Gastroesophageal Cancer (Case Study)
Gastroesophageal Cancer (Case Study)
INTRODUCTION
formidable group of upper digestive tract cancers. These cancers which are distinguished by their
aggressive nature and frequent late-stage diagnosis, pose a substantial worldwide health concern.
cancer is critical for healthcare providers, researchers, and policymakers working towards
effective prevention, early detection, and treatment strategies to mitigate its impact.
Gastroesophageal cancer is divided into two types: esophageal cancer and stomach
cancer. Esophageal cancer develops in the esophageal lining, whereas stomach cancer develops
in the mucous-producing cells lining the stomach. These cancers are generally asymptomatic in
their early stages, resulting in a delayed diagnosis and a poorer prognosis. Chronic
gastroesophageal reflux disease (GERD), tobacco use, heavy alcohol use, dietary factors, and
genetic predisposition are all common risk factors for gastroesophageal cancer.
Squamous cell carcinoma and adenocarcinoma are the two main histological forms of
esophageal cancer. Squamous cell carcinoma primarily affects the upper and middle esophagus
and is frequently associated with tobacco and alcohol use. Adenocarcinoma, on the other hand,
often develops in the lower esophagus and is frequently related with persistent GERD, obesity,
Stomach cancer, on the other hand, is more common in older adults and is frequently
associated with Helicobacter pylori infection, particular dietary habits, and hereditary
vulnerability.
B. Statistical Incidence
The global incidence of gastroesophageal cancer varies by type and geographic region.
According to the American Cancer Society, an estimated 19,260 new cases of esophageal cancer
were diagnosed in the United States in 2022, leading to 15,530 deaths (American Cancer Society,
2022). The incidence of esophageal cancer can fluctuate by subtype, with adenocarcinoma
Esophageal cancer is the sixth most common cancer in the world, with over 500,000 new
cases diagnosed each year. It is one of the leading causes of cancer death, claiming the lives of
around 500,000 people each year. The 5-year survival rate for patients with esophageal cancer is
less than 20%. The majority of esophageal cancer cases are diagnosed in developing countries.
Its global burden, however, varies widely, ranging from the second most common malignancy in
Regarding stomach cancer, it remains a major public health concern worldwide. Stomach
cancer was one of the top causes of cancer-related mortality in 2020, accounting for roughly 1.0
million new cases and over 768,000 deaths worldwide (World Cancer Research Fund, 2020). The
incidence of stomach cancer exhibits significant regional disparities, with higher rates in Eastern
Esophageal and stomach cancers have a significant global disease burden, emphasizing
the need for improved prevention, early detection, and treatment measures to reduce their impact
on public health.
C. Current Trends (new approach/method of treatment)
In recent years, the landscape of gastroesophageal cancer treatment has seen tremendous
improvements and developments that provide new hope and improved outcomes for people
dealing with this difficult disease. According to Shitara (2019), Immunotherapy has emerged as
nivolumab showing excellent results in clinical trials. These medications function by preventing
cancer cells from evading the immune system, and they have produced long-term responses in
gastric cancer treatment methods. Trastuzumab, a HER2-targeted medication, for example, has
been approved for the treatment of HER2-positive advanced gastric or gastroesophageal junction
gastric cancer, demonstrating the trend toward more customized and effective treatment
surgery and adjuvant chemotherapy has become the usual treatment. Radiation therapy and
proton therapy are also utilized to improve local tumor control while minimizing side effects,
As a student nurse, the case study regarding gastroesophageal cancer is significant because it
provided an opportunity to gain practical insights into the complexities of patient care, develop
critical thinking skills, and apply theoretical knowledge to real-world scenarios. It also highlights
the importance of communication, collaboration, and evidence-based practice, all of which are
crucial aspects of nursing. Moreover, this case study will enable student the nursing student to
prepare for future nursing roles, fostering empathy, competence, and a patient-centered approach
categorized into esophageal or gastric cancer, with varying subtypes. It arises from the
uncontrolled growth of abnormal cells in the gastroesophageal junction, posing significant health
Gastroesophageal cancer significantly impacts the digestive system, with the esophagus and
stomach being the primary sites of involvement. Esophageal cancer, for example, may lead to the
formation of malignant tumors along the lining of the esophagus, potentially causing narrowing
(stenosis) and difficulty in the passage of food. This interference with the normal swallowing
process can result in symptoms like dysphagia, impacting the individual's ability to eat and
Similarly, gastric (stomach) cancer can affect the structure and function of the stomach.
Tumors may impede the normal digestive process, leading to symptoms such as persistent
indigestion, bloating, and a feeling of fullness. As the cancer progresses, it may also interfere
B. Risk Factors
Several risk factors contribute to the development of gastroesophageal cancer. This involves
the following:
Family History. Genetic factors play a role, and individuals with a family history of
Age. The risk of gastroesophageal cancer increases with age, with most cases
bacterium that can infect the stomach lining, is linked to an elevated risk of gastric
cancer.
Tobacco and Alcohol Use. Both tobacco and alcohol are established carcinogens, and
Obesity. Excess body weight, particularly around the abdomen, is associated with an
changes.
Recognizing the signs and symptoms of gastroesophageal cancer is crucial for early
detection and timely intervention. These indicators often manifest as subtle yet progressively
leading to difficulty in swallowing solids and liquids (World Cancer Research Fund,
2018).
reduced appetite and unintentional weight loss (World Cancer Research Fund, 2018).
Chest Pain. Discomfort or pain in the chest, especially behind the breastbone, can be a
associated with irritation of the respiratory tract due to gastroesophageal cancer (Fazio,
2017).
