"Europe's Psychedelic Research: An Interview with Professor Robert Schoevers"

As many as one-third of patients with major depression do not achieve remission with oral antidepressants. Although single ketamine infusions produce rapid antidepressant effects, these benefits typically dissipate within days. In the latest episode of the JAMA Psychiatry Author Interviews podcast, Declan McLoughlin, PhD, Research Professor of Psychiatry at St Patrick’s University Hospital and Trinity College Dublin, discusses the KARMA-Dep 2 randomized clinical trial with host John Torous, MD. 🎧 Listen now: https://ja.ma/4oxbf1p

We’re excited to share that Dr. Mike Browning presented data from the results from the PAX-D study, as previously published in The Lancet, at the #ECNP Congress 2025 today. The PAX-D results guided Alto Neuroscience’s acquisition of ALTO-207, designed to induce rapid antidepressant effects while mitigating dose-limiting adverse events of pramipexole. This presentation highlights the potential of ALTO-207, which we believe represents an important step forward in bringing precision psychiatry to those living with depression. #ECNP2025 #AltoNeuroscience #PrecisionPsychiatry #MentalHealthInnovation

The European College of Neuropsychopharmacology has since its start in the mid-1980 become a highly influential organization to drive progress in the neuropsychopharmacology field. As one of many examples, ECNP is running a set of "New Frontiers Meetings" that have taken on the ambitious task to strongly drive the building the fundament to "let the biology speak" in psychiatry. The Precision Psychiatry publication earlier this year is a prime example of that effort (Mol Psychiatry 30, 3846–3855 (2025). https://lnkd.in/dRKxHe-H). ECNP also organizes its yearly congress, the ECNP 2025 is held in Amsterdam. The meeting serves as an excellent check-in on where psychiatry is heading; its breakthroughs, but also clearly shows that much work remains. I was happy to see the interest in a mini-session organized by Lundbeck and Otsuka on how critical treatment of anxiety in schizophrenia is to early intervene in the disease and aim to provide essential functional recovery. Two great talks by professors Cinzia Niolu, Sapienza University of Rome and Leslie Citrome, New York Medical College. Thanks to the MA team in Lundbeck for a well-organized session.

A new study in Biological Psychiatry reveals that childhood trauma leaves a measurable and enduring imprint on the body’s metabolism, a biological signature that may explain why survivors face higher health risks later in life. Analyzing blood samples from nearly 3,000 adults over six years, researchers found 18 metabolites consistently linked to childhood trauma, showing a clear dose–response pattern with trauma severity. These changes involve pathways tied to energy metabolism, stress regulation, and mitochondrial efficiency. Importantly, many of these metabolic alterations were distinct from those seen in depression, suggesting that trauma exerts its own long-lasting biological influence. This work underscores how early adversity becomes biologically embedded and points toward new preventive and therapeutic strategies targeting these metabolic pathways. https://lnkd.in/dc7C6B8c

The release of the web tool, the Psymatik Treatment Optimizer, has been accompanied by the publication of an umbrella review in Lancet Psychiatry. Researchers reviewed all available data on 69 medications – 32 antipsychotics and 37 antidepressants – which was then used to create a database of side effects and effectiveness of each one. Researchers hope the analysis—and the online tool they had previously developed—will help practitioners better tailor prescriptions to meet patients' unique concerns and preferences. https://lnkd.in/eKxqs83Y

💡 Antidepressants can be transformative but their physical side effects vary significantly. New research published in The Lancet Group from Institute of Psychiatry, Psychology & Neuroscience King’s College London and the University of Oxford, Department of Psychiatry supported by NIHR Oxford Health Biomedical Research Centre (OH BRC) , has ranked 30 #antidepressants, revealing notable differences in their impact on physical health, including heart rate, blood pressure, weight and sleep. These findings offer valuable insights for clinicians aiming to personalise treatment and improve patient care. Researchers are now calling for national prescribing guidelines to be updated to reflect this evidence. Read more on our website: https://lnkd.in/ea8fFHK8

🚨 Webinar series on how genetics and big data are transforming psychiatry! Access fresh insights into ground-breaking findings from the REALMENT project. Designed for clinicians, researchers, and anyone passionate about precision psychiatry, these fast-paced, interactive webinars are your front-row seat to the future of mental health research. ➡️AI-driven insights into genetics and symptoms in psychiatry 4 November at 16.00 CET | Nathaniel Bell, the Netherlands, and Piergiuseppe Di Palo, Italy Read more: https://ow.ly/HmT550X4VRf ➡️Genomics of bipolar disorder and physical health comorbidities 6 November at 16.00 CET | Kevin O'Connell, Norway, and Djennifer Kappel, UK Read more: https://ow.ly/XzZF50XgIUZ ➡️Integrating genomics and prescription data to advance precision psychiatry 11 November at 16.00 CET | Maris Alver, Estonia, and Guðmundur Einarsson, Iceland Read more: https://ow.ly/z0fC50XgIWQ Organised by ECNP in collaboration with the REALMENT EU Project consortium. #Psychiatry #Neuroscience #AIinMentalHealth #PrecisionPsychiatry

Curiosity Drives Viewers To Ignore Trigger Warnings: alternative_right shares a report from Phys.org: For the first time, a new study has tested the effectiveness of trigger warnings in real life scenarios, revealing that the vast majority of young adults choose to ignore them. A new Flinders University study has found that nearly 90% of young people who saw a trigger warning still chose to view the content, saying that they did so out of curiosity, rather than because they felt emotionally prepared or protected. The findings published in the Journal of Behavior Therapy and Experimental Psychiatry aligned with a growing body of lab-based research suggesting that trigger warnings rarely lead to the avoidance of potentially distressing material. Read more of this story at Slashdot.

AI isn’t replacing psychiatry. It’s transforming it. Mental health care is evolving from trial-and-error toward precision. For decades, psychiatry has relied on symptoms and self-report. But neuroscience and AI are reshaping the landscape: ✅ Biomarkers can predict relapse before symptoms appear. ✅ Smart data tools analyze speech, sleep, and activity patterns to detect early warning signs. ✅ AI-assisted models help clinicians tailor treatment with greater accuracy. This isn’t about replacing human care, it’s about giving clinicians tools that make care more precise, proactive, and effective. The shift from reactive psychiatry to precision psychiatry is already underway. #PrecisionPsychiatry #AIHealthcare #DigitalHealth #MentalHealthResearch #Neuroscience

MUSC researchers are advancing precision medicine in brain health and addiction. A study led by Dr. Xingbao Li in the Department of Psychiatry and Behavioral Sciences found that using machine learning to analyze brain imaging may predict which smokers are most likely to benefit from repetitive transcranial magnetic stimulation (rTMS). This breakthrough offers a roadmap for more personalized treatments not only for smoking cessation but potentially for other substance use disorders as well. Read more: https://lnkd.in/eb68wR9V #ChangingWhatsPossible