H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation
By Ariel Klavaris, Costas Koufaris, Roberta Noberini, Maria Kouma, Christina Demetriadou, Alessandro Ghiringhelli, Nikolas Dietis, Tiziana Bonaldi & Antonis Kirmizis
Our findings identify H2A.X as a novel bona fide substrate of NAA40. Moreover, the responsiveness of H2A.X N-terminal acetylation to UV-induced DNA damage indicates that this is a dynamic modification with potential biological functions. Read full article here.
The multitalented TIP60 chromatin remodeling complex: wearing many hats in epigenetic regulation, cell division and diseases
By Maria Virginia Santopietro, Diego Ferreri, Yuri Prozzillo, Patrizio Dimitri & Giovanni Messina
This new review in Epigenetics & Chromatin discusses the TIP60 complex, a key player in DNA repair and transcription regulation, highlighting its roles across species and its implications in cancer and neurodevelopmental disorders. Read full article here.
Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine
By Karishma Sahoo, Prakash Lingasamy, Masuma Khatun, Sajitha Lulu Sudhakaran, Andres Salumets, Vino Sundararajan & Vijayachitra Modhukur
Epigenetics & Chromatin is pleased to announced publication of a new review article, which is synthesizing current advancements in this field and envisions a future where “AI-powered epigenetic diagnostics can enable earlier detection, more effective treatments, and improved patient outcomes, globally”. Read full article here.
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation
by Kei Fukuda, Chikako Shimura & Yoichi Shinkai
“In this study, we successfully analysed the transcription, epigenome and 3D genome organization in mammalian cells that, for the first time, lacked all three major repressive chromatin modifications: H3K9 methylation, H3K27me3, and uH2A. Our findings revealed that, in the absence of H3K9 methylation, H3K27me3 and PRC1-uH2A can independently or some inter-dependently contribute to maintain gene/TE silencing and nuclear compartments”. Read full article here.