tang

, James Blachly, Stephen Edge, Yasminka A Jakubek, Martin McCarter, Abdul Rafeh Naqash, Kenneth G. Nepple
, Afaf Osman, Matthew J. Reilley, Gregory Riedlinger, Bodour Salhia, Bryan P. Schneider, Craig Shriver, Michelle L. Churchman, Robert J. Rounbehler, Jamie K. Teer, Nancy Gillis, Mingxiang Teng:
qcCHIP: an R package to identify clonal hematopoiesis variants using cohort-specific data characteristics. - Sebastian Persson

, Fabian Fröhlich, Stephan Grein
, Torkel Loman, Damiano Ognissanti, Viktor Hasselgren, Jan Hasenauer, Marija Cvijovic
:
PEtab.jl: advancing the efficiency and utility of dynamic modelling. - Seokjun On

, Yujin Jeong
, Eun-Sol Kim:
Structure-guided sequence representation learning for generalizable protein function prediction.
Volume 41, Number 10, 2025
- Armin Rauschenberger

, Petr V. Nazarov
, Enrico Glaab
:
Estimating sparse regression models in multi-task learning and transfer learning through adaptive penalisation. - Marcos Lopez-De-Castro

, Alberto García-Galindo
, José González-Gomariz
, Rubén Armañanzas
:
Conformal inference for reliable single cell RNA-seq annotation. - Daniel Kim

, Carissa Chen, Lijia Yu
, Jean Yee Hwa Yang
, Pengyi Yang
:
CLUEY enables knowledge-guided clustering and cell type detection from single-cell omics data. - Wouter Duverger

, Georg Ramer
, Nikolaos N. Louros
, Joost Schymkowitz
, Frederic Rousseau
:
AXZ viewer: a web application to visualize unprocessed AFM-IR data. - L. Moritz Blumer

, Jeffrey M. Good, Richard Durbin
:
WinPCA: a package for windowed principal component analysis. - Chunfeng He, Yue Xu

, Yuan Zhou, Jiayao Fan, Chunxiao Cheng, Ran Meng, Lang Wu
, Ruiyuan Pan, Ravi V. Shah, Eric R. Gamazon
, Dan Zhou
:
Integrating population-level and cell-based signatures for drug repositioning. - Qicheng Zhao

, Anji Deng, Qihuang Zhang
:
DiSTect: a Bayesian model for disease-associated gene discovery and prediction in spatial transcriptomics. - Cem Ata Baykara

, Ali Burak Ünal
, Nico Pfeifer, Mete Akgün
:
Privacy-preserving federated unsupervised domain adaptation with application to age prediction from DNA methylation data. - Austin M. Marcus, Jordan C. Rozum

, Herbert Sizek, Luis M. Rocha
:
CANA v1.0.0: efficient quantification of canalization in automata networks. - Shengli Zhang

, Jingyi Ren, Yunyun Liang:
An innovative peptide toxicity prediction model based on multi-scale convolutional neural network and residual connection. - Hongxin Xiang

, Mingquan Liu, Linlin Hou
, Shuting Jin
, Jianmin Wang
, Jun Xia
, Wenjie Du, Sisi Yuan, Xiangzheng Fu, Xinyu Yang, Li Zeng, Lei Xu
:
An image-based protein-ligand binding representation learning framework via multi-level flexible dynamics trajectory pre-training. - Xinyu Zhou, Yi Yan, Kevin Hu, Haixu Tang, Yijie Wang

, Lu Wang, Chi Zhang, Sha Cao
:
Predicting the trend of SARS-CoV-2 mutation frequencies using historical data. - Elias Dohmen

, Margaux Aubel
, Lars A Eicholt
, Paul Roginski
, Victor Luria
, Amir Karger
, Anna Grandchamp
:
DeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation. - Güliz Akkaya, Nesli Erdogmus, Mete Akgün:

PRISM: privacy-preserving rare disease analysis using fully homomorphic encryption. - Hung-Ching Chang, Yusi Fang, Michael T. Gorczyca

, Kayhan Batmanghelich, George C. Tseng
:
High-dimensional causal mediation analysis by partial sum statistic and sample splitting strategy in imaging genetics application. - Hukam C. Rawal, Qi Chen, Tong Zhou

