E Souvenir
E Souvenir
S. No Contents Page No
1 Introduction 1
2 Messages 2
4 Organizing committee 16
6 Glimpses of AIIA 38
8 Invited Articles 62
As per 2018 estimates of GLOBOCAN cancer incidence in India is rising continuously. From 28 types
of cancers were increased to 36 types in 2018. Showing the growing burden. Cancer mortality in India
has doubled from 1990 to 2016. India’s cancer incidence is estimated at 1.15 million new patients in
2018 and is predicted to almost double as a result of demographic changes alone by 2040.
Management including combating side effects of conventional therapy of cancer has become the real
challenge for present medical practice. About the conditions like cancer and its management has been
mentioned in ancient Ayurveda literature. Now it’s the time to explore the hidden potentials of
Ayurveda medicines with scientific backgrounds.
At this juncture joining hands towards the management of cancer, identifying the strength and
weaknesses of each other system of medicine with integration is the need of hour. With this background
“Jivaneeyam 2020” National seminar has been conceived. All the experts in the field of cancer
management through Ayurveda form different parts of the country are invited for the seminar.
Integrative Protocol to prepare for major cancerous conditions is the main objective of the seminar. The
seminar is one of the effective reflections of its scientific, academic, and social contribution.
Information about the seminar was sent through website of AIIA and public media. Online registration
method was followed looking to the convenience of registration. Nearly 180 PG & PhD scholars,
scientists, practitioners, Research officers of different institutions have registered for the seminar.
Abstracts and full papers from delegates were received in considerable number and out of those 25
paper presentations and 20 poster presentations selected for presentation in seminar by the scientific
committee. The abstracts submitted in the conference could be a good marker of Ayurveda research. It
can be indicative of the quality, quantity and the areas of research being carried out. It can also serve as
a source for identifying strengths and opportunities for exploring collaborative research.
Let us together infuse new enthusiasm in young and veteran Ayurveda educationists, scientists,
clinicians to make Ayurveda relevant, dynamic and most sought after discipline. We whole heartedly
appreciate all the endeavours of our colleagues and scholars from around the world who helped us to
make this event more effective and possible.
12
PATRONS
CHIEF PATRON PATRON
ADVISORY BOARD
Organizing Chairman
Dr V G Huddar
Organizing Secretaries
16
RECEPTION COMMITTEE
Chairman
Prof. P K Prajapati
Chairman
Dr Kamini Dhiman
18
SCIENTIFIC/PUBLICATION COMMITTEE
Chairman
PRINTING COMMITEE
Chairman
20
ACCOMMODATION AND TRANSPORT COMMITTEE
Chairman
Dr Vyasdev Mahanta
CATERING COMMITTEE
Chairman
Prof Manjusha R
22
PRESS & MEDIA COMMITTEE
Chairman
Dr Sisir Mandal
Dr Prashant D Dr Divya Kajaria
FINANCE COMMITTEE
Chairman
Dr R K Yadava
24
PUBLIC AWARENESS COMMITTEE
Chairman
Mr Man Singh
26
RESOURCE PERSONS
OF WORKSHOP
&
SEMINAR
28
Resource Persons of the Pre-Seminar workshop held on 10th & 11th
Feb 2020 for Developing Integrated Protocol of Management of
Cancer
30
Dr Gaurang Joshi, Director,
Atharva Multispeciality Dr Rajagopal, Chief Dr Yogesh Bendale, Chief
Ayurveda Hospital, Cancer Consultant, SKV Ayurveda consultant, Rasayu cancer
Research Center, Rajkot, Clinic, Kollam Kerala care clinic, Pune,
Gujarat Maharashtra
Prof. Anita Dhar, Dept of Vd Tapan Kumar, Director, Dr Suresh Rao, Mangalore
Surgery, AIIMS, New Delhi Research Ayurveda, SGVP Institute of Oncology,
Holistic Hospital, Mangalore, Karnataka
Ahmadabad, Gujarat
Dr Ravishankar B, Former
Director, SDM Centre for
Research in Ayurveda,
Udupi, Karnataka
32
Resource Persons of Seminar
Dr Shripad Banavali
Dr. Anurag Shrivastava, Prof Prof. & Head, Dept. of Medical
& Head, Dept of Surgery, Prof Ravi Mehrotra & Pediatric Oncology, Tata
AIIMS, New Delhi CEO, ICRC-ICMR, New Memorial Hospital, Mumbai,
Delhi, Former Director, Maharashtra
NICPR-ICMR – Noida.
Vd Balendu Prakash,
Dr Dilip Ghosh Founder Director, VPC Dr Dilip Gadgil
Director, Nutriconnect, Cancer Research Foundation, Consultant, Niramaya
Sydney. Adjunct- Industry Uttarakhand Ayurvedic Research &
Fellow, NICM, Western Consultancy Pvt Ltd. Pune,
Sydney University. Maharashtra.
34
Dr Pankaj Wanjarkhedekar
Consultant, Deenanath Dr. Showket Hussain Prof. Alpana Sharma
Mangeshkar Hospital & Scientist D, Division of Department of Biochemistry,
Research Centre, Pune, Molecular Oncology and AIIMS, New Delhi
Maharashtra Head, Division of Cellular
and Molecular Diagnostics,
NICPR-ICMR, Noida
Dr Manohar Gundeti
Prof. Savita Yadav Research Officer In-charge, Dr Gopikrishna Maddikera
Department of Biophysics, (RRAP) Central Ayurveda Professor & HOD, Dept of
AIIMS, New Delhi Research Institute for Rasashastra & Bhaishajya
Cancer, CCRAS, Mumbai, Kalpana, S.J.G Ayurvedic
Maharashtra Medical College & P.G
Centre, Koppal, Karnataka
36
Glimpses of AIIA
The First Ever All India Institute of Ayurveda (AIIA), set up along the lines of AIIMS,
was dedicated to the Nation by the Honorable Prime Minister, Shri Narendra Modi on 2nd
Ayurveda Day on 17th October, 2017 at New Delhi. Set up as an apex institute under the
Ministry of AYUSH, AIIA is bringing synergy between the traditional wisdom of Ayurveda
and modern diagnostic tools and technology. AIIA has also been awarded with NABH
Accreditation, therefore becoming the first Ayurveda Hospital in Public Sector to be conferred
with NABH accreditation in July, 2017, indicating the quality patient services it is rendering.
AIIA is first of its kind in the country to make use of tools & technology of modern
science and modern medicine for scientific validation of fundamental principles and for
undertaking R&D, quality control & standardization and safety evaluation of Ayurveda
medicines. Interdisciplinary Clinical research and human resource development programs of
the institute is helping in capacity building in addressing unmet needs of Ayurveda sector. The
Institute initially set-up as an Autonomous registered body of Ministry of AYUSH
(Registration No. S-E/93/Distt. South-EAST/2013) fully funded by the Central Government
with the objective of raising it to the status of National Importance in next 10 years. All India
Institute of Ayurveda, New Delhi, strives hard to improve health status and expand preventive,
promotive, curative, palliative and rehabilitative services to large sectors of the society. The
clinical services for out patients were initiated in 2014 whereas the academic session
commenced from 2016.
AIIA received the approval from Ministry of AYUSH, for the 2nd phase construction
including the Residential Quarters for Staff, Hostels for the scholars, Auditorium, International
Guest House, State of Art Library, Sports Complex, Pharmacy, Panchakarma Unit etc.
Vision: “To be an Outstanding Center of Excellence for Ayurveda Tertiary Health Care and
set highest standards of Education, Research and Patient Care through Ayurveda for
the benefit of humanity”
Mission: Our mission is to be a role model by setting up benchmarks for Postgraduate and
Post-Doctoral Education in Ayurveda, bringing Ayurveda Health care of highest
standards within the reach of every individual at National and International Level and
to undertake interdisciplinary research focused on validation of Ancient Wisdom of
Ayurveda using modern tools and technology.
Objectives:
To provide postgraduate/doctoral and post-doctoral teaching, research facilities and
quality patient care services under the Ayurveda system of medicine.
To act as a referral hospital and a “Centre of Excellence” to set highest standards of
education, research, patient care and also function as a model center for international
collaboration.
38
To act as a model institution to show the strength, efficacy and popularity of Ayurveda.
The institute will be used for promoting Ayurveda in India and abroad.
To provide the services in specialties like Panchakarma, Kayachikitsa, Vata-Vyadhi,
Rasayna, Kayakalpa, Twacha roga (Skin disorders), Vajikaran, Shalya Tantra, Kshar
evam Anushastra Karma (Jalauka and Rakta Mokshan, Agni Karma etc.), Marma
Chiktisa, Vrikka roga (Nephrology), Mutra roga (Urology), Shalkya (Eye, ENT and
Dental disorders), Stri Roga and Prasuti Tantra, Bal Roga, Rog Nidan, Lifestyle and
Metabolic disorders, Yoga and Swastha Vritta, Ahara Bidhi Vigyan (Dietetics),
Ayurvedic Pharmacy, Fundamental Principles of Ayurveda and their application in a
set up that combines the ancient tradition of Ayurveda along with the Advantages of
biomedicine, current management & information technology tools.
To impart interdisciplinary post-graduate- doctoral and post-doctoral teaching, training
and research in all Ayurvedic specialties and also health and hospital management
programmes. It will have all necessary infrastructure to cater to secondary and tertiary
level health care facilities for diagnosis and treatment in collaboration with national and
international institutions.
To give highest priority to explore and explain the scientific basis of various aspects of
Ayurveda through collaborative, inter-disciplinary research. In this direction the
required infrastructure would be developed with the help of various R&D institutions
including Central Council for Research in Ayurveda and Siddha (CCRAS), Indian
Council of Medical Research (ICMR), Council for Scientific and Industrial Research
(CSIR), National Institute for Pharmaceutical Education and Research (NIPER) and
other national level institutes. Human resources and infrastructure of participating
institutions will be utilized in conducting project-based research programmes on need
specific clinical and drug studies.
To develop model teaching tools, demonstration modules of teaching in Postgraduate/
Doctoral and Post –doctoral Ayurveda Medical education in all branches so as to
demonstrate high standards of education for use in Ayurvedic institutions.
In persuance of Vision, Mission and Objectives, AIIA has undertaken intiatives in the
following areas during the year 2017-18:
39
AIIA provides public health outreach programmes through health camps, patient
awareness lectures etc. During year 2017-18, 10 (ten) such outreach programmes were
conducted by AIIA on thrust areas.
Approximately 242331 patients in the OPD and 662 patients in IPD were benefitted
with Holistic Ayurveda treatment in year 2017-18.
Various days like International Yoga Day, Cancer Day, Diabetes Day, Asthama Day,
Nutrition week, Swachchhata Pakhwada etc. were celebrated with great zeal. Free
medical camps, awareness lectures etc. were organized to mark the celebration of these
days.
IEC material and booklets viz. ‘Delicacies for Diabetes’, ‘Common painful conditions
and its management through Ayurveda’ etc. for patient and public awareness were
published by AIIA.
b) Quality Education:
At present MD/MS courses in 11 specialties are being offered with intake
capacity of 84 seats per year. This courses are affiliated to Delhi University.
During the year 2017-18, 111 post graduate scholars were admitted including
two batches.
AIIA aslo conducts short term skill development Certificate courses viz.
Panchakarma Technician Course. First batch of Panchakarma
Technician Course completed with 100% placement and second batch
is ongoing training
Foundation course in Yoga Science for wellness. A batch of 40
candidates completed the training of one-month Foundation course in
Yoga Sciences and Wellness organized in collaboration with MDIYN.
Certificate course in Hospital Management. Institute has launched the 6
months Certificate Course in Hospital management from mid-January
2018 onwards
For streamlining the admission process in Postgraduate cources (MD/MS) in
AYUSH systems, AIIA was mandated by Ministry of AYUSH to conduct and
supervise ‘All India AYUSH Post Graduate Entrance Test (AIAPGET)’ - the
first centralized National level Online entrance examination for qualifying PG
Entrance in all AYUSH courses. AIIA successfully conducted AIAPGET Exam
which was attended by approx. 25,000 students at around 104 centres across the
nation
AIIA alos coordinated HACKATHON activity as entrusted by Ministry of
AYUSH
In this financial year, AIIA also established language lab, National
Pharmacovigilance Coordination Centre for ASU&H drugs etc.
Certain National Protocols for the Management of Diabetes & its
Complications, Ante Natal Care were developed by AIIA through conducting
40
brainstorming workshops, Conference, Symposium etc. involving experts from
all over the country.
Various CMEs for other Government Organizations like Rashriya Ayurveda
Vidyapeeth. Drug Regulatory board, CME for students of European Academy
of Ayurveda, Birstein, Germany were also conducted by AIIA in year 2017-18
c) Quality Research:
AIIA has a separate division namely Translational Research for fostering Quality
Research. In all, 111 Research proposals are being supervised by this division in
the year 2017-18.
The Translational Research Division has constituted the Instittuional Review
Board (IRB) and Institutional Ethics Committee (IEC) as per the WHO &
AYUSH Guidelines.
In the year 2017, the IEC developed the Standard Operating Procedures (SOPs) for
the functioning of IEC and the same has been uploaded on Institute Website.
Adhering to these guidelines the Research proposals are approved and supervised.
To standardize the efficacy and safety measures so as to ensure supply good quality
medicine AIIA has developed the Quality Control Laboratories as Central Reseach
Laboratory equipped with preliminary QC instruments and sophisticated
equipments viz.
TLC kit
HPTLC System
HPLC system
AAS etc.
In addition to this, collaborative Researches are ongoing viz.
‘Development and Validation of Pralriti Questionnaire/Scale” with Central
Council of Research in Ayurveda Sciences (CCRAS)
App for identification of Medicinal Plant by APP with Ministry of HRD/
Ministry of AYUSH under the Hackathon – 2017
Games for propogating AYUSH systems of medicines with Ministry of
HRD/ Ministry of AYUSH under the Hackathon – 2017
Online portal for the submission and real time tracking of grant applications
with Ministry of HRD/ Ministry of AYUSH under the Hackathon – 2017
Conversion of Ancient Ayurveda measurements into ISI Standards with
Ministry of HRD/ Ministry of AYUSH under the Hackathon - 2017
d) Publications:
In this financial year, with a view of fostering research through Quality
Publications, the publication division of AIIA has taken some concrete steps
like releasing of Ayurveda Case Reports (AyuCaRe), an exclusive journal for
Case Reports, first of its kind in field of Ayurveda for promoting documentation
of case studies
41
Besides this, for providing uniform guidelines in management of diseases
through Ayurveda, AIIA has released Standard Treatment Guidelines for
Diabetes.
