ProRenew Complex CLR™

Table of Contents Print Pages

Raw Material Documentation (7 pages) 2 - 8

Product Specification (4 pages) 9 - 12
Safety Data Sheet (7 pages) 13 - 19
ProRenew Complex CLR
Raw Material Documentation

1. Trade name: ProRenew Complex CLR

Use: Active for cosmetics
Manufacturer Supplier:
CLR – Chemisches Laboratorium
Dr. Kurt Richter GmbH
Sperenberger Straße 3
D-12277 Berlin / Germany
Tel.: +49 30 851026 – 0
Contact for information:
Sales Department

2. Raw Material Documentation

Chemical Name (IUPAC), Formula
Not applicable, as mixture

Characterization
ProRenew Complex CLR is obtained from a lysate of the Gram positive bacterial species
Lactococcus lactis, which is fermented under special conditions of catabolic repression. The
biotechnologically obtained suspension contains fragments such as DNA, metabolites,
cytoplasmic compounds and cell wall materials in a moderate acidic, aqueous medium.

Origin
biotechnologically produced.

3. INCI Name
(composition in percentages [ranges] according to FDA
recommendations)

INCI Name EU Name Range (FDA)

Lactococcus Ferment Lysate Lactococcus Ferment > 50 %

4. Registration
EINECS Designation: EINECS No.: CAS No.:
Lactococcus Ferment Lysate ./. ./.

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according to (EC) 1223/2009
ProRenew Complex CLR
Raw Material Documentation

5. Pharmacopoeial Registration
./.

6. Manufacturing Procedure
ProRenew Complex CLR is obtained by means of fermentation of Lactococcus lactis. After
growth is complete, the bacteria are disintegrated by means of high-pressure
homogenization, thus releasing the cytoplasm fractions and cell wall components. No
fractions are isolated after cell disintegration, thus ensuring the presence of all components in
ProRenew Complex CLR in their natural distribution.

7. Raw Material Properties

Appearance, Odor
Yellowish-white opalescent suspension with characteristic odor.

Solubility
Miscible with water and water-alcohol mixtures containing a maximum alcohol concentration
of 50% w/w, but yields no clear solutions

Recommended Use:
Recommended for products that aim for stimulation of skin's renewal processes. Both
accelerating it and improving its quality. ProRenew Complex CLR can be used in formulation
concepts to accelerate the recovery of skins barrier function, regardless of type of impairment
(environmental stress, aging).

Preferably used in emulsions but also in gel-type type formulations or serums, which are
stabilised with suitable hydrocolloids or polymers.

8. Analytical Data
Quality Control

Density 20 °C 1.005 - 1.015 g/ml

pH value 3.5 - 4.5
Dry residue (2 h, 120 °C) 1.8 – 2.5 %
Total Nitrogen (Kjeldahl) 0.05 - 0.15 %

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ProRenew Complex CLR
Raw Material Documentation

L-lactic acid* 7.0 – 10.0 mg/ml

Preservative: Sodium Benzoate 0.25 - 0.35 %
Colony forming units
Total aerobic microbial count (TAMC) < 100/ml
Total combined yeasts/moulds count (TYMC)
< 10/ml
in absence of non conforming organisms

* During fermentation, Lactococcus lactis mainly metabolizes glucose into L-Lactic acid.
Therefore, quantification of this characteristic metabolite allows estimation of the final germ
count to be obtained in the bioreactor before inactivation and disintegration, which usually
8 9
is in the range of 10 to 10 germs per ml.

9. Methods of Identification
(a) Total of quality control data.
(b) Through comparison with original strain using Matrix-Assisted Laser Desorption/Ionization
Time-of-Flight (MALDI-TOF) Mass Spectrometry. Typically performed on a Bruker MALDI
Biotyper.

