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Join us at the 9th World Congress of Pediatric Cardiology & Cardiac Surgery

The the 9th World Congress of Pediatric Cardiology & Cardiac Surgery (WCPCCS) is going to be held at the Hong Kong Convention and Exhibition Centre, Hong Kong, China from December ... More >>

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles More >>

New Impact Factor for Translational Cancer Research: 1.7

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2024 citation year: 1.7. More >>

Original Article

Identification of the immune subtypes associated with the prognosis and immunotherapy of metastatic melanoma
Feng Zhang, Xiaodong Zhang, Huanzhong Su, Longcheng Hong, Yuhui Wu, Chang Shu
Identification and validation of an immune-related programmed cell death signature for predicting prognosis and immunotherapy in large-scale multicenter cohorts for lung adenocarcinoma
Zhetao Li, Chuyun Fu, Jie Chen, Wenbo Ji, Zaiqi Ma
Identification and validation of RAS signaling-related genes for prognostic prediction and immunological characterization in gastric cancer
Jinhong Cao, Jun Liu, Lingling Ye, Xiaojuan Zheng
The timing of surgery for elderly patients with locally advanced breast cancer
Jiameng Liu, Hehui Mao, Zijie Wu, Wei Zhuang, Yiyin Weng, Juli Lin, Jujiang Guo, Zhipeng Hua
Cervical cancer molecular subtype identification and prognosis classification by a metabolism-related gene expression
Xiaohong Chen, Caixia Hong, Guohui Zhang, Bixian Lin, Jingyi Liu, Ronglong Wang, Chunbo Li
Epidemiological and clinicopathologic characteristics, and prognostic factors of patients with extra-skeletal osteosarcoma: a Surveillance, Epidemiology, and End Results population study
Zhenzhong Liu, Fapeng Gao, Li Du, Zheng Liu
Predictive factors for clinical outcome of palliative ventriculoperitoneal shunt in the treatment of leptomeningeal metastasis
Lingzhao Min, Ningning Zhang, Qing Zhang, Mingzhe Zheng, Yiqian Zhu
Identification of lysine crotonylation-driven molecular clusters and immune dysregulation in HBV-related hepatocellular carcinoma via bioinformatics and machine learning
Jinlian Li, Linbin Huang, Baoren He, He Xie, Qunying Wu, Limin Chen
Transcriptomics combined with in vitro experimental validation probes polyamine metabolic profiles in low-grade gliomas
Linfeng Pan, Huili Chen, Xinyu Zhang, Jing Zhang, Chaoqun Lian
Ultrasound and immunohistochemical predictors of neoadjuvant chemotherapy response in breast cancer
Yanqiang Ma, Yangyang Zhu, Jiali Zhu, Fang Nie
Development and validation of nomograms predicting survival in operable breast cancer patients at reproductive age after breast conserving surgery and postoperative radiotherapy based on SEER database
Sirui Zhu, Ke Zhang, Wei Lu, Huaiyu Yang, Chenxuan Yang, Changyuan Guo, Lei Guo, Xuemin Xue, Zhongzhao Wang, Lixue Xuan
Identification of cancer-associated fibroblast subpopulation and construction of an immunotherapy signature for gastric cancer
Kunqin Wang, Dong Xue, Chao Yin, Guanghui Wang
Integration of single-cell and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of sodium overload-induced cell death in lung adenocarcinoma
Yilun Shi, Xiangyu Qu, Dayu Liu, Huihong Zhang, Suchen Wang, Jiarui Song, Li Wang, Wenrui Wang
Integrative analysis of polo-like kinase family identifies a prognostic signature and validates PLK2 as a therapeutic target in glioma
Chengjun Zheng, Qiaodong Chen, Zheng Fang, Delong Zhang, Yutong Feng, Shuqing Yu, Ying Zhang, Zhaoshi Bao
