About
Prof. Cryan’s current research interests include the neurobiological basis of…
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"AI optimism has turned into an over-hyping of the technology that is misplaced” warns Professor Barry O'Sullivan O’ Sullivan, Director of UCC…
"AI optimism has turned into an over-hyping of the technology that is misplaced” warns Professor Barry O'Sullivan O’ Sullivan, Director of UCC…
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📢 DEADLINE EXTENDED You’ve got 1 more week to submit your abstract! The new deadline is November 10th. Don’t miss the chance to take the stage as…
📢 DEADLINE EXTENDED You’ve got 1 more week to submit your abstract! The new deadline is November 10th. Don’t miss the chance to take the stage as…
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This weekend we had an University College Cork alumni gathering in Toronto. Its purpose was to meet & network with, celebrate, and acknowledge our…
This weekend we had an University College Cork alumni gathering in Toronto. Its purpose was to meet & network with, celebrate, and acknowledge our…
Liked by John Cryan
Experience
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Publications
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Collective unconscious: How gut microbes shape human behavior
Journal of Psychiatric Research
The human gut harbors a dynamic and complex microbial ecosystem, consisting of approximately 1 kg of bacteria in the average adult, approximately the weight of the human brain. The evolutionary formation of a complex gut microbiota in mammals has played an important role in enabling brain development and perhaps sophisticated social interaction. Genes within the human gut microbiota, termed the microbiome, significantly outnumber human genes in the body, and are capable of producing a myriad of…
The human gut harbors a dynamic and complex microbial ecosystem, consisting of approximately 1 kg of bacteria in the average adult, approximately the weight of the human brain. The evolutionary formation of a complex gut microbiota in mammals has played an important role in enabling brain development and perhaps sophisticated social interaction. Genes within the human gut microbiota, termed the microbiome, significantly outnumber human genes in the body, and are capable of producing a myriad of neuroactive compounds. Gut microbes are part of the unconscious system regulating behavior. Recent investigations indicate that these microbes majorly impact on cognitive function and fundamental behavior patterns, such as social interaction and stress management. In the absence of microbes, underlying neurochemistry is profoundly altered. Studies of gut microbes may play an important role in advancing understanding of disorders of cognitive functioning and social interaction, such as autism.
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Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy
The Journal of Pediatrics
First investigation into the miRNA profile of umbilical cord blood from infants with perinatal asphyxia and hypoxic ischaemic encephalopathy
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Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: A comparison of ketamine and ECT
Journal of Affective Disorders, In Press
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More activity by John
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Excited to see the results of our collaboration with the Marama Labs lead by my PhD student Aida López Espinar published in Analytical Chemistry…
Excited to see the results of our collaboration with the Marama Labs lead by my PhD student Aida López Espinar published in Analytical Chemistry…
Liked by John Cryan
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It was a pleasure to chair the #CLRG25 symposium tonight in University College Cork Thank you to Lord Mayor Fergal Dennehy for opening the event, and…
It was a pleasure to chair the #CLRG25 symposium tonight in University College Cork Thank you to Lord Mayor Fergal Dennehy for opening the event, and…
Liked by John Cryan
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It was a pleasure to meet with the delegation of city officials from Shanghai on Monday. They were in University College Cork as part of the…
It was a pleasure to meet with the delegation of city officials from Shanghai on Monday. They were in University College Cork as part of the…
Liked by John Cryan
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Cork Chamber was delighted to support University College Cork’s business engagement event "AI For Business Leaders: Ethics, Regulation and Business…
Cork Chamber was delighted to support University College Cork’s business engagement event "AI For Business Leaders: Ethics, Regulation and Business…
Liked by John Cryan
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🎉 World Anatomy Day 2025 🎉 Delighted to celebrate World Anatomy Day with our amazing MSc Human Anatomy students at UCC! 🧠 Our students were…
🎉 World Anatomy Day 2025 🎉 Delighted to celebrate World Anatomy Day with our amazing MSc Human Anatomy students at UCC! 🧠 Our students were…
Liked by John Cryan
