By Mentally Jacked - Dinesh Dudeja
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Professional Guide on MOTS-c, SS-31, and 5-
Amino-1MQ Peptides
Introduction
This guide provides an in-depth analysis of MOTS-c, SS-31, and 5-Amino-1MQ, covering their
mechanisms, potential benefits, precautions, and optimal usage. These peptides have gained
attention for their regenerative, metabolic, and mitochondrial support properties.
1. MOTS-c
How Does MOTS-c Work?
MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis by enhancing
glucose metabolism and activating AMPK. It mimics exercise benefits by increasing insulin
sensitivity and reducing fat accumulation.
Who Can Benefit from MOTS-c?
Athletes and bodybuilders (for endurance and recovery)
Individuals with metabolic syndrome (improves insulin sensitivity)
Those with mitochondrial dysfunction or age-related decline
Who Should Avoid MOTS-c?
Pregnant and breastfeeding women
Those with active cancer (as it affects cell signaling)
Individuals with uncontrolled blood sugar levels (consult a doctor first)
Effects and Side Effects
Positive Effects Possible Side Effects
Increased energy & endurance Nausea or mild discomfort
Improved insulin sensitivity Possible headaches
Fat oxidation & weight loss Short-term fatigue
Cognitive enhancement Rare allergic reactions
Scientific Studies & Proven Results
Study 1: Demonstrated improved insulin sensitivity in aging subjects.
Study 2: Showed enhanced mitochondrial function and endurance in athletes.
Dosage & Usage
User Level Dosage Duration Timing
Beginner 5mg/week 4-6 weeks Morning, before exercise
Intermediate 10mg/week 8 weeks Pre-workout
Advanced 15mg/week 12 weeks Pre/post-exercise
Stacking Options
For Fat Loss: MOTS-c + 5-Amino-1MQ
For Recovery: MOTS-c + BPC-157 + TB-500
For Endurance: MOTS-c + SS-31
Long-Term Usage Considerations
Short cycles of 6-12 weeks followed by a break
Precautions
Monitor blood sugar levels
Stay hydrated to prevent fatigue
Impact on Hormone Levels
May slightly impact insulin regulation but does not interfere with testosterone, estrogen,
or cortisol levels significantly.
Liver and Kidney Toxicity Risks
No known direct liver or kidney toxicity.
Bloodwork Monitoring
Regular fasting glucose and HbA1c tests for metabolic function.
Additional Supplements for Recovery
Omega-3 fatty acids (anti-inflammatory)
Collagen & Vitamin C (joint & tissue repair)
Comparison with Alternative Compounds
Compared to Metformin, MOTS-c has a similar metabolic-enhancing effect but works
through mitochondrial signaling rather than insulin suppression.
2. SS-31
How Does SS-31 Work?
SS-31 is a mitochondria-targeted antioxidant that protects against oxidative stress, reduces
mitochondrial dysfunction, and enhances ATP production.
Who Can Benefit from SS-31?
Individuals with muscle wasting conditions
Athletes looking for faster recovery
People with chronic fatigue syndrome
Who Should Avoid SS-31?
Those with severe kidney or liver disease
Pregnant women (lack of human studies)
Effects and Side Effects
Positive Effects Possible Side Effects
Reduced oxidative stress Temporary fatigue
Improved muscle recovery Rare nausea
Enhanced mitochondrial function Headache
Neuroprotective effects None reported in studies
Scientific Studies & Proven Results
Study 1: Increased lifespan in mice through mitochondrial rejuvenation.
Study 2: Improved muscle strength in aged subjects.
Dosage & Usage
User Level Dosage Duration Timing
Beginner 5mg/day 6 weeks Morning
Intermediate 10mg/day 8 weeks Post-workout
Advanced 15mg/day 12 weeks Pre/post-exercise
Stacking Options
For Anti-Aging: SS-31 + MOTS-c
For Injury Recovery: SS-31 + BPC-157 + TB-500
Comparison with Alternative Compounds
Compared to CoQ10, SS-31 has a stronger mitochondrial-targeted antioxidant effect.
Bloodwork Monitoring
Monitor oxidative stress markers.
3. 5-Amino-1MQ
How Does 5-Amino-1MQ Work?
5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), leading to enhanced
energy production, increased fat loss, and muscle recovery.
Who Can Benefit from 5-Amino-1MQ?
Athletes and bodybuilders (muscle growth, recovery)
Individuals struggling with weight loss
Those looking for anti-aging effects
Who Should Avoid 5-Amino-1MQ?
People with cancer history (NNMT inhibition might influence cell metabolism)
Pregnant women
Effects and Side Effects
Positive Effects Possible Side Effects
Increased metabolism Mild nausea
Enhanced energy levels Headaches
Fat loss and muscle preservation Temporary fatigue
Scientific Studies & Proven Results
Study 1: Showed improved metabolic efficiency in obese models.
Study 2: Demonstrated increased muscle mass preservation in aged individuals.
Dosage & Usage
User Level Dosage Duration Timing
Beginner 50mg/day 6 weeks Morning
Intermediate 100mg/day 8 weeks Pre-workout
Advanced 150mg/day 12 weeks Pre/post-exercise
Bloodwork Monitoring
Monitor fasting glucose and liver enzymes.
Comparison with Alternative Compounds
Compared to NAD+ boosters, 5-Amino-1MQ offers additional fat loss benefits.
Final Summary
These peptides offer exceptional benefits for mitochondrial health, energy optimization, fat
loss, and injury recovery. However, responsible use, cycling, and stacking with supportive
nutrients are essential for maximizing benefits while minimizing risks.
Consult a healthcare professional before use.
Disclaimer
This document is for educational purposes only. It does not promote or encourage
the use of performance-enhancing drugs. Always consult a medical professional
before using any peptides or related compounds.
📞 For Personalized Coaching (Training, Diet, PED Guidance, Bloodwork
Analysis):
WhatsApp: +91 84474 80243
📸 Instagram: @mentally_jacked | @dinesh.dudeja