Regurgitation. The return of stomach contents into the mouth, often accompanied by a
sour taste, can be a symptom of gastroesophageal reflux and, in some cases, cancer
Hoarseness or Voice Changes. Gastroesophageal cancer affecting the upper part of the
esophagus can lead to changes in voice quality or persistent hoarseness (Johnson et al.,
2019).
Nausea and Vomiting. Gastroesophageal cancer may cause nausea and vomiting,
particularly if the tumor obstructs the normal passage of food (Katz, 2018).
(Ginsberg, 2021).
Change in Bowel Habits. Altered bowel habits, such as constipation or diarrhea, may
The digestive system is a complex network of organs that work together to break down
and absorb nutrients from the food we consume. It includes series of organs, including the
mouth, esophagus, stomach, small intestine, large intestine, and associated accessory organs like
Gastroesophageal cancer, affecting the esophagus and stomach, disrupts this system.
Esophageal cancer, for instance, can lead to narrowing of the esophagus, causing difficulty in
swallowing. Gastric cancer may impact the stomach's normal function, resulting in digestive
discomfort and potential nutritional deficiencies (Yamada et al., 2020). These disruptions
underline the critical need for early detection and intervention to preserve digestive system
functionality. This condition disrupts the following organs and their normal function to the
human body.
specialized gastric mucosa that secretes digestive enzymes and gastric juices. Its primary
function involves both mechanical and chemical processes to break down ingested food
(Johnson, 2017). Through muscular contractions and gastric acid secretion, the stomach
transforms food into a semi-liquid substance known as chyme. It serves as a reservoir, regulating
the gradual release of processed food into the small intestine for further digestion and absorption.
Furthermore, it initiates the breakdown of proteins and activates digestive enzymes which is a
critical step in nutrient extraction (Richardson, 2016). The stomach is also responsible for the
following:
Secretes gastric acid to create an acidic environment, aiding in the breakdown of proteins
Releases digestive juices containing enzymes like pepsin to further break down food
components.
Produces mucus to protect its lining from the corrosive effects of gastric acid.
Acts as a reservoir for food, regulating its controlled release into the small intestine for
optimal digestion.
Begins the digestive process by breaking down food into chyme, a semi-liquid mixture.
Facilitates the absorption of certain substances, such as alcohol and certain medications.
transfer of food from the mouth to the stomach (Yamada 2020). Its main functions include the
following:
Facilitates the movement of ingested materials, including food and liquids, from the
Utilizes rhythmic muscular contractions (peristalsis) to propel contents forward along its
length.
Unlike other digestive organs, the esophagus does not participate directly in digestion or
nutrient absorption.
Plays a crucial role in preventing the backward flow of stomach contents into the throat,
Ensures a one-way flow of ingested materials, contributing to the overall efficiency and
Produces mucus to lubricate and protect the esophageal lining from abrasive food
particles.
Synchronizes with the swallowing reflex to initiate the movement of food into the
stomach.
The esophageal wall can stretch to accommodate varying food volumes during
swallowing.
Initiates reflexes, such as the lower esophageal sphincter relaxation, essential for the
In summary, the stomach and esophagus are essential components of the digestive system,
with the esophagus facilitating food transport and the stomach playing a key role in digestion.
swallowing, disruptions in digestive processes, and discomfort. Recognizing the anatomy and
physiology of these organs is crucial for early detection and effective management of
gastroesophageal cancer, emphasizing the significance of maintaining their normal functionality
DIAGNOSTIC/
GENERAL INDICATION OR NORMAL ANALYSIS AND
LABORATORY NURSING RESPONSIBILITIES
DESCRIPTION PURPOSE VALUES INTERPRETATION
PROCEDURES
Upper Also known as It is commonly Normal findings Abnormal findings Before the Procedure:
Gastrointestinal esophagogastroduodenoscop indicated for the during upper may include lesions, Confirm patient identification
Endoscopy y (EGD), is a medical evaluation of endoscopy include a inflammation, ulcers, and consent.
procedure where a flexible gastroesophageal healthy esophagus, or tumors, which Ensure the patient has been
endoscope is used to examine cancer. It helps in stomach, and require further appropriately prepared, such
the upper part of the the detection, duodenum with no investigation and may as fasting for a specified
gastrointestinal tract, biopsy, and staging signs of lead to the period.
including the esophagus, of tumors in the inflammation, identification of Assess and document the
stomach, and the first part of esophagus and ulcers, or abnormal conditions such as patient's medical history,
the small intestine stomach, providing growths. The gastroesophageal allergies, and current
(duodenum). This procedure crucial information gastroesophageal reflux disease medications.
is performed for diagnostic for diagnosis and junction should be (GERD), Barrett's Start an intravenous (IV) line
and therapeutic purposes, treatment planning. well-defined, and esophagus, or cancer. as needed.
allowing direct visualization the mucosa should Biopsies may be Provide education to the
of the upper digestive system appear normal taken during the patient about the procedure,
to identify and treat various without any procedure for including expectations and
conditions (ASGE, 2020). structural histological potential risks.
abnormalities. examination.
During the Procedure:
Assist with positioning the
patient for the procedure.
Monitor vital signs throughout
the procedure.
Collaborate with the
endoscopy team to ensure a
smooth process.
Provide emotional support and
reassurance to the patient.
Document any adverse events
or complications during the
procedure.