10. Contaminants/Reaction Intermediates occurring in the Raw Material

Contaminants not to be expected Concentrations Methods

Formaldehyde x
Nitrosamines x
1,4-Dioxane x
Free ethylene oxide x
Monochloroacetic acid x
Dichloroacetic acid x
Monomers x
Halogenous organic compounds x
Polycyclic aromatic hydrocarbons *
Pesticides *

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according to (EC) 1223/2009
ProRenew Complex CLR
Raw Material Documentation

Contaminants not to be expected Concentrations Methods

Heavy metals
As < 0.10 ppm ICP-MS**
Cd < 0.01 ppm “
Pb < 0.05 ppm “
Hg < 0.005 ppm AAS
Sb < 0.05 ppm ICP-MS

Allergenic substances
(acc. to 2003/15/EC)
24 allergens < 1 mg/kg
Oakmoss and Treemoss negative
(qualitative)
Others ./.
* no data available ** spot-checked

11. Stabilizing Additives

Preservative: approx. 0.25 – 0.35 % Sodium Benzoate; CAS: 532-32-1; EINECS: 208-534-8
Other ingredients: approx. 0.3 % Sodium Chloride; CAS: 7647-14-5; EINECS: 231-598-3
0.7 – 1.0 % Lactic Acid; CAS: 50-21-5; EINECS: 200-018-0

12. Microbiology
Colony forming units (the total of aerobic, anaerobic and fungal colonies): < 100/g.
Check for absence of characteristic pathogenic germs (Aspergillus brasiliensis, Candida albicans,
Staphylococcus aureus, E. coli, Pseudomonas aeruginosa) is done using a sample of 0.5 ml.

13. Physiological Safety

Acute Toxicity
ProRenew Complex CLR is based on ingredients, which have a long tradition in food industries
as well as in cosmetic applications. It is considered to be non-toxic and safe in cosmetic
products usage at the levels advised by us.

Primary Skin Irritation

A 48 hour Patch test with a 50% solution of ProRenew Complex CLR has been performed on a
panel of 50 volunteers (18-67 years; 24 normal healthy, 3 eczema, 3 allergy and 20 subjects
with sensitive skin). All participants completed the study. Under the test conditions, SDS (1% in
water) caused positive reactions in 14 subjects. The negative control water showed no

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ProRenew Complex CLR
Raw Material Documentation

reactions. None of the subjects showed any reaction to the test product. On the basis of these
test results and under the test conditions, the product "ProRenew Complex CLR " is to be
classified as 'harmless' with regard to the possibility of skin irritation.

Eye irritation potential

ProRenew Complex CLR was tested undiluted using the Bovine Corneal Opacity and
Permeability Assay (BCOP) assay. The calculated mean in vitro irritation score was: 0.97.
According to the evaluation criteria ProRenew Complex CLR is classified into UN GHS “No
Category”. Therefore, ProRenew Complex is not posing a risk when applied in formulations
to the eye area region.
ProRenew Complex CLR was additionally tested, undiluted, on the chorioallantoic membrane of
the hen's egg where it produced an irritation index of 0.00. It therefore was classified as "non-
irritant".

Experienced Skin Tolerance under Use Conditions

Skin incompatibilities have not been reported.

Sensitization
Human Repeated Insult Patch Test (HRIPT):
ProRenew Complex CLR was tested on 50 volunteers (repeated application) using a 50%
solution of the active in 0.9% NaCl buffer. The methodology used corresponds to the guideline
« Test Clinique Final de Securité d’un Produit Cosmétique en vue de confirmer son absence de
potentiel sensibilisant cutané retardé: Recommandations aux promoteurs de recherche et aux
prestataires de service », from AFSSAPS. Two study phases, induction phase followed by
challenge phase, allow to conclude on the skin compatibility and cumulative irritation of the
product and its allergenic potential.
The repeated application of 50% ProRenew Complex CLR solutions allowed to conclude that
this product has a very good skin compatibility and has no allergenic potential (supporting
hypoallergenic claims).

14. Information on Percutaneous Permeation

no data available

15. Genotoxicity
Bacterial Testing
no data available

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according to (EC) 1223/2009
ProRenew Complex CLR
Raw Material Documentation

Non-Bacterial Testing
no data available

16. Human Experience (as far as available)

cf. 13. “Primary Skin Irritation”

17. Other Information

Chronic Toxicity
no data available

Subchronic Toxicity
no data available

Teratogenicity
no data available

Toxicokinetics
no data available

Additional Genotoxicological Tests (as far as required)

no data available

Mutagenicity
ProRenew Complex CLR was investigated for its potential to induce gene mutations according
the bacterial reverse mutation assay using 4 different strains of Salmonella typhimurium and
E. coli WP2 uvrA bacteria, with and without metabolic activation. No mutagenic effects could
be observed in any of the five tester strains up to the highest dosage.

BSE Hazard
ProRenew Complex CLR does not imply any risk of BSE since it contains neither animal nor
animal-derived raw materials.

