FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

Time allowed: 2 hours

Instruction: Choose the best answer for the following question from the given
alternatives
1. Which one of the following belongs to non-renewable natural resource?
A. Salt C. Water
B. Wind D. Sun
2. Food security is ensured only if
A. large technology is used C. garden plantation is applied
B. barrier exist to access food D. enough food is available for all

3. Which one of the following belongs to social equity in a model for sustainable development?

A. Preserving biodiversity C. Income quality

B. Demand satisfaction D. Viability of companies

4. Biology has a vital role in creating conscious citizen by

A. expanding awareness of the society C. minimizing practical applications

B. initiating citizens to negative impact D avoiding the use of modern technology

5. The scientific study of heredity and variation of inherited characteristics is called

A. Genetics C. Physiology
B. Anti- aging medicine D. Caloric restriction

6. Which is the most useful change made to crops using applications of biotechnology?

A. Crops use more nutrients C. Crops resist more disease

B. Crops need more fertilizer D. Crops take more time to grow

7. Which area of biotechnology would most likely create ethical issues with human society?

A. Insulin production by bacteria

B. Genetic engineering to improve agriculture yields
C. Organ cloning for use in trans plants
D. DNA and forensic testing of crime scene evidence

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

8. When DNA is manipulated and moved from one source to another it is known as

A. genetic engineering C. genetically modified organisms

B. gene therapy D. electrophoresis

9. Organism that contains genes from other organisms are called.

A. Polygenic C. Mutagenic
B. Transgenic D. Donors
10. One of the following is the example of an antibiotic.

A. Vaccine C. Pathogen
B. Penicillin D. Antibody

11. Which of the following disease is correctly matched with its causative agent?
A. Malaria - female anopheles mosquito. C. Tuberculosis -Mycobacterium leprae
B. Leishmaniasis - Schistosoma mansoni D. Taeniasis - Taenia saginata

12. Which part of a bacterial cell could be primarily attacked and destroyed by antibiotics?
A. DNA C. Cell Membrane
B. Cytoplasm D. Cell Wall

13. One of the following is used to investigate crime by using blood, saliva and hair.

A. Health science C. Physical science

B. Forensic science D. Ecology
14. Waste water is best described as

A. Water that you can cook with

B. Water that goes down your drain or toilet
C. Water in a local pond
D. River water
15. One of the following is the use of living organism or their products for the detoxification and
degradation of environmental pollutants
A. Bioengineering C. Bioremediation
B. Biotransformation D. Biosensors

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

16. One of the following is the application of using living organism or their products from
another living organism for the development of products that benefit humans.
A. Biotechnology C. Genetic engineering
B. Cell biology D. Biosensors

17. The main goal of using biological warfare in modern conflict is to

A. promote peace and cooperation.

B. improve public health in the affected area.
C. provide medical aid to the enemy.
D. kill the enemy using disease- causing microorganisms or their toxins.

18. Which one of the following belongs to the general characteristics of bacteria.

A. They are multicellular organisms.

B. They have similar mode of nutrition.
C. They lack membrane bounded organelles.
D. Their locomotion is by pseudopodia.
19. If you saw a rod-shaped bacteria under microscopic observation, then these bacteria belongs
to ____________ bacteria.

A. Cocci C. Spirochaetes
B. Bacilli D. Comma

20. Which of the following is commonly contaminated by Mucor

A. Bread C. Meat
B. Cereals D. Rice

21. Penicillin is an antibiotic that acts upon bacteria by

A. acting on the nucleus of bacteria.
B. blocking the bacterial cell wall formation.
C. breaking the cell membrane of the bacteria.
D. preventing DNA formation.

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22. Which one of the following is the best reason in that treating viral infection is more difficult
than bacterial infection,

A. Viruses are smaller in size than bacteria

B. Viruses have no cell wall
C. Viruses have fewer targets for drugs.
D. Bacteria have peptidoglycan.
23. Which one of the following protozoan disease is more common in Ethiopia?
A. malaria C. trichuriasis
B. amoebiasis D. trypanosomiasis
24. Which of the following is a beneficial microorganism to make bread?
A. Bread mould C. Penicillium
B. Asperigillus D. Yeast
25. What should you do if you want to make safe an orange from mould?
A. Buying from different market place.
B. Putting the orange in a warm place.
C. Staying the orange in a dark room.
D. Keeping the orange in a refrigirator.
26. Which of the following is the dark structure found at the tip of growing bread mould?
A. Sporangium C. Mycelium
B. Spores D. Hyphae
27. Which one of the following organism is grouped under the evolutionary line of archaea.
A. Fungi C. Spirochetes
B. Methanococcus D. Chloroflexi
28. Which of the following is correct with regard to gram negative bacteria?
A. Have narrow periplasmic space
B. Have porein proteins.
C. Have thicker cell wall.
D. Gram negative results in pink color

