About: VR-RNA

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In molecular biology, VR-RNA is a small RNA produced by Clostridium perfringens. It functions as a regulator of the two-component VirR/VirS system. VR-RNA regulates numerous genes including: * Toxin-encoding genes plc, colA and cpb2 * Other virulence-related genes such as hyaluronidases and sialidase * Possible collagen adhesin gene (cna) * Extracellular nuclease, cadA * Enzymes such as Acid phosphatase, Heme oxygenase HemO and N-acetylglucosaminidases * Genes encoding transport proteins * Genes involved in carbohydrate metabolism * Genes encoding transport proteins * Arginine deiminase (ADI) pathway genes * Genes involved in citrate metabolism

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  • In molecular biology, VR-RNA is a small RNA produced by Clostridium perfringens. It functions as a regulator of the two-component VirR/VirS system. VR-RNA regulates numerous genes including: * Toxin-encoding genes plc, colA and cpb2 * Other virulence-related genes such as hyaluronidases and sialidase * Possible collagen adhesin gene (cna) * Extracellular nuclease, cadA * Enzymes such as Acid phosphatase, Heme oxygenase HemO and N-acetylglucosaminidases * Genes encoding transport proteins * Genes involved in carbohydrate metabolism * Genes encoding transport proteins * Arginine deiminase (ADI) pathway genes * Genes involved in citrate metabolism VR-RNA regulates the toxin colA (collagenase) by base-pairing to colA mRNA, the 3′ end of VR-RNA base-pairs to a region in the of the colA mRNA. This induces cleavage of the colA mRNA in the 5′ UTR and leads to stabilisation of the mRNA and increased translation. (en)
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  • In molecular biology, VR-RNA is a small RNA produced by Clostridium perfringens. It functions as a regulator of the two-component VirR/VirS system. VR-RNA regulates numerous genes including: * Toxin-encoding genes plc, colA and cpb2 * Other virulence-related genes such as hyaluronidases and sialidase * Possible collagen adhesin gene (cna) * Extracellular nuclease, cadA * Enzymes such as Acid phosphatase, Heme oxygenase HemO and N-acetylglucosaminidases * Genes encoding transport proteins * Genes involved in carbohydrate metabolism * Genes encoding transport proteins * Arginine deiminase (ADI) pathway genes * Genes involved in citrate metabolism (en)
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  • VR-RNA (en)
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