Trends in Chemistry

Online now: Rational design of therapeutic RNA molecules http://dlvr.it/TNwzL2

Trends in Chemistry's October issue is online now: Tiny bags, big discoveries: https://hubs.li/Q03P4RMc0 Membrane proteins are vital drug targets, yet their structural characterization is often hindered by instability in conventional detergents. In their Review, Chae and colleagues present pendant-bearing detergents as next-generation tools to address this challenge. Pendant chains positioned at the hydrophilic-hydrophobic interface enhance protein stabilization in multiple ways, including filling micelle voids, mediating transitions from bola- to facial amphiphiles, inverting pendant orientation, and tuning detergent architecture in the presence of membrane proteins. By combining stability with versatility, these innovative detergents open new opportunities for high-resolution structural biology of membrane proteins. Cover artwork by Yewon Lee, created with Cinema 4D, Blender and Photoshop.

Online now: Steroids under voltage: unlocking reactivity with electrochemistry http://dlvr.it/TNtNth

Online now: Electrospun mesh electrodes advance paper-based nucleic acid detection http://dlvr.it/TNqLtz A Spotlight article from Thiago Regis Longo Cesar da Paixão at USP - Universidade de São Paulo 🧬 From our upcoming special issue The Chemistry of Nucleic Acids, highlighting some exciting research in Cell Reports Physical Science by Cell Press!

Happy to share our latest review in Trends in Chemistry: We highlight the biosynthesis of unusual and highly modified amino acids in complex peptide natural products. We compare different biosynthetic routes in the different pathway types (ribosomal vs. nonribosomal) and especially focus on recently discovered pathway interconnections. Great work by talented PhD student Lukas Zimmer!

Online now: Amino acid tailoring strategies in peptide natural product biosynthesis http://dlvr.it/TNmG8c #OpenAccess A Review article from Max Crüsemann and colleagues Goethe University Frankfurt

Online now: Electrosynthesis unleashed: green pathways to natural product synthesis http://dlvr.it/TNlZnl A Forum article from Kyoungsuk Jin and colleagues Korea University

Online now: Non-carbohydrate syntheses of nucleoside analogues http://dlvr.it/TNklJM From our upcoming special issue on The Chemistry of Nucleic Acids Thanks to Robert Britton and colleagues for the contribution! Simon Fraser University

🧪 Check out the October issue of Trends in Chemistry! Our cover article and artwork comes from the team of Pil Seok Chae at Hanyang University. Their Review article in this issue covers recent developments in and novel strategies for pendant-bearing detergent design, and their use as valuable tools for membrane protein structural studies: https://lnkd.in/eG4hEafH 📰 Read our full October issue at: https://lnkd.in/ePj5_M6Q Additional highlights from the rest of the issue include: - Two Spotlight articles from Seol Baek and Sihai Yang covering recent research highlights in Chem by Cell Press - a Science & Society article from Fun Man Fung and colleagues on bridging the gender gap in chemistry #OpenAccess - a Forum article from M. Carmen Galan and colleagues on sigma-hole donor catalysts for oligosaccharide synthesis (also Open Access!) - A Review from Hoi-Ri Moon and colleagues on strategic approaches to structural complexity in MOFs - timely for the recent #ChemNobel! - A Review from Kate Waldie and colleagues on recent developments in molecular transition metal catalysis for electrocatalytic hydrogenation. Thanks as always to all our contributors this month for such a great issue - we'll see you in November for the next issue!

Online now: Adenosine deaminase: structure–activity relationships and harnessing biocatalysis to access purine nucleoside analogues http://dlvr.it/TNcZpJ From our upcoming special issue on The Chemistry of Nucleic Acids Thanks to Sebastian Cosgrove, Gavin J. Miller and colleagues for the contribution! Keele University