AIIA also publishes the IEC material for creating health awareness in the public,
for which ‘Delicacies for Diabetes’, ‘Common painful conditions and its
management through Ayurveda’ etc. were published in the year 2017-18.
In the year 2017-18, around 53 Research articels are published by faculty and
scholars in different scientific journals.
42
Important milestones of 2017-18:
1. Dedication of AIIA to nation by Hon’ble Prime Minister, Shri Narendra Modi: All
India Institute of Ayurveda (AIIA) has the vision to be an outstanding center of
excellence for Ayurveda tertiary health care, Education and Research for the benefit of
humanity. The institute was formally inaugurated and dedicated for service to nation
by Hon’ble Prime Minister of India, Shri Narendra Modi on the occasion of 2 nd
Ayurveda Day celebrated on Dhanwantari Jayanti (17th October, 2017).
The Inauguration ceremony was witnessed by Minister of State (I/c) Shri Shripad Yesso
Naik, Ministry of AYUSH, Padmashree Vaidya Rajesh Kotecha, Secretary, Ministry of
AYUSH and was graced by many other dignitaries from Ministry of AYUSH, various
Government Authorities, Research Councils and more than 2500 Ayurveda practitioners,
academicians, researchers and general public gathered all across India. On this occasion, a
thematic exhibition of herbs useful for Pain Management, was also inaugurated by Hon’ble
Prime Minister. . In his address, Prime Minister Narendra Modi appreciated the efforts of
Ministry of AYUSH in envisioning AIIA as “Centre of Excellence” in AYUSH and wished
for the prosperity of AIIA for its cause.
2. NABH Accreditation: To provide quality service to the patients visiting AIIA hospital
and to acquaint all the staff of AIIA hospital to comply with the quality practice as well
as to maintain the continuous quality improvement with emphasis on safety and
infection control measures in Hospital, AIIA iniitaed the procedure for NABH
accreditation. In its 2nd year of it’s establishment itself, AIIA became the first Ayurvedic
Government Hospital to get the Coveted status of NABH Accreditation and was granted
the NABH accreditation certification on 06th July 2017.
43
3. Approval & Sanction of the second phase construction: In the current financial year,
AIIA was given the approval of the second phase of its and approx. 220 crores are
sanctioned to accomplish the 2nd phase construction. Total constructed area would be
approx. 60966 sq.m. The construction plan has the following salient features
Phase II, AIIA, Sarita Vihar would comprise of eight blocks and 3 level
basement
An auditorium with state of the art facilities having 500 seating capacity
AYUSH Sports Complex
Pharmacy Unit
State of Art Central Library
Panchakarma Wing
International Guest House
Residential Complex
Boy’s and girl’s hostel etc.
44
5. Establishment of National Pharmacovigilance Coordination Centre: Considering
negligible number of adverse reactions to ASU & H Drugs in the National
Pharmacovigilance Program in India; Ministry of AYUSH initiated a National Level
Pharmacovigilance Program for ASU & H drugs with an objective of developing
culture of ADR reporting, documentation and analysis for further regulatory action.
Ministry of AYUSH has designated All India Institute of Ayurveda, New Delhi as a
National Pharmacovigilance Coordination Centre in March, 2018
Other achievements:
Foreign visits by Faculty members: AIIA takes the pride that during the year 2017-18, around
11 faculty members were depute/invited for visiting various countries for establishing
International Collaboration & promotion of Ayurveda across the globe.
45
1. Prof. Abhimanyu Kumar visited Chicago from 22-28 April, 2017 and Germany in 8-10
September, 2017 and participated in the European Academy of Ayurveda Annual
Conference, and delivered a guest lecture deputed by the Ministry of AYUSH,
Government of India
2. Prof. Tanuja Nesari visited European Academcy of Ayurveda, Birstein, Germany, 8-10
September, 2017 to attend 19th International Ayurveda Symposium
Prof. Manjusha R delivered Key note address in SALAKYA SANDIPANI -2017, Sri
Lanka, Recent advances in Salakaya Tantra, International Conferernce on Salakya
Tantra 2017, 3rd International conference of TAS-India organized by Gampaha
Wockramarachchi Ayurveda Institute, University of Kelaniya, Sri Lanka with the
collaboration of The Association of Salaki - India, on 16th and 17th September 2017.
4. Prof. Sujata Kadam visited Sri Lanka for participating in SALAKYA SANDIPANI -
2017, Sri Lanka, Recent advances in Salakaya Tantra, International Conferernce on
Salakya Tantra 2017 on 16th and 17th September 2017
5. Dr. Rajagopala S: Visited Austria (Graz Medical University, Graz) in the month of Sept
- October, 2017 and participated in a Symposia on Ayurveda and delivered a guest
lecture, deputed by the Ministry of AYUSH, Government of India
46
6. Dr. Galib attended a business seminar and bilateral meetings on ‘AYURVEDA’ during
27 - 28 March, 2018 in Kyiv to discuss possibilities of bilateral cooperation for the
promotion of Ayurveda trade, educational courses and profession in Ukraine.
Discussions were made with Ukranian Chamber of Commerce and Industry (UCCI),
Kyiv to explore possibilities of import and registration of Ayurveda products in
Ukraine. Discusions were also made with KYIV Medical University for possibility of
initiating short term Ayurveda courses and possibilities of establishing an Ayurveda
Chair at KYIV Medical University or to have an MoU with Ministry of AYUSH.
7. Dr. Shiva Kumar Harti was deputed from Ministry of AYUSH, New Delhi as a speaker
at ‘Festival of India, Bangkok, Thailand’ Sept 23rd& Sept 24th, 2017.
8. Dr. Mangalagowri V Rao visited Morocco as an expert in AYUSH for celebration of
Ayurveda Week at Casablanca and Rabat, Morocco, from 27th February to 2 nd Mach
2018. Conducted Dietetics workshop for Moroccans and delivered lectures to on
Dietetic and culinary practices in Ayurveda for prevention and management of diseases
and Ayurveda care for pregnancy to the University students, officials and common
public at Casablanca and Rabat, Morocco.
9. Dr. VG Huddar visited Srilanka from 16 – 19 July 19 during International Day of Yoga
2017 as an Ayurveda expert in Colombo.
10. Dr. Prasanth D visited Reunion Island, France on 16 – 27 June 2017 for providing
Ayurveda consultaion and delivering awareness lectures.
11. Dr. Mahapatra Arun Kumar visited Tajikistan for Propagation of Ayurveda in the
month of February, 2018 and participated in programs for propagation of Ayurveda and
delivered guest lectures, Organized by Ministry of AYUSH, Government of India.
47
Important milestones of 2018-19:
Visit by foreign delegations to AIIA: In the short duration of its establishment, AIIA is
attracting International visitors & is on the verge of becoming a Hub for Medical Tourism in
Ayurveda. The following delegations visited AIIA dring the year 2017-18
1. Visit of delegation from NIH, USA visit, 7th July, 2017
2. Visit of WHO delegates, 11th October, 2017
3. BIMSTEC delegation visit, 25th October, 2017
4. Visit of Mauritius delegation, 3rd November, 2017
5. Visit by foreign delegates of Aarogya, 6th December, 2017
6. Visit of Dr. Jorge Berra, Argentina, 6th December, 2017
7. Visit of Korean delegation, 20th December, 2017
8. Visit of US Delegation on 5th Jan, 2018 comprising of Dr. Tej Pareek, Dr Sandeep
Agarwal, Prof. Sharon Milligan
9. Visit of African Delegation from 11 countries (30 delegates), 13th Feb, 2018
10. Visit & CME of European Academy of Ayurveda, Germany during 14th – 19th Feb,
2018.
c) Prof. Tanuja Manoj Nesari, Director participated in 3rd US-India Health Dialogue, USA
during 18th-20th March, 2019.
48
Prof. Tanuja Manoj Nesari at 20th Dr. Rajagopals S., with delegates of
International Ayurveda Symposium Collaboration in Ayurveda at Sao Paulo,
at European Academy of Ayurveda Brazil
(EAA), Bristein, Germany
MoU:
a) An MoU was signed between AIIA & CSIR- Institute of Genomics & Integrative
Biology (CSIR-IGIB), New Delhi on Collaboration Research under the Center of
Excellence scheme of the Ministry of AYUSH on 25th April, 2018.
b) MoU signed between AIIA & IIT Delhi on Collaboration in the field of Research &
Development and Academic in Ayurveda on 17th July, 2018.
c) MoU signed between AIIA & Spaulding Rehabilitation Hospital, USA, Boston on the
establishment of an Academic Collaboration in Ayurveda on 28th March, 2019.
d) MoU signed between AIIA, New Delhi and The Medical University of Graz, Graz,
Austria on Cooperation and Collaboration in the field of Ayurveda on 26th September,
2018.
49
Delegation of 2nd BRICS Nurses WHO delegation at AIIA Bhutanese delegation at
Forum at AIIA AIIA
50
ABOUT CENTER FOR INTEGRATIVE
ONCOLOGY(CIO)
PREFACE
As a joint venture of All India Institute of Ayurveda (AIIA) and National Institute of Cancer
Prevention and Research (NICPR), Center of Integrative Oncology (CIO) has been established with
a intention of integrative practice in the field of cancer prevention and management. MoU has been
signed between AIIA & NICPR with the following agendas. The status of work done as per agendas
is as follows.
51
ACTIVITIES:
Guest lectures by AIIA faculty in Workshop conducted at AIIMS on 3rd November 2017
Inauguration of Integrated Cancer Care Unit 25th April 2018
Statistics:
Total patients in last 18 months – 410
Major Cancerous conditions
Lung cancer – 30
Oral cancer - 22
Hepatic carcinoma = 20
Leukemia - 17
Other cancers seen are
Renal carcinoma
Ca Esophagus
Glioblastoma brain
Pitutary adenoma
Leukaemia
Acoustic neuroma
Ca Prostate
Sarcoma
Multiple myeloma
Many other
52
53
IMAGE GALLERY OF CANCER AWARENESS WEEK
Inaugural function, Address by director, Skit by students
54
55
56
57
Agenda of collaboration – NICPR
Awarding research fellowships every year
Collaborative research projects
Develop center of excellence
Formation of steering committee and scientific advisory committee – jointly constituted by
the Ministry of AYUSH and Dept of health research, ministry of Health and F.W
Conducting international conferences
Data collection from Network For AYUSH Cancer Care (NFACC), developed by AIIA.
Agenda of collaboration – AIIMS
Combined conference
Combined integrative oncology clinic
Collaborative research products
Journal of integrative oncology
Research and observer fellowship program
One week cancer curriculum for AYUSH practitioners
“A clinical study to evaluate the effect of ayurveda intervention and add on effect of
rajyoga meditation in breast cancer”
Practitioners & practice trend of cancer management through Ayurveda: A cross
sectional study
“Evaluation of add on effect of Vardhamana Pippali Rasayana and yoga intervention
over conventional therapy in breast cancer: an exploratory study”
“Development of clinical validation of synergistic effect of Vardhamana Pippali
Rasayana along with conventional treatment after unraveling its complex molecular
mechanism of action in Breast cancer: From Experimental model to Clinical trial”.
“Evaluation of add on effect of vardhamana pippali rasayana and yoga intervention
over conventional therapy in lung cancer; an exploratory study”
58
Regional coordinators:
Sl. No Regional coordinators State coordinators State
1 Dr S K Gupta Dr Pankaj Kundal Jammu & Kashmir,
Professor & HOD, Dept of Asst. Prof. Dept of Shalakya Himachalpradesh
2 Shalya Dr. Vyasadeva Mahanta Panjab
Assoc. Prof. Dept of Shalya
3 Dr Shivani Gildiyal Uttarakhand,
Asst. Prof. Dept of Dravyaguna Lakshadweep, Andaman
& Nicobar
4 Dr P K Prajapati Dr. Kamini Dhiman Delhi
Professor & HOD, Dept of Assoc. Prof. Dept of SRPT
5 RSBK Dr. Rama kant Yadav Uttarpradesh
Assoc. Prof. Dept of Kayachikitsa
6 Dr. Santosh Kumar Bhatted Rajasthan
Assoc. Prof. & HOD Dept of
Panchakarma
7 Dr Divya Kajaria Haryana
Asst. Prof. Dept of Kayachiktsa
8 Dr Mahesh Vyas Dr. Galib Gujarat
Professor & HOD, Dept of Assoc. Prof. Dept of RSBK
9 Samhita Dr Shalini Rai Madhyapradesh
Asst. Prof. Dept of Roganidana
10 Dr. Deepak Bhati Chattisgarh, Daman &
CMO Diu
11 Dr Narayan Bavalatti Tripura, Mizhoram,
Asst. Prof. Dept of Shalakya Manipur, Nagaland
12 Dr Tanuja Nesari Dr Rahul Sherkhane Maharashtra
Professor & HOD, Dept of Asst. Prof. Dept of Shalya
13 Dravyaguna Dr Shivakumar Harti Karnataka, Goa
Asst. Prof. Dept of Swasthavritta
14 Dr. Rajagopala S. Andhrapradesh
Assoc. Prof. Dept of
Koumarabhritya
15 Dr. Mangalagowri V. Rao Telangana
Assoc. Prof. Dept of Swasthavritta
16 Dr Manjusha Dr Minakshi Tamilnadu
Professor & HOD, Dept of Asst. Prof. Dept of SRPT
17 Shalakya Dr Prashant D Kerala
Asst. Prof. Dept of Panchakarma
18 Dr. Raju Singh Assam, Puducherry,
MO, Blood bank Meghalaya
19 Dr Meera Bhojani Aunachalpradesh, Sikkim
Asst. Prof. Dept of Samhita
20 Dr Sujata Kadam Dr Arunkumar Orissa
Professor & HOD, Dept of Asst. Prof. Dept of Koumarabhritya
21 SRPT Dr Pramod Yadav Jharkhand, Westbengal
Asst. Prof. Dept of RSBK
22 Dr Rajaram Mahto Bihar
Asst. Prof. Dept of Kayachikitsa
59
Workshop at AIIMS:
Faculty from different department delivered lectures on different aspects of
cancer prevention and management of cancer through Ayurveda
60
PROGRAM SCHEDULE
62
Day 1 (12.02.2020)
Venue: Scope complex auditorium, CGO complex, New Delhi
Registration 9.00 am to 10.00 am
INAUGURAL CEREMONY 10.00 am to 11.00 am
Lord Dhanwantari Vandana, lighting of lamp and welcome of guest 10.00 am – 10.10 am
Welcome address and opening remarks: 10.10 am to 10.15 am
Prof Tanuja Nesari, Director, All India Institute of Ayurveda, New Delhi.