18. Potential Risks presented by UV Exposure and on Inhalation

Phototoxicity
no data available

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according to (EC) 1223/2009
ProRenew Complex CLR
Raw Material Documentation

Photosensitization
no data available

Toxicity on Inhalation
no data available

19. Ecology
Biodegradability
ProRenew Complex CLR, as a lysate from Lactococcus lactis, is non-toxic and
easily biodegradable.

Acute Aquatic Toxicity

- Bacteria
- Algae
- Daphnia no data available

- Fish

Water Pollution Hazard Class:

Product presents no water pollution hazard (self-classification).

authorized by:

W. Reinhold
(Director Quality Assurance)
– valid without signature –

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according to (EC) 1223/2009
ProRenew Complex CLR
Product Specification

Characteristics
ProRenew Complex CLR is obtained from a lysate of the Gram positive bacterial species
Lactococcus lactis, which is fermented under special conditions of catabolic repression. The
biotechnologically obtained suspension contains fragments such as DNA, metabolites,
cytoplasmic compounds and cell wall materials in a moderate acidic, aqueous medium.

INCI Name CAS No. EINECS No.

Lactococcus Ferment Lysate ./. ./.

Analytical Data

Density 20 °C 1.005 - 1.015 g/ml

pH value 3.5 - 4.5
Dry residue (2 h, 120 °C) 1.8 – 2.5 %
Total Nitrogen (Kjeldahl) 0.05 - 0.15 %
L-lactic acid* 7.0 – 10.0 mg/ml
Preservative: Sodium Benzoate 0.25 - 0.35 %
Colony forming units
Total aerobic microbial count (TAMC) < 100/ml
Total combined yeasts/moulds count (TYMC) < 10/ml
in absence of non conforming organisms
Identification Through comparison with original strain using
Matrix-Assisted Laser Desorption/Ionization Time-
of-Flight (MALDI-TOF) Mass Spectrometry.
Typically performed on a Bruker MALDI Biotyper.

* During fermentation, Lactococcus lactis mainly metabolizes glucose into L-lactic acid.
Therefore, quantification of this characteristic metabolite allows estimation of the final germ
count to be obtained in the bioreactor before inactivation and disintegration, which usually
8 9
is in the range of 10 to 10 germs per ml.

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ProRenew Complex CLR
Product Specification

Physiological Safety
Acute oral toxicity
ProRenew Complex CLR is based on ingredients, which have a long tradition in food industries as well
as in cosmetic applications. It is considered to be non-toxic and safe in cosmetic products usage at the
levels advised by us.

Eye irritation potential

ProRenew Complex CLR was tested undiluted using the Bovine Corneal Opacity and Permeability
Assay (BCOP) assay. The calculated mean in vitro irritation score was: 0.97. According to the
evaluation criteria ProRenew Complex CLR is classified into UN GHS “No Category”.
Therefore, ProRenew Complex CLR is not posing a risk when applied in formulations to the eye
area region.

ProRenew Complex CLR was additionally tested, undiluted, on the chorioallantoic membrane of the
hen's egg where it produced an irritation index of 0.00. It therefore was classified as "non-irritant".

Mutagenicity
ProRenew Complex CLR was investigated for its potential to induce gene mutations according the
bacterial reverse mutation assay using 4 different strains of Salmonella typhimurium and E. coli WP2
uvrA bacteria, with and without metabolic activation. No mutagenic effects could be observed in any
of the five tester strains up to the highest dosage.

Skin compatibility
A 48 hour Patch test with a 50% solution of ProRenew Complex CLR has been performed on a panel
of 50 volunteers (18-67 years; 24 normal healthy, 3 eczema, 3 allergy and 20 subjects with sensitive
skin). All participants completed the study. Under the test conditions, SDS (1% in water) caused
positive reactions in 14 subjects. The negative control water showed no reactions. None of the
subjects showed any reaction to the test product. On the basis of these test results and under the test
conditions, the product "ProRenew Complex CLR " is to be classified as 'harmless' with regard to the
possibility of skin irritation.

Sensitization
Human Repeated Insult Patch Test (HRIPT):
ProRenew Complex CLR was tested on 50 volunteers (repeated application) using a 50% solution
of the active in 0.9% NaCl buffer. The methodology used correponds to the guideline « Test
Clinique Final de Securité d’un Produit Cosmétique en vue de confirmer son absence de potentiel
sensibilisant cutané retardé: Recommandations aux promoteurs de recherche et aux prestataires

Page 2 04/17
ProRenew Complex CLR
Product Specification

de service », from AFSSAPS. Two study phases, induction phase followed by challenge phase,
allow to conclude on the skin compatibility and cumulative irritation of the product and its
allergenic potential.
The repeated application of 50% ProRenew Complex CLR solutions allowed to conclude that this
product has a very good skin compatibility and has no allergenic potential (supporting
hypoallergenic claims).

