Done by ALQARNI ‫دعواتكم‬

6/6/2023

1- What is the best type of scientific study for side effects or adverse effect?

- Systemic review

2-The phenytoin metabolism by?

- Aspartate

- Cyp2a1

-Cyp3a4

- Cyp2c9 OR Cyp2c19

3- Plant with 5HT3 antagonistic activity?

- Ginger

4- Type II hypersensitivity example?

- Hemolytic anemia

- Anaphylaxis

5- Verapamil?

- Non dihydropyridine CCBs

6- Patient has mild pain of osteoarthritis?

- Paracetamol

7- Which of the following of the hypertensive therapies is preferred to be used during the
acute phase of ischemic stroke if elevated blood pressure should be treated?

-lisinopril

-Nicardipine

-hydrochlorothiazide

8- Which chemical reaction is involved in conversion of morphine to codeine?

-Reduction

9- Patients with angina with high troponin, how we differentiate between other type of
angina?

ECG ST

10-Patients with anaphylaxis, what is the drug of choice?

Epinephrine

11- What is the first intervention in patient with rash and hives?

- Antihistaminic
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-Epinephrine

-Cortison

12-Long case about pt on dual therapy in the ICU and asking about stress ulcer
prophylaxis?

-Omeprazole

-No needed

- Mg hydroxide

- Sucralfate

13- Myrrh used for what?

Cough

14-Rodenticide?

-Warfarin

15- Healthy Woman afraid from respiratory infection in winter what you recommend?

-Hand sanitizer

-Vitamin C

-Zinc sulfate

-Ask her to bring prescription for Antibiotics

16-Metabolism of epinephrine?

-Rapid MAO or COMT

17- Price of product was increased from 100 SA Riyals to 105 SA Riyals. This resulted in a
large decline on demand from 120 to 80 Which of the following types of demand does this
product follow?

-Elastic

-Latent

-Inelastic

-Unaffected

18- Abbreviations TID?

Thrice a day
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19: Patient has ulcerative colitis and dysmenorrhea, based on the given structures, which
treatment should be given?

Mefenamic Acid

20-Which one of the following can be used in absence seizure?

Ethosuximide

21- lorazepam structure?

22- What is the effect of the isopropyl group of isoprenaline with phenyl?

-Improve binding to target

23- 22 years female patient with pneumonia and taking Td before 7 years and influenza
before 6 months, what your recombination to take today??

-Influneza

-Pneumococcal vaccine
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-Td

24-Medication used in neonates to prevent perinatal transmission of HIV??

Zidovudine

25-Who is (Last) one to prevent medication error?

- Pharmacist

- Nurse

- Doctor

- Patient

26- Patients with kidney impairments, which form of vitamin D is recommended?

- Calcitriol

27- DOC prophylactic malaria in pregnancy?

Chloroquine or mefloquine

28-Why we increase the dose of the lamotrigine gradually ?

To minimize the risk of side effects, particularly a serious rash called Stevens-Johnson
syndrome.

29- Mosquito in malaria considered?

- Carrier

- Vector

30- Leflunomide category in pregnancy?

- Category X

- Category C

- Category B

31 A 29-year-old man presents with complaints of excessive checking and cleaning habits
since childhood Obsessive compulsive disorder is diagnosed Which of the following is the
most appropriate management?

- Clomipramine

- Phentermine

- Levetiracetam

- Methylphenidate

32- Long case about pregnant female patient with HTN and list of medication??
Done by ALQARNI ‫دعواتكم‬

- Stop Lisinopril

33- Which of the following is the best treatment for patient with urinary incontinence?

- Darifenacin

- Imipramine

- Mirabegron

34- Patients with HTN on CCB and the patient did not improve, so what we add??

-ARBs

- Spironolactone

-Hydrochlorothiazide

35- Long case with lab results that showed high aldosterone level so, what the effect of the
aldosterone elevations?

-Hyperkalemia

-Hypernatremia

36- A patient is taking hydrochlorothiazide and Eplerenone (and other medications.

- Eplerenone

37 -Nephrotoxicity is the side effect of: a- Paracetamol b-Metronidazole c- Vancomycin *d-

- Paracetamol

- Metronidazole

- Gentamycin

39-Ledipasvir and sofosbuvir in HIV combination? (I did not understand the question)

40-Which of the following medications is safe and cheap in pregnancy?

