This document discusses political economy factors that influence policy reform. It identifies common constraints to reform like collective action problems, lack of trust, rent-seeking, delegation problems, and institutional manipulation. Specific constraints discussed include motivational problems from misaligned individual and group incentives, information asymmetries, and conflicting interests between policy principals and their agents. The document proposes solutions to these constraints like leadership, communication, bundling reforms together, properly choosing the timing and sequencing of reforms, and controlling the policy agenda.