Mode of action
ProRenew Complex CLR is produced by fermentation of probiotic bacteria in a bioreactor, with
subsequent inactivation and mechanical disintegration.

Probiotic bacteria are well-established in the food industry and their benefits for the human
body are described in many scientific, peer-reviewed papers. In the gut they beneficially
influence the composition and metabolic activity of the endogenous bacteria and some
probiotic strains are even able to inhibiPt the growth of pathogenic bacteria. Probiotic bacteria
are also reported to be able to modulate the immune system, essentially improving
immunocompetence and, therefore, our body's ability to adapt to negative influences.
Interestingly, it is not the whole living probiotic bacterial cell which is needed for the latter
activity, it is the constituents and metabolites from these bacteria which are essential. A lysate
of Lactococcus lactis, as in ProRenew Complex CLR, essentially containing the cell debris of this
bacterium, has shown in the studies performed by CLR GmbH, that it is able to improve both
the skin renewal processes and the processes involved in the skin's adaptation to negative
influences.

Application
Recommended for products that aim for stimulation of skin's renewal processes. Both
accelerating it and improving its quality. ProRenew Complex CLR can be used in formulation
concepts to accelerate the recovery of skins barrier function, regardless of type of impairment
(environmental stress, aging).

Preferably used in emulsions but also in gel-type type formulations or serums, which are
stabilised with suitable hydrocolloids or polymers.

Dosage
3%

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ProRenew Complex CLR
Product Specification

Appearance/Odor
Yellowish-beige, opalescent suspension with characteristic odor.

Solubility
Miscible with water and water-alcohol mixtures containing a maximum alcohol concentration of
50% w/w, but yields no clear solutions.

Processing
The microorganism fragments contained will form a sediment after some time of storage.
Shake or agitate before use to obtain homogenous solutions. When formulating ProRenew
Complex CLR it has to be considered, that electrolyte sensitive components of formulations
might be influenced. Electrolyte sensitive rheology modifiers and hydrocolloids might lose some
efficacy, depending on the percentage of ProRenew Complex CLR used in final formulations.

During the production process ProRenew Complex CLR should not be exposed to temperatures
exceeding 40 °C. The pH of final formulations containing ProRenew Complex CLR should range
between 4 and 7.

Storage
At room temperature (15 - 25 °C), in well-closed containers, protected from light.
ProRenew Complex CLR should not be stored for longer than 1 year before processing. Once
opened, the packs should be fully used. Any remaining product should be discarded.

Packing
Available pack sizes: 1 kg; 5 kg; 25 kg
Sample size: 50 g

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Safety Data Sheet
according to Regulation (EC) No. 1907/2006 (REACH)

Trade name : ProRenew Complex CLR

Revision date : 24.06.2016 Version (Revision) : 2.1.0 (2.0.1)
Print date : 13.06.2018

SECTION 1: Identification of the substance/mixture and of the company/ undertaking

1.1 Product identifier

ProRenew Complex CLR (421)
1.2 Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses
Cosmetics, personal care products
Uses advised against
No information available.
Remark
The product is intended for professional use.
1.3 Details of the supplier of the safety data sheet
Supplier (manufacturer/importer/only representative/downstream
user/distributor)
CLR Chemisches Laboratorium
Dr. Kurt Richter GmbH
Street : Bennigsenstrasse 25
Postal code/city : D-12159 Berlin
Telephone : +49 30 851026 0
Telefax : +49 30 851026 85
Information contact : [email protected]
1.4 Emergency telephone number
+49 30 851026 0 (Available at: Mon.-Thu. 8.00 am - 4.30 pm; Fri. 8.00 am - 3.30 pm)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 [CLP]
None
2.2 Label elements
According to EC directives or the corresponding national regulations the product does not have to be labelled.
2.3 Other hazards
None

