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- Cholesterol 24-hydroxylase (EC 1.14.13.98), also commonly known as cholesterol 24S-hydroxylase, cholesterol 24-monooxygenase, CYP46, or CYP46A1, is an enzyme that catalyzes the conversion of cholesterol to 24S-hydroxycholesterol. It is responsible for the majority of cholesterol turnover in the human central nervous system. The systematic name of this enzyme class is cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating). This enzyme is a member of the cytochrome P450 (CYP) superfamily of enzymes. Like many other CYP enzymes that act on cholesterol, cholesterol-24 hydroxylase is a monooxygenase that hydroxylates the side-chain of cholesterol. Because 24S-hydroxycholesterol is more polar than cholesterol, it can more easily pass the blood-brain barrier to exit the brain and pass into the bloodstream, where it can then travel to the liver to be further degraded. This enzyme has also been found at low quantities in the retina, where it performs the same function to a lesser degree. Genetic cloning of the encoding gene (CYP46A1) was first accomplished in 1999 and an extensive E. coli expression and purification system was later developed in 2003. (en)
- La colesterolo 24-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: colesterolo + NADPH + H+ + O2 ⇄ (24S)-24-idrossicolesterolo + NADP+ + H2O L'enzima è una proteina eme-tiolata (P-450). Può produrre anche 25-idrossicolesterolo. Inoltre, può idrossilare ulteriormente il prodotto a 24,25-diidrossicolesterolo e 24,27-diidrossicolesterolo. Questa reazione è la prima tappa della degradazione enzimatica del colesterolo nel cervello poiché l'idrossicolesterolo, a differenza del colesterolo, può oltrepassare la barriera sangue-cervello. (it)
- コレステロール-24-ヒドロキシラーゼ（cholesterol 24-hydroxylase）は、次の化学反応を触媒する酸化還元酵素である。 コレステロール + NADPH + H+ + O2 (24S)-24-ヒドロキシコレステロール + NADP+ + H2O この酵素の基質はコレステロール、NADPH、H+とO2で、生成物は(24S)-、NADP+とH2Oである。 組織名はcholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating)で、別名にcholesterol 24-monooxygenase、CYP46、CYP46A1、cholesterol 24S-hydroxylase、cytochrome P450 46A1がある。 (ja)
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- Structure of cholesterol-24 hydroxlase in Homo sapiens. Based on PyMOL rendering of PDB . (en)
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- Cholesterol-24 hydroxylase (en)
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- La colesterolo 24-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: colesterolo + NADPH + H+ + O2 ⇄ (24S)-24-idrossicolesterolo + NADP+ + H2O L'enzima è una proteina eme-tiolata (P-450). Può produrre anche 25-idrossicolesterolo. Inoltre, può idrossilare ulteriormente il prodotto a 24,25-diidrossicolesterolo e 24,27-diidrossicolesterolo. Questa reazione è la prima tappa della degradazione enzimatica del colesterolo nel cervello poiché l'idrossicolesterolo, a differenza del colesterolo, può oltrepassare la barriera sangue-cervello. (it)
- コレステロール-24-ヒドロキシラーゼ（cholesterol 24-hydroxylase）は、次の化学反応を触媒する酸化還元酵素である。 コレステロール + NADPH + H+ + O2 (24S)-24-ヒドロキシコレステロール + NADP+ + H2O この酵素の基質はコレステロール、NADPH、H+とO2で、生成物は(24S)-、NADP+とH2Oである。 組織名はcholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating)で、別名にcholesterol 24-monooxygenase、CYP46、CYP46A1、cholesterol 24S-hydroxylase、cytochrome P450 46A1がある。 (ja)
- Cholesterol 24-hydroxylase (EC 1.14.13.98), also commonly known as cholesterol 24S-hydroxylase, cholesterol 24-monooxygenase, CYP46, or CYP46A1, is an enzyme that catalyzes the conversion of cholesterol to 24S-hydroxycholesterol. It is responsible for the majority of cholesterol turnover in the human central nervous system. The systematic name of this enzyme class is cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating). Genetic cloning of the encoding gene (CYP46A1) was first accomplished in 1999 and an extensive E. coli expression and purification system was later developed in 2003. (en)
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- Cholesterol 24-hydroxylase (en)
- Colesterolo 24-idrossilasi (it)
- コレステロール-24-ヒドロキシラーゼ (ja)
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