Summary of workshop: 10.15 am to 10.20 am
Dr V G Huddar, Chief Organizing Secretary, Jivaneeyam 2020.
Address by: 10.20 am to 10.25 am
Dr Shalini Singh, Director, ICMR-NICPR, Noida, UP
Address by 10.25 am to 10.30 am
Dr Bhushan Patawardhan, Vice- Chairman, University Grants Commission (UGC),
New Delhi
Address by 10.30 am to 10.35 am
Vd. Rajesh Kotecha, Secretary, Ministry of AYUSH, New Delhi.
Release of Booklet and IEC materials 10.35 am to 10.45 am
Scientific Sessions
63
Chairperson – Prof. Maqsood Siddiqi Chairman, Cancer foundation of India, Former Director CNCI & Bose
Institute, Kolkatta.
Co-chairpersons – Prof Anand More, AIIA, Dr Ramakant Yadava, AIIA, Dr Vyasdev Mahanta, AIIA
Moderators – Dr Meenakshi Pathak, AIIA
Rapporteur: Dr Bhargav Vijay Bhide, AIIA
Key note speaker: Ayurvedic herbal Prof. Alpana Sharma
extracts and their integration in Myeloma Department of Biochemistry, AIIMS, New 2.00 pm to 2.20 pm
management Delhi
Speaker: Characterization of proteins form Prof. Savita Yadav
medicinal plant and scope in management Department of Biophysics, AIIMS, New Delhi 2.20 pm to 2.40 pm
of cancer
Speaker: Integrative impact of genomics, Dr. Showket Hussain
epigenomics and personalized physical Scientist D, Division of Molecular Oncology
2.40 pm to 3.00 pm
activity on the quality of life in breast and Head, Division of Cellular and Molecular
cancer" Diagnostics, NICPR-ICMR, Noida
Paper presentations 5 presentations- 5+2 mins each 3.00 pm to 3.35 pm
Comments by Chairperson/Co-Chairperson 3.35 pm to 3.40 pm
Tea break 3.40 pm to 3.55 pm
Panel discussion – Challenges and scope of integration–
Chairperson: Dr Manoj Nesari, Advisor (Ayurveda), Ministry of AYUSH, Govt of India,
New Delhi
Co-chairperson: Dr Ishwar Basavaraddi, Director, Morarji Desai National Institute of
3.55 pm to 4.30 pm
Yoga, New Delhi.
Experts: Dr Shalini Singh, Prof. Maqsood Siddiqui, Prof Anurag Shrivastava, Dr Raghavedra
rao - Director, CCRYN, New Delhi, Prof. Alpana Sharma, Prof. Savita Yadav, Dr Shripad
Banavali, Dr Balendu Prakash, , Dr Pankaj Wanjarkhedekar and Cancer survivor.
Cultural programs 4.30 pm to 5.30 pm
Day 2 (13.02.2020)
64
Evidenced based clinical practice – Role of Herbal/Herbo-mineral preparations and
Shodhana chikitsa in prevention & management of cancer
Chairperson: Prof P K Prajapati, AIIA
Co-chairpersons: Dr Galib, AIIA, Dr Sisir Mandal, AIIA
Moderator: Dr Pramod Yadav, AIIA
Rapporteur: Dr Raja Ram Mahto, AIIA
Key note speaker: Vd. Balendu Prakash
Prevention of pancreatic cancer by managing Founder Director, VCP Cancer 12.00 pm to 12.30 pm
chronic pancreatitis through Rasa Chikitsa research foundation, Uttarakhand
Dr Dilip Gadgil
Speaker: Clinical experiences with case stories in Consultant, Niramaya Ayurvedic
12.30 pm to 12.50 pm
management of cancer through Ayurveda Research & Consultancy Pvt Ltd.
Pune, Maharashtra.
Dr Gopikrishna Maddikera
Professor & HOD, Dept of
Speaker: Role of Rasoushadhis in cancer practice
Rasashastra & Bhaishajya Kalpana, 12.50 pm to 1.10 pm
with clinical evidences
S.J.G Ayurvedic Medical College
& P.G Centre, Koppal, Karnataka
Paper presentations 5 presentations, 5+2 mins each 1.10 pm to 1.45 pm
Comments by Chairperson/Co-Chairperson 1.45 pm to 1.50 pm
Lunch break - 1.50 pm to 2.30 pm
2.30 pm to 3.25 pm
Session 5 - Summary of Pre seminar workshop
Chairperson – Dr Manjusha Rajagopala, AIIA
Co-chairperson – Dr Kamini Dhiman, AIIA, Prof Medha Kulakarni, AIIA
Moderator – Dr Prashant D, Asst. Prof. Dept of Panchakarma, AIIA, Delhi.
Rapporteur: Dr Rahul Sherkhane, AIIA
Integrative protocol prepared in workshop Rapporteur/Moderator of each
2.30 pm to 3.20 pm
(10 min each ) – 5 presentations group
Comments by Chairperson/Co-Chairperson 3.20 pm to 3.25 pm
Session 6
Public awareness and traditional practices in cancer management 3.25 pm to 4.00 pm
Public interaction with experts
Chairperson – Dr Umesh Tagade, AIIA
Co-chairperson - Prof Anil Kumar, AIIA
Moderator – Dr Meera Bhojani, AIIA
Rapporteurs - Dr Tejashwini, AIIA, Miss Jyoti Arora, AIIA
Sharing experiences from traditional practitioner – Shri Shri Krishnanand Swamiji –
3.25 pm to 3.35 pm
Krishnagiri, Basareddypalli village, Telangana.
Sharing experiences from traditional practitioner – Mr Hamsaraj Choudhary – Rajasthan 3.35 pm to 3.45 pm
Interaction with public/Comments by Chair/Co-chairperson 3.45 pm to 4.00 pm
Panel discussion – Summary and Way forward
Chairperson: Prof. K S Dhiman, Director General, Central Council for Research in
Ayurveda in Ayurveda sciences, New Delhi.
Co-chairpersons: Prof Ravi Mehrotra, CEO, ICRC-ICMR, New Delhi, Dr Raghu, 4.00 pm to 4.30 pm
Joint Advisor (Ayurveda), Ministry of AYUSH, New Delhi.
Experts: Vd Balendu Prakash, Dr Dilip Gadgil, Dr Dilip Ghosh and others.
Moderator: Dr V G Huddar, AIIA, New Delhi.
Valedictory
4.30 pm to 5.00 pm
Prize distribution for paper/poster presentations followed by vote of thanks
Welcome: Prof Tanuja Nesari, Director, AIIA, New Delhi.
Chief Guest:
Shri Pramod Kumar Pathak, Additional secretary, Ministry of AYUSH, Govt of
India
4.30 pm to 5.00 pm
Guest of Honour:
Shri Dharmendra S Gangwar, Additional Secretary & Finance Advisor, Ministry of
Health and Family Welfare, Govt of India
Vote of Thanks: Prof Sujata Kadam, Dean PG studies, AIIA, New Delhi
65
SCHEDULE OF ORAL PRESENTATIONS
SESSION 1
“SCOPE OF INTEGRATION IN CANCER MANAGEMENT WITH AYURVEDA”
SESSION 2
“LEAD & INTEGRATION WITH BASIC SCIENCES & AYURVEDA IN CANCER
MANAGEMENT”
66
SESSION 3
“UPDATE & SCOPE OF RESEARCH IN INTEGRATIVE ONCOLOGY”
Sr. No. Title Name Of Presenter
1. Possible Role Of Kavala, Gandoosha In Oral Cancer Dr. Amrish P. Dedge
Lesions At Various Stages
2. Assessment Of Dehaprakriti In Mamsarbuda (Myoma) In Dr. Bibhu Prasad
Purview Of Predictive And Preventive Medicine – A Naik
Cross Sectional Study
3. Role Of Kamala (Nelumbo Nucifera) In Prevention And Dr. Priyankahajare
Management Of Garbhashaya Arbuda With Special
Reference To Uterine Cancer
4. Ayurvedic Management Of Oral (Palate) Carcinoma: A Dr. Priyanka Katru
Case Study
5. Role Of Yastimadhu Ghrita Pratisarana In Management
Of Oral Cancer Dr Ravindra Bhati,
6. Abiding Ayurveda Principles in Cancer Pain Dr. Santosh F. Patil
Management: A Case Series.
7 Ayurveda And Palliative Care: Scopes And Oppportunity Dr. Vikas Nariyal
SESSION 4:
“EVIDENCE BASED CLINICAL PRACTICE IN PREVENTION & MANAGEMENT OF
CANCER”
67
INVITED ARTICLES
68
INVITED ARTICLES
A Comparative case study on complete Remission of pediatric Acute Myeloid Leukemia
M5b and adult Myelo dysplastic syndrome with Precision Ayurvedic therapy
Dr. Rajagopal K. Chief Consultant, SKV Ayurveda Clinic, Kollam Kerala
Abstract
Acute myeloid leukemia M5b is a type of pediatric AML accounting for 1-3% of primary childhood
AML. Here we aim to do a comparative study of precision Ayurvedic therapy in pediatric AML-M5b
and adult Myelo dysplastic syndrome. The subject is a 8 week old baby showing Nausea, paleness and
reddish firm rashes on skin. Diagnosis was made on the basis of peripheral blood smear,
immunophenotyping with flow cytometry and clinical symptoms. Chemotherapy and stem cell
transplant were excluded because of the age and physical condition of the baby. The child was managed
with Ayurvedic regime within 7 days of diagnosis.
The second subject is a 48 years old male from Gwahati Assam. Showing symptoms of paleness, fatigue
breathlessness during exertion and erection problems. Diagnosis was made as MDS on the basis of
peripheral smear, Bone narrow biopsy and chromosomal studies. The patient was not responding to any
conventional standard Allopathic therapies with progressive worsening of refractive Cytopenia. The
subject was started with Ayurvedic therapy one year after diagnosis.
In this research article we aim to discuss pediatric AML M5b and adult MDS managed to complete
remission by Ayurvedic regime. Both patients have completed over 5 years of complete remission from
their respective conditions. Here we elaborate the treatment modalities used to manage these deadly
conditions and highlight the necessary scientific literature.
Key Words: Acute Myeloid Leukemia Myelo dysplastic Syndrome Promonocytic Leukemia,
Refractive Cytopenia, Blast cells
INTRODUCTION
Acute myeloid leukemia (AML) is the most common Leukemia in adults. It accounts for 3-5
cases per 100000 people per year. AML in contrast accounts for less than 10% cases of acute Leukemia
in children less than 10 years of age. A significant increase in AML incidence has occurred over the
past 10 years. AML comprises a type of hematologic malignancies with clonal proliferation of myeloid
precursors with reduced capacity to differentiate into more mature cellular elements. As a results of
mutations in precursor cells immature Leukemia cells called blasts are produced in the bone marrow
which enter into peripheral blood and occasionally other body tissues. When the percentage of blasts in
the bone narrow and peripheral blood is above 20-30% the condition is considered as Acute Leukemia.
A major difference between the WHO and French American British (FAB) classification is the blast
cutoff for a diagnosis of AML as opposed to Myelo dysplastic syndromes (MDS), it is 20% in the WHO
classification and 30% in the FAB system. Because of the Leukemic blasts cells normal hematopoiesis
is hindered resulting with a variable reduction in the production of normal white blood cells, Red blood
cells and platelets. This results in reduced immunity, Anemia and hemorrhagic tendencies. This
reduction of the blood elements is named Cytopenia. In AML and MDS Cytopenia cannot be improved
by treatment, the cytopenia not responding to any medication is termed as Refractive cytopenia.
However, in Acute Leukemia a large increase in WBC count is common, this Leukocytosis is caused
by the circulation of immature Myeloid blasts in peripheral blood, they are dysfunctional mutated cells
in circulation. The un-differentiated Myeloid cells show chromosomal abnormalities in about 55% of
AML. Translocations are used for disease classification. The French American British classification
sub types AML based on morphology and cytochemical staining and immunophentyping by flow
cytometry. Typer (M0, M1, M2, M3) are granulocytic with different stages of maturation. M4 is
69
granulocytic and monocytic where as M5 is predominantly monocytic. M6 is Erythro Leukemia and
M7 is Megakaryocyte Leukemia.
In AML-M5 the patient must have greater than 20% blasts in bone narrow, and of these, greater
than 80% must be of the monocytic lineage. A further sub classification M5a and M5b is made
depending on whether the monocytes cells are predominantly monoblastic (80%) (acute monoblastic
Leukemia) or a mixture of mono blasts and promonocytes (<80% blasts) (acute peomonocytic
Leukemia). The immune Phenotyping by flow cytometry revealed the 8-week old patient had
promonocytic fractures. Immunophenotypically, M5AML variably express myloid (CD13, CD33) and
monocytic (CD11b, CD11c) markers. Cells may aberrantly express BCell maker CD20 and the NK
marker CD56. Monoblasts may be positive for CD34, Fever, anorexia, weightloss, Hepato
Splenomegaly are common with AML. Bleeding associated with coagulopathy may occure in M5.
Infiltration of the gingivae, skin, soft tissues or the meninges with Leukemia blasts at diagnosis is
characteristic of the Monocytic subjects and those with 11q23 chromosomal abnormalities gum
hypertrophy and skin infiltration or nodular (leukemia cuti) is common in M5 subjects. High WBC
count, blasts count in circulation, Refractive anemia and refractive thrombocytopenia along with poor
patient health conditions in monocytic subtypes are associated with a lower complete remission rate
and shorter survival time.
Myelo dysplastic Syndromes (MDS) are a heterogeneous group of hematological disorders
broadly characterized by cytopenia associated with a dysmorphic (abnormal appearing) and usually
cellular bone narrow. This consequently results in ineffective blood cell production. MDS is a relatively
common form of bone narrow failure with reported incidence rates of 35100 per million persons in
general population and 120-500 per million elderlies. MDS is rare in children but monocytic Leukemia
can be seen.
In both AML and MDS mutation in the hematopoitic precursor cells results in ineffective
production of blood components. In AML percentage of Leukemia blasts cells has to be above 20-30%.