:
FUSION: a family-level integration approach for robust differential analysis of small non-coding RNAs. - Trevor Schneggenburger

, Jaroslaw Zola
:
SKiM: accurately classifying metagenomic ONT reads in limited memory. - Daniel E. Schäffer

, Samuel Sledzieski
, Lenore Cowen
, Bonnie Berger:
Memory-efficient, accelerated protein interaction inference with blocked, multi-GPU D-SCRIPT. - Daphne van Ginneken

, Valentijn Tromp, Lucas Stalder, Tudor-Stefan Cotet, Sophie Bakker, Anamay Samant, Sai T. Reddy, Alexander Yermanos:
Delineating inter- and intra-antibody repertoire evolution with AntibodyForests. - Cecilia B. Rodriguez, Ronaldo Romario Tunque Cahui, Nicolás Demitroff, Layla Hirsh, Damien P. Devos

, Graciela Boccaccio, Gustavo D. Parisi
:
BAV-LLPS: a database of bacterial, archaea, and virus liquid-liquid phase separation proteins. - Evan Komp, Kristoffer E. Johansson, Nicholas Paul Gauthier, Japheth E. Gado, Kresten Lindorff-Larsen, Gregg T. Beckham

:
Accessible, uniform protein property prediction with a scikit-learn based toolset AIDE. - Dickson Aruhomukama:

Balancing complexity and clarity - towards clinician-ready antibiotic resistance prediction models. - Jiaqing Xie

, Yuqiang Li, Tianfan Fu:
DeepProtein: deep learning library and benchmark for protein sequence learning. - Yue Luo, Lei Deng:

MolCL-SP: a multimodal contrastive learning framework with non-overlapping substructure perturbations for molecular property prediction. - Suleiman Aminu

, Abdulaziz Ascandari, Rachid Benhida, Rachid Daoud:
GRUMB: a genome-resolved metagenomic framework for monitoring urban microbiomes and diagnosing pathogen risk. - Donn Liew, Akesha Dinuli Dharmatilleke, Edwin See, Ee Hou Yong

:
G4STAB: a multi-input deep learning model to predict G-quadruplex thermodynamic stability based on sequence and salt concentration. - Rok Kogoj, Mauro Petrillo

, Samo Zakotnik, Alen Suljic, Misa Korva
, Gabriele Leoni
:
Misdetection of frameshifts in SARS-CoV-2 genomes: need for additional harmonisation and efficient monitoring of data workflows. - Md Masud Rana

, Md. Nurul Haque Mollah
, Mohammed H. Albujja, Sibte Syed Hadi, Fan Liu
:
ToxAssay: a hierarchical model-driven tool for advanced toxicogenomics biomarker discovery. - Michael L. Sierk

, Daniel Danis, Sujay Patil, Nobal Kishor, Rajdeep Mondal, Abhishek Jha, Qingrong Chen, Chunhua Yan, Monica C. Munoz-Torres, Daoud M. Meerzaman, Peter N. Robinson
, Justin T. Reese:
Oncopacket: integration of cancer research data using GA4GH phenopackets. - Alexandre Boulay

, Emma Cremelie
, Clovis Galiez, Yves Briers, Elsa Rousseau, Roberto Vázquez Fernández
:
SPAED: harnessing AlphaFold output for accurate segmentation of phage endolysin domains. - Sunjae Lee

, Jaebeom Kim
, Milot Mirdita
, Cameron L. M. Gilchrist
, Martin Steinegger
:
Easy and interactive taxonomic profiling with Metabuli App. - Melis Gencel, David Gagné-Leroux, Adrian W. R. Serohijos

:
Doblin: inferring dominant clonal lineages from high-resolution DNA barcoding time series. - Wenzhe Xu, Xiaorong Liu, Jie Wang, Fan Zhang, Dongfeng Hu, Liansong Zong:

UAMRL: multi-granularity uncertainty-aware multimodal representation learning for drug-target affinity prediction. - Nigreisy Montalvo, Francisco Requena, Emidio Capriotti

, Antonio Rausell
:
Federated learning for the pathogenicity annotation of genetic variants in multi-site clinical settings. - Yurou Wang

