About: CpG island hypermethylation

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CpG island hypermethylation is a phenomenon that is important for the regulation of gene expression in cancer cells, as an epigenetic control aberration responsible for gene inactivation. Hypermethylation of CpG islands has been described in almost every type of tumor.

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  • CpG island hypermethylation is a phenomenon that is important for the regulation of gene expression in cancer cells, as an epigenetic control aberration responsible for gene inactivation. Hypermethylation of CpG islands has been described in almost every type of tumor. Many important cellular pathways, such as DNA repair , cell cycle (p14ARF), apoptosis (DAPK), and cell adherence (CDH1, CDH13), are inactivated by it. Hypermethylation is linked to , DNA methyltransferases and histone deacetylase, but the degree to which this process selectively silences tumor suppressor genes remains a research area. The list for hypermethylated genes is growing. (en)
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  • CpG island hypermethylation is a phenomenon that is important for the regulation of gene expression in cancer cells, as an epigenetic control aberration responsible for gene inactivation. Hypermethylation of CpG islands has been described in almost every type of tumor. (en)
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  • CpG island hypermethylation (en)
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