Whears in MDS percentage of blasts is very low. Both canditional usually become severe because of
refractive cytopenia. Refactory cytopenia with Multilineage dysplasia (RCMD) is a subtype of MDS in
world health organization classification of MDS. It is characterized by cytopenias, less than 5% blasts
and dysplasia. It constitutes 24% cases of MDS and about 11% of RCMD progress to AML. Because
of this MDS is often considered a preLeukemic condition. The bone narrow is usually normal or hyper
cellular, but in 20% of cases it is sufficiently hypo cellular to be confused with aplasia. Dyserythropoitic
changes and ringed sideroblasts in erythroid lineage are seen, Megaloblastic nuclei associated with
defective hemoglobinization in the erythroid teenage are common. Most patients die as a result of
complications of pancytopenia and not due to Leukemic transformation. Precipitous worsening of
pancytopenia, acquisition of new chromosomal abnormalities and increase in the number of blasts are
all poor prognostic factors. The outlook in therapy related MDS is very poor and most patients progress
within a few months to refractory AML. Anemia, Thrombocytopenia (Reduced platelets) Leucopenia
(reduced WBC) are seen in bone narrow neoplasms like AML, chronic Myeloid Leukemia, MDS etc.
WBC count may be raised in Leukemia due to influx of blast cells in blood. Severe paleness of skin,
weakness, reduced blood production, fever and deterioration of immune system are consistent with the
deadly disease ‘Pandu’ described in Ayurveda.
The term ‘Pandu’ means white color or pale nature. Any hemato physiological condition
resulting in severe paleness of body is defined as ‘Pandu’ by Susrutha. Susrutha points out that body
becomes affected by Pandu because of severe blood loss on due to the complications of Arbuda (arbuda
peeda). All pandu conditions are considered caused by vitiation of all 3 doshas vata, Pitha and Kapha.
But due to relative dominance it is considered a Pithika disease. According to symptoms and causative
factors it is classified into 5.
70
Due to excess intake of acidic foods, alcohol, salts, other inflammatory habits and foods
overtime causes changes in the body owing to recurrent inflammations. This causes vitiation of doshas
in the body especially pitha dosha. Due to reduced metabolic fire and blocked channels in the body, the
aggravated pitha is initiated and carried by vata to different parts of the body resulting in paleness,
yellowness in skin, eyes etc. This condition in which paleness is seen predominantly is called pandu.
Pita is synonymous to fire and has yellowish red properties. But in pandu due to increased vitiation of
other doshas. The fire element in pitha becomes relatively reduced due to increase in water and space
elements. As a result of this pitha vikrithi (change) it obtains paleness and this affects all the 5 types of
pitha in the body. Chakrapani considers this change in pitha the cause of paleness. Pandu caused by
vitiation of all the 3 doshas are considered deadly as they cause destruction of dhathus (body elements)
reduces ojas (immunity), reduces blood production resulting in sequential complications like
hemorrhage, fever, dyspnea, cough and eventually death
Case presentation
The subject is a 8 week old baby boy with no previous familial history of any malignant involvement.
He started developing low grade fever with firm rashes on the skin, minimal scalp hair, restlessness, not
taking food properly and fatigued. On routine blood check up his WBC count was seen very high 1.6
lakhs (5000-10000 normal) with peripheral blast cells. The subject was taken to Regional Cancer Center
in Trivandrum. Diagnosis was made based on physical symptoms, peripheral blood smear and flow
cytometry for Immuno phenotyping tumor markers. Peripheral smear and blood count revealed
Haemoglobin 8.7% (12-16 normal), WBC – 268500 (5000-10000 normal) Blasts – 86%, platelets –
150000 (15000 – 400000) Neutrophils– 1% (65-75% normal). As it is clear from the blood picture
patient was entering blast crisis. As a result, WBC count increased from 160000 to 268500 in a span of
3 days and blast cells were rising rapidly. The blasts cells mainly promonocytes with abundant
cytoplasm, indented nuclice and immature chromatin, indented nuclei and immature chromatin. 5% of
blasts were weakly peroxidase positive. Flow cytometry revealed cells were positive for Myeloid
markers CD13, CD14, CD33, CD64, CD11c. The blasts co express CD56 (dim), other markers CD34
and HLA DR were positive. This confirmed the diagnosis as Acute Myeloid Leukemia FAB type
AMLM5B (promonocytic Leukemia). The biochemical parameters such as uric acid, bilirubin,
creatinine, lever enzymes were normal. Serum LDH was raised to 8240 (313-618 normal). The health
and hematological condition of the subject was severely compromised. Chemotherapy or SCT (Stem
cell transplant) could not be done because of the age and health conditions. Subject was discharged after
diagnosis from Regional Cancer Center. The body developed reddish hard mass all over body called
Leukemia cuti and swollen gums due to Leukemic infiltrates characteristic of monocytic Leukemia.
Ayurvedic treatment was initiated 6 days after diagnosis.
The therapy was started with the following regime of medicines.
Drug Dose
1. Drakshadi Kashaya 8 ml twice daily
2. Thikthaka grithm 1g
3. Chyavanaprash 1g
4. Loha Bhasma 50mg
5. Abraka Bhasma 50 mg
6. Swarnamakshika bhasma 50 mg
(Thrice Daily with honey)
71
Results
The following changes in blood picture and physical symptoms were observed and recorded
After 15 days of starting Ayurvedic medication blast cell percentage in peripheral circulation
showed drastic reduction from 86% to 10% All the blood parameters WBC, Hemoglobin and platelet
count showed progressive improvement. This shows progressive improvement in refractive cytopenia,
improved hematopoiesis and the rise in Neutrophil level from 1% to 20% suggested improvement in
immunity. The physical symptoms like rashes of Leukemia cuti completely vanished after 30days, the
child was feeding properly and his overall health improved drastically. The child entered complete
remission from diasease at 40 days of therapy. All medicines were continued for 5 years except for
bhasma preparations which were stopped at 3 years. Now the child Is 7 years old free from any signs
of relapse, healthy and energetic.
Case II
The subject is a 48-year-old man from Guahati Assam with no familial history of any hematological or
malignant involvement. The subject has a history of malaria attack twice in four years, he was treated
with chloroquinine on both instances. One year after second malarial attack he developed paleness
edema severe fatigue, breathlessness with physical exertion and crection problems, mild Hepato spleno
Megally. Following blood examination revealed extremely low counts of Hemoglobin – 6% (normal
13-18%), platelets – 10,000 (normal 1.5 – 5 lakhs) and WBC count – 1000 -2000 (normal 5000-10000).
Due to persisting cytopenias bone marrow biopsy was done in Gwahati Medical College, later he was
referred to Tata Medical College and Christian Medical College Vellore. Bone marrows biopsy was
done in all these 3 institutions revealed scanty moderately hypo cellular marrow with absent
megakaryocytes. Predominantly erythroid precursors are seen which are megaloblastic in maturation
with 1% blasts. These features were suggestive of Myelo dysplastic syndrome. Refractory cytopenia
with multi lineage hypo cellularity was seen with less than 5% blasts. The biochemical parameters such
as uric acid, bilirubin, creatinine liver enzymes were normal. Due to seuere Refractive cytopenia subject
was given regular blood transfusions from the time of diagnosis. Initially one-two transfusions were
done but in 6-8 months the number of transfusions was increased to 8-10 per month. The subject was
not responsive to any Allopathic medications and refractive cytopenia worsened over the course of one
year. Stem cell transplant was advised by Christian medical college Vellore but was given only 10%
chance of success owing to his health, financial and hematological condition it was ruled out. One year
after diagnosis the subject was having 10 transfusions per month. He was started with precise Ayurvedic
medication one year after diagnosis.
72
Medication
Medication Dosage
1. Kalyanakam Kashayam 15 ml twice daily, before food
2. Kalyanaka grithm
3. Hareethaki Choornam 5gm each Thrice daily
4. Gandeera Rasayanam
5. Loha Bhasma
6. Abraka Bhasma 100mg each thrice daily with honey
7. Swarnamakshika bhasma
8. Chandraprabha Vati 1 tab BID with Kashaya
Results
The following changes in blood prameters and physical conditions were noted after medications.
Blood parameters Before Starting 30 days after 3 months after 2 years after
Medication starting starting starting
Medication Medication medication
Haemoglobin % 6.5% 8.9 % 12.4% 14.7%
WBC Count 1000 3000 4000 5000
Platelets count 18000 40000 70000 140000
Blast cells 1% ND Nd ND
No. of blood 8-10 per month Nil Nil Nil
transfusion per
month
After one month of medication all blood parameters showed improvement cytopenias were improved
drastically. The subject was managed by 8-10 blood transfusions per month before starting medicines.
Since starting medications blood transfusion was never again needed. All the blood parameters were
progressively improving. His paleness reduced, fatigue edema and crection problems were better after
30 days. Anxiety issues were better after improvement in hematological parameters cytopenia was
completely resolved in 2 years. With 2 years of medication all his counts and physical conditions were
normal. The medicines were continued for 3 years continuously and stopped thereafter. At 5 years the
subject is fully stable even after 2 years of medication free period.
73
Discussion
A neoplasm is a type of abnormal and excessive growth called neoplasia of tissue. This
abnormal growth usually forms a mass. Some neoplasms do not form a tumor (swelling or mass) these
includes leukemia and carcinoma in situ. Tumor is also not synonymous with cancer. While cancer by
definition is malignant, a tumor can be benign or malignant. Bone marrow neoplasm is the unusual
growth of marrow tissue. This overgrowth are associated with a genetic disorder, immunogenic,
mutation and radiation exposure. In Myeloid
leukemia abnormal cancerous white cells
(WBC) are produced in excess in bone
marrow. In Myelo dysplastic Syndrome prior
to abnormal growth of tissue as neoplasia
cells often undergo abnormal pattern of
growth called dysplasia in the bonemarrow.
Both these conditions, inhibits the production
of other essential components RBC, WBC
and Platelets. They develop severe anaemia,
infections and bleeding.
Anaemia is a decrease in the total amount of Red blood cells or a lowered ability of the blood
to carry oxygen. Anaemia is caused by 3 main reasons. Anaemia along with Thrombocytopaenia
(reduced platelets), Leucopenia (Reduced WBC) are seen in Neoplasms of bone marrow, WBC count
may be raised in Leukemia due to influx of cancerous blast cells in blood. Severe paleness of skin,
weakness, reduced blood production and deterioration of immune system are consistent with the deadly
disease 'pandu' described in Ayurveda
The Enigma of Pandu - The term pandu means white colour or pale nature. Any hemato physiological
condition resulting in severe paleness of body is defined as 'pandu' by Susrutha. While describing
Raktaja Arbuda (which is essentially a bleeding tumor) Susrutha points out that body becomes afflicted
by Pandu because of severe blood loss and due to the complications of Arbuda (arbuda peeda). All
Pandu conditions are considered caused by vitiation of all 3 doshas vata Pitha & kapha. But due to
relative dominance it is considered a pithika disease. According to symptoms and causative factors it is
classified into 5.
74
Pandu Samprapti - Samprapthi is a Sanskrit technical term translating to 'pathogenesis'. It is the
complete attainment or acquisition of pathological route of a disease. The cracking of disease
samprapthi of an individual patient is the primary goal for starting Individualized precision therapy.
Due to excess intake of acidic foods, Alcohol, Salts, other inflammatory habits and foods overtime
causes changes in the body owing to recurrent imflammations. This process causes vitiation of doshas
in the body especially pitha dosha. Due to reduced metabolic fire and blocked channels in the body.
The aggravated pitha is initiated and carried by vata to different parts of the body resulting in paleness,
yellowness in skin eyes etc. This condition in which paleness is seen predominantely is called 'pandu'.
Pitha is synonymous to fire and has yellowish — red properties. But in pandu due to increased vitiation
of other doshas. The fire element in pitha becomes relatively reduced due to increase in water and space
elements. As a result of this pitha vikrithi (change) it obtains paleness and this affects all the 5 types of
Pitha in the body. Chakrapani considers this change in pitha the cause of paleness. The changes in the
basic elements of Panchabhoota air, Water, Fire, earth and Space affects the composition and nature of
body and universe. Complications Succeeding Pandu - When Pandu roga (disease) become severe it
results in deterioration of health immune system and deficient blood production succeeding this
condition it can move forward producing
various complications. These dangerous
complications can lead to death of a
patient. Preceeding death Rishta (sign of
death) become visible in last stage of
Pathogenises (samprapthi). The different
complication pathways are listed below
according to doshas. Pitha Upadrava
Samprapthi (Complications). Succeeding
Pandu all these complications can lead to
rishta (Signs of death) the pathway taken
varies from one person to other according
to the preceeding environmental and
genetic factors. These complication
pathways can be seen together adding to
the difficulty in treatment in Leukemia and
MDS initially the disease starts with
Anaemia, thrombocytopenia, resulting in
paleness, extreme weakness etc. and when
disease manifest further gets into
complications like Raktha Pitha (haemorhagic conditions) in which Pandu being a Pitha predominent
disease undergoes further Pitha vitiation leading to increased pitha in blood which in turn makes it less
viscous, thus reducing the clotting capacity of blood. This condition can be seen with existing Hepato-
sptenomegally in leukemias and will result in Internal haemorhage, bleeding through orifices and finally
death, showing signs of Tridoshaja Raktha Pitha.
Pandu Tridosha Rakthapitha (bleeding disorder) Rishta (signs of death) - These complications
may be seen together in a patient. It is of utmost importance that the physician can predict the path of
the disease by keen observation of individual patient symptoms, triggering factors, genetics and existing
complications. Each patient develops a
separate pathway, the physician who can
predict this pathway from the above
factors can give apt treatment before
manifesting to next stage. This is the
75
primary goal of individualized precision medicine.
In Ayurveda, treatment is based on individual’s state of health, his signs and symptoms and the strength
of pathogenesis pathway and manifestation of disease in that particular individual. Two main type
therapies namely, Shodhana (purifying therapy) and Shamana (pacifying therapy). Shodhana therapy
which includes various procedure of panchakarma is done in comparatively healthy individuals. In
cancer patients whose health immunity are severely compromised along with other complications only
Shamana therapy is possible. By this we aim at reducing the severity of the disease and its
complications. Prevent influx of other diseases by improving immunity along with the maintenance and
healing of normal body hemostasis.
Pandu is disease of Pitha dosha predominance. The symptoms are consistent with reduced metabolism
reduced blood production and loss of Immunity. In Ayurveda Pitha and Raktha (blood) are considered
relatively proportional (Asraya - Ashrayi bandha) as Pitha is formed from Raktha yet in Pandu, Pitha is
vitiated and Raktha is reduced which is a paradox. Why is this happening? Blood (Raktha) is formed
from food broken down by Metabolic fire (agni). The Rasa (food) is broken into nourishment part (sara)
of wasteful part (Kitta). Due to reduced Metabolic fire Raktha Sara is reduced and Raktha Mala is
formed in abundance. As a result of this, blood nourishment is reduced and causes reduction in blood
whereas the wasteful part is increased resulting in increased Pitha which is formed from Raktha Mala.