, Zhixiang Lin, Tao Wang
:
InterVelo: a mutually enhancing model for estimating pseudotime and RNA velocity in multi-omic single-cell data. - Xiaoyi Liu, Na Zhang, Chenglong Kang, Chengwei Ai, Hongpeng Yang, Jijun Tang, Fei Guo:

HyperPhS: a pharmacophore-guided multimodal representation framework for metabolic stability prediction through contrastive hypergraph learning. - Thomas Minotto, Antoine Claessens, Thomas D. Otto:

Exploring homology detection via k-means clustering of proteins embedded with a large language model. - Saba Zerefa, Jesse Cool

, Pramesh Singh, Samantha Petti:
An interpretable alphabet for local protein structure search based on amino acid neighborhoods. - Bokeum Cho

, Seunggeun Lee:
PTL-PRS: an R package for transfer learning of polygenic risk scores with pseudovalidation. - Jinpu Li, Mauminah Raina, Yiqing Wang, Chunhui Xu, Li Su, Qi Guo, Ricardo Melo Ferreira, Michael T. Eadon, Qin Ma

, Juexin Wang, Dong Xu:
scBSP: a fast and accurate tool for identifying spatially variable features from high-resolution spatial omics data. - Alberto Cattaneo, Stephen Bonner

, Thomas Martynec, Edward R. Morrissey, Carlo Luschi, Ian P. Barrett, Daniel Justus:
The role of graph topology in the performance of biomedical Knowledge Graph Completion models. - Nele P. Quast

, Charlotte M. Deane
, Matthew I. J. Raybould
:
STCRpy: a software suite for T-cell receptor structure parsing, interaction profiling, and machine learning dataset preparation. - Mariia Pospelova, Yana Safonova

:
PatchWorkPlot: simultaneous visualization of local alignments across multiple sequences. - Zirui Chen, Jiao Hua, Lu Ba, Tianyun He, Boran Yang, Jing Qi, Shuilin Jin:

reDA: differential abundance testing on scATAC-seq data using random walk with restart. - Omri Peleg

, Maya Raytan, Elhanan Borenstein:
KADAIF: an anomaly detection method for complex microbiome data. - Pavel P. Kuksa

, Matei Ionita, Luke Carter, Jeffrey Cifello
, Prabhakaran Gangadharan, Kaylyn Clark, Otto Valladares, Yuk Yee Leung
, Li-San Wang:
BTS: a scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across >1000s of omics datasets. - Huiying Jiang, Wenlan Chen, Fei Guo, Cheng Liang:

Cancer survival prediction based on soft-label guided contrastive learning and global feature fusion. - Taushif Khan

, Mohammed Toufiq, Marina Yurieva, Nitaya Indrawattana, Akanitt Jittmittraphap, Nathamon Kosoltanapiwat, Pornpan Pumirat, Passanesh Sukphopetch
, Muthita Vanaporn, Karolina Palucka, Basirudeen Syed Ahamed Kabeer, Darawan Rinchai, Damien Chaussabel:
Automating candidate gene prioritization with large language models: from naive scoring to literature-grounded validation. - Shawn T. O'Neil

, Brian M. Schilder
, Kevin Schaper, Corey Cox, Daniel R. Korn, Sarah Gehrke
, Christopher J. Mungall, Melissa A. Haendel
:
monarchr: an R package for querying biomedical knowledge graphs.
Volume 41, Number 11, 2025
- Leo Hermet, Leo Laoubi

, Martial Scavino, Anne-Claire Doffin, Alexia Gazeu, Justine Berthet, Berenice Pillat, Stephanie Tissot, Sylvie Rusakiewicz, Marie-Cécile Michallet, Nathalie Bendriss-Vermare, Jenny Valladeau-Guilemond, Jean Hausser, Christophe Caux, Margaux Hubert
:
IntegrAlign: a comprehensive tool for multi-immunofluorescence panel integration through image alignment. - Tiberiu Totu, Rafael Riudavets Puig, Lukas Jonathan Häuser, Mattia Tomasoni

, Hella Anna Bolck, Marija Buljan
:
NOODAI: a webserver for network-oriented multi-omics data analysis and integration pipeline. - Amir Hassan Shariatmadari

, Alireza Jafari
, Sikun Guo
, Sneha Srinivasan
, Nathan C. Sheffield
, Aidong Zhang
, Kishlay Jha
:
ConceptDrift: leveraging spatial, temporal and semantic evolution of biomedical concepts for hypothesis generation. - Yu Xu

