I-CARE

SM

EARLY COVID TREATMENT

A Guide to Early Treatment of COVID-19 About this protocol
Infection with SARS-CoV-2, the virus that causes COVID-19, progresses through a number of stages and
At the beginning of the
phases. Treatment is therefore highly stage-specific and should be initiated immediately after the onset of flu-
pandemic, FLCCC
like symptoms. A confirmed antigen or PCR test is not required. The multiple therapies and drugs in this
developed the MATH+
protocol have different mechanisms of action and work synergistically during various phases of the disease.
protocol to guide treatment
FIRST LINE THERAPIES In order of priority; not all required of the advanced
(pulmonary) phase of
Ivermectin: 0.4 to 0.6 mg/kg – one dose daily for at least 5 days or until symptoms resolve. If COVID-19, with the goal of
reducing hospital mortality.
symptoms persist longer than 7 days, consult a healthcare provider. See Table 1 for help with
calculating correct dose. Due to a possible interaction between quercetin and ivermectin, these drugs However, it soon became
should be staggered throughout the day (see Table 2). For COVID treatment, ivermectin is best taken obvious that our emphasis
with a meal or just following a meal, for greater absorption. needed to shift to
Hydroxychloroquine (HCQ): 200 mg twice a day for 5 to 10 days. Best taken with zinc. HCQ may be prevention and early
treatment to keep patients
taken in place of, or together with, ivermectin. While ivermectin should be avoided in pregnancy, the
from requiring
FDA considers HCQ safe in pregnancy. Given the pathway used by the Omicron variant to gain cell hospitalization in the first
entry, HCQ may be the preferred drug for this variant. place and from dying from
Mouthwash: 3 times a day. Gargle three times a day (do not swallow) with an antiseptic-antimicrobial this largely preventable
mouthwash containing: chlorhexidine, cetylpyridinium chloride; 1% povidone-iodine; or eucalyptus, disease.
menthol, and thymol. If tooth staining occurs, discontinue use and try another product. More information
Nasal spray with 1% povidone-iodine: 2-3 times a day. Do not use for more than 5 days in pregnancy.
Products include Immune Mist™, CofixRX™, Viraldine™, or IoNovo™. If premixed product is not To learn about nutritional
therapeutics and how they
available, dilute the more widely available 10% solution (see box) and apply 4-5 drops to each nostril
can help with
every 4 hours. COVID-19, visit
Quercetin (or a mixed flavonoid supplement): 250-500 mg twice a day. Due to a possible interaction geni.us/COVID_nutrition
between quercetin and ivermectin, these drugs should not be taken simultaneously (i.e., should be
staggered at different times of day.) As supplemental quercetin has poor solubility and low oral For additional information
on early treatment, the
absorption, lecithin-based and nanoparticle formulations are preferred.
rationale behind these
Nigella sativa (black cumin): If using seeds, take 80 mg/kg once a day (or 400 to 500 mg of medications, and other
encapsulated oil twice a day). optional treatments, see
Honey: 1 g/kg one to two times a day. Do not give honey to infants (under 12 months of age). I-CARE: Early COVID
Melatonin: 5-10 mg before bedtime (causes drowsiness). Slow- or extended-release preferred. Treatment Protocol

Curcumin (turmeric): 500 mg twice a day. Take with full-fat milk and black pepper to enhance
Early treatment is critical
absorption. Treatment for more than 14 days is not suggested. and the most important
Zinc: 75-100 mg daily. Take with HCQ. factor in managing this
Probenecid: 1000 mg twice daily for five days. disease.
Aspirin: 325 mg daily (unless contraindicated).
Read about the safety of
Kefir and/or Bifidobacterium Probiotics: NOTE: Depending on the brand, these products can be
vitamins and
very high in sugar, which promotes inflammation. Look for brands without added sugar or fruit jellies nutraceuticals in
and choose products with more than one strain of lactobacillus and bifidobacteria. Try to choose pregnancy.
probiotics that are also gluten-free, casein-free, and soy-free.
Vitamin C: 500-1000 mg twice a day. Search directories of
providers and
Metformin: 5 ​ 00 mg on day 1, 500 mg twice daily ​on days 2 through 5, then 500 mg in the ​morning
pharmacies.
and 1000 mg in the evening u ​ p to day 14.