Prognostic significance of key immune cell functional alterations in clear cell renal cell carcinoma
Yuhai Wu, Yantao Zhang, Ke Sun, Wenjie Niu, Yanhui Mei, Shimiao Zhu, Changyi Quan
Comparative microbiome profiling reveals unique signatures in multiple primary lung cancers
Yun Chen, Yang Wang, Shuai Shen, Jiagui Lu, Qihui Peng, Xiangyun Yan, Hao Peng, Zheyuan Xu
PLCXD2 expression relates to the immune microenvironment and prognosis of head and neck squamous cell carcinoma: a retrospective cohort study
Mingming Tang, Qingwen Chen, Xinjiang Xu, Zihao Zhang, Liang Han, Hao Wu
CCT4 as a prognostic biomarker correlated with immune infiltration and hepatocyte dedifferentiation in hepatocellular carcinoma
Xinglin Zhang, Peirong Li, Hongbo Zhao
Anti-ovarian cancer effects of forsythiaside A: insights from in vitro and in vivo studies
Haocheng Guan, Yongchao Li, Menglong Xu, Wenqiang Sun, Ruijun Shi, Shuwei Li
A pentacyclic triterpene tormentic acid inhibits the proliferation and migration of pancreatic ductal adenocarcinoma cells
Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh
shRNA-based PD-1 suppression preserves memory phenotype and function of CD19-targeted CAR-T cell
Jiaxuan Zhao, Han Wu, Zhe Sun, Yeting Cui, Nan Liu, Yixuan Wang, Youyong Wang, Jiangzhou Shi, Tongcun Zhang
Unveiling PIK3CA mutation: a prognostic beacon in endometrial carcinoma and its immune implications
Shuai Cao, Yucheng Zhao, Lu Zhang, Junhong Zhuang, Peiqi Jia, Dongmei Han, Hao Jin, Liming Xu
Methylation-regulated tumor suppressor gene HOXB4 inhibits human lung adenocarcinoma A549 cell invasion and metastasis through the RAP1 signaling pathway
Lingxiang Zhang, Zhong Xu, Shu Wu, Yamen ahmed Muad, Weiyan Peng, Lin Ye
The role of cancer stem cells in the progression of colorectal cancer and the tumor microenvironment: new perspectives from single-cell RNA sequencing and spatial transcriptomics analyses
Yuting Wu, Xianglin Liu, Wenqiang Liu, Qingliang Jiang, Yangyang Li, Hengyu Li, Liqiang Hao
KRT23 promotes proliferation invasion and metastasis of gastric cancer through epithelial-mesenchymal transition mediated by the PI3K/AKT/mTOR signaling pathway
Yi Xie, Fanghui Zhou, Xuelian Li, Pailan Peng
B7 homolog 6 promotes the killing activity of natural killer cells against cervical cancer through the downstream ERK pathway of NKp30
Ruimeng Guo, Ou Chai, Changying Li, Yanying Xu, Xuewang Guo
LINC01314 suppresses proliferation and invasion via epithelial-to-mesenchymal transition regulation in lung adenocarcinoma
Wen Zhu, Xue Pan, Anyuan Zhong, Yongkang Huang, Minhua Shi
Development and validation of a prognostic prediction model for gastric cancer based on lipophagy-related genes
Laibijiang Wusiman, Dingding Song, Alimu Tulahong, Abulajiang Abudukelimu, Juan Liu, Xuying Wei, Shu He, Wenbin Zhang
Bioinformatics analysis identifies ULK3 as a novel prognostic and immune-related biomarker in esophageal cancer
Kai Cui, Jinxi He, Nan Zhao, Rong Ma, Yanyang Wang
Development and validation of a nomogram comprising GLUT1 and clinical characteristics for predicting overall survival in intrahepatic cholangiocarcinoma
Li-Ping Gong, Yulan Weng, Jing Zhou, Xiangqi Huang, Jian-Ning Chen, Dan He, Yi-Wang Zhang, Yongmei Cui, Jing Liang, Chun-Kui Shao
Integrative analysis of the potential of DISP3 as a biomarker for thyroid cancer
Chenghui Lu, Xufu Wang
Liriopesides B inhibits proliferation and metastasis and induces apoptosis of oral squamous cell carcinoma via the PI3K/Akt/mTOR signaling pathway
Jinzhi Wei, Hejia Guo, Binghua Feng, Wei Lv, Xiaoping Su, Cuiping Li, Xuanping Huang
