![Today’s aim
n=21 n=55 n=88 n=94 n=85
72.2
53.8
108.6
166.6 180.7
NS. *** NS. NS.
0
10
100
1000
<=10 10-42 42-84 84-126 126-180
Age at ART initiation [days]
Mostaccuratetimetoreach400VL[days]
approxT400
calcT400
obsT400
N=343](https://image.slidesharecdn.com/rcourse-ggplot2-171213080649/85/R-course-ggplot2-2-320.jpg)
![What would the ideal case look like?
γ: slope
V∞: VL asymptote
ART
400 VL
log10 [viral load]
Time
log10[V(t)] = ( log10[V0] - log10[V∞] ) exp-γt + log10[V∞]
T400: time to control
x
birth 0
V0: initial VL
(Asbjörnsdottir et al., 2016)](https://image.slidesharecdn.com/rcourse-ggplot2-171213080649/85/R-course-ggplot2-7-320.jpg)
![Today’s aim
n=21 n=55 n=88 n=94 n=85
72.2
53.8
108.6
166.6 180.7
NS. *** NS. NS.
0
10
100
1000
<=10 10-42 42-84 84-126 126-180
Age at ART initiation [days]
Mostaccuratetimetoreach400VL[days]
approxT400
calcT400
obsT400
N=343](https://image.slidesharecdn.com/rcourse-ggplot2-171213080649/85/R-course-ggplot2-9-320.jpg)
R course ggplot2
- 1. R course – ggplot2 Juliane Schröter
- 2. Today’s aim n=21 n=55 n=88 n=94 n=85 72.2 53.8 108.6 166.6 180.7 NS. *** NS. NS. 0 10 100 1000 <=10 10-42 42-84 84-126 126-180 Age at ART initiation [days] Mostaccuratetimetoreach400VL[days] approxT400 calcT400 obsT400 N=343
- 3. Background HIV mother-child transmission < 1% with treatment 15-45% without treatment HIV diagnose in infants takes up to several weeks/months 2 positive HIV test before lifelong antiretroviral treatment (ART) More rapid disease progression than in adults Mississippi baby (Persaud et al., 2013) - ART initiation within 30 h after birth - Rapid and successful viral control - Treatment interruption: no sudden HIV rebound
- 4. Natural HIV infection course
- 5. Fast viral decay, keeps HIV reservoir size small Viral load CD4+ memory cells (potential HIV reservoir) Time Reservoir size Very early ART Functional cure for HIV??? Off treatment!?
- 6. My Research European Pregnancy and Paediatric HIV Cohort Collaboration - 499 patients - parentally HIV-infected infants - 1st ART within 6 months of age Aim: Modelling of successful virological response to 1st ART Assess time to control ( viral load ≤ 400)
- 7. What would the ideal case look like? γ: slope V∞: VL asymptote ART 400 VL log10 [viral load] Time log10[V(t)] = ( log10[V0] - log10[V∞] ) exp-γt + log10[V∞] T400: time to control x birth 0 V0: initial VL (Asbjörnsdottir et al., 2016)
- 9. Today’s aim n=21 n=55 n=88 n=94 n=85 72.2 53.8 108.6 166.6 180.7 NS. *** NS. NS. 0 10 100 1000 <=10 10-42 42-84 84-126 126-180 Age at ART initiation [days] Mostaccuratetimetoreach400VL[days] approxT400 calcT400 obsT400 N=343