About: Z-FA-FMK

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Z-FA-FMK, abbreviating for benzyloxycarbonyl-phenylalanyl-alanyl-fluoromethyl ketone, is a very potent irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, , and papain. It also selectively inhibits effector caspases 2, 3, 6, and 7 but not caspases 8 and 10. This compound has been shown to block the production of IL1-α, IL1-β, and TNF-α induced by LPS in macrophages by inhibiting NF-κB pathways.

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  • Z-FA-FMK, abbreviating for benzyloxycarbonyl-phenylalanyl-alanyl-fluoromethyl ketone, is a very potent irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, , and papain. It also selectively inhibits effector caspases 2, 3, 6, and 7 but not caspases 8 and 10. This compound has been shown to block the production of IL1-α, IL1-β, and TNF-α induced by LPS in macrophages by inhibiting NF-κB pathways. (en)
dbo:alternativeName
  • Z-Phe-Ala-Fluoromethyl Ketone (en)
dbo:iupacName
  • N-[(1S)-2-[(3-Fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl ester (en)
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  • 43558540 (xsd:integer)
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  • 1900 (xsd:nonNegativeInteger)
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  • 1087038089 (xsd:integer)
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dbp:imagefile
  • Z-FA-FMK.png (en)
dbp:iupacname
  • N-[-2-[amino]-2-oxo-1-ethyl]-,phenylmethyl ester (en)
dbp:name
  • Z-FA-FMK (en)
dbp:othernames
  • Z-Phe-Ala-Fluoromethyl Ketone (en)
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rdfs:comment
  • Z-FA-FMK, abbreviating for benzyloxycarbonyl-phenylalanyl-alanyl-fluoromethyl ketone, is a very potent irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, , and papain. It also selectively inhibits effector caspases 2, 3, 6, and 7 but not caspases 8 and 10. This compound has been shown to block the production of IL1-α, IL1-β, and TNF-α induced by LPS in macrophages by inhibiting NF-κB pathways. (en)
rdfs:label
  • Z-FA-FMK (en)
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foaf:depiction
foaf:isPrimaryTopicOf
foaf:name
  • Z-FA-FMK (en)
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