Intratumoral disulfidptosis heterogeneity in triple-negative breast cancer, a multiomics integration analysis
Zi-Xian Dong, Yang Ou-Yang, Lan Fang, Xiao-Qing Song
TIPE3 promotes breast cancer progression and metastasis via the AKT-GSK3β-β-catenin/Snail pathway
Yiling Bai, Jing Wu, Dongmei Yu, Qiang Li, Yan Li, Yufeng Xie
Multi-omics analysis reveals intratumoral microbiota as modulators of the immune environment within thyroid cancer
Zihao Liang, Jie Gao, Qin Zheng
Prognostic prediction nomogram of elderly patients with metastasis colon cancer and distant metastasis pattern: a SEER database analysis
Xing Luo, Jincheng Tang, Wei Peng, Fang Liu
Machine learning models for predicting survival in patients of hepatocellular carcinoma with second primary malignancy
Yu Nie, Lu Nie, Boyu Li, Yuanyuan Wang, Liyuan Wang, Xingyan Lv, Runjie Sun, Mengting Xia, Ruiyang Wang, Xing Cui
Integrative analysis identified THBS1 as a key prognostic biomarker with therapeutic vulnerability in patients with laryngeal cancer
Shaokun Huang, Xuan Shan, Fan Song, Min Wu, Chaofan Li, Xiaohui Wang, Ruiping Zhao, Juan Ye
Construction and verification of a prognostic model for cervical cancer based on genes associated with the p53 regulatory pathway
Zhaoming Wu, Jing Zhang, Bohao Sun, Yichen Wu, Nan Wang, Changqing Li
Unveiling critical genes and molecular subtypes in ovarian cancer: insights into tumor immunity and carbohydrate-lipid metabolism
Yuxuan Zhang, Wei Zhang, Wenli Xie, Xiangyu Wang, Ping Wei
Integrated multi-omic analysis unravels the characteristics of the metabolism-related intratumoral microbes and establishes a novel signature for predicting prognosis and therapeutic response in lung adenocarcinoma
Huan Liu, Yueguang Liu, Yixuan Dai, Lei Zhang, Mei Long
Decoding the genomic landscape of adenoid cystic carcinoma: a retrospective cohort study of MYB family alterations, NOTCH pathway activation, and clinical outcomes
Jun Wu, Xi Zhao, Yi-Xuan Liu, Ting-Yao Ma, Yue Zhao, Guo-Liang Yang, Xiao-Hong Chen
Single-cell analysis revealed a diagnostic model of hepatocellular carcinoma based on cancer stem cell-related gene
Yang Ding, Qi Liang, Songbo Ma, Jia Yang, Zengrui Ma, Zhiqi Yang, Baoding Li
Role of 18F-FDG PET/CT in the diagnosis and treatment response assessment of primary pulmonary lymphoma
Yongzhu Pu, Ran Xie, Kun Li, Chunhong Zhang, Sheng Zhao, Xin Liu, Haicheng He, Ningning Chen, Yuqiang Xiao, Qiuyuan Hu, Zhiyong Deng, Long Chen
CC/CXC chemokine risk signature at single-cell resolution: a machine learning model for precision stratification in cervical cancer
Bing Xu, Xinyan Shi, Yanfei Liu, Lyuping Xu, Qingxue Zhou
Identification of PDGFRB as a prognostic immune-related biomarker in gastric cancer through bioinformatics and clinical analysis
Shujing Wang, Bo Meng, Yuanan Liu, Qiang Wu
NSD2 mediates NF-κB and matrix metalloproteinases to drive hepatocellular carcinoma malignant progression
Meng Xiong, Qianshan Ding, Yingjie Wu, Muhammad Jamal, Xingruo Zeng, Yufei Lei, Hengjing He, Di Xiao, Qiuping Zhang, Liang Shao, Xiaoxing Huang, Xinran Li
Molecular dynamics simulation and single-cell and spatial transcriptomics validate immune and prognostic biomarkers in colorectal cancer and construct a clinical prognostic model
Xuanting Chen, Yuan Zhou, Hongyu Li, Wang Guo, Songqi Li, Zhen Zhang, Qiang Tang
Study of non-surgical therapeutic patterns and prognosis in elderly patients with stage II non-small-cell lung cancer: an investigational study based on the SEER database
