“I’m not trying to do science just for scientists. I’m doing it to try to solve important problems that will make a difference.” Jussi Taipale and his team are using AI to see if they can predict when and where genes are activated by looking at just the DNA sequence, which has implications across cancer research and beyond. 👩💻 His team combines cutting-edge lab experiments with advanced computational models to tackle a fundamental challenge in biology: the sequence-to-expression problem – the gap between knowing a DNA sequence and predicting gene activity in a cell. Their work could shape how we understand gene control, cancer risk, and disease at the molecular level. 🧬 Read more on the blog ⤵️ https://lnkd.in/eiSF7jtR
Wellcome Sanger Institute
Research Services
Hinxton, Cambridgeshire 91,442 followers
The Wellcome Sanger Institute is a world leading genomics research centre.
About us
The Wellcome Sanger Institute is a world leader in genomics research. We generate and analyse data at a scale not easily possible elsewhere. We apply and explore genomic technologies to advance the understanding of biology and improve health. Our ambition is vast – we take on projects that are not possible anywhere else. We use the power of genome sequencing to understand and harness the information in DNA. Funded by Wellcome, we have the freedom and support to push the boundaries of genomics. Our findings are used to improve health and to understand life on Earth.
- Website
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http://www.sanger.ac.uk/
External link for Wellcome Sanger Institute
- Industry
- Research Services
- Company size
- 1,001-5,000 employees
- Headquarters
- Hinxton, Cambridgeshire
- Type
- Nonprofit
- Founded
- 1992
- Specialties
- genetic sequencing, bioinformatics, medical research, software development, conservation, malaria, cancer, genomics, research, scientific research, science innovation, and big data
Locations
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Primary
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Wellcome Sanger Institute
Wellcome Genome Campus
Hinxton, Cambridgeshire CB101SA, GB
Employees at Wellcome Sanger Institute
Updates
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Wicken Fen has recorded its 10,000th species of wildlife, with experts believing it is the first known UK site of its kind to do so. 👏 Technology plays an important role in the recording of species. As part of the Bioscan Project, Sanger scientists have been working with the National Trust to collect the DNA of insects found in Wicken Fen, as well as other sites. 🧬 “The Bioscan Project aims to revolutionise our understanding of insect diversity in the UK by using DNA barcoding to identify both known species and species that would otherwise remain unknown to science. Our ambition is to use this approach to track how diversity changes through space and time across the country. Sites like Wicken Fen, with their rich biodiversity and long-term monitoring, are invaluable partners in creating comprehensive baselines of UK insect species that will inform conservation efforts for years to come.” said Lyndall Pereira-da-Conceicoa, Bioscan Science Lead at the Wellcome Sanger Institute. Read the full story of the 10,000 species, including the Top 10 “Weird and Wonderful” species that can be found at Wicken Fen ⤵️ https://lnkd.in/e6rqUjZ5
*VERY EXCITING NATURE NEWS INCOMING* Wicken Fen has become the first UK nature reserve to record an incredible 10,000 species. A moth that imitates a wasp was the 10,000th species to be recorded. Wildlife records date back 200 years, and during the 20th century, 13 species that are new to science were discovered on the reserve. But it is during the last 25 years that records have really surged in number. This boom in biodiversity is thanks to the major expansion of wetland habitats, as well as warmer temperatures and pioneering species monitoring. Some of the weird and wonderful species at Wicken Fen include: glow worms, whose larvae sometimes ride on snails’ backs and deliver a toxic bite to paralyse their prey; water scorpions (not real scorpions, FYI), whose tails are a kind of snorkel, rather than a sting, which they use to breathe underwater; and clearwing moths, who have the remarkable ability to mimic wasps and hornets, which helps them avoid predators. The 10,000th species to be recorded on Wicken Fen was the Six-belted Clearwing, a nationally scarce species. We’re aiming for even more biodiversity through the addition of nature-rich reservoirs, which will help manage water levels and support wildlife. It’ll form part of a wider push to turn the UK’s degrading lowland peat soils into thriving ecosystems. This work is possible thanks to a major grant from The Nature Recovery Project.
