International Society for Stem Cell Research

You might have heard about epigenetics, chemical modifications to DNA and histones, that highly correlate with gene expression and aging. But have you heard about RNA epigenetics or epitranscriptomics? How chemical modifications to RNA affect gene expression? https://lnkd.in/gJyx46SR In our recently published paper International Society for Stem Cell Research ‘s journal, Stem Cell Reports, we use a special form of CRISPR (dCas13-FTO) that “erases” RNA modifications to conclude that RNA modifications control stem cell to retina formation. Blocking the enzyme that controls RNA modifications, METTL3, stops stem cells from becoming retinal organoids but not other non retinal, brain organoids. In a world where stem cell derived tissues are playing an important role in regenerative medicine , clinical trials for blindness, etc we are happy to contribute to new discoveries in the field of stem cells , retinal organoids and epitranscriptomics. Major thanks to our team University of Michigan Kellogg Eye Center and U.S. Department of Veterans Affairs (Jing Xu, Qiang Li, Charukesi Sivakumar , Jie Liu, Yuanhao Huang , and Zhaowei Han) for making this work possible . We could not do this without our funders Research to Prevent Blindness , National Eye Institute (NEI) , U.S. Department of Veterans Affairs , and grateful patients and their families for community support of this work.

New #organoid research from University of Michigan Kellogg Eye Center published in Stem Cell Reports: Multi-omics establishes METTL3-dependent m6A as a critical epitranscriptomic layer in retinal development, unveiling a genomic paradigm in which chromatin accessibility diverges from transcriptional output. https://ow.ly/a5mL50XhKGv Gairdner Foundation | SickKids Foundation | Cell Press

Organizing Committee Member, Stefan Irion, shares his insights on what excites him about the upcoming PSC-Derived Therapies in Boston this December. Join him and others by registering today! https://lnkd.in/e493wFTK

Organizing Committee Member, Stefan Irion, shares his insights on what excites him about the upcoming PSC-Derived Therapies Symposium in Boston this December. Join him, myself, and others by registering today! https://lnkd.in/eqDabGxu. International Society for Stem Cell Research

Join me and register for the upcoming Digital Webinar by the International Society for Stem Cell Research! 🌟 I’ll be presenting our latest work on prostate cancer patient-derived organoids, featured in our recent paper “Single-cell analysis uncovers preserved prostate cancer lineages and universally altered pathways in Matrigel-free patient-derived organoids.” Register here: 👉 https://lnkd.in/e5FeSZT5

I am excited to share that I have been selected as an #ISSCR2026 Ambassador! The ISSCR 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 and features 4 days of scientific sessions with talks from global researchers! I will share updates in the coming months to keep you posted. For now, explore the scientific program and ways to participate! https://lnkd.in/eTsKKzh9 International Society for Stem Cell Research

New #hematopoiesis research from University of Wisconsin-Madison published in Stem Cell Reports: GABA produced by multiple bone marrow cell types regulate hematopoietic stem and progenitor cells. #microenvironment #bonemarrow #Bcells https://ow.ly/es0G50XeaPA Gairdner Foundation | SickKids Foundation | Cell Press

🎉 Really excited to share that our first lab publication is out in Stem Cell Reports! A fantastic milestone for the lab and a major achievement for Maria’s PhD! Our data reveal for the first time that EGFR, JNK, & ROS mediate a bidirectional feedback between somatic cyst cells and encapsulated germ cells in the Drosophila testis. 🔬🧬 Follow-up studies will continue, supported by my #Springboard2025 award from the Academy of Medical Sciences . Medway School of Pharmacy Faculty of Engineering and Science University of Greenwich University of Kent International Society for Stem Cell Research #StemCellBiology #Drosophila #Signaling #Spermatogenesis #germline #polarity #endocytosis #cellcommunication https://lnkd.in/eNpqnNH3

International Society for Stem Cell Research recently released Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies. The comprehensive, interactive document is designed for academic and industry scientists and regulators to address critical areas of the translational pipeline and key decision points essential for successful translation to a licensed therapy. BlueRocker Mark Tomishima is a member of a working group that contributed to this publication. Access the resource and learn more: https://lnkd.in/e4dSVffy

Online now in Stem Cell Reports! EGFR, JNK & ROS signaling mediate bidirectional feedback between cyst cells and encapsulated germ cells in Drosophila testis. #germline #polarity #endocytosis #cellcommunication https://ow.ly/pVOj50Xeakh Medway School of Pharmacy | Gairdner Foundation | SickKids Foundation | Cell Press