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© 2020-2024 FLCCC Alliance. Some rights reserved pursuant to Creative Commons CC BY-NC-ND license, which generally permits others to
distribute the work, with attribution, provided it is not altered or used commercially.
 FIRST LINE THERAPIES
About ivermectin
Home pulse oximeter: Monitoring of oxygen saturation is recommended in symptomatic patients,
due to the chance of asymptomatic hypoxia (no shortness of breath). Take multiple readings over the Ivermectin is a well-known,
course of the day and regard any downward trend as ominous. Baseline or ambulatory desaturation FDA-approved drug that has
under 94% should prompt consultation with primary or telehealth provider, or evaluation in an been used successfully around
emergency room. (See box for further guidance.) the world for more than four
decades. One of the safest
drugs known, it is on the WHO’s
Only accept values associated with a strong pulse signal list of essential medicines, has
Observe readings for 30–60 seconds to identify the most common value been given over 3.7 billion
Warm up extremities prior to taking a measurement times, and won the Nobel Prize
Use the middle or ring finger for its global and historic
Remove nail polish from the finger on which measurements are made impacts in eradicating endemic
parasitic infections in many
parts of the world.

SECOND LINE THERAPIES In order of priority/importance Review the totality of

supporting evidence for
Add the following to first line therapies above if: 1) more than 5 days of symptoms; 2) poor response to ivermectin in COVID-19.
first line agents; 3) significant comorbidities).
Ivermectin is a remarkably safe
Nitazoxanide: 500 mg twice a day for 5 days. drug with minimal adverse
Fluvoxamine: 25-50 mg twice a day for 1 week. NOTE: Due to serious risks of acute anxiety that reactions (almost all minor),
may progress to mania or suicidal/violent behavior, this drug should not be prescribed for however its safety in pregnancy
COVID for longer than two weeks. has not been definitively
established. Talk to your doctor
Vitamin D3: For patients with acute COVID-19 infection, calcifediol as dosed in Table 3 is suggested.
about use in pregnancy,
Lactoferrin: 100-400 mg daily particularly in the first
Diphenhydramine (Benadryl): 25-50 mg every 6 hours trimester.
B complex vitamins
N-acetyl cysteine (NAC): 600-1200 mg orally twice a day. Potential drug-drug
interactions should be
Omega-3 fatty acids: 4 g daily.
reviewed before prescribing
Table 1. How to calculate ivermectin dose ivermectin (see I-CARE: Early
Ivermectin is available in different strengths (e.g., 3, 6, or 12 mg) and administration forms (tablets, capsules, COVID Treatment Protocol
drops, etc.). Note that tablets can be halved for more accurate dosing, while capsules cannot. Do not crush for more information). The
the tablets. most important drug-drug
interactions occur with
cyclosporin, tacrolimus,
antiretroviral drugs, and certain
antifungal drugs.
High-risk patients may
consider:
• Combining HCQ & ivermectin
• Nattokinase 2000-4000
FU/day for 15 days OR
Apixaban 5 mg daily for 15
days OR Rivaroxaban 10 mg
daily for 15 days.
Anticoagulants should only be
considered in patients with low
risk of bleeding.
• Spironolactone 200 mg once
daily for 7 days (avoid in
patients with impaired renal
function).

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 Table 2. Proposed medication schedule for first line treatments Disclaimer

The information in this

document is our recommended
approach to COVID-19 based
on the best (and most recent)
literature.

It is provided as guidance to
healthcare providers worldwide
on the early treatment of
COVID-19.

Our guidance should only be

used by medical professionals
in formulating their approach
to COVID-19.

Patients should always consult

with their providers before
starting any medical treatment.

As this is a highly dynamic

topic, we will update these
guidelines as new information
emerges.
Table 3. A Single-Dose Regimen of Calcifediol to Rapidly Raise Serum Levels above 50 ng/mL
Please check to ensure you are
using the latest version of this
protocol.

Please note our full disclaimer

at: www.flccc.net/disclaimer

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A note about anesthesia and surgery: Please notify your anesthesia team if you are using the
following medications and/or nutraceuticals, as they can increase the risk of Serotonin
Syndrome — a life-threatening condition — when opioids are administered:
• Methylene blue • Curcumin • Nigella Sativa • Selective Serotonin Reuptake Inhibitors (SSRIs)

For updates and more information on our treatment protocols please see: www.flccc.net I-CARE Early COVID Treatment Summary · February 1, 2024 · Page 3/3