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Route 5 is a bus route operated by the Maryland Transit Administration in Baltimore. The line currently runs from Cedonia in northeast Baltimore to the Mondawmin Metro Subway Station. The line has two alternating routes in East Baltimore: one via the area of Johns Hopkins Hospital, and one via a one-way pair of streets a few blocks north. A small number of trips also operate to/from Federal Street or Lanvale & Patterson Park. The current bus route is the successor to the 5 Druid Hill Avenue, 27 Federal Street, and Preston Street streetcar lines.