Product overview

Name 1-Naphthyl PP1
Alternative names 1-NA-PP 1
Purity >99%
Description Potent, selective src family kinase inhibitor
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Biological Data

Biological description Potent and selective src family kinase inhibitor, including v-Src and c-Fyn. Selective for analogs rather than wild-type kinase (IC50 values are 1.5 nM and 1 µM for v-Src analog versus wild-type). Also inhibits c-AbI and Aurora A kinase and is a potent PKD inhibitor. Shows anti-cancer actions. Cell-permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (20mg/ml) or chloroform
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Molecular Weight 317.39
Chemical structure 1-Naphthyl PP1  [221243-82-9] Chemical Structure
Molecular Formula C19H19N5
CAS Number 221243-82-9
PubChem identifier 4877
SMILES CC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N
InChiKey XSHQBIXMLULFEV-UHFFFAOYSA-N

References for 1-Naphthyl PP1

References are publications that support the biological activity of the product
  • Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.

    Reboutier D et al (2013) J Cell Biol 201(1) : 65-79.
  • New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells.

    Tandon M et al (2013) PLoS One 8(9) : e75601.
  • A chemical switch for inhibitor-sensitive alleles of any protein kinase.

    Bishop AC et al (2000) Nature 407(6802) : 395-401.

3 Item(s)