This document discusses evidence-based practice (EBP) in nursing. It defines EBP as integrating the best research evidence, clinical expertise, and patient values in clinical decision making. The document outlines several models of EBP and describes the 5-step EBP process developed by Johns Hopkins which involves: formulating an answerable clinical question using PICO, searching for evidence, critically appraising the evidence, integrating the evidence with clinical expertise and patient preferences, and evaluating outcomes. The full 18-step EBP process developed by MacIntyre is also summarized.