SECTION 3: Composition/information on ingredients

3.2 Mixtures
Description
ProRenew Complex CLR is obtained from a lysate from the Gram positive bacterial species Lactococcus lactis. The
biotechnologically obtained suspension is present in a moderate acidic, aqueous medium.
Hazardous ingredients
None
This mixture contains the following substances of very high concern (SVHC) which are included in the
Candidate List according to Article 59 of REACH
None
This mixture contains the following substances of very high concern (SVHC) which are subject to
authorisation according to Annex XIV of REACH

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Safety Data Sheet
according to Regulation (EC) No. 1907/2006 (REACH)

Trade name : ProRenew Complex CLR

Revision date : 24.06.2016 Version (Revision) : 2.1.0 (2.0.1)
Print date : 13.06.2018

None

SECTION 4: First aid measures

4.1 Description of first aid measures

Following inhalation
Provide fresh air.
In case of skin contact
Water and soap
After eye contact
After contact with the eyes, rinse with water with the eyelids open for a sufficient length of time, then consult an
ophthalmologist immediately.
After ingestion
Do NOT induce vomiting.
4.2 Most important symptoms and effects, both acute and delayed
No information available.
4.3 Indication of any immediate medical attention and special treatment needed
None

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media
Water Carbon dioxide (CO2) Foam
Unsuitable extinguishing media
None
5.2 Special hazards arising from the substance or mixture
Hazardous combustion products
The product itself does not burn.
5.3 Advice for firefighters
Do not inhale explosion and combustion gases.
5.4 Additional information
Do not allow run-off from fire-fighting to enter drains or water courses.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

No special measures are necessary.
6.2 Environmental precautions
Do not allow to enter into surface water or drains.
6.3 Methods and material for containment and cleaning up
Absorb with liquid-binding material (e.g. sand, diatomaceous earth, acid- or universal binding agents).
6.4 Reference to other sections
None

SECTION 7: Handling and storage

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( EN / D )
Safety Data Sheet
according to Regulation (EC) No. 1907/2006 (REACH)

Trade name : ProRenew Complex CLR

Revision date : 24.06.2016 Version (Revision) : 2.1.0 (2.0.1)
Print date : 13.06.2018

7.1 Precautions for safe handling

None
7.2 Conditions for safe storage, including any incompatibilities
Hints on joint storage
Storage class : 10
Storage class (TRGS 510) : 10
Further information on storage conditions
Protect against : UV-radiation/sunlight Frost
Storage temperature : 15 - 25 °C (59 - 77 °F)
7.3 Specific end use(s)
None

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

DNEL/DMEL and PNEC values
DNEL/DMEL
No substance related limit value derivable.
PNEC
No substance related limit value derivable.
8.2 Exposure controls
Personal protection equipment

Eye/face protection
Suitable eye protection
Eye glasses with side protection
Skin protection
Hand protection
Suitable gloves type : Disposable gloves.
Suitable material : PE (polyethylene) NR (natural rubber, natural latex) NBR (Nitrile rubber)
Thickness of the glove material : > 0.1 mm
Respiratory protection
Usually no personal respirative protection necessary.
General health and safety measures
When using do not eat, drink, smoke, sniff. Minimum standard for preventive measures while handling with working
materials are specified in the TRGS 500.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

Appearance
Physical state : liquid
Colour : Slightly yellow.
Odour

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Safety Data Sheet
according to Regulation (EC) No. 1907/2006 (REACH)

Trade name : ProRenew Complex CLR

Revision date : 24.06.2016 Version (Revision) : 2.1.0 (2.0.1)
Print date : 13.06.2018

characteristic
Safety relevant basis data
Physical state : liquid
Initial boiling point and boiling approx.
( 1013 hPa ) 100 °C
range :
Flash point : > 100 °C
approx.
Vapour pressure : ( 50 °C ) 123 hPa

Density : ( 20 °C ) 1,005 - 1,015 g/cm3

Solvent separation test : ( 20 °C ) No data available
pH : 3,5 - 4,5
approx.
Viscosity : ( 20 °C ) 10 mPa.s

9.2 Other information

None

SECTION 10: Stability and reactivity

10.1 Reactivity
No information available.
10.2 Chemical stability
No information available.
10.3 Possibility of hazardous reactions
No information available.
10.4 Conditions to avoid
No information available.
10.5 Incompatible materials
No information available.
10.6 Hazardous decomposition products
No information available.