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I have postdoc vacancy in my lab! This is a full-time, on-site position for a Postdoctoral Researcher, located in Davis, CA. The project focuses on…
I have postdoc vacancy in my lab! This is a full-time, on-site position for a Postdoctoral Researcher, located in Davis, CA. The project focuses on…
Liked by John Cryan
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I offered to deliver a seminar within our School of Clinical Therapies to share some of my experiences on the long and winding road that is research,…
I offered to deliver a seminar within our School of Clinical Therapies to share some of my experiences on the long and winding road that is research,…
Liked by John Cryan
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We were happy to generate this preclinical evidence that probiotic treatment during pregnancy can thwart environmental risks and safeguard brain…
We were happy to generate this preclinical evidence that probiotic treatment during pregnancy can thwart environmental risks and safeguard brain…
Liked by John Cryan
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John Carpenter
This excellent new paper by Kronsbein et. al. describes studies on advancing forced degradation studies: design of experiments for enhanced structure-function relationship analysis in biotherapeutics. Quoting from the abstract: "Understanding the relationship between structure and function is crucial in drug development. Recombinant proteins present unique challenges when establishing structure–function relationships (SFR) due to the extensive options for potential modifications across numerous residues. Even simple stress studies lack degradation selectivity as they lead to multiple, simultaneous modifications. Co-occurring modifications at amino acid residues make direct correlations with a specific stressor and resolving the causal impact on functionality difficult. The introduction of more variance into the data set would reduce the correlation structure. In this study, we demonstrate the feasibility and benefits of a multifactorial design approach for SFR establishment. Design of experiments (DoE) allows for the parallel investigation of stress factors via combined experiments, resulting in a higher variance of stress conditions and consequently a broader variation in degradation. This approach enables a more insightful correlation analysis along with model-based data evaluation strategies, thereby facilitating significantly improved data interpretation results during SFR studies."
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Li-Huei Tsai
In Nature today my lab led by Djuna von Maydell dissects how ABCA7 loss of function variants contribute strongly to Alzheimer’s disease risk, including disruption of mitochondrial function and lipid metabolism in excitatory neurons from human brain samples. Importantly, after observing disrupted phosphatidylcholine metabolism in iPSC cultures engineered with ABCA7 variants, we treated cells with CDP-choline and found this rescued the metabolic deficit, reversing many of the disease-associated abnormalities associated with the variants, including amyloid secretion and neuronal hyper excitability. The study strengthens the evidence base suggesting that disruption of lipid metabolism plays a key role in the pathophysiology of Alzheimer’s disease. News: https://lnkd.in/d3WJTXSv Study: https://lnkd.in/dCszM-Pa
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Andrés D. Klein
Restoration of Lysosomal Hydrolase Activities by LRRK2 Inhibition in GBA1- and LRRK2-Associated Parkinson's Disease Patient-Derived Cells A recent study published in the Journal of Neurochemistry https://lnkd.in/eCQSps5W explored the therapeutic potential of LRRK2 inhibitors for both GBA1 and LRRK2-associated Parkinson's disease (PD). Researchers evaluated the effects of LRRK2 inhibition on lysosomal hydrolase activity and alpha-synuclein levels in various patient-derived cell types, including PBMC-derived macrophages and iPSC-derived dopaminergic neurons. They discovered that LRRK2 inhibition enhances the activity of multiple lysosomal hydrolases, including glucocerebrosidase (GCase), and promotes GCase's translocation to lysosomes. This effect was notably more pronounced in cells from GBA1-PD patients than in those from LRRK2-PD patients. Additionally, the study found that LRRK2-PD patient macrophages exhibited reduced galactosylceramidase (GALC) activity and elevated levels of lysosphingolipids, which are known to stabilize neurotoxic alpha-synuclein. These findings suggest that LRRK2 inhibitors may improve lysosomal function by enhancing the activity of key enzymes, offering a potential therapeutic strategy for PD that extends beyond LRRK2 mutation carriers. #genetics #genomics #precisionmedicine #genomicmedicine #brain #neurology #neuroscience #neurodegeneration #neuroinflammation #inflammation #immunity #aging #longevity #cognition #dementia #movementdisorder #geroscience #raredisease #parkinson #gaucher #lysosomalstoragedisorder #metabolism #lysosome #mitochondria #biomarkers #therapeutics #biotechnology #innovation #research #science #sciencecommunication
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