Treatment is aimed at empowering the metabolic fire (agni) pacifying the vitiated pitha and kapha
doshas also routing the normal movement of vata in the body. In order to improve immunity and health
Rasayana (rejuvenation therapy) drugs are included in treatment.
In this subject Myelo dysplastic syndrome (MDS) tiredness, Hepato splenomegally, dyspnea and
erection problems. His Haemoglobin 4-6% (normal 13-18%), Platelets - 40,000(normal 1.5 - 5 lakhs)
and WBC count - 1000-2000 (normal (5000-10000). He had severe anaemia thrombocytopenia and was
doing blood transfusions at 8-10 per month. Because of the presence of dyspnea, oedema and hepoto-
splenomegally his pathogenesis pathway was predominantly Kapha dominated.
Pandu Oedema (Shopha) Urasthoya (pleurisy) Swasa (dysnoea) Rishta - This essentially means his
treatment has to be increasing Agni and pacifying kapha dosha. Even though he had very low platelet
count petichae, purpura or other hemorhagic symptoms (Raktha Pitha) were absent. Because of these
reasons kalyanaka grthm which is a primary choice medicine in Pandu and unmada (Mental disorders)
was used for its immunological, metabolic and anti oedematous action. It is a wonder drug used in many
diseases including erection and infertility issues and is seen in many cases to improve haemopoesis
(blood formation), 2.5 gm of the medicine was given with 2.5 Terminalia chebula powder hour before
food twice daily. The dosage and choice of ghee has to be precise in cancer patient because due to
reduced digestive fire it can result in worsening of symptoms. Trial and error is not advisable in a cancer
patient as an error may result in ending a family's hope forever. Along with this Kalyanakam Kashayam
was given with Chandraprabha tablet. As for Rasayana drug gandeera Rasayana (said in Sahasrayoga
text) was used. Along with purified bhasmas of Abhraka and iron were used.
Whereas for the 2-month baby who was suffering from an extremely aggressive and deadly form of
Leukemia (AML M5B) showed redish hard mass all over body called Leukemia cuti. He was weak and
his gums Swollen red. It is common in AML M5B the patient can bleed from mouth and other orifices.
Rayyan was showing such signs along with deteriorating blood picture. His WBC count shot up from
1.2 lakh to 2.5 lakhs in two days, blast cell count was
86%. Another worrying factor was severe neutropenia 1% (normal 6075%) any slight infection and
baby won't survive further. The baby literally had few more days to hold on. He was given Thiktaka
grithm ¼ teaspoon (1g) with ¼ tsp Chyvanaprash thrice daily. This case pandu had undergone
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Pathogenesis transformation to tridosha Raktha Pitha and related complications. As a result of vitiations
of vata and Pitha dosha the condition was worsening quickly to Rishta.
Pandu Rakthapitha Ristha (Haemorhagic)- It is for pacifying bleeding and to reboot haemopoesis
the former drugs were used. Thiktaka grithm is an excellent medicine for pandu and Rakthapitha along
with its anti inflammatory action. Chyavanaprash is the medicine of gods. It purifies Vata-Raktha,
improves metabolic fire rejuvenates organ and tissue formation in children (balanama Anga
Vardhanam). The chyavanaprash made from indigenous Amla (emblica officianalis) and organic
ingredients under fire burnt with medicinal- woods prepared with precise traditional methods under
watchful eyes is of a different pedigree and potency. Drakshadi kwatha 8 ml. was given twice daily.
Also 50 mg of Iron, Abhraka (mica), Swarnamakshika bhasmas with honey. All the drugs of choice
were precisely included to both patients in accordance to textual references and individual patient
conditions. The entire process is elaborate and beyond the scope of this article.
Medicine was given to both patient's and was advised to take blood tests after 10 days. Both patients
had no other medical options left in the world both were dying. All cancer patients are advised to
practise mindfulness by Yoga or pramayama and individual diet habit modifications according to their
climate, food and social upbringing are mandatory.
Both these cases are literally incurable by any medicines anywhere in the world and yet how did this
happen? There are 2 theories that explain this process.
1. Immune Theory - The Immune system reboots and rejuvenated by medicine food regime
starts clearing off cancer cells. The immune system is our primary and only weapon against cancer in
the years to come. That is the sole reason oncology is visioning towards targeted immune, therapy.
Susrutha when he describes the treatment regime for Arbuda. Suggests, One should better the health
and Immune system (bala) of the patient as that bala ( Immune system) itself will clear the disease from
its roots —" Tad rakshitam Vyadhi balam Nihanthi".
Susrutha states-liver, spleen, kidneys and lungs during organogenesis arc closely retated to
Raktha (blood) in their development and formation. When the body gets cleared of blasts by immune
system along with healthy stem cells present in circulation the chances of rebooting haemopoeisis
become greater. The chance of this happening in a newborn are higher because of his undeveloped
immune system. All the medicines and regimes of therapy are aimed at bringing this natural hemostasis
in body. Standardized medicine was introduced to accommodate and minimize clinical error in 3rd
world countries. In diseases caused by microbes like bacteria and viruses, 100 cases can be tested and
treated with a single drug. This is effective in community medicine. But in diseases of Auto Immune
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origin each individual cause, symptoms and pathogenesis vary accordingly. We cannot treat -everyone
who has-Rheumatism with-same drug and regime. Individual complications like diabetes, Piles, thyroid
co-exist often and every individual has to be treated as a separate entity or system. This type of approach
in which individual genetics, habits and, pathogenesis are precisely noted in treatment, diet- habit
modifications done according to individual specifications is called precision medicine. Modern world
has entered into precision medicine in Auto Immune related diseases in the past decade, but in India it
will take time to establish it. Ayurveda has been a pioneer in Precision medicine based on individual
patient specifications since 5000 yrs. Ayurveda is a "Sidhantha" means something that is proved over
time by several experimentations and established over cause- effect relationship. Here individual
symptoms of subjects were noted, their pathogenesis pathway assessed (samprapthi) and in accordance
to that, Individual medicine and diet- habit regimes were done. A sidhanta is known and understood by
the effect it produces. Here the effect of Ayurveda sidhanta is the life of the subjects.
Ayurveda is a way of life, its primary aim is to give vitality and longevity without diseases. A
true purpose of life, physically active life style and healthy diet are key to prevent diseases especially
cancers. A low calorie vegetarian diet is the best anti inflammatory diet possible. Processed meat used
in burger, pepperoni, pizza, Sausages are classified as group I carcinogen by WHO. Tobacco, asbestos
and Plutonium are the other group I carcinogens. 'Yes, you heard that correct "plutonium" and "tobacco"
are as cancerous as processed meat. Chicken, Beef, Mutton all meats have dead meat bacterial toxins
that trigger a cascade of Inflammation. In fact, chicken when cooked has greater amounts of carcinogen
Heterocyclic amines than beef and is in par with cholesterol content in beef. Each 50g portion of
processed meat daily increases the risk of colorectal cancer by 18 %. One serving of meat per day
increases risk of diabetes by 51 percent based on harward research paper. It is the gluten, meat and dairy
that kill you. Going on vegetarian diet and cassein free can infact reverse Autoimmune pathology and
even reverse mutation. Yes you heard it right healthy diet, changes gut microbe structure which can
actually correct mutations and Auto immunity. Food alone has capacity to reverse mutations, imagine
the potential results when we involve mindfulness and physical activity the possibilities of prevention
and cure become endless when supplemented with rejuvenating Ayurvedic therapy. In cancer care our
primary goal is prevention, then comes curing and palliation. Ayurveda has endless possibilities in Auto
immune diseases and oncology. The plant cannabis has huge role to play in further improving cancer
care and palliation. It is a wonder drug used in Ayurveda for thousands of years. It is used as a sedative,
pain relief, immune system booster for anxiety, nausea related to chemotheraphy and dozens of other
uses. The opiates and morphine use by modern medicine sustains its palliative care. Let me assure you
my friends when medical marijuana is legalized for oncology and chronic illness, Ayurveda will be a
pioneer in global oncology care. The formulations like "madanakameswari" said in sahasrayoga text in
which cannabis is a main ingredient known for its aphrodesiac properties is a great pain reliever and
has anticancer immune modulating properties and will be a major player in Leukemia related
complications. This is just a tip of the iceberg, imagine the many traditional formulations with cannabis,
have to offer. This has to be of prime importance in political, humanitarian and medical level. All India
Institute of medical science, Ayush department and the best Ayurveda oncologists should join hands
for research, on the subject of Curative and palliative care by Ayurveda supplemented with medical
marijuana use. This is future, India have the potential might of unmountable traditional knowledge that
can be supplemented by modern methods. Ayurveda is based on individual’s system, pathogenesis
undergoes in accordance to the overall health and disease condition which is understood by the effects
they produce according to Ayurveda Sidhantha In the years to come India will epitomize global
oncology care, at the helm of prevention and care will be Ayurveda. When this is perceived in reality
we are gonna see a renaissance of incredible beauty.
CONCLUSION
Mechanisms of origin and cellular immunology of AML and MDS are yet to be elucidated with
complete certainty. They are heterogeneous conditions and can present in varied ways. It is only after
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the nosologic limits of these entities are fully delineated that strict criteria can be laid out for their
management. Individualized therapy can be expected to provide significant relief in patients. The
benefit of standardized protocol medicine is minimal in immune system related malignant conditions.
So the new approach of precision medicine which take into account individualistic genes, environment
and habits are the way forward. Both subjects 8-week old baby with AML M5B and 49 years old with
MDS were successfully managed with precision Ayurveda therapy. Refractive Cytopenia were
corrected, blast cell percentage in circulation were reduced and all physical symptoms were improved.
Complete remission was seen in AML M5B and MDS. No signs of relapse are noted in both cases for
over 7 years in the former and 5 years with the latter. Both subjects continue to be healthy even after
stopping medication for over 2 years. Ayurveda in its full essence aims at this precision approach in
healing.
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ABSTRACTS OF
ORAL PRESENTATIONS
80
SESSION 1
THEME: “SCOPE OF INTEGRATION IN CANCER MANAGEMENT WITH AYURVEDA”
1. Evaluation of Management of Stress in Cancer Patients through Shirodhara W.S.R. to
Cancer Metastasis and stress Hormones.
Dr. Kavita*Dr. Santosh Kumar Bhatted**
*Pg. Scholar**Associate Professor (Department of Panchakarma, All India Institute of
Ayurveda)
ABSTRACT - The psychosocial factors on the development and progression of cancer has
been a longstanding hypothesis since ancient times. In fact, epidemiological and clinical studies
over past 30 years have provided strong evidence for links between chronic stress, depression,
social isolation and cancer progression. By contrast, there is only limited intervention for
managing behavioral factors in cancer progression. The major cause of death in cancer is
metastasis that is resistant to conventional therapy. The outcome of cancer metastasis depends
on multiple interactions between metastatic cells and homeostatic environment of the body.
Epinephrine Norepinephrine Cortisol Catecholamine’s are known to be elevated in individuals
with stress. The physiological stress response is thought to be one of the likely mediators in
cancer progression, Hypothalamic Pituitary Adrenal (HPA) axis is considered to be the main
neurophysiological mechanism of Shirodhara, the tactile stimulation of skin or hair follicles
innervated by Trigeminal cranial nerve stimulate the thalamus and provide the subject an
altered state of consciousness and a relief from anxiety, stress and depression. Other route from
the principal nucleus to the reticular formation and posterior region of thalamus, which is
Centre of autonomic nervous system, would be possible. This provides changes in autonomic
nervous balance, Shirodhara can be treated as a good option to prevent stress and maintain
homeostasis.
KEY WORDS – Homeostasis, Metastasis, Shirodhara, Hypothalamus Pituitary Adrenal axis.
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3. Role of Kalpa Chikitsa in the management of lynch syndrome- a case report
Dr Pooja Sharma, PG Scholar, All India institute of Ayurveda
Abstract:
Background-Lynch syndrome (hereditary non-polyposis colorectal cancer) is an autosomal dominant
condition and it is caused by germline mutations in the DNA mismatch repair genes.
Case presentation -A 28-year-old male was diagnosed with lynch syndrome in 2016. Patient was
operated 3 times followed by chemotherapy. In 2019, he was diagnosed with adenocarcinoma and
advised for surgery. But despite of getting surgery patient prefer to take Ayurvedic consultation
considering his miserable condition after previous surgeries. Decided to give the kalpa method of
therapy prescribed in Ayurveda for rejuvenation and overall improvement of health.
Result-After the 15 days of treatment with Kalpa chikitsa, the patient showed significant improvement
in quality of life (p<0.001 for SPF) and CT abdomen showed reduction in circumferential thickening
from 2.8cm to 1.5 cm (~ 50% improvement) with no worsening complications.
Conclusion - Although the pathogenesis cannot be done revert back to the normalcy as the patient
already had resection of total colon, but it can be concluded that with the help of Ayurveda, appearance
of complications can be delayed and quality of life can be improving in such patients.
Key-words: Lynch syndrome, Madhuyasti Ksheerpaka, kalpa chikitsa
4. “A Comparative case study to assess the effect of Draksha-guduchyadi kavala in oral side effects of
Radiotherapy in non-metastatic Squamous Cell Carcinoma of Head and Neck”
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5. Need for awareness of organic or natural food among medical practitioners.
Vd. Sushrut Dilip Gadgil, PG scholar Swasthavritta TAMV, Pune; Guide – Vd. Mihir S. Hajarnavis
Many technological advances are being done in different fields of science, agriculture, medicine
etc. The most dangerous and harmful diseases like cancer, diabetes are increasing in the population.
The society and the medical professionals are not aware about the causes of these diseases and they and
their close relatives are susceptible to these diseases. So there is a dire need to educate medical
professionals even from Ayurvedic stream, for natural food to maintain health. The food hybridization
and the use of chemical fertilizers and pesticides are done since almost fifty years in the world. About
fifty years ago there was natural, healthy, organic food available everywhere. As the science advanced
and many inventions and researches were done in the fields of agriculture lot of efforts were taken to
increase crop yield by unnatural way. Genetic mutations, biotechnological use are some examples of
this. The crops were made such that they will not have further reproductive capacity or fertilizing
capacity. The farmers also were encouraged to farm such genetically modified seeds to yield more and
to have more money. Thus the basic need of mankind that is the food got vitiated by these chemical
fertilizers and pesticides. To overcome these hazardous food effects Subhash Palekar has started an
aggressive step against unnatural farming. He has motivated many farmers from Maharashtra to have
natural farming only. Thus need of awareness about organic or natural food for the medical practitionres
will be explained in the paper presentation.
