Potent protein kinase C (PKC) inhibitor (IC50 = 0.10 µM). Displays less activity at protein kinase A (PKA) and pyruvate kinase (PK) (IC50 values are 2.0 and 0.70 µM respectively).Also β1.3 subunit of Kv 1.5 channel inhibitor (IC50 = 12.4 µM) and non-competitive nicotonic cholinergic receptor antagonist (approx IC50 = 0.031 µM).
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.
Mahata M et al (2002) Mol Pharmacol 61(6) : 1340-7.
![Bisindolylmaleimide II [137592-45-1] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0135.png "Bisindolylmaleimide II [137592-45-1]")
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