, Chonghao Wang, Ke Xu
, Yi Ding, Aiping Lyu, Lu Zhang
:
TRAFICA: an open chromatin language model to improve transcription factor binding affinity prediction. - Oscar Rojas Labra, Carla M. Martinez-Garcia, Nelly Beatriz Santoyo-Rivera, Daniel Montiel-Garcia, Vijay S. Reddy:

Viral Diseases Explorer: a webtool to identify viral disease information derived from multiple LLMs. - Enzo Battistella, Nick Jiang, Chris Rohlicek, Ilya Shlyakhter, Victoria Popic:

insilicoSV: a flexible grammar-based framework for structural variant simulation and placement. - Stefaan Verwimp, Rob Lavigne, Cédric Lood, Vera van Noort:

AFragmenter: schema-free, tuneable protein domain segmentation for AlphaFold protein structures. - Yanli Wang, Frimpong Boadu, Jianlin Cheng:

MPBind: a multitask protein binding site predictor using protein language models and equivariant GNNs. - Ryuichiro Nakato, Luis Augusto Eijy Nagai:

ShortCake: an integrated platform for efficient and reproducible single-cell analysis. - William Gilpin:

The cell as a token: high-dimensional geometry in language models and cell embeddings. - Melissa Van Norden, William Mangione, Zackary Falls, Ram Samudrala:

Strategies for robust, accurate, and generalizable benchmarking of drug discovery platforms. - Charles Tapley Hoyt, Klas Karis, Benjamin M. Gyori:

Assembly and reasoning over semantic mappings at scale for biomedical data integration. - Kangsheng Qi, Can Cenik:

Topological and functional characterization of human translation efficiency covariation network. - Feng Chen, Chunhe Li:

Reconstructing gene network structure and dynamics from single cell data. - Florestan De Moor, Olivier Boulle, Dominique Lavenier:

De-Bruijn graph partitioning for scalable and accurate DNA storage processing. - Philip Hartout, Dexiong Chen, Paolo Pellizzoni, Carlos G. Oliver, Karsten M. Borgwardt:

Endowing protein language models with structural knowledge. - Yangyang Chen, Zixu Wang, Pengyong Li, Li Zeng, Xiangxiang Zeng, Lei Xu:

ZeroGEN: leveraging language models for zero-shot ligand design from protein sequences. - Andrew J. Bass, David J. Cutler, Michael P. Epstein:

A powerful framework for differential co-expression analysis of general risk factors. - Jan Pielesiak, Maciej Antczak, Marta Szachniuk, Tomasz Zok:

RNAtive to recognize native-like structure in a set of RNA 3D models. - Mark Chernyshev, Aron Stålmarck, Martin Corcoran, Gunilla B. Karlsson Hedestam, Ben Murrell:

Detection of PCR chimeras in adaptive immune receptor repertoire sequences. - Ana Laura Chenoweth Galaz, Nadia Tahiri:

aPhyloGeo: a Python application for correlating genetic and climatic conditions. - Yicong Mao, Zhiwen Jiang, Tianying Wang, Yijuan Hu, Xiang Zhan:

TCVS: tree-guided compositional variable selection analysis of microbiome data. - Yinan Zheng, Feng Gao, Lifang Hou:

PathwayVote: an R package for robust pathway enrichment analysis for DNA methylation data using a consensus-based voting framework. - Minsoo Kim, Hanjin Bae, Gyeongpil Jo, Kunwoo Kim, Sung Jong Lee, Jejoong Yoo, Keehyoung Joo:

DeepFold-PLM: accelerating protein structure prediction via efficient homology search using protein language models. - Michael B. Hall, Chenxi Zhou, Lachlan J. M. Coin:

Genome size estimation from long read overlaps. - Jacqueline M. Boccacino, Martin Del Castillo Velasco-Herrera, Mathew A Beale, Jamie Billington, Ian Vermes, Sofia Obolenski, Kim Wong, Laura Torrens, Sarah J. Moody, Sandra Perdomo, Saamin Cheema, Bailey Francis, Victoria Offord, Adam P. Butler, David J. Adams:

SPARKI: a tool for the statistical analysis of pathogen identification results.

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