Lixia Zhang, Xin Xu, Yunbin Gao
TOP2A promotes non-small cell lung cancer progression via LDHA-mediated glycolysis and histone lactylation
Qiong Wu, Ye Fan, Weiqin Wang, Feng Hu
Identification of prognostic genes associated with sphingosine-1-phosphate in gastric cancer to construct a risk mode
Jing Han, Lan Lei, Jiangfeng Wang
Development and verification of risk prediction nomograms for overall and specific mortality in primary small bowel cancer: a population-based study
Yingxiang Wu, Wen Luo
ATP citrate lyase (ACLY) promotes the occurrence of gastric cancer through regulating lipid metabolism
Sijia Zhang, Yihuang Liu, Xia Zhang, Nailin Zhang, Jianhui Sun, Pingping Chen
Development and validation of a machine learning-based prognostic model using mitochondrial dysfunction-related genes for colorectal cancer patients
Chang Liu, Yaxuan Li, Jiaxu Song, Yijing Zhao
Prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography metabolic parameters combined with serum apolipoprotein A1 in patients with diffuse large B-cell lymphoma: a clinical study
Zhengong Jia, Lin Liu, Weipeng Li, Hui Li, Shujie Ge, Yongquan Hu
A novel prognostic tool for triple-negative breast cancer: creating and testing a parthanatos-related gene model
Zitong Yang, Siyi Chen, Jiahong Sun, Guangmin Wu, Delu Mu, Jiandong Wang
Development and validation of a machine learning model for predicting 3-year overall survival in metastatic nasopharyngeal carcinoma: a SEER database and web visualization study
Lei Qiu, Yinjiao Fei, Yuchen Zhu, Kexin Shi, Jinling Yuan, Gefei Jiang, Xingjian Sun, Yuandong Cao, Weilin Xu, Shu Zhou
A novel disulfidptosis-related lncRNAs index to predict prognosis and therapeutic target in hepatocellular carcinoma
Xun-Feng Gao, Xiao-Lu Xu, Jin-Hui Zhang, Heng Zhang, Li-Quan Cai, Feng Gao, Jin-Long Zhang, Dan Yu, Qin-Wen Tai
Constructing an immune-related prognostic model and exploring the function of HMGB3, TNFSF4, and CORO2A in breast cancer
Meng Tang, Tingting Huang, Wei Zhang, Chi Wang, Rui Pan, Yaqin Zhao
Single-cell analysis of tumor microenvironment immune homeostasis and identification of prognostic biomarkers in head and neck squamous cell carcinoma
Hongyu Xie, Shenling Liao, Libo Liang, Ga Liao
Efficacy, safety and cost-effectiveness of chemo-immunotherapy combinations for recurrent or metastatic nasopharyngeal carcinoma: an updated systematic review and cost-effectiveness analysis
Lei Qiu, Qiran Wei, Yachun Hu, Jinling Yuan, Mengxing Wu, Yurong Li, Yuting Xu, Xin Guan, Yuandong Cao, Juan Pu, Zhou Ding, Yinjiao Fei, Weilin Xu, Shu Zhou
Integrative single-cell and bulk transcriptomes analyses reveal T cell-related prognostic risk model and tumor immune microenvironment modulation in colorectal cancer
Ping Liu, Yizhou Wang, Shu Huang, Rui Luo, Ruiheng Xie, Jieyv Peng, Ruiyu Wang, Ping Wang, Xiaomin Shi, Wei Zhang, Lei Shi, Xian Zhou, Xiaowei Tang
Identification of molecular subtypes for breast cancer based on butyrate metabolism-related genes to assess prognosis and immune landscape
Huitao Yao, Xiuping Hu, Jiazhen Feng, Lunan Tan
RNA sequencing and bioinformatics analysis have identified MAST1 as a potential biomarker and therapeutic target for cervical cancer
Zhijia Xie, Tao Shen, Yuhong Wang, Ruyue Ma, Hong Xu, Ruirui Zhang, Hailan Su
Clinical significance of CD155 expression and correlation with immune cell infiltration in triple-negative breast cancer
Yan Zhao, Jinlu Wang, Tongjun Sun, Sijuan Jiang, Zongyu Xie, Jingru Lai, Ganyu Sang, Xin Jin