TYPE OF
GENERAL INDICATION OR
MEDICAL NURSING RESPONSIBILITIES
DESCRIPTION PURPOSE
MANAGEMENT
Normal Saline It is a sterile solution of salt Normal saline is not a direct Before the Procedure:
(0.9% NaCl) in water that closely treatment for gastroesophageal Assess the patient's medical history, including any known
resembles the electrolyte cancer. However, it is often allergies or sensitivities to medications or solutions.
balance of the body. It is used in supportive care for Verify the healthcare provider's prescription and the correct
commonly used in cancer patients, including those concentration of the normal saline solution.
healthcare for various with gastroesophageal cancer. Explain the purpose of the normal saline infusion to the patient,
purposes, including Intravenous administration of addressing any concerns or questions.
intravenous (IV) hydration, normal saline may be indicated Ensure that the IV access site is appropriate and patent.
dilution of medications, and for hydration, especially if the
as a vehicle for certain patient is experiencing During the Procedure:
medical procedures (World dehydration due to cancer- Prepare the IV infusion set and normal saline solution according
Health Organization, 2013). related symptoms, treatments, to institutional protocols.
or surgery. Adequate hydration Monitor the patient's vital signs and assess for any signs of
is essential for maintaining adverse reactions, such as swelling or redness at the IV site.
overall health and supporting Administer the normal saline at the prescribed rate and observe
the body's response to cancer for any signs of fluid overload or complications.
therapies (National Ensure that the infusion is running smoothly and troubleshoot any
Comprehensive Cancer issues as needed.
Network, 2022).
After the Procedure:
Monitor the patient for ongoing hydration status and assess for
any signs of improvement or complications.
Document the administration of normal saline, including the
amount infused and the patient's response.
Provide post-procedure care instructions, including any
recommendations for oral hydration and follow-up.
Lactated Ringer's It is a sterile intravenous Cancer patients, especially Before the Procedure:
Solution fluid composed of those undergoing treatments Assess the patient's medical history, including any known
electrolytes, including like chemotherapy, may allergies or sensitivities to medications or solutions.
sodium chloride, potassium experience dehydration due to Verify the healthcare provider's prescription and the correct
chloride, calcium chloride, various factors, and concentration of the Lactated Ringer's solution.
and sodium lactate. It is intravenous fluids such as Explain the purpose of the intravenous hydration to the patient,
designed to closely Lactated Ringer's can help addressing any concerns or questions.
resemble the electrolyte maintain fluid and electrolyte Ensure that the IV access site is appropriate and patent.
composition of human balance.
plasma and is commonly During the Procedure:
used for fluid resuscitation, Prepare the IV infusion set and Lactated Ringer's solution
intravascular volume according to institutional protocols.
expansion, and electrolyte Monitor the patient's vital signs and assess for any signs of
replacement (Baxter adverse reactions, such as swelling or redness at the IV site.
Healthcare Corporation, Administer the Lactated Ringer's solution at the prescribed rate
2019). and observe for any signs of fluid overload or complications.
Ensure that the infusion is running smoothly and troubleshoot any
issues as needed.
Total Parenteral Total Parenteral Nutrition TPN may be indicated for Before the Procedure:
Nutrition (TPN) (TPN) is a method of patients with gastroesophageal Assess the patient's nutritional status, including weight, laboratory
providing complete cancer who are unable to values, and any pre-existing nutritional deficiencies.
nutritional support tolerate oral or enteral nutrition Verify the healthcare provider's prescription for TPN, ensuring it
intravenously. It involves due to complications such as meets the patient's specific nutritional needs.
delivering a balanced obstruction, dysphagia, or post- Confirm the patient's vascular access for TPN administration,
mixture of nutrients, surgical recovery. In situations such as a central venous catheter.
including carbohydrates, where the gastrointestinal tract Educate the patient and their family about the purpose of TPN,
proteins, fats, vitamins, and is compromised or non- potential complications, and the importance of close monitoring.
minerals, directly into the functional, TPN provides a
bloodstream. TPN is used way to maintain adequate During the Procedure:
when patients are unable to nutrition and prevent Collaborate with the healthcare team to prepare and administer the
meet their nutritional needs malnutrition in cancer patients TPN solution according to the prescribed regimen.
through oral or enteral undergoing treatment. Monitor the patient's vital signs, fluid balance, and laboratory
routes, often due to values regularly.
conditions affecting the Ensure the correct placement and functioning of the central
gastrointestinal tract venous catheter used for TPN infusion.
(ASPEN, 2021). Educate the patient on signs of complications, such as infection or
catheter-related issues.
GENERIC
ROUTE, DOSAGE, SIDE EFFECTS AND
NAME & DRUG INDICATION OR
AND FREQUENCY ADVERSE NURSING RESPONSIBILITIES
BRAND CLASSIFICATION PURPOSE
ADMINISTRATION REACTIONS
NAME
Generic Name: Antimetabolite, Indication: Indicated for gastric Side Effects: Provide patient education on
Fluorouracil Antineoplastic Fluorouracil is indicated adenocarcinoma: Nause dietary modifications,
chemotherapy agent for the treatment of various Vomiting including small, frequent
Brand Name: cancers, including 200-1000 mg/m²/day Diarrhea meals and bland foods.
Adrucil colorectal cancer, breast as a continuous IV Rash Monitor daily pattern of
cancer, and certain types of infusion over 24 hr Chest pain bowel activity, stool
skin cancer (basal cell (as part of a platinum- Shortness of consistency.
carcinoma and squamous containing regimen) breath Assess skin for rash.
cell carcinoma). It is used Duration and Monitor cardiac function.
as part of combination frequency of each Adverse Reactions: Assess for signs and
chemotherapy regimens in cycle varies based on symptoms of cardiotoxicity,
Myelosuppression
these cancers dose and regimen. such as chest pain or
Stomatitis
(Micromedex, 2022). It is shortness of breath.
also used for some cases of Hand-foot
Syndrome Monitor complete blood
advanced or metastatic counts (CBC) regularly.
gastroesophageal cancer as
Assess and manage
part of combination
dermatologic reactions, such
chemotherapy regimens.
as redness, swelling, and
pain in the palms of the
Mechanism of Action:
hands and soles of the feet.