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

29. Which one of the following is the correct step in gram staining?
A. Fixation-----Iodine treatment-----Crystal violet-----Decolonization-----Staining with Safranin
B. Fixation-----Staining with Safranin -----Crystal violet-----Decolonization----- Iodine treatment
C. Fixation-----Crystal violet-----Iodine treatment-----Decolonization----- Staining with Safranin
D. Fixation-----Iodine treatment-----Crystal violet----- Staining with Safranin-----Decolonization

30. Syphilis is a bacterial disease caused by

A. Treponema pallidum C. Mycobacterium tuberculosis

B. Salmonella typhi D. Bordetella pertusis
31. Which of the following are organisms that use reduced inorganic substances as their electron
Sources?
A. Lithotrophes C. Chemohetrotrophes
B. Organotrophes D. Photoautotrophes
32. Bacteria that live in very saline environment are
A. acidophiles C. halophiles
B. psychrophiles D. thermophiles
33. Which of the following fungi belongs to Basidiomycota
A. Mucor C. Yeast
B. Smut D. Rhizopus
34. One of the following is a harmful aspect of fungi
A. Molds that cause deterioration of leather
B. Yeasts that ferment 'Tej'
C. Asperigillus species that produce oxalic acid
D. Mushrooms that serve as a source of food
35. Thrush is a fungal disease caused by
A. Trichophyton rubrum C. Candida albicans
B. Asperigillus fumigatus D. Microsporum canis
36. Which one of the following protozoan category has different asexual form of reproduction
from the rest
A. Flagellates C. Amebae
B. Ciliates D. Sporozoa

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

37. Leishmaniasis is a disease transmitted by

A. Sand fly C. Black fly
B. Tsetse fly D. House fly
38. Which one of the following is a characteristic of virus.
A. Nucleic acid of a viral genome contains both DNA and RNA.
B. They can be grown on artificial cell free media.
C. They possess enzymes necessary for protein synthesis
D. Viruses are inert filterable agents.
39. Covid-19 is a contagious disease caused by
A. protozoa C. virus
B. bacteria D. fungi
40. Attachment of virus to host cell is called
A. adsorption C. synthesis
B. maturation D . penetration
41. Which of the following is true with regard to normal microbiota
A. produce toxic compounds to other bacteria
B. are not found in healthy individuals.
C. usually affect healthy individuals.
D. should be avoided by taking antibiotics.
42. Cholera is a disease transmitted by
A. sexual intercourse C. direct body contact
B. drinking contaminated water D. blood-to-blood contact
43. Which of the following terms refer to a comma shaped prokaryotic cell
A. vibrio C. spirillum
B. coccus D. cocco bacilli
44. One of the following is a type of metabolism reaction that leads to the synthesis of larger
biomolecules
A. Catabolic reactions C. Metabolic pathway
B. Anabolic reactions D. Metabolism

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45. Which of the following is true of metabolism in its entirety?

A. Metabolism depends on a constant supply of energy from food

B. Metabolism depends on an organism's adequate hydration
C. Metabolism is a property of an organism's life
D. Metabolism utilizes all of an organism's resources
46. Which of the steps in cellular respiration is anaerobic process?
A. Krebs cycle C. Glycolysis
B. Electron transport chain D. Link reaction
47. In which of the following cell structure metabolism begins?
A. Mitochondria C. Cell Cytosol
B. Nucleus D. Chloroplast
48. What are the products of Krebs cycle?
A. Two pyruvate molecules C. Glucose and oxygen
B. CO2, ATP, NADH, and FADH2 D. ADP and H2O
49. In which part of chloroplast does light dependent reaction of photosynthesis take place?