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"A genome is like a time machine – it allows scientists to study how species adapt and respond to climate and environment over time." Mark Blaxter was recently featured in this WWT piece discussing how genomes from wetland species are being used to support future conservation and give researchers a clearer picture of the UK’s ecological web. 🦢 This piece dives into how samples travel from wetlands to the Natural History Museum and on to the Sanger Institute, where the secrets of their DNA are unlocked. Read on to find out more about their journey ⤵️ https://lnkd.in/eh3vy8nR
Imagine knowing the full genetic code of all 70,000 wetland species in Britain and Ireland. 🧬 What could that mean for the future of our wetlands? 🌿 In a collaboration called the Darwin Tree of Life project, including WWT, Natural History Museum, and the Wellcome Sanger Institute, we're helping write the genomic story of the UK's wetland species. Through brilliant fieldwork, expert processing, and state-of-the-art lab work, our teams are helping provide samples that can be turned into invaluable data. This is vital for: 🦆 Understanding species origins, the pressures they face and how we can help. 🌱 Supporting future conservation. 🕸️ Giving researchers a clearer picture of the UK’s ecological web. Discover how this team effort is helping to map the genealogy of the wetland species across the UK, including its 3,000th species, the humble smew: https://lnkd.in/eBxPPGG9 #DarwinTreeOfLife #GenomeSequencing #Conservation [PDF carousel description: Slide 1: A male smew stretching out of the water and flapping its wings. Text says ‘Cracking the code for 70,000 wetland species’. Slide 2: A hand wearing a blue medical glove holds two Eppendorf tubes. Text says ‘In a collaboration with the Darwin Tree of Life project and the Wellcome Sanger Institute, we're helping write the genomic story of the UK's wetland species.’ Slide 3: An aerial view of a wetland featuring a long body of water with grasses along the edges. Text says ‘The project aims to sequence the genome of Britain and Ireland’s wetland species, starting with samples collected by WWT.’ Slide 4: Frozen test tubes sit in rows in a purple rack. Text says ‘These samples make their way to the Natural History Museum to be transformed into valuable genomic data.’ Slide 5: A computer screen shows a Hi-C map. Text says ‘And the Sanger Institute take this forward to get one step closer to a fully pieced together genome puzzle.’ Slide 6: Three people stand taking notes and observing at the edge of a wetland, a large pool of water in front of them. Text says ‘Helping support future conservation and giving researchers a clearer picture of the UK’s ecological web.’]
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We're #hiring a new Laboratory Equipment Repair Team Leader in Hinxton, England. Apply today or share this post with your network.
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We're #hiring a new Postdoctoral Fellow- Cancer Functional Genomics in Hinxton, England. Apply today or share this post with your network.
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A new technique can reveal hidden genetic changes in healthy cells, marking a major step forward in understanding how tissues change over time. 🧬 Researchers at the Wellcome Sanger Institute have refined NanoSeq, an ultra-accurate DNA sequencing tool, to uncover over 340,000 genetic changes, including those linked to cancer, ageing, smoking, and alcohol. This improved technology opens the door to studying how lifestyle, environment, and inherited factors shape our DNA, potentially enabling earlier interventions and cancer prevention. Read our full story here 👇 https://lnkd.in/dUJxcbBw
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A hidden evolutionary process has been uncovered in sperm — where certain harmful DNA changes are naturally favoured as men age. This subtle form of evolution gives some genetic changes a competitive edge, increasing the risk of genetic conditions. 🔬 Conducted by the Wellcome Sanger Institute in collaboration with the TwinsUK cohort at King's College London, the new study used ultra-accurate sequencing to reveal how natural selection occurs within sperm-producing cells. These findings pave the way for further exploration into how lifestyle and environmental factors may influence genetic risks for future generations. Read more about the study here ⤵️ https://lnkd.in/eyVrjKGE
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Lupus affects thousands of people across the world yet remains one of the most complex autoimmune diseases to understand and treat. 🌍 This #LupusAwarenessMonth, we are spotlighting how our research at the Wellcome Sanger Institute is helping to unravel the genetic and molecular mechanisms of lupus. 🧬 By recruiting patients with varied ancestral backgrounds, Catherine Sutherland and her colleagues are trying to understand how ancestry influences differences seen in lupus patients. This will hopefully pave the way for personalised care that is effective for everyone. 💊 Read more in our blog: https://lnkd.in/eePzrhg7
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Our PhD Applications are now open! Become part of a community nurturing the next generation of world-class genome scientists and clinicians. Our PhD students work at the cutting edge of science, contributing to discoveries that advance understanding of health and disease. Apply now to start your journey: https://lnkd.in/g_JfNuFE 📅 Closing date: 27 November 2025 #ScienceCareers
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We're #hiring a new HR Services On-Boarding Administrator in Hinxton, England. Apply today or share this post with your network.