SECTION 11: Toxicological information

11.1 Information on toxicological effects

ProRenew Complex CLR is based on ingredients, which have a long tradition in food industries as well as in cosmetic
applications. It is considered to be non-toxic and safe in cosmetic products usage at the levels advised by us.
Irritant and corrosive effects
Primary irritation to the skin
Parameter : Primary irritation to the skin
Species : Human
Result : Not irritant
Method : Patch-Test (50% in Water)
Irritation to eyes
Parameter : Irritation to eyes
Species : Bovine eye/corneal
Result : No objections to the use in the vicinity of the eye.
Parameter : Irritation to eyes
Species : hen's egg
Result : Not irritant
Method : HET-CAM
CMR effects (carcinogenicity, mutagenicity and toxicity for reproduction)

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( EN / D )
Safety Data Sheet
according to Regulation (EC) No. 1907/2006 (REACH)

Trade name : ProRenew Complex CLR

Revision date : 24.06.2016 Version (Revision) : 2.1.0 (2.0.1)
Print date : 13.06.2018

The ingredients in this mixture do not meet the criteria for classification as CMR category 1A or 1B according to CLP.
Germ cell mutagenicity
In vitro mutagenicity
Parameter : Ames-Test
Species : Salmonella typhimurium
Test result : not mutagen
Parameter : Ames-Test
Species : E. coli WP2 uvrA
Test result : not mutagen

SECTION 12: Ecological information

12.1 Toxicity
Effects in sewage plants
Biodegradable.
12.2 Persistence and degradability
Biodegradation
Biodegradable.
12.3 Bioaccumulative potential
No information available.
12.4 Mobility in soil
No information available.
12.5 Results of PBT and vPvB assessment
This substance does not meet the PBT/vPvB criteria of REACH, Annex XIII.
12.6 Other adverse effects
No information available.
12.7 Additional ecotoxicological information
None

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product/Packaging disposal
Waste treatment options
Appropriate disposal / Product
Dispose of waste according to applicable legislation.
Appropriate disposal / Package
Completely emptied packages can be recycled.

SECTION 14: Transport information

14.1 UN number
No dangerous good in sense of these transport regulations.
14.2 UN proper shipping name
No dangerous good in sense of these transport regulations.
14.3 Transport hazard class(es)
Land transport (ADR/RID)
No dangerous good in sense of these transport regulations.

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( EN / D )
Safety Data Sheet
according to Regulation (EC) No. 1907/2006 (REACH)

Trade name : ProRenew Complex CLR

Revision date : 24.06.2016 Version (Revision) : 2.1.0 (2.0.1)
Print date : 13.06.2018

Class(es) : -
Sea transport (IMDG)
No dangerous good in sense of these transport regulations.
Class(es) : -
Air transport (ICAO-TI / IATA-DGR)
No dangerous good in sense of these transport regulations.
Class(es) : -
14.4 Packing group
No dangerous good in sense of these transport regulations.
14.5 Environmental hazards
No dangerous good in sense of these transport regulations.
14.6 Special precautions for user
None
14.8 Additional information
Transport temperature: 10 – 25 °C / 50 – 77 °F, protect from frost.

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or

15.1
mixture
National regulations
Water hazard class (WGK)
Class : nwg (Non-hazardous to water) Classification according to VwVwS
15.2 Chemical safety assessment
No information available.

SECTION 16: Other information

16.1 Indication of changes

02. Label elements · 03. This mixture contains the following substances of very high concern (SVHC) which are included
in the Candidate List according to Article 59 of REACH · 03. This mixture contains the following substances of very high
concern (SVHC) which are subject to authorisation according to Annex XIV of REACH
16.2 Abbreviations and acronyms
None
16.3 Key literature references and sources for data
None
Classification for mixtures and used evaluation method according to regulation (EC)
16.4
No 1272/2008 [CLP]
No information available.
16.5 Relevant H- and EUH-phrases (Number and full text)
None
16.6 Training advice
None
16.7 Additional information
None

The above information describes exclusively the safety requirements of the product and is based on our present-day
knowledge. The information is intended to give you advice about the safe handling of the product named in this safety data

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( EN / D )
Safety Data Sheet
according to Regulation (EC) No. 1907/2006 (REACH)

Trade name : ProRenew Complex CLR

Revision date : 24.06.2016 Version (Revision) : 2.1.0 (2.0.1)
Print date : 13.06.2018

sheet, for storage, processing, transport and disposal. The information cannot be transferred to other products. In the case of
mixing the product with other products or in the case of processing, the information on this safety data sheet is not necessarily
valid for the new made-up material.

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