A. Inter membrane space C. Stroma

B. Thylakoid D. On the inner membrane surface

50. The reaction in which Acetyl CoA formed is _____________

A. Link reaction C. Lactic acid fermentation

B. glycolysis D. Kreb’s cycle
51. One of the following is ATP production by direct enzymatic transfer of phosphate from an
intermediate substrate in catabolism to ADP.
A. Substrate –level phosphorylation C. Electron transport chain
B. Oxidative phosphorylation D. hydrolysis

52. One of the following is the sum of chemical reactions that takes place within each cell of
living organism.

A. Cellular respiration C. Metabolism

B. Catabolism D. Anabolism

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

53. Where organisms get energy to do work?

A. Solar energy C. Thermal energy

B. Chemical energy D. Nuclear energy

54. Which of the following is true for anabolic pathway?

A. They do not depend on enzyme

B. They are usually spontaneous chemical reactions
C. They consume energy to build polymers from monomers
D. They release energy as they degrade polymers to monomers

55. One of the following is the main cellular energy molecule.

A. ATP C. cAMP
B. ADP D. NADH2

56. During cellular respiration, where is energy stored in ATP?

A. Between phosphate bonds C. In sugar

B. In oxygen D. In nitrogenous base

57. In what step of cellular respiration glucose is broken down to Pyruvic acid?

A. Aerobic respiration C. Electron transport chain

B. Glycolysis D. Krebs cycle

58. How would you describe cellular respiration?

A. Sunlight and CO2make ATP

B. ATP and O2 are used to make sugar
C. ATP and CO2 are used to make ADP and water
D. Carbon- based molecules from food and oxygen are used to make ATP

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

59. What is the equation for aerobic cellular respiration?

A. C6H12O6 + 6O2 6CO2+6H2O +energy

B. 6CO2+6H2O 6O2+C6H12O6
C. C6H12O6+6CO2 6O2+6H2O
D. C6H12O6+ 6H2O 6O2+6CO2

60. In which of the following organelle does aerobic cellular respiration happen?
A. Nucleus C. Chlorophyll
B. Mitochondoria D. Chloroplast
61. During aerobic respiration, from which process does most of the ATP molecules is
produced?
A. Krebs cycle C. Conversion of glucose to pyruvate
B. Substrate level phosphorylation D. Chemiosmotic phosphorylation

62. Which of the following is NOT a stage of cellular respiration?

A. Krebs cycle C. Glycolysis

B. Electron transport D. Fermentation

63. Which of the following processes takes place in the cytoplasm of a cell?
A. Glycolysis C. Electron transport
B. Krebs cycle D. Acetyl CoA formation
64. In cellular respiration, high-energy electrons that move down the electron transport chain
ultimately provide the energy needed to
A. Transport water molecules across the membrane
B. Convert ADP molecules in to ATP molecules
C. Convert carbon dioxide into water molecules
D. Break down glucose into pyruvic acid molecules

65. In which of the following lactic acid fermentation occurs?

A. Bread dough C. Muscle cells

B. Any environment containing oxygen D. Mitochondria

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

66. What is needed from Krebs cycle for the Electron transport chain to occur?
A. ATP C. CO2
B. FADH2 D. H2O
67. What is a product of the Electron Transport Chain?

A. CO2 C. O2
B. C6H12O6 D. H2O

68. How many NADH molecules are produced by a molecule of glucose through Krebs cycle?

A. Two C. Three
B. Four D. Six

69. Where Krebs cycles takes place?

A. Matrix C. Cytoplasm
B. Ribosome D. Inter membrane space

70. Which organelle is responsible for conducting photosynthesis?

A. Ribosome C. Chloroplast
B. Mitochondoria D. Nucleus

71. Which one of the following is INCORRECT about the Calvin cycle?

A. Produce NADP+
B. Produce carbon dioxide
C. Use the light reactions products
D. Produce a three carbon sugar (G3P)

72. Which of the following is a product of photosynthesis?

A. Carbon dioxide C. Glucose

B. Oxygen D. Oxygen and Glucose

73. One of the following is the site in which carbon dioxide enter the leaf of a plant.

A. Lenticels C. Root
B. Stem D. Stomata

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74. One of the following is the function of NADP.