Inhibits the synthesis of
DNA and RNA within
cancer cells. It interferes
with the replication and
repair of DNA, preventing
the growth and division of
cancer cells.
Generic Name: Antineoplastic Indication: Testicular Cancer: Side Effects: Monitor the patient for signs
Cisplatin chemotherapy agent, For the treatment of 20 mg/m2 by slow IV Nausea of allergic reactions, such as
Alkylating agent various cancers, including infusion daily for 5 Vomiting rash, itching, or difficulty
Brand Name: testicular, ovarian, bladder, days per cycle in Hypokalemia breathing, and provide
Platinol and lung cancers, among combination with Hypomagnesemia emergency care if necessary.
others. It is used in other approved Bone marrow Monitor for hypersensitivity
combination with other chemotherapeutic suppression reactions, such as fever,
chemotherapy agents for agents. Nephrotoxicity chills, or hypotension, and
these indications. provide appropriate
Ototoxicity
Ovarian Cancer: interventions.
Mechanism of Action: 75 to 100 mg/m2 by Regularly monitor electrolyte
Adverse Reactions:
Exerts its anticancer slow IV infusion once levels.
Allergic
effects by binding to DNA every 3 to 4 weeks on Encourage small, frequent
Reactions
and causing DNA cross- Day 1 meals.
linking. This disrupts DNA Hypersensitivity
Reactions Monitor and assess patient’s
replication and Bladder Cancer: hearing.
transcription, leading to 50 to 70 mg/m2 by Monitor renal function.
cell death and inhibiting slow IV infusion once
Encourage increased fluid
the growth of cancer cells. every 3 to 4 weeks;
intake.
for heavily pretreated
Monitor CBC to detect
patients, an initial
myelosuppression.
dose of 50 mg/m2 by
slow IV infusion once
every 4 weeks is
recommended
Generic Name: Antineoplastic Indication: For the Oxaliplatin 85 mg/m² Side Effects: Monitor body temperature.
Oxaliplatin chemotherapy agent treatment of colorectal IV + leucovorin 200 Diarrhea Encourage adequate rest.
cancer, both in adjuvant mg/m² IV infused Fatigue Inform patient to avoid fatty,
Brand Name: and metastatic settings. It over 2 hr. Nausea spicy, or acidic foods.
Eloxatin is often used in Vomiting Encourage small, frequent
combination with other Fever meals.
chemotherapy agents, such Decreased Advise patient to avoid cold
as fluorouracil and Appetite exposure and drink room
leucovorin, for these temperature fluids.
Peripheral
indications. Monitor the patient for signs
Neuropathy
of severe anaphylactic
Mechanism of Action: reactions, such as difficulty
Adverse Reactions:
Exerts its anticancer breathing or a drop in blood
Anaphylactic
effects by forming pressure and provide
Reaction
platinum-DNA adducts. emergency care if necessary.
These adducts interfere Renal
Dysfunction Monitor renal function.
with DNA replication and
transcription, leading to
cell death and inhibiting
the growth of cancer cells
Generic Name: Antineoplastic Indication: Indicated in Side Effects: Advise patient to avoid
Docetaxel chemotherapy agent For treatment of various combination with Fatigue activities that requires
cancers, including breast cisplatin and Diarrhea alertness.
Brand Name: cancer, non-small cell lung fluorouracil advanced Nause Encourage small, frequent
Taxotere cancer, prostate cancer, gastric Vomiting meals.
and certain types of gastric adenocarcinoma, Hair loss Monitor body temperature.
and head and neck cancers. including Neutropenia Assess skin for rash.
It may be used as a single adenocarcinoma of Monitor daily pattern of
Dizziness
agent or in combination the gastroesophageal bowel activity, stool
Fever
with other chemotherapy junction, in patients consistency.
medications. who have not received Rash
Itching Watch out for any signs of
prior chemotherapy infection.
for advanced disease. Fainting
Monitor hypersensitivity
Mechanism of Action: Adverse Reactions: reactions, such as fever,
Exerts its anticancer Day 1: 75 mg/m IV2
Hypersensitivity chills, or hypotension.
effects by promoting infusion over 1 hour, Reactions Monitor for heart rhythm,
microtubule stabilization followed by cisplatin Cardiotoxicity pattern, and quality.
and inhibiting their 75 mg/m2 as a 1-3 hr Pulmonary Report signs of pulmonary
depolymerization during infusion. toxicicity toxicity such as cough,
cell division. This leads to shortness of breath.
cell cycle arrest and
ultimately cell death
Generic Name: Antimicrotubular Indication: Dose: 80 mg/m2 Side effects: Monitor CBC regularly.
Paclitaxel agent Paclitaxel is used in the Hypertension Advise the patient to report
treatment of Route: IV infusion Chest pain any signs of infection
Brand Name: gastroesophageal cancer, Bradycardia promptly.
Taxol often in combination with Frequency: Days 1,8 Fever Monitor the following vital
other chemotherapy and 15 of a 28 day Cough signs: temperature, BP, HR,
agents. It inhibits cancer cycle, until disease Breathlessness RR, and O2 saturation.
cell growth and division, progression. Headache Encourage adequate rest.
contributing to the Anxiety Assess mental status.
management of the Dizziness Monitor daily pattern of
disease. Diarrhea bowel activity, stool
Mechanism of Action: Rash consistency.
Stabilizes microtubules in Dry skin Assess skin color, integrity,
the cell during the process Muscle pain temperature, and texture.
of cell division, disrupting Mouth sores Encourage the use of warm
normal microtubule Hair loss compresses and gentle
dynamics. This exercises.
interference prevents the Adverse reactions: Provide emotional support
separation of Hypersensitivity and provide information on
chromosomes, leading to reaction coping with hair loss.
cell cycle arrest and Peripheral Encourage the use of head
inhibiting cell neuropathy coverings.
proliferation. Neutropenia Monitor closely during
infusion for any signs of
allergic response.