Epidemiological characteristics and prognostic factors of high-grade brainstem glioma for all ages and the establishment of a nomogram
Bowen Huang, Ting Liu, Hongfei Li, Xiang Li, Gonggong Lu, Jiuhong Li
A deep learning-based prognostic prediction model for distal cholangiocarcinoma incorporating the metabolism-inflammation marker monocyte-to-high-density lipoprotein cholesterol ratio
Hai-Bin Zhang, Xiao-Ting Han, Lian Wang
Exploration of efferocytosis-related genes as potential therapeutic targets in endometrial cancer
Huiping Zhang, Man Di, Shan Wang, Mingming Wei, Mingxia Jia, Zhuo Zhou
FBXO5 drives hepatocellular carcinoma progression and is a target for tea polyphenol-mediated inhibition
Xinyu Wang, Dandan Yang, Jiao Wang, Zheng Huang, Junjie Gao, Jun Xia, Yingjie Zhang, Jia Ma, Xueshan Pan
Ferroptosis-associated RNA-binding proteins predict clinical outcomes in head and neck squamous cell carcinoma
Ming Liu, Zhiyu Zhang, Lei Shi, Guanggang Shi
Deciphering immune landscapes: an ICD-lncRNA-derived prognostic signature for pancreatic adenocarcinoma
Hao Zhu, Xiaojie Gan, Danyang Shen, Ding Sun
Immune-related long noncoding RNAs in predicting the prognosis and immune landscape of intrahepatic cholangiocarcinoma: a bioinformatics analysis with experimental verification
Gao Huang, Yuan-Shu Lian, Wen-Ting He, Fang Xiao, Wen-Bo Zou
The role of liquid-liquid phase separation in hepatocellular carcinoma: single-cell analysis and identification of prognostic biomarkers
Wenjie Lei, Rui Luo, Xiaohong Wang, Xiaomin Shi, Jieyu Peng, Qi Chen, Shiqi Li, Wei Zhang, Lei Shi, Yan Peng, Shu Huang, Xiaowei Tang
A novel manganese metabolism- and immune-related prognostic risk model for acute myeloid leukemia
Lin Guo, Yue Cao, Wei-Ying Gu, Yan Lin
Radiomics-based machine learning for glioma grade classification: a multicenter study with SHapley Additive exPlanations interpretability analysis
Yumeng Shi, Wei Jiang, Li Zhou, Yu Shi, Xinran Ji, Wenjie Zheng, Hongyu Zhao, Ninghua Yao
The systemic immune-inflammation index in the efficacy prediction of neoadjuvant chemotherapy in patients with endometrial cancer
Jing Lin, Lingli Gu, Filomena Marino Carvalho, Luigi Della Corte, Jie Dang
CXCR3 enhanced murine chimeric antigen receptor T cells in the treatment of solid tumors
Xiangzhi Zhang, Luyu Zhu, Qiang Wang, Qinggang Xu, Xiaoyan Wang, Feng Yu
A diagnostic test evaluation: dynamic optical functional imaging system for early-stage breast cancer detection
Xiangming He, Linyin Fan, Jian Huang, Xiping Zhang, Naohiro Ishii, Xiaojia Wang, John Zhang
Bulk and single-cell transcriptomics of stomach adenocarcinoma provide prognostic insights via the application of a novel gene signature associated with manganese metabolism
Dou Li, Dan Wei, Lianyong Li, Changqing Zhong, Xinwei Bao, Wenjuan Zhang, Xinke Sui
CST7+ macrophages/monocytes in melanoma: single-cell insights into immunotherapy response
Kaitao Yao, Fan Wu, Daiwei Liu, Boying Zheng, Jing Li, Yang Liu, Li Wang, Liuqing Zheng, Zhanlin Li, Gang Zhou
The association of geriatric nutritional risk and perioperative anesthesia–related adverse reactions in elderly patients with colorectal cancer—a prospective study
Xiaofeng You, Yangxiuzi Xu, Jingxuan Zhao, Jacopo Crippa, Aaron C. Lim, Zoltan H. Nemeth, Feiyue Zhang
Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
Review Articles 
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Published online: 01 August 2012
Review Article 
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Published online: 30 June 2017

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.