03 Guerra, Rudy
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The document discusses statistical genetics and bioinformatics research being conducted by Rudy Guerra and colleagues in the Department of Statistics at Rice University. The research involves identifying genetic factors associated with phenotypes through techniques like heritability studies, genotype-phenotype correlations, genetic linkage and linkage disequilibrium. It also involves bioinformatics analysis of large datasets using algorithms and statistics to study relationships in nucleotide sequences, protein structures and other molecular data. The research has applications in diseases like cancer, heart disease and genomic disorders.
03 Guerra, Rudy
- 1. Rudy Guerra, PhD Department of Statistics, Rice University
- 2. Statistical Genetics Heritability - phenotype caused in part by genes Genotype-phenotype correlations Genetic Linkage (family studies) Linkage disequilibrium (association) - Population based samples Genes and environment Genome scans Problems center on identifying and characterizing associations between genes and phenotypes (diseases, cholesterol, plant height).
- 3. Bioinformatics: The New Era The National Center for Biotechnology Information (2001) Bioinformatics is the field of science in which biology , computer science , and information technology merge into a single discipline. There are three important sub-disciplines within bioinformatics: the development of new algorithms and statistics with which to assess relationships among members of large data sets ; the analysis and interpretation of various types of data including nucleotide and amino acid sequences, protein domains, and protein structures; and the development and implementation of tools that enable efficient access and management of different types of information."
- 6. Microarray Corner of 2-sample cDNA slide Corner of Affymetrix Human chip
- 7. Areas of significant correlation on chr 4
- 8. Down Syndrome (Trisomy 21)
- 9. DNA copy number profiles of 57 medulloblastomas based on SNP array Tumor Chromosome 6 7 17 1 22 Gain Loss
- 12. Rice Statistics Department: Statistical Genetics & Bioinformatics Major Research Components of Research Rudy Guerra Dennis Cox Marek Kimmel Javier Rojo Marina Vannucci Collaborators Applications Intra-department Cancer, heart disease, metabolic syndrome, MD Anderson, BCM-TCH genomic disorders, obesity, cholesterol