Introduction: Apollo with its 72 hospitals, 11000 beds across the country with more than 80000 health
professional committed to delivery world class care closer to every individual. Apollo in light of the
growing prevalence of non-communicable disease –diabetes, heart diseases, cancer and stroke have
stepped up efforts in preventive healthcare recently by introducing Apollo Pro Health powered by AI
for assessment of risk factors in cancer management in one hand and on otherhand with Apollo Total
Health- an integratedcancer management model under CSR initiative for rural population at
ThavanampalleMandal of Chittoor District in Andhra Pradesh. Objective: To identify and provide
health services to thepatients with several types of cancer, at an early and treatable stage when the
disease is largely asymptomatic and treatable throughan integrated approach. Method: All women
across Thavanampallemandal between age group of 30 – 70 years will undergo screening for cervix,
oral and breast cancer within specified period of time. Between August – December 2019, 974 women
of age group of 30 to 70 years undergone screening for cervix cancers through mobile clinics team
which includes health professionals from Allopathic and AYUSH. Pap smear, Colposcopy and Biopsy
were the diagnostic procedure used while screening the women for cervix cancer. Other investigation
such as blood sugar, Hemoglobin and blood pressure also done. Outcome: Out of 974 women who had
undergone screening for cervix cancer, 7 found to be in pre cancerstage, 12 cellulitis whereas 3
confirmed cases of cervix cancer. All 22 cases where treated with an integrated approach of allopath
and AYUSH. In case of Ayurveda, patients undergone Shaman Chikitsa, ShodhanChikitsa– Yoni Basti
and lifestyle modification through yoga.
Affiliation: Total Health (A CSR initiative of Apollo Hospitals Enterprises Limited), Aragonda,
Chittoor, Andhra Pradesh.
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SESSION 2
“LEAD & INTEGRATION WITH BASIC SCIENCES & AYURVEDA IN
CANCER MANAGEMENT”
1. Psychological Healing in Oncology – In Purview of Epigenetics
Dr. Sharma Akanksha1, Dr. Sabharwal Pooja22
1. PG Scholar, PG Department of Rachana Sharir, CBPACS, New Delhi; 2. Assistant Professor (MD,
PhD), PG Department of Rachana Sharir, CBPACS New Delhi.
Abstract: Cancer is a disease which manifests not only at physical level but at psychological level also.
Stress is one of the major cause as well as major symptom after manifestation of this dreadful disease.
Previous studies have revealed that stress can trigger the causation of cancer by changing the genetic
expression. Considering the impact of stress as one of the major cause and as major symptom and
aggravating factor, non-pharmacological interventions to heal the subtle body is of equal importance as
pharmacological interventions. These non pharmacological interventions for example- Prana healing,
Aura cleansing, Chakra healing & various other forms of bioenergetics medicine are of great potential
for the psychological healing in oncology. Stress can damage the Aura, causing gaps and interrupting
Prana, the life-force. Patient will be treated with various unconventional therapies to control the defect
in brain controlling mechanism through the stimulation of Chakras known as “Psychoneurotherapy”.
Method- Meta-Analysis; Aim & Objective- To describe briefly the continuum of ecology- biology-
genetic and energetic process of life and their application in Oncology. Conclusion-. Thus, it can be
concluded that the application of Shadchakra pranic healing as a noninvasive, non pharmacological
intervention in reduction of stress, which is cause itself, & one of the major symptom of cancer is of
great potential in oncology. Keywords- Cancer, Chakras healing, Bioenergetic Medicine
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3. CURCUMIN AND 2-DG AMALGAMATION INHIBITS ANCHORAGE-
INDEPENDENT GROWTH OF MALIGNANT GLIOMA CELLS
a
Kavita Peter, bRagini Gothalwal, cPuneet Gandhi
a
Research Scholar, bProf. and Head, Deptt. of Biotechnology, cProf. and Head, Department of Research,
Bhopal Memorial Hospital and Research Centre, Bhopal
Objective: Glial stem-cells (GSCs) and glial stem-like cells (GSLCs) are a major hurdle in
glioblastoma (GB) therapy because of the inherent resistance mechanism. Efforts to mitigate
resistance and relapse have led to the development of combination therapy to induce tumor and
stem-cell death and have the potential to improve cancer therapeutics. The current initiative
was to investigate the anti-stemness effect of the natural polyphenol curcumin (CUR); in
combination with 2-deoxyglucose (2DG), a glucose analog and glycolytic inhibitor, on human
GB cells. Methods: U-87 GB tumor cells were treated singularly with CUR, 2-DG, and
CUR plus 2-DG for 48hr. Cell cycle inhibition was assessed by flow cytometry to look for
distribution of cells in different phases of division on treatment. The tumorigenicity of the cells
was evaluated by clonogenic assay and soft agar assay for the anchorage dependent and
anchorage independent clone forming capacity, respectively. Results: Earlier, we have
established that the combination of 2-DG and Cur is synergistic for inhibition of proliferation
and cell migration. The combination arrested the cells in G2/M phase and also inhibited the
anchorage independent and anchorage dependent clone forming capacity which is
characteristic of GSCs. Conclusion: This novel combination exhibited the potential to inhibit
GSCs responsible for relapse and resistance. The study suggests that tailor-made combination
using established drugs can target multiple signaling molecules to yield optimal therapeutic
outcome and is the right approach to address resistance in GB.
ABSTRACT:
Synthetic anticancer drugs, apart from their high cost are well acknowledged for their unwarranted side
effects. We studied the effects of four different extracts of Bhringraj - Eclipta alba Hassk., in the hepatic
cancer cell line – (HepG2). Apart from the studies for the phytochemical analysis, TLC, HPLC analysis
to test active chemical components in the ethanol, methanol, aqueous and petroleum-ether extracts of
Bhringraj, we have evaluated these extracts for their activities against HepG2. We have used the
Sulforhodamine B (SRB) assay for the investigation of cytotoxicity produced by the different extracts
of Bhringraj in HepG2 cell line, as it is the most preferred and cost-effective method of screening. After
the evaluation of the percentage of cell growth and cell viability values from the SRB assay, it was
revealed that the percentage of growth inhibition were 79.33%, 77.36%, 68.74% and 55.06% for
ethanol, methanol, aqueous and petroleum ether respectively. From the analysis of the results, we have
reached to a conclusion that the ethanol extract of Eclipta alba Hassk. is in possession of highly
significant anti-cancer activity in comparison to other three extracts of Eclipta alba Hassk.
KEY WORDS- Ethanol, Methanol, Eclipta alba Hassk., Srb assay, HepG2 cell line.
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5. In vivo anticancer activity and toxicity of Ayurveda compound W.S.R. to leukemia
Dr. Monika Sharma, Ph. D Scholar, Department of Agad Tantra, National Institute of Ayurveda, Jaipur,
Rajasthan, India
Introduction: A diseased caused by an uncontrolled division of abnormal cells in any tissue of any
organ of the body is called cancer. There are various types of cancers on the basis of primary abnormal
growth in tissues. Leukemia is a type of cancer of blood, which is caused by the rapid production of
abnormal white blood cell. In Ayurveda, the reference of the cancer and blood cancer is found indirectly
under the heading of Arbuda (cancer) and Rakta Arbuda (leukemia), respectively. In Ayurveda, there
are so many herbo‑ mineral drugs that are useful in treating cancer. Aims and Objectives: 1. To study
the in vivo anticancer (blood cancer) activity of Ayurveda compound. 2. To compare the toxicity of
Ayurveda compound with injection/tablet arsenic trioxide. 3. To evaluate, elaborate, and discuss the
etiology of leukemia as per Ayurveda. Materials and Methods: An in vivo study was conducted in
Institute of Biomedical and Industrial Research. The in vivo anti-leukemic effect was carried out by
using benzene‑ induced (carcinogen) model in Swiss albino mice and the acute toxicity study was
conducted according to fixed single‑ dose toxicity. The herbo‑ mineral drugs have been prepared by
using purified arsenic (arsenic trioxide), Vinca rosea, and Urginia indica to study in vivo anti‑leukemic
effect and toxicity. This study was conducted according to organisation for economic co‑operation and
development Guidelines 423 and the antileukemic activity was carried out by benzene‑induced
leukemia in albino mice after animal ethical clearance. Result: The highest dose of the test drug (2000
mg/kg) in the acute toxicity study shows minimal adverse effect of toxicity on liver and no adverse
effect was found on kidney and spleen. The result was found better in study group 1 having myelocytic
leukemia than study group 2 having lymphocytic leukemia. Conclusion: The effect of study drug shows
good antileukemic activity, although standard drug was found better than study drug. Overall, the study
was found safe and effective on blood cancer.Keywords: Ayurveda compound, lymphocytic leukemia,
myelocytic leukemia, Rakta arbuda
6. Deciphering the anticancer potential and the mechanism of action of Cissampelos pareira (L.)
Poir. (Patha) extract on human and animal derived cancer cell lines using proteomics as a tool.
Shraddha Bharsakale, Shridhar Chougule, Sudesh Gaidhani, Sangeeta Sangvikar and Sharad Pawar.
Regional Ayurveda Institute for Fundamental Research (CCRAS) , Pune-411038.
ABSTRACT
Among the various plants attributed for possessing anti-cancer potential, Patha has been reported to be used
in the management of Gulma (~Abdominal tumor/swelling) in Bhavprakash nighantu. In the present study,
anticancer potential and the mechanism of action of Cissampelos pareira (L.) Poir. (Patha) hydroalcoholic
extract on human and animal derived cancer cell lines was deciphered through proteomics as a tool. Cancer
cell lines viz., Breast Cancer-MCF7, Liver Cancer-Chang Liver, Cervical Cancer-HeLa, Pancreatic Cancer-
RIN5F and Mesenchymal Stem cells-MSC were treated with different concentrations of extracts. To
decipher the anticancer potential of extracts various in vitro assays viz., MTT cytotoxicity assay, glycation
assay, DNA fragmentation assay and Multi-caspase analysis were employed. Further, proteome level
analysis was conducted in order to probe into the mechanism of action of plant extract on cancer cell lines.
Proteome extraction was carried out for untreated and treated samples in RIN5F cell line, and quantified
samples were subjected to in-solution digestion prior to MS analysis. Out of four cancer cell lines, the extract
has shown potent anticancer activity against RIN5F with IC50 value being at 37.5µg/ml, whereas no
cytotoxicity was observed in MSC normal control cell line, indicative of selective cytotoxicity against
pancreatic cancer. DNA fragmentation assay and Multi-caspase analysis resulted in affirmation of mode of
action of plant extracts via apoptosis induction. The proteomic analysis yielded the evidence of probable
mode of action i.e. the apoptotic pathway activation mediated by p53 upregulation in pancreatic cancer cell
line.
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7. Exploring the mechanism of action of Balanites aegyptiaca (L.) Del, (Ingudi) extract
on human and animal derived cancer cell lines using cell based assays and proteomic
tools.
Shridhar Chougule, Shraddha Bharsakale, Sudesh Gaidhani, Sangeeta Sangvikar and Sharad Pawar
Regional Ayurveda Institute for Fundamental Research (CCRAS, New Delhi under Ministry of
AYUSH, Govt. of India), Nehru Garden, Gandhi Bhavan, Kothrud, Pune-411038.
ABSTRACT
Many plants are known to have anticancer effects according to ancient Ayurvedic text. They are known
to reduce the proliferation of cells and the size of tumor after treatment. However, their mode of
pharmacological action is yet to be elucidated. The present study has explored the mechanism of action
of Balanites aegyptiaca (L.) Del, (Ingudi) hydroalcoholic extract on human and animal derived cancer
cell lines using cell based assays and proteomic tools. Cancer cell lines viz., Breast Cancer-MCF7, Liver
Cancer-Chang Liver, Cervical Cancer-HeLa, Pancreatic Cancer-RIN5F and Mesenchymal Stem cells-
MSC (normal control) were treated with different concentrations of extract. The cytotoxic activity was
analyzed by using MTT cytotoxicity assay. The cytotoxic activity was ensured with cell death via
apoptotic pathway, using two methods viz., DNA fragmentation assay and Multi-caspase analysis. In
order to decrypt the molecular mechanism of action of plant extract on cancerous cell line, proteome
level analysis was mandatory. Thus, proteome extraction was carried out for untreated and treated
samples, and quantified samples were subjected to in-solution digestion prior to LCMS analysis. The
extract has shown anticancer activity against all the cell lines used under the study (IC50 values being
30µg/ml for MCF7, 30µg/ml for Chang Liver, 60µg/ml for HeLa, 30µg/ml for RIN5F). DNA
fragmentation assay and Multi-caspase analysis resulted in affirmation of mode of action of plant
extracts is via apoptosis induction. The proteomic analysis yielded the evidence of probable mode of
action i.e. the apoptotic pathway activation mediated by p53 upregulation.
SESSION 3
“UPDATE & SCOPE OF RESEARCH IN INTEGRATIVE ONCOLOGY”
1. POSSIBLE ROLE OF KAVALA, GANDOOSHA IN ORAL CANCER LESIONS AT VARIOUS
STAGES.
Dr. Amrish P. Dedge, Research Officer (Ay.), CCRAS, Ministry of AYUSH.
ABSTRACT
Introduction- As per Globocan 2018 data, oral cancer is the most common cancer in India amongst
men and the second most common cancer in India amongst women (16.1 % and 10.4 % of all cancers
respectively). Kavala, Gandoosha procedures mentioned in Ayurveda can contribute at various levels
in management of oral cancer and oral lesions. Methods- A comprehensive literature review of Kavala,
Gandoosha procedures from classics and published research evidences is performed. Discussion-
Kaval, gandoosha can be introduced with integrative approach at various levels like primary prevention
in susceptible population, secondary prevention in remission cases, management of active lesions,
management of precancerous lesions like OSMF, treatment hazards like radiation induced oral
mucositis, lesions of left out cases for pain management and palliative care etc. Classical medicinal
regimes like decoction, medicated oils, ghees, honey, milk can be used according to symptoms and
dosha specificity of lesion. Along with appropriate classical formulations as per the indications,
evidence based drugs like Curcuma longa, Tinospora cordifolia, Withania somifera, Aloe vera, honey,
Semicorpus anacordium can be used for Kavala, gandoosha. Subjective (like EORTC scoring) and
objective assessment (imaging, histopathological evaluation) will be the standard treatment outcomes
to assess efficacy. Case studies, case series followed by pilot studies may provide further directions for
well designed clinical trials with integrative approach. Keywords- Kavala, Gandoosha, Integrative
oncology.