A. Store electron C. Store energy

B. Carry electron and oxygen D. Carry protons and electrons

75. Where are the proteins that carry out light-dependent reaction located?

A. Thylakoid membrane C. Thylakoid space

B. Stroma D. Cytoplasm

76. Where does the Calvin cycle occur?

A. Lumen C. Mitochondoria
B. Stroma D. Thylakoid

77. What is the function of ATP and NADPH produced during the light- dependent reactions?
A. Give electrons to ATP synthase
B. Give electrons to chlorophyll
C. Are used to make sugar in the Calvin cycle
D. Combine with oxygen to make glucose

78. One of the following wavelengths of light is NOT absorbed by chlorophyll

A. Red C. Violet
B. Blue D. Green
79. Electron transport chain proteins using energy from moving electrons to pump into the
thylakoid space.
A. H+ ions C. Glucose
B. Phosphates D. Oxygen atoms

80. During the light-dependent reactions, the final electron acceptor at the end of the electron
transport chain is
A. NADP+ C. ATP synthase
B. Chlorophyll D. Glucose

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 FIRST SEMESTER FINAL EXAM OF BIOLOGY FOR GRADE 12, 2016

81. A process by which organism use light to make their food is

A. Chlorophyll C. Chemosynthesis
B. Electron transport D. Photosynthesis
82. What is the ultimate original source of energy for living things?
A. Carbon dioxide C. Moon
B. Sugar D. Sun

83. The process of carbon dioxide combining with RuBP is

A. Carboxylation C. Decarboxylation
B. Oxidation D. Reduction

84. Which of the following pigment is water-soluble?

A. Carotenoids C. Chlorophyll
B. Fucoxanthin D. Phycobilins
85. Which one is the first electron donor in non-cyclic photophosphorylation?
A. ATP C. NADP
B. Oxygen D. Water
86. Which one is NOT correct about photorespiration?
A. Produce ATP
B. Absent in CAM plants
C. Releases carbon
D. It is oxidation of organic compounds in the presence of light
87. Which of the metabolic processes can occur without a net influx of energy from some other
process?
A. Amino acids Protein
B. ADP + Pi ATP + H2O
C. C6H12O6 + 6O2 6CO2 + 6H2O
D. 6CO2 + 6H2O C6H12O6 + 6O2

88. Which of the following processes takes place during the dark reaction of photosynthesis?

A. Photolysis of water C. Fixation of CO2

B. Production of ATP D. Production of NADPH
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89. If Kedir take part in one hundred meter running, how do the cells generate most of the
energy that is needed?
A. Aerobic respiration in muscle cell
B. Alcoholic fermentation in muscle cell
C. Lactate fermentation in muscle cell
D. Oxidative phosphorylation in muscle cell

90. Under normal condition as electron flow down the electron transport chain of mitochondria,
one of the following could NOT happen?
A. NAD and FAD are reduced C. The electron lose free energy
B. Chemiosmosis synthesis of ATP D. Proton chemical gradient is formed

91. One of the following could happen in Calvin-Benison cycle of photosynthesis?

A. Photolysis of water C. ATP is synthesis
B. NAD is produced D. Carbon dioxide is reduced
92. Which of the following happen in both cyclic and non-cyclic phosphorylation?
A. Water is splitting C. Formation of ATP
B. NADP is the last electron acceptor D. Oxygen is evolved as by product
93. Which of the following does NOT characterize the link reaction?
A. Decarboxylation C. Dehydrogenation
B. ATP formation D. Used for citrate production

94. Which of the following stages of the aerobic respiration responsible for production of both
FADH and NADH?
A. Glycolysis C. link reaction
B. Krebs cycle D. chemiosmosis

95. Which one is correct about theories of special creationism?

A. The formation of life on earth due to super natural or divine forces
B. Life can evolve spontaneously from non-living objects.
C. There is no beginning and no end to life on Earth.
D. Life on Earth originally came from another planet

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96. Recognized theory of evolution was developed by?

A. Gregor Mendel C. Alfred Russel Wallace
B. Jean Baptiste Lamark D. Charles Darwin
97. Which of the following is needed for evolution by Natural selection?

A. Respiration C. Evolution
B. Variation D. Selection

98. Who tries to explain how new species evolve for the first time?

A. Darwin C. Cuvier
B. Lamarck D. Aristotle

99. Which of the following is the correct sequence of events in the origin of life?
I. formation of protobionts
II. synthesis of organic monomers
III. synthesis of organic polymers
IV. formation of DNA-based genetic systems

A. I, II, III, IV C. II, III, I, IV

B. I, III, II, IV D. IV, III, I, II

100. Which of the following pairs of structures is least likely to represent homology?

A. The wings of a bat and the arms of a human

B. The hemoglobin of a baboon and that of a gorilla
C. The wings of a bird and those of an insect
D. The mitochondria of a plant and those of an animal

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