- Acyclovir

- Valaciclovir

41- History of intermittent asthma 3 time in month with salbutamol inhaler and inhaled
corticosteroid PRN and the patient has complication and FEV 65 what is your
recommendations?

A) Omalizumab as Monotherapy

B) Salmeterol monotherapy

C) Formoterol and cortisol

42 Patient has a test and he is nervous (anxiety) so, what your recommendation??

- Drink water before sleeping

- Exercise before sleeping

-Sleeping in comfortable room

- Eating before sleeping

43- See image?

44- Cyclophosphamide side eefect?

Hemorrhagic cystitis

45- What medications are administered intrathecally?

-Methotrexate

46- What is the rate-limiting step of (statin)?

- ………

47- Which of the following best describe the main pharmacological property of
cholestyramine?

A. Decreases excretion of cholesterol

B. Lowers high density lipoprotein (HDL) level

C. Increases low density lipoprotein (LDL) level

D. Increase the efficiency of lipoprotein removal

48-See image?

49- Case 87 old man with HTN on amlodipine but not control what can add??

-Propranolol

- Atenolol

-Furosemide

- Irbesartan

50- Old women depression history of arrhythmia and CV problem?

Amitriptyline

Imipramine

Fluoxetine

Sertraline

51- Pharmacovigilance definition?

Pharmacovigilance (PV) is defined as the science and activities relating to the detection,
assessment, understanding and prevention of adverse effects

52- Pharmacogenomics definition?

Pharmacogenomics looks at how your DNA affects the way you respond to drugs

53- Polymorphism definition?

A common change in the genetic code in DNA. Polymorphisms can have a harmful effect, a
good effect, or no effect

54- How we can increase Itraconazole absorption??

-Should be taken with a full meal.

55- Naranjo 8?

Probable
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56- Clindamycin 400mg use as oral tablet and iv solution AUC is 480 and 8.4 What is
absolute bioavailability?

- I think 0.57

57- Noranjo score?

The Naranjo Algorithm, or Adverse Drug Reaction Probability Scale, is a method by which to
assess whether there is a causal relationship between an identified untoward clinical event
and a drug using a simple questionnaire to assign probability scores.

58- Patient came with INR 11 and minor bleeding what to do?

-Oral Vit k

-Prothrombin complex concentrate

-Recombinant activated factor VII

59- Which medication increase the INR?

Amiodarone

60-Potency, efficacy?

61- Which group are acid neutral Base?

-COOH

- NH3

CH3

62- What is the antidote for paracetamol?

-Acetylcysteine
Done by ALQARNI ‫دعواتكم‬

-Desflurane

63- Which of the following If given intrathecally, is nearly fatal and associated with an
irreversible, painful ascending paralysis?

Vincristine

64- What is the urine alkalinization method for methotrexate?

-Urine alkalinization with sodium bicarbonate and hyperhydration are given with
methotrexate

65- Long case about female patient taking cimetidine and anxiolytic drugs, after that she
can't drive the car why?

- Cimetidine inhibit the metabolism of the anxiolytic drugs, resulting in an increase in half-life
and decrease in the clearance of drugs.

66- How long to stop mycophenolate before pregnancy??

-6 weeks

- 4 weeks

- 2 weeks

67- Epinephrin?

-Inhibit Insulin

68- Which of the following is the reason of using verapamil as an antiarrhythmic drug?

A. it suppresses phase four depolarization

B. it stimulates the break down of adrenaline

C. it inhibits slow inward current of phase two of action potential

D. it increases the excitability of pyramidal neurons in the amygdala

69- Which of the following medications to be used under caution is in patients with
ischemic heart disease?

A. lisinopril

B. celecoxib

C. metoprolol

D. simvastatin
Done by ALQARNI ‫دعواتكم‬

70- Which of the following describe the mycoplasma?

- Bacteria that can cause illness by damaging the lining of the respiratory system
(Pleomorphic)

71-?

72-?
Done by ALQARNI ‫دعواتكم‬

73?

74?

57- Noranjo score 8?

- Probable