Assess and manage
symptoms like tingling or
numbness. Educate the
patient on proper foot care
and balance to prevent
injuries.
Generic Name: Topoisomerase I Indication: Regimen 1 (Weekly): Side effects: Monitor for dehydration and
Irinotecan inhibitor, Cytotoxic Irinotecan is used in the 125 mg/m² IV Nausea electrolyte imbalance.
antineoplastic agent treatment of various infusion over 90 Vomiting Encourage small, frequent
Brand Name: cancers, including minutes on days 1, 8, Breathlessness meals.
Camptosar metastatic colorectal 15, 22, then 2 weeks Diarrhea Monitor daily pattern of
cancer. off, then repeat. Cough bowel activity.
Fatigue Encourage adequate rest and
Mechanism of Action: Regimen 2 (Once balance of activity.
Alopecia
Inhibits topoisomerase I, Every 3 Weeks): 350 Provide emotional support
Loss of appetite
an enzyme involved in mg/sq.meter IV and information about coping
DNA replication and infusion over 30-90 Anemia
Mouth sores with hair loss.
repair. By binding to and minutes q3Weeks Encourage gentle oral
inhibiting this enzyme, Fever
hygiene with a soft-bristle
irinotecan induces DNA toothbrush or sponge-tipped
damage, preventing cancer Adverse reactions:
Myelosuppression applicators.
cells from dividing and
Hypersensitivity Monitor complete blood
ultimately leading to cell
reactions counts regularly.
death.
Interstitial Lung Monitor for signs of
Disease hypersensitivity, such as rash
or difficulty breathing.
Monitor for signs of dyspnea,
cough, and fever.
Generic Name: Antineoplastic Indication: 100 mg/m² IV q21 Side effects: Monitor cardiac function
Epirubicin medication, While not a first-line days x 6 cycles Fast or irregular regularly through
anthracycline treatment for heartbeat echocardiograms or other
Brand Name: chemotherapy drug gastroesophageal cancer, it Rash cardiac tests.
Ellence may be included in certain Itching Encourage small, frequent
chemotherapy regimens Cough meals.
for advanced or metastatic Fever Assess skin color, integrity,
cases. Its use is often part Chest pain temperature, and texture.
of combination therapies to Monitor vital signs.
Sore throat
target cancer cells. Assess pain level.
Difficulty
breathing Provide emotional support
Mechanism of Action: and education about potential
Inhibits DNA and RNA Weakness
Nausea hair loss.
synthesis by intercalating
Vomiting Encourage adequate fluid
with the DNA helix and
intake to dilute the urine and
interfering with the
Adverse reactions: minimize irritation to the
function of topoisomerase
Cardiotoxicity urinary tract.
II. It generates free
Alopecia Advise the patient to avoid
radicals, causing DNA
Hematuria excessive pressure on hands
strand breaks and
and feet and to wear
inhibiting cell replication. Hand-Foot
comfortable shoes.
This mechanism disrupts Syndrome
the cancer cell cycle and
leads to cell death.
Generic Name: Monoclonal Indication: Initial dose of 4 Side Effects: Monitor temperature
Trastuzumab antibody Trastuzumab is indicated mg/kg as an Fever regularly.
for the treatment of HER2- intravenous infusion Nausea Encourage small, frequent
Brand Name: positive gastroesophageal over 90 minutes then Vomiting meals.
Herceptin cancer. HER2 (human at 2 mg/kg as an Diarrhea Monitor for dehydration.
epidermal growth factor intravenous infusion Cough Monitor daily pattern of
receptor 2) is a protein that over 30 minutes Headache bowel activity, stool
can promote the growth of weekly during consistency.
Fatigue
cancer cells. Trastuzumab chemotherapy for the Dyspnea Encourage deep breathing
specifically targets and first 12 weeks Rash exercises.
inhibits the activity of (paclitaxel or Advise pt to have adequate
HER2-positive cancer docetaxel) Adverse Reactions: rest.
cells, making it an Hypersensitivity Assess respiratory status
important component of reactions regularly.
treatment for eligible Anemia Monitor for signs of
patients with Left Ventricular anaphylaxis (e.g., rash,
gastroesophageal cancer. Dysfunction respiratory distress).
Monitor hemoglobin and
Mechanism of Action: hematocrit levels.
Monitor cardiac function
Trastuzumab is a regularly.
monoclonal antibody that
works by binding to the
HER2 receptor on the
surface of cancer cells.
This binding:
Inhibits the HER2
signaling pathway.
Suppresses cancer
cell growth.
Promotes antibody-
dependent cellular
cytotoxicity
(ADCC), leading to
the destruction of
HER2-positive
cancer cells by the
immune system.
Generic Name: Tyrosine Kinase Indication: 160 mg orally once a Side Effects: Encourage adequate rest.
Regorafenib inhibitor Used in the treatment of day for the first 21 Fatigue Provide a therapeutic
advanced gastrointestinal days of each 28-day Hypertension environment.
Brand Name: stromal tumors (GIST) and cycle until disease Hand-foot skin Monitor blood pressure and
Stivarga metastatic colorectal progression or reaction temperature regularly.
cancer. unacceptable toxicity. Decreased Assess for signs of urinary
appetite tract infection (UTI).
Mechanism of Action: Mucositis Provide oral care before and
Inhibits multiple kinases Fever after each dose.
involved in angiogenesis
Painful urination Advise the patient to avoid
and tumor proliferation. friction and pressure on
Adverse Reactions: hands and feet.
