The increasing dynamics of today’s work impacts the business processes. Agile workflow technology is a means for the automation of adaptable processes. However, the modification of workflows is a difficult task that is performed by human experts. This article discusses the novel approach of agile workflow technology for dynamic, long-term scenarios and on change reuse. First, it introduces new concepts for a workflow modeling language and enactment service, which enable an interlocked modeling and execution of workflows by means of a sophisticated suspension mechanism. Second, it provides new process-oriented methods of case-based reasoning in order to support the reuse of change experience. The results from an experimental evaluation in a real-world scenario highlight the usefulness and the practical impact of this work.