About: Thermospray

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Thermospray is a soft ionization source by which a solvent flow of liquid sample passes through a very thin heated column to become a spray of fine liquid droplets. As a form of atmospheric pressure ionization in mass spectrometry these droplets are then ionized via a low-current discharge electrode to create a solvent ion plasma. A repeller then directs these charged particles through the skimmer and acceleration region to introduce the aerosolized sample to a mass spectrometer. It is particularly useful in liquid chromatography-mass spectrometry (LC-MS).

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  • Thermospray is a soft ionization source by which a solvent flow of liquid sample passes through a very thin heated column to become a spray of fine liquid droplets. As a form of atmospheric pressure ionization in mass spectrometry these droplets are then ionized via a low-current discharge electrode to create a solvent ion plasma. A repeller then directs these charged particles through the skimmer and acceleration region to introduce the aerosolized sample to a mass spectrometer. It is particularly useful in liquid chromatography-mass spectrometry (LC-MS). In more technical terms thermospray is the controlled partial vaporization of a liquid as it flows through a heated capillary tube. The nebulization is accomplished by pumping a liquid sample at moderately high pressure through an electrothermally heated capillary tube. When sufficient power is coupled to the flowing sample stream, a partially vaporized mixture is produced consisting of some fraction of vaporized sample and some remaining liquid sample. Upon exiting the heated capillary, the rapidly expanding sample vapor converts the remaining liquid stream to an aerosol. The produced vapor acts as a nebulizing ‘gas’ and aids the breakup of the liquid stream into droplets, in a process similar to pneumatic nebulization. Thus, conceptually this can be thought of as a pneumatic process where the expanding solvent vapor is used as a nebulizer gas. The solution leaves the tube as a supersonic jet or spray of very small droplets in solvent vapor. Qualitatively, the aerosols appear dense with a moderately narrow particle size distribution. (en)
  • In spettrometria di massa il thermospray (o termospray) è una tecnica di ionizzazione evaporativa e un'interfaccia per la cromatografia liquida. Questa tecnica produce poca frammentazione, è una tecnica di ionizzazione soft. Comunemente si indica con TS, TSP o TSI. Questa tecnica è stata soppiantata dall'elettrospray. (it)
  • Термоспрей — метод ионизации в масс-спектрометрии. В термоспрее раствор, содержащий анализируемые вещества, подаётся через нагретый до высокой температуры стальной капилляр в камеру с пониженными давлением. Перегретый растворитель мгновенно испаряется и ионы из жидкой фазы переходят в газовую. Если молекулы анализируемого вещества не были ионами в растворе, они могут ионизоваться в газовой фазе при взаимодействии с другими ионами, аналогично химической ионизации. В некоторых конструкциях, для того, чтобы повысить эффективность ионизации, применяется коронный разряд, так же как и в . В настоящее время термоспрей практически вытеснен методами ионизации при атмосферном давлении. (ru)
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  • In spettrometria di massa il thermospray (o termospray) è una tecnica di ionizzazione evaporativa e un'interfaccia per la cromatografia liquida. Questa tecnica produce poca frammentazione, è una tecnica di ionizzazione soft. Comunemente si indica con TS, TSP o TSI. Questa tecnica è stata soppiantata dall'elettrospray. (it)
  • Thermospray is a soft ionization source by which a solvent flow of liquid sample passes through a very thin heated column to become a spray of fine liquid droplets. As a form of atmospheric pressure ionization in mass spectrometry these droplets are then ionized via a low-current discharge electrode to create a solvent ion plasma. A repeller then directs these charged particles through the skimmer and acceleration region to introduce the aerosolized sample to a mass spectrometer. It is particularly useful in liquid chromatography-mass spectrometry (LC-MS). (en)
  • Термоспрей — метод ионизации в масс-спектрометрии. В термоспрее раствор, содержащий анализируемые вещества, подаётся через нагретый до высокой температуры стальной капилляр в камеру с пониженными давлением. Перегретый растворитель мгновенно испаряется и ионы из жидкой фазы переходят в газовую. Если молекулы анализируемого вещества не были ионами в растворе, они могут ионизоваться в газовой фазе при взаимодействии с другими ионами, аналогично химической ионизации. В некоторых конструкциях, для того, чтобы повысить эффективность ионизации, применяется коронный разряд, так же как и в . (ru)
rdfs:label
  • Thermospray (it)
  • Thermospray (en)
  • Термоспрей (ru)
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