Hepatotoxicity Encourage small, frequent
meals and nutritional
supplements.
Educate the patient on signs
of hepatotoxicity (e.g.,
jaundice, abdominal pain).
Generic Name: Immune checkpoint Indication: IV: 200 mg every 3 Side effects: Encourage balanced rest and
Pembrolizumab inhibitor (PD-1 Used in advanced or weeks or Fatigue activity.
inhibitor) metastatic gastric or 400 mg every 6 weeks Nausea Encourage small, frequent
Brand Name: gastroesophageal junction Rash meals.
Keytruda cancer with PD-L1 Chest pain Assess rash severity and
expression. Irregular characteristics.
heartbeat Monitor vital signs and
Mechanism of Action: Shortness of perform an ECG.
Blocks PD-1, enhancing breath Assess respiratory status
the immune response regularly.
Confusion
against cancer cells. Ensure a safe environment;
Blurry vision
minimize stimuli.
Adverse reactons: Advise pt to avoid activities
Immune related that requires alertness.
adverse events Monitor for signs of
autoimmune reactions.
Generic Name: Immune checkpoint Indication: 240 mg IV q2Weeks Side effects: Monitor daily pattern of
Nivolumab inhibitor (PD-1 Used in advanced or or 360 mg IV Diarrhea bowel activity, stool
inhibitor) metastatic gastric or q3Weeks plus a Pruritus consistency.
Brand Name: gastroesophageal junction platinum-containing Fatigue Encourage balanced rest and
Opdivo cancer with PD-L1 therapy (eg, Nausea activity.
expression. oxaliplatin) and a Weakness Encourage small, frequent
fluoropyrimidine (eg, Vomiting meals.
Mechanism of Action: fluorouracil, Assess respiratory status
Shortness of
Blocks PD-1, promoting capecitabine) regularly.
breath
an anti-tumor immune Continue until disease Monitor nutritional status
Decreased
response. progression, and weight regularly.
appetite
unacceptable toxicity, Monitor temperature
or up to 2 yr Fever
Headache regularly.
Educate the patient on signs
Adverse effects: of hepatitis (e.g., jaundice,
Hepatitis abdominal pain).
Pneumonitis Monitor for respiratory
symptoms (cough, dyspnea).
Generic Name: Serotonin (5-HT3) Indication: IV: 8 mg started 30 Side effects: Provide a quiet, dimly lit
Ondansetron receptor antagonist Used for prevention and minutes before Headache environment.
treatment of chemotherapy, then Constipation Monitor bowel habits and
Brand Name: chemotherapy-induced q12hr for 1-2 days Dizziness stool consistency.
Zofran nausea and vomiting. after chemotherapy Difficulty Monitor bowel habits and
breathing stool consistency.
Mechanism of Action: Irregular Monitor cardiac rhythm
Blocks serotonin receptors heartbeat continuously.
in the chemoreceptor Polydipsia Monitor fluid intake and
trigger zone. output.
Chest pain
Decreased urine Encourage adequate rest.
Adverse reactions:
Arrythmias
Generic Name: Opioid analgesic Indication: 1-2 mcg/kg IV bolus Side effects: Monitor bowel habits and
Fentanyl Used for pain management or 25-100 mcg/dose Constipation stool consistency.
in cancer patients, PRN or 1-2 mcg/kg/hr Respiratory Encourage increased fluid
Brand Name: including those with by continuous IV depression intake and fiber-rich foods.
Duragesic gastroesophageal cancer. infusion or 25-200 Nausea Monitor respiratory rate and
mcg/hr Confusion effort regularly.
Mechanism of Action: Sedation Encourage small, frequent
Bids to opioid receptors, Drowsiness meals.
altering pain perception. Ensure patient safety and
Adverse reactions: minimize environmental
Overdose stimuli.
Educate the patient on
avoiding activities requiring
alertness.
Monitor for signs of
overdose (e.g., respiratory
distress, extreme sedation).
d. Diet
INDICATION(S) OR
TYPE OF DIET GENERAL DESCRIPTION NURSING RESPONSIBILITES
PURPOSE
High-calorie, A high-calorie, high-protein Gastroesophageal cancer and Regularly assess the patient's nutritional status, dietary
high-protein diet diet is designed to provide its treatments can lead to habits, and weight.
increased energy and protein weight loss and muscle Work closely with a registered dietitian to individualize the
intake to meet the elevated wasting. A high-calorie, high- dietary plan based on the patient's specific needs,
nutritional needs of protein diet aims to counteract preferences, and treatment regimen.
individuals undergoing cancer these effects, supporting Provide education on the importance of a high-calorie,
treatment. This diet overall strength and high-protein diet in supporting overall health and treatment
emphasizes foods rich in minimizing malnutrition. outcomes.
calories and protein to Adequate protein and calorie Assist in developing meal plans that incorporate calorie-
support the body's demands intake are essential for the dense and protein-rich foods, considering any dietary
during the cancer journey. body to heal, recover, and restrictions or preferences.
tolerate cancer treatments. Monitor the patient's dietary adherence, weight changes,
and any signs of nutritional deficiencies or intolerances.
Recognize and address potential challenges or concerns
related to dietary changes, offering emotional support to
promote compliance.
Fiber-rich diet A fiber-rich diet emphasizes For individuals with Evaluate the patient's current dietary habits, fiber intake,
the consumption of foods gastroesophageal cancer, and gastrointestinal symptoms.
high in dietary fiber, incorporating a fiber-rich diet Work with a registered dietitian to develop an
including fruits, vegetables, proves beneficial in mitigating individualized meal plan that includes a variety of fiber-
whole grains, and legumes. constipation—a prevalent side rich foods, considering the patient's preferences and any
This dietary approach aims to effect of cancer treatments. dietary restrictions.
promote digestive health, Beyond its role in promoting Provide education on the benefits of a fiber-rich diet for
regulate bowel movements, regular bowel movements, a digestive health and overall well-being.
and support overall well- varied selection of fiber-rich If the patient is not accustomed to a high-fiber diet,
being. foods contributes to a nutrient- encourage a gradual increase in fiber intake to minimize
dense diet, playing a pivotal gastrointestinal discomfort.
role in maintaining overall Emphasize the importance of adequate fluid intake along
nutritional status. with increased fiber consumption to prevent constipation.
Monitor for any gastrointestinal symptoms and adjust the
fiber intake as needed based on the patient's tolerance.
Low-fat diet A low-fat diet involves A low-fat diet is often Evaluate the patient's current dietary habits, preferences,
reducing the intake of dietary recommended for individuals and any digestive symptoms related to fat intake.
fats, especially saturated and with gastroesophageal cancer Collaborate with a registered dietitian to develop a low-fat
trans fats, to support to alleviate digestive meal plan tailored to the patient's individual needs.
cardiovascular health and discomfort commonly Provide education on identifying and choosing low-fat
manage weight. associated with symptoms like food options, reading food labels, and cooking methods
nausea or reflux during cancer that reduce fat content.
treatment. Additionally, Assist the patient in planning meals that are low in fat but
embracing a low-fat dietary still nutritionally adequate and palatable.
approach can contribute to Monitor for any digestive symptoms or changes in weight
supporting cardiovascular and adjust the diet plan as needed.
health, particularly relevant for
patients with pre-existing heart
conditions or concerns.
e. Activity
Bed Rest Bed rest involves limiting Bed rest may be recommended to Monitor for any signs of complications
physical activity and remaining manage symptoms like fatigue, associated with prolonged bed rest, such
in a supine or semi-supine weakness, or discomfort during periods as muscle atrophy or pressure ulcers.
position. of heightened illness or treatment. Encourage gentle movements within the
limitations of bed rest to prevent
deconditioning.
Mind-Body Activities Mind-body activities encompass These activities can help manage stress, Facilitate access to mind-body programs
practices that integrate the mind improve mood, and enhance the overall and resources.
and body, such as yoga, tai chi, quality of life for individuals dealing Provide guidance on appropriate
or meditation, promoting with gastroesophageal cancer. modifications to accommodate physical
relaxation and holistic well- limitations.
being. Encourage consistent practice for optimal
benefits.
Meditation Meditation involves techniques This can alleviate stress, anxiety, and Provide guidance on meditation
that promote mindfulness, enhance coping mechanisms for techniques and resources.
relaxation, and focused attention individuals facing the challenges of Encourage regular practice and adapt
to foster mental well-being. gastroesophageal cancer. methods based on the patient's preferences
and physical capabilities.
e. Surgical Management
i. Definition of Operation:
between the esophagus and the stomach. It is a complex and challenging condition that
crucial role in the treatment of gastroesophageal cancer, aiming to remove or address cancerous
tissue and, when possible, restore normal digestive function. Throughout the surgical process,
nursing considerations focus on preparing patients for surgery, providing postoperative care,
addressing nutritional needs, and offering emotional support to enhance the overall well-being of
individuals facing this diagnosis. Gastroesophageal cancer is often managed surgically, and the
specific surgical approach depends on the location, stage, and characteristics of the cancer.
Esophagectomy involves the removal of part or all the esophagus. The remaining
stomach or other tissue is then connected to the remaining portion of the esophagus or to
the small intestine. It is performed to eliminate or reduce the extent of cancerous growth
in the esophagus.
Gastrectomy entails the removal of a portion or the entirety of the stomach, depending
on the location of the cancer. It may be performed when the cancer affects the upper part
Esophagogastrostomy involves the removal of both the esophagus and a portion of the
stomach. The remaining stomach is then reconstructed and connected to the remaining
part of the esophagus or the small intestine. It is utilized when cancer involves both the
assess the spread of cancer. It helps determine the extent of cancer spread and aids in
1. Esophagectomy
Preoperative:
function.
nutritional support.
Educate the patient about the procedure, potential complications, and postoperative
expectations.
Intraoperative:
Facilitate communication between the surgical team and the patient's family.
Postoperative:
complications.
Collaborate with the dietitian to progress from intravenous to oral nutrition gradually.
Provide emotional support and education regarding postoperative care and lifestyle
changes.
2. Gastrectomy
Preoperative:
Collaborate with the anesthesia team to optimize the patient's overall health.
Intraoperative:
Collaborate with the surgical team to address any intraoperative concerns promptly.
Communicate with the patient's family regarding the progress of the surgery.
Postoperative:
complications.
3. Esophagogastrectomy
Preoperative:
nutritional concerns.
Collaborate with dietitians to optimize nutritional status and plan preoperative nutritional
support.
Educate the patient about the surgical procedure, potential complications, and recovery
expectations.
Implement preoperative respiratory exercises to enhance lung function.
Intraoperative:
Coordinate with the surgical team for patient positioning and preparation.
Communicate with the patient's family regarding the progression of the surgery.
Postoperative:
vein thrombosis.
4. Lymphadenectomy
Preoperative:
Perform imaging studies, such as CT scans or PET scans, to identify and map the lymph
Educate the patient about the purpose of lymphadenectomy, potential risks, and the
Obtain informed consent, ensuring the patient understands the procedure, potential
Collaborate with the healthcare team to optimize the patient's overall health, addressing
Ensure proper positioning of the patient, providing optimal access to the lymph nodes of
interest.
Coordinate with the anesthesia team to maintain hemodynamic stability and monitor fluid
balance.
Systematically dissect and remove lymph nodes in the designated areas, guided by
Continuously monitor vital signs and respond to any intraoperative changes promptly.
Collaborate with pathologists for real-time assessment of lymph nodes to guide the extent
of dissection.
Postoperative:
Monitor the patient in the post-anesthesia care unit (PACU) for immediate postoperative
Monitor fluid and electrolyte balance, addressing any imbalances resulting from surgery.
thrombosis.
Esophageal Retractors: Used to gently hold and expose the esophagus during surgery.
Gastric Staplers: Employed for creating anastomoses or closures during resection and
reconstruction.
procedures.
Suction and Irrigation Devices: Essential for maintaining a clear surgical field.
Electrocautery Devices: Used for cutting and coagulating tissues during the procedure.
Bipolar and Monopolar Electrocautery Devices: Utilized for cutting and coagulating
tissues.
Gastric Suction Tubes: Essential for maintaining a clear field and evacuating gastric
contents.
Ligating Instruments: Employed for ligating blood vessels and controlling bleeding
during resection.
Lymph Node Dissectors: Specialized instruments for precise dissection and removal of
lymph nodes.
Fine Forceps and Scissors: Used for delicate tissue handling during lymph node
removal.
iv. Overall Nursing Responsibilities for Procedures (Esophagectomy, Gastrectomy,
psychological needs.
Optimize the patient's health status, collaborating with the healthcare team.
postoperative care.
3. Collaboration:
Collaborate with the surgical team, anesthesia, and other healthcare professionals
4. Medication Administration:
anesthetic medications.
5. Safety Measures:
procedural details.
addressing concerns.
2. Aseptic Technique:
Ensure aseptic technique during the procedure, minimizing the risk of infection.
1. Complication Monitoring:
or bleeding.
2. Pain Management:
3. Nutritional Support:
4. Recovery Support:
coping.
comprehensive care and positive outcomes for patients undergoing esophagectomy, gastrectomy,
NURSING EXPECTED
ASSESSMENT PLANNING NURSING INTERVENTION SCIENTIFIC RATIONALE
DIAGNOSIS OUTCOME
Subjective Data: Nutritional Short-term goal: Independent: Independent: Short-term goal:
N/A imbalance less
than body After 3 days of nursing 1. Assess the etiological 1. It should be noted that other After 3 days of
Objective: requirements intervention, the patient variables causing the chemotherapeutic drugs nursing intervention,
Facial related to will be able to help decline in nutrient may suppress appetite. the patient was able to
grimace and abdominal pain keep dietary inputs to intake. help keep dietary
guarding secondary to metabolic needs up and 2. This assessment serves as a inputs to metabolic
behavior stomach cancer running, as well as 2. Monitor weight foundation for nutrient and needs up and running,
noted. as evidenced by increased appetite. accurately and calorie requirements and as well as increased
Abdominal difficulty of regularly. should thus be correct. appetite.
pain rated at swallowing. Long-term goal:
a scale of 3. Instruct pt to eat small, 3. To prevent nausea and Long-term goal:
8/10 After 1 week of nursing frequent meals. vomiting by keeping the
Difficulty of intervention, the patient patient’s nutritional status After 1 week of
swallowing will be able to consume 4. Perform good oral care steady. nursing intervention,
observed adequate nutrition for and arrange the patient the patient was able to
when pt was metabolic needs as in the best possible 4. This increases the pt’s consume adequate
instructed to evidenced by position. appetite, and elevating the nutrition for metabolic
demonstrate. acceptable weight or HOB or placing pt on needs as evidenced by
Inconsistent tissue regeneration, 5. Allow pt to have ample sitting position wile eating acceptable weight or
eating positive nitrogen time to finish the meal offers the optimal posture tissue regeneration,
schedule was balance, muscle-mass and offer help with for food digestion. positive nitrogen
verbalized measures, and increased eating. balance, muscle-mass
energy levels. 5. Allowing adequate time measures, and
6. Promote the use of makes the meal more increased energy
nutritious supplements enjoyable and encourages pt levels.
and healthful snacks. to consume as much as
possible.
Dependent:
6. Caloric consumption
1. Collaborate with a increased through
registered dietitian. additional food
supplements, such as
2. Administer analgesics nutritional smoothies.
as prescribed.
Dependent:
Focus: Data:
and coherent.
noted.
pain scale.
cancer.
Action:
Assessed pt condition.
signs.
prescribed.
exercises.
Response:
As student nurse, I have learned about the importance of being knowledgeable regarding
the gastroesophageal cancer Gastroesophageal cancer is divided into two types: esophageal
cancer and stomach cancer. These cancers which are distinguished by their aggressive nature and
frequent late-stage diagnosis, pose a substantial worldwide health concern. This case study
subtle symptoms and understanding a patient's history during clinical assessments. Secondly, it
highlights the role of nurses in supporting the diagnostic process, such as facilitating patient
Additionally, the acquired knowledge from this study has been derived by the student
nurse in accordance with the three aspect of learning and these are as follows:
i. Cognitive Learning
After the completion of the case study on appendicitis, the student nurses shall be able to:
Define various diagnostic and laboratory procedures used for prior to gastroesophageal
cancer.
Explain the responsibilities of the nurse before, during, and after the procedures.
Identify the various surgical instrument used during the surgical procedures.
After the completion of the case study on appendicitis, the student nurse shall be able to:
Describe and explain the steps and procedures for the management of gastroesophageal
cancer.
Describe and explain dietary and activity measures that are indicated for the patient.
After the completion of the case study on appendicitis, the student nurse shall be able to:
Integrate the proper surgical, medical, and nursing management of the disease for the
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