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3. ROLE OF KAMALA (NELUMBO NUCIFERA) IN PREVENTION AND MANAGEMENT
OF GARBHASHAYA ARBUDA WITH SPECIAL REFERENCE TO UTERINE CANCER
Dr. Priyanka Hajare*, Dr. K. Bharathi** *M.S Final Year Scholar **HOD & Professor
Prasuti tantra & Stri roga dept, National Institute of Ayurveda, Jaipur
ABSTRACT- “Arbuda” is a disease which grows very fast and causes either destruction of local tissues
or body part or even death. In India, uterine cancer ranks 3rd among genital malignancy next to cervix
and ovary. Uterine cancer differentiated into 2 types on the basis of their site of origin. One is
endometrial cancer, most common form of uterine cancer and accounts for 95% of all the cases. Second
is Uterine sarcoma (mamsaja arbuda), initiates in other tissues or muscles of uterus and accounts for
5% of all uterine cancer cases. The symptoms of uterine cancer includes- excessive and prolonged
menstrual bleeding, watery-sticky foul smell discharge per vagina, bleeding after coitus and pain in
lower abdomen. So in order to combat these problems of women, Ayurveda has the potential in
prevention as well as in management of garbhashaya arbuda. Kamala (Nelumbo nucifera Gaertn.)
helps in vitiation of pitta dosha and has cooling effect by sheeta veerya. It helps in blood clotting, thus
stops excessive and prolonged menstrual bleeding. As well as it acts as haemostatic agent due to
madhura and kashaya rasa. Presence of tannin shows coagulation property; presence of iron shows
haematinic property. Acharya Vagbhata mentioned it as rasayana, hence it promotes strength, virility
and intellect. Kamala seeds contain polyphenols, flavonoids, hyperin. These effectively scavenge free
radicals and maintain the balance of reactive oxygen metabolism at cellular level as well as delay ageing
of a uterine cell. Neferine has anti-cancer activities. It inhibits cancer cell proliferation by inducing
apoptosis. Kamala is also useful in heat created due to chemotherapy and radiotherapy.
KEYWORDS- Visha nasnama, Ascorbic acid, Sangrahika, Raktaja arbuda, Uterine fibroid.
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5. ROLE OF YASTIMADHU GHRITA PRATISARANA IN MANAGEMENT OF ORAL
CANCER
*Dr Ravindra Bhati **Dr Manindra Kumar Vyas ***Dr Monika Das
*PG Scholar **Professor& HOD Panchakarma ***Associate Prof. Department of Panchakarma,
Shubhdeep Ayurved Medical College & Hospital-PG institute, Indore, M.P.
ABSTRACT: - Oral cancer is the Sixth most common malignancy in the world.
According to Ayurveda, 65 varieties of oral diseases can arise in seven anatomic locations. Ayurveda
recommends some daily use therapeutic procedures for the prevention of and maintenance of oral
health. These include: Pratisarana, Dhavani (Brushing), Jivha Lekhana (Tongue scrapping)
and Gandoosha (gargling) or oil pulling and tissue regeneration therapies. Some of the scientifically
proven beneficial effects of these procedures are Pratisarana with Yashtimadhu Ghrita significantly
reduced intensity of radiation and chemotherapy induced mucositis. Yastimadhu has madhura rasa,
sheeta virya, madhura vipaka and is vata-pitta shamaka property. Yastimadhu has vrana shodhana and
vrana ropana properties that help for healing of the wound of oral cancer. Ghrita has a soothing property
and form a thin film layer over them and that allows early epitheliazation of wound. Yastimadhu is anti-
ulcerogenic and anti-inflammatory in property. Licochalcone A is a flavonoid found in liquorice root
(Glycyrrhiza glabra). It is known for anti-microbial activity and reported ability to inhibit cancer cell
proliferation. Glycyrrhetinic acid has proved to have anti-inflammatory effect similar to glucocorticoid
and mineralocorticoids.
KEYWORDS: Licochalcone A, Vrana, Mucositis, Regeneration.
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7. AYURVEDA AND PALLIATIVE CARE: SCOPES AND OPPPORTUNITY
Dr. Vikas Nariyal1, Dr. Priyanka Sharma2
1. Research Officer (Ayu.), Regional Ayurveda Research Institute for Nutritional Disorders, CCRAS,
Pandoh, HP; 2. M.S. and Ph.D. Stree Roga evam Prasuti Tantra, A.M.O. Distt. Ayurveda Hospital, HP
ABSTRACT
Incurable and debilitating disease are often associated with many suffering. Sufferings like pain,
nausea, vomiting, ulcers, limb paralysis, anxiety, depression etc. make life unbearable not only to person
but also for family. These sufferings have gross impact on social, financial, emotional and spiritual
issues. Families often get financially ruined; losing their homes, going to debt, all these because high
treatment costs add to the problem and sometimes the sufferer is family’s wage-earner. Palliative care
is an approach that is focused on people living with serious illness irrespective of the diagnosis or
prognosis. Its motive is to improve quality of life of a patient and their family through early
identification, correct assessment and treatment of pain and other suffering, whether physical,
psychosocial or spiritual. According to World Health Organization (WHO) palliative care fact sheet
(February 2018), every year an estimated 40 million people are in need of palliative care, 78% of whom
live in low- and middle-income countries. Although country specific data is not available, this also
reflects need and concern disproportionate for palliative care in India. In December 2015, the Kerala
government roped in Ayurveda doctors to offer palliative care to patients suffering from long-term
illnesses who required home visits. How Ayurveda health care provider treated bed sores of 75 years
old bed ridden diabetic female patient with Triphla-quath gives boost to Ayurveda professionals for
looking further scopes and opportunities in palliative care. No system is perfect in providing health care
needs. We have to spotlight best of each system to fulfill lacunae. As popularly said: “strength in unity”
fits true here. For beneficence of terminally ill person, all systems have to come forward and agree with
that integration is proven best for patient care. This article is written in an attempt to explore such scopes
and opportunities in Ayurveda for delivering palliative care nationwide.
Key words: Ayurveda, Palliative Care, Scopes, Opportunity
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SESSION 4
“EVIDENCE BASED CLINICAL PRACTICE IN PREVENTION &
MANAGEMENT OF CANCER”
1. EFFECT OF AYURVEDA TREATMENT IN BREAST CANCER AS A PALLIATIVE
CARE: A CASE STUDY
Dr. Amit Awadhiya, PG Scholar, IPGT AND RA GAU JAMNAGAR
Introduction - Breast cancer is the most common cancer in women and second most common cancer
overall worldwide and India, where advance stages at diagnosis and rising incidence and mortality rate.
At that time care of breast survivals got difficult. Chemotherapy is only option as conservative treatment
in modern sciences. Through Ayurveda palliative care of those survival may increase the quality of life
of survival and life spam also. By virechana and local application of Jatyadi tail followed by
Panchavalkal Kwatha parishek may reduce infection and improve quality of life.
Case presentation: A 61year female patient with Know case of ductal carcinoma of right breast with
open wound came with complain of pain at right breast with frequent bleeding tendency. Other
complain were foul smell from pus discharge and bleeding also, loss of appetite and loss of sleep, pain
aggravating during walk. After taking detail history treatment was started. In treatment virechana planed
with regular local application of Jatyadi tail followed by Panchvalkala Kwatha and rakta stambhaka
yoga used when bleeding occure. After two cycle of virechana assessment was done on the basis of
RECIST criteria and Karnofsky performance scale. Result and Conclusion – after treatment
symptomatic relief in pain, bleeding tendency, foul smell, itching, loss of appetite and loss of sleep.
RECIST criteria shows stable disease and Karnofsky performance scale shows result 50 to 80.
Keyword- Ayurveda treatment, Breast cancer prevalence, need of alternative treatment.
2. Survival outcome of the patients with advanced hepato-celluar carcinoma treated with
Ayurveda medication: Case series
Ashok Kumar Panda, Research Officer (Ayurveda), CCRAS, Bhubaneswar, Odisha.
Ayurveda focuses on correcting the internal disequilibrium responsible for tumor development
and progression. Arbuda and grandhi terms used in Ayurveda can be correlated for cancer and tumor
respectfully. Hypothesis -The aim of this study was to investigate if use of Ayurvedic formulation with
modification, adjuvant to Conventional Therapy or alone, might prolong survival for patients with
intermediate-advanced HCC. Method-The HCC patient of advance stage (stage C & D as per Barcelona
liver cancer staging system) were explained about the limitation of our treatment and diseases process.
The survival time was measured by Kaplan -meier method. Hepatocellular carcinoma (HCC) patients
were retrospectively enrolled to evaluate treatment response, survival, and tolerability following
administration of Lokanath rasa 250 mg twice daily before food along with katuki, chieta, punnnava,
and guguchi churna 20 gram were administrated to all advanced HCC patients.
Observation & Results: Twelve patients were enrolled where seven patients were female and five were
male. Eight patients were diagnosed as primary HCC whereas four were secondary. Nine patients had
jaundice along with ascites. Ten patients had more than two tumors in liver. Abdominal pain , anorexia
, fullness of abdomen are the common symptom of all 12 patients. Eleven patients received
conventional treatment and one patient was freshly diagnosed by our hospital. Five patients were used
alcohol and nicotine. Five patients had hepatitis B positive and three patients have cirrhosis. All patients
have elevated SGOT and SGPT level. Elevan patient’s alfa feto protein rose. Extra hepatic lesion
observed three cases. Five patients survived upto six months whereas four patients survived 13 months,
two patients survived more than 18 months and one patient survived more than five years.
Conclusion - Ayurveda medication in advanced hcc showed more survival outcome and remission of
HCC than predicted outcome. More control clinical trials are encouraged and recommendation
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3. GENITAL LICHEN SCLEROSUS ET ATROPHICUS - A PRE MALIGNANT
LESION IN POST MENOPAUSAL AGE GROUP - A CASE REPORT.
Dr Charu Sharma, PG Scholar, All India Institute of Ayurveda, New Delhi
Background: Lichen sclerosus (LS) is a benign, progressive, inflammatory disease characterized by
epithelial thinning. In cases of vulvar LS, the risk of developing squamous cell carcinoma (SCC)
increases. In ad- dition, differentiated vulvar intraepithelial neoplasia is a pre- cursor lesion of SCC and
is frequently associated with LS Case presentation: A 55-year-old woman is post menopausal age group,
came with a complaint of irritation in Vulvar region since 2.5 months along with dyspareunia. On
Vulvar examination, the clinical picture confirmed the diagnosis of lichen sclerosus. Cytology
examination reported prominent bandlike inflammatory infiltrate in the sample. Oral as well as local
treatment was given for 21 days followed by oral treatment only for 7 more days. The lesions were
resolved, pigmentation was restored and the presenting complaints also resolved. Though theatripic
changes remained as such. The cytology reports were normal. Keywords: Lichen sclerosus; leukoplakia;
cytology; vulva
Introduction- Lung cancer is the one of the most common carcinoma and cause for death. Lung cancer
mainly originates from the tissues of the lung, usually from the cell lining the air passage. There are
two main types of lung cancer one is small cell lung carcinoma and another is non- small cell lung
cancer. Small cell carcinoma is slightly more common in man as compare to women. Because all small
cell carcinoma is due to cigarette smoking only and it is most aggressive form of lung cancer. According
to the GLOBOCAN 2012 report, lung cancer in India was 70,275 in all ages and both sexes.
Aim and objectives- To evaluate the effect of Ayurvedic medicine on Lung carcinoma.
Material and Method-Patient of lung cancer presented in cancer consultation and treatment unit NIA-
Jaipur, who managed with Ayurvedic formulations
Result and Conclusion- A 65 years old male patient was presented to cancer consultant and treatment
unit NIA, Jaipur with complaints of breathing difficulty, burning sensation, mild chest pain, loss of
sleep, fatigue, cough with expectorant, shoulder pain with headache. CECT of patient reveals that
approx measuring 43x41x40 mm size soft tissue density mass showing contrast enhancement,
speculated margin of lower lobe of left lung close abutting to the major fissure and demoplastic reaction-
likely neoplastic, who was successfully managed with Ayurvedic formulations like Arbudahara kashaya
Gokshuru churna, Ashwaghanda churma, suvarna basantmaliti, hirak bhasma, Abhraka, bhasma,
pushkarmula churna, tankan bhasma. After giving 8 months of treatment patient responded well to
treatment and MRI reports reveals that, the lobulated mass lesion measuring approx 38x39x38 mm seen
in left lower lobe, lesion is not limited by major fissure. Patient is still under observation and improved
clinically.
Keywords: Cancer, Lung carcinoma, Arbudahara kashaya, suvarna basantmaliti.
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5. ROLE OF AYURVEDA IN MANAGEMENT OF MULTIPLE
MYELOMA: A CASE STUDY
Dr Peeyush Kaushik MD, Fellowship scholar, Ayurveda Oncology, KAHER’s Shri B M Kankanawadi
Ayurveda Mahavidyalaya, Belagavi, Karnataka-590003
Introduction
Multiple myeloma which represents 1.8 % newly diagnosed cancer cases is relatively uncommon 1,
which affects the plasma cells, leading to proliferation and accumulation of defective immunoglobulins
in bone marrow and later infiltrating to other organs2.
Case study
In the present study a 60-year-old male patient diagnosed with Multiple myeloma in January, 2017
visited Abhaya cancer OPD in June, 2017. Rasayana management of this patient was planned as per the
symptoms and dhatu involvement. He was treated with various Rasayu herbomineral formulations that
chiefly composed of Hiraka bhasma, swarna bhasma, sutshekhar rasa, Rajat bhasma, mouktik, loha,
Makshik bhasma and some other compounds. The aim of the treatment was to improve the QOL of the
patient with symptomatic reform. Though “Vyadhipratyanik Chikitsa” was not the primary goal
however it was kept on check and results were obtained in the scope of disease stability. During the
treatment, the patient’s liver and kidney profile was also followed up to check the safety of the drugs
used and it was markedly reported to be stable during the whole follow up period of 30 months. The
tumor marker profile including β2microglobulin, IgG, IgM, IgA, κ free light chain, ᵞ free light chain
and κ/ ᵞ ratio were tested every 3-6 moths.
Results and Discussion - During the course of follow up his symptoms were regularly checked to
corroborate his quality of life (QOL) and ECOG was consistently observed to get the precise idea of
life style improvement. As per patient he was satisfied with his life and felt comfortable in pursuing his
job and routine activities. Though some age related symptoms occur occasionally but overall
improvement in this patient is remarkable. Multiple herbomineral formulations were used for a long
duration but no damage to any vital organ (has been observed which indicates the safety and efficacy
of herbomineral preparations in chronic disease management. A combination of oral
cyclophosphamide, dexamethasone, and bortezomib in 50 patients with relapsed/refractory MM has
been reported to achieve ORR in 88% of patients, with a median event-free survival of 10 months and
median overall survival not yet reached6. The subject was refractory to bortezomib, that makes the OS
to be 15.2 months but the subject followed up for 30 months of event free survival with very good QOL
and ECOG 0. All of his complains has subsided with occasional episodes of body ache and sleep
disturbances that can be attributed to season change and Paricharya. His liver and kidney profile was
stable throughout the follow up period so it can be concluded that herbomineral preparations are safe to
use in multiple myeloma cases. At the time of his first consultation he had very high levels of β2
microglobulins but during the course of medication the levels fluctuated as were the symptoms but
stayed on lower side also other tumor markers like Kappa free light chain and Lambda free light chain
immunoglobulin were within limits.
Conclusion
The present study outcomes indicate towards an encouraging and valuable role of Ayurveda therapy in
the management of refractory Multiple Myeloma. More work should be done to evaluate the actual
efficacy and significance acquired by adopting Ayurveda line of treatment instead of conventional
methods in such cases and to establish a standard Ayurvedic protocol for the management of all three
stages of Multiple Myeloma.
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6. TITLE: ROLE OF AYURVEDA IN HOGKINS LYMPHOMA -A CASE REPORT
Dr. Seema Gupta, PG scholar, Deptt of Kaumarbhritya, All India Institute of Ayurveda, New Delhi
Hodgkin lymphoma is a lymphoreticular neoplasm primarily if B cell lineage that involves lymph
nodes and lymphatic system. The incidence ranges from 5-7/100000 population, the condition is
uncommon below the age of 5 years and exhibits three distinct forms in developing countries. There is
male preponderance in child affected below 7years of age, with equal sex distribution beyond 12 years
of age. A male patient having Hodgkin's lymphoma having nonreducing cervical lymph node
enlargement treated with Ayurvedic medicine got remarkable reduction in the nodular enlargement and
disease come to non active state. Prolonged study is required for more improvement and results.
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POSTER PRESENTATIONS
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POSTER PRESENTATIONS
1. Fundamental principles of management of Vyadhi’s as explained in Ayurved
Samhita’s w.s.r Cancer and its management
Dr Aishwarya Ashish Joglekar, PG Scholar, AIIA, New Delhi
Introduction: Cancer is the second most commonly occurring Non communicable disease in the world
after Ischemic heart disease (IHD), With recent advances in the fields of chemotherapy and radiation
the longevity of life of cancer survivors has improved a bit however the quality of life is compromised
to greater extent. Integrative approach to management of cancer can help in enhancing both the
longevity and quality, thus it can be concluded that the fundamental principles ayurveda can help in
diagnosis, prognosis and management of cancer. Aim: To study and apply the fundamental principles
of management of Vyadhi’s as explained in Ayurved Samhita’s w.s.r Cancer and its management
Objectives: 1) To study the fundamental modalities of treatment and diagnosis of Vyadhi’s as explained
in Ayurved Samhita’s in context of Cancer 2) To study the treatment modalities of Cancer according to
the Conventional medicine 3) To derive integrative approach to cancer in order to enhance the longevity
and quality of life of cancer patients. Methods: Study of fundamental principles of disease management
in context of cancer will be done from the Charak, Sushrut and Vagbhat Samhita’s
1) Study of Cancer, Diagnosis and management according to the Conventional medicine will be
done.
2) Comparative study of the advantages and disadvantages of conventional and alternate medicine
(here ayurveda) will be done
3) An integrative approach will be derived in order to improve the quality of life of patients of
cancer
2. CANNABIS SATIVA IN THE MANAGEMENT OF CANCER
Dr Kajal Kashyap, PG Scholar, AIIA, New Delhi
ABSTRACT
Introduction: The side effect of anti-cancer chemotherapy is of prime concern now-a-days despite
efficient and improved treatment techniques. Loss of appetite, nausea, vomiting, skin/nail and GIT
problems are the most common side effect which degrades the quality of life of cancer patients.
Methods: Review of literature has been conducted from Ayurvedic texts and published papers to help
relieve these side effects. Results: It has been found in ayurvedic literature that Vijaya (bhanga) has
excellent therapeutic potential which helps in the management of these symptoms. Contemporary
review also suggests that cannabis sativa supresses chemotherapy induced vomiting, increases appetite
and strengthen GIT.
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3. IMPACT OF MATRIJA EVUM RASAJA BHAVA (MATERNAL &
NUTRITIONAL FACTORS) FOR THE CAUSATION OF CHILDHOOD
CARCINOMA IN PURVIEW OF EPIGENETICS
Bhardwaj Priyanka 1 Sabharwal Pooja 2 MD Scholar, PG Department of Rachana Sharir, Ch. Brahm
Prakash Ayurved Sansthan, New Delhi 2 Assistant Professor
According to Indian Cancer Society, around 50,000 adolescents and children are diagnosed with Cancer
every year. In addition, childhood cancer is the ninth biggest cause of illness in childhood and accounts
for the sixth largest contributor to the global burden of Cancer. The main reason of childhood Cancer
is unknown; however, risk factors include genetic, environmental, and exogenous factors such as diet,
weight etc of both mother (during pregnancy) and the child. It is well mentioned in classical texts that
there is a huge impact of maternal and nutritional factorsMatrija & Rasaja bhava) in prevalance of
diseases in childhood and adult life. Prenatal and Antenatal period may show teratogenic effects on
developing embryo on exposure to toxins, alcohol, non vegetarian diet etc. which changes the “gene
expression”. Also, Shodhana and Rasayana sevana by the desired couple before conception also
provided significant effect on delivering healthy progeny.METHOD: A systematic review
CONCLUSION: There is a huge impact of nutritional and maternal factors which may alter the intra
uterine environment with capacity to change genetic expression of the developing embryo leading to
the manifestation of childhood carcinoma.KEYWORDS: Cancer, Matrija bhava, Rasaja bhava,
Epigenetics
Cancer is the most vulnerable threat now days to the society. For cancer usually everyone choose
pharmacological interventions like chemotherapy, radiotherapy, immunotherapy, surgery, medicine.
But these pharmacological treatments do not always meet patient needs and may produce difficult side
effects. In Cancer most threatful condition is pain and usually the analgesics which are given for pain
management cause more side effects. So non pharmacological treatment (intervention) may provide
more relief like acupuncture, oleation, touch healing etc. Most of the cancer hospitals now days have
separate unit to render such kind of non- pharmacological services to cancer patients for pain
management. One of the non pharmacological approaches in Ayurveda is Marma therapy. These Marma
therapies can help in reducing pain by providing mild pressure over vital points. As these vital points
related to chakras and nadis which help in transferring prana over whole body. There is no direct
mention of Marma therapeutic use in Ayurvedic literature but now day an effective therapy evolved i.e
Marma therapy. Marma therapy is based on the utilization of 107 points in the body which are
considered as access points to body, mind and consciousness. Marma points can be used to balance the
tridosha and triguna. In Ayurveda, the traditional medicine of India, these pressure points may be called
as Marma, meaning “vulnerable or sensitive zones”. Such points can be used specifically for treating
disease or generally for promoting health and longetivity. MethodA systematic review. Conclusion By
offering treatment to cancer patients with intervention of Marma therapy may reduce the global burden
of cancer treatment expenses. The further methodology related to intervention of Marma therapy will
be discussed in full paper. Key words: Cancer, pain, Marma therapy
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5. Scope of Palliative Care for Cancer Through Panchakarma
Dr. Latika, PG Scholar, AIIA
Introduction: Palliative care is a treatment that seeks to relieve suffering in patients. Cancer being a
major illness and a leading cause of death worldwide the scope of Palliative care is too large. In modern
medicine the line of treatment adopted for cancer is Chemotherapy and radiotherapy which are highly
proved to have side effects. Those most commonly include nausea, vomiting, diarrhoea, alopecia,
constipation, Sleep disturbance, anorexia, Fatigue etc. These arrays of side effects have a devastating
effect on the quality of life of cancer survivors. It is moral responsibility of health care system to provide
or make possible effort for betterment of terminally ill cancer patients . Ayurvedic principles has an
immense contribution in various chronic disease in bettering the quality of life especially Panchakarma
Therapies. Here, in this study Panchakarma procedures were reviewed in the context of their
applicibality in palliative care in cancer to improve quality of life. Materials and Method: Various
Ayurveda classical literature and modern literature along with published authentic sources from Internet
were reviewed thoroughly to derive conclusions. Discussion: Palliative care through panchakarma in
cancer is non-invasive and considered to be the best, since the side effects are reduced or eradicated.
Need of the hour is to raise awareness and encourage implementation of Palliative care through external
therapies (Panchakarma) for combating cancer and its side effects. Result: This review shows a good
prospect of palliative care in cancer through Ayurveda with special reference to Panchakarma
Therapies.
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7. MULTIMODAL AYURVEDIC APPROACH IN THE MANAGEMENT OF
CENTRAL NEUROCYTOMA – A CASE REPORT.
Dr Mythri H S 1 , PG Scholar, AIIA
Central Neurocytomas (CN) are rare, benign neoplasms of the central nervous system,
comprising 0.25-0.5% of brain tumours, often located in the lateral ventricles. Typically,
benign, though atypical variants have been reported and believed to have potential for
malignant transformation. The combined overall annual incidence is 0.032. Peak incidence is
found at 20-34 years of age, with higher incidence in Korea, India, and Japan. The symptoms
of CN can be well correlated with Vatavyadhi especially due to Pittavrita Prana and Pranavrita
Vyana pathologies. The main goal of management of CN are gross total resection, adjuvant
radiosurgery and radiotherapy. However, these treatment types may cause different side
effects, and chemotherapy-based regimens appear to have reached a therapeutic plateau.
Therefore, this rare case of CN which was manged by multimodal Ayurvedic therapies is being
reported here. A 37-year-old male approached the OPD of AIIA with the complaints of
severe headache with heaviness in head, dizziness, nausea and forgetfulness in day to day
activities, along with ocular complaints like heaviness in eyes, blurred vision and diplopia for
45 days. For which patient was diagnosed as Central Nuerocytoma with punctate calcification
and lateral ventriculomegaly through CECT Head. On the basis of features patient was
diagnosed with Pittavrita Prana Vatavyadhi after considering Rogi-Roga Pariksha. Patient was
treated on the line of Pittaghna and Maruta avirodhi chikitsa with combination of herbal and
herbo-mineral oral medications along with panchakarma, netra kriyakalpa and athyahara. Pre
and post therapy assessment were done based on Karnofsky performance scale, NANO scale,
MMSE and HVLT- revised scale. Post therapy assessment showed notable improvement in
disease symptoms. KEY WORDS: Central Neurocytoma, Punctate calcification, Avrita
Vatavyadi, Karnofsky performance scale, Panchakarma
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9. ROLE OF PANCHAKARMA IN INTEGRATED CANCER REHABILITATION
10. Prevent Cancer with Samshodhana, A new vision with old sight
Dr Nisha Singh* *Assistant professor, Ankerite Ayurvedic Medical College and Hospital, lucknow
Our body is a perfect combination of cells each assigned to do its work and die at certain period of time.
Beside our various efforts like proper Dincharya , Ritu charya Ahara and Vihar they go through various
problems . Kala Viparya, Pagyan Apradha and Asatmya-Indriyartha Sanyoga are the other modalitie
which interferes with normal physiology and deranges it. Cancer is one such killer whose cause is
unknown in 80% cases. It can start in any body part with an abnormal growth of cells which tend to
proliferate in an uncontrolled way and, in some cases, to metastasize (spread). So our Acharya’s had
given solution for that also i.e. Shodhan chikitsa. Timely Expulsion of toxins and purification of body
can leads to healthy life. The benefits includes , Mala-paham (expulsion of waste/toxins), Roga-haram
(treats d’s) , Bala- Varna Prasadnam (rejuvenate body ) and Chirayau Prapti (extends healthy life span)
. Key words - Viparya, Pagyan Apradha and Asatmya-Indriyartha Sanyoga , Mala-paham, Roga-haram
, Bala- Varna Prasadnam Chirayau Prapti
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11. FACTORS FOR THE CAUSATION OF CHILDHOOD LEUKEMIA IN PURVIEW
OF EPIGENETICS
Dr. Neha Diwedi, CBPACS
Introduction:-Ayurveda have enumerated a number of factors, which together lay the physiological and
physical make-up of an individual. The combination and quality of these procreative factors and the
state of Doshas in Shukra and Artavaat the time of conception determines the physical, temperamental,
psychological and spiritual composition of progeny. These six procreative factors (Shad
Garbhkarabhavas i.e; Matrija, Pitrija, Rasaja, Atmaja, Satmyaja, and Sattvaja) have the influence on
changes on the individual caused by modification of gene expression rather than alteration of the genetic
code itself (epigenetics). Each procreative factor is assigned with a certain organogenesis, functional,
psychological phenomenon, to develop in the progeny, during its intrauterine life. Ayurveda says any
lag on the part of these six procreative factors may cause to physical and psychological defects. The
causes of childhood leukemia as the most common malignancy in children are vastly
unknown.Leukemia is a type of malignant neoplasm, having malignant clonal expansion of immature
myeloid or lymphoid blast cells characterized by increase in circulating WBCs. Aim:-To evaluate the
role of these six procreative factors for causation of childhood leukemia. Method:-A Systematic review.
Conclusion:-Ayurvedic classical literature related to genetics and epigenetics advocates that six
procreative factors are responsible for manifestation of childhood diseases like childhood leukemia.Key
Words:-Shadgarbhakarbhav, Leukemia, Epigenetics.
“He, who constantly thinks, examine, introspect that how his day and night are passing will never
become a victim of sorrow.”Today, Cancer forcing us to revisit this teaching of Vagbhatacharya and to
redirect our focus from mere Cancer cure to its prevention, rehabilitation and Apunarbhav chikitsa.
Ayurveda: the way of life, where emphasis is given not only to physical aspect of life but to know and
aquire skills to live and lead the life qualitatively. Rasayana and its role in healthy & diseased persons,
Yoga and Vedic philosophical aspects, Apuarbhava chikitsa with various herbs and herbomineral
compounds, Aaharkalpana& vihar nirdesh are general guidelines to be followed by healthy and diseased
individuals. This holistic approach of Ayurveda potentially helps to reduce morbidity of Cancer.
Further, while rehabilitating cancer patient onus is on society to enable them to lead a dignified and
socially accepted life without any undue fear and pressure, without any stigma attached. We, AYUSH
and Modern medicine can work together to overcome this challenging role of cancer treatment, as a
teamwork. Because coming together is beginning, keeping together is progress